DE59405410D1 - Tetrazolderivate von Gallebnsäuren, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel - Google Patents

Tetrazolderivate von Gallebnsäuren, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel

Info

Publication number
DE59405410D1
DE59405410D1 DE59405410T DE59405410T DE59405410D1 DE 59405410 D1 DE59405410 D1 DE 59405410D1 DE 59405410 T DE59405410 T DE 59405410T DE 59405410 T DE59405410 T DE 59405410T DE 59405410 D1 DE59405410 D1 DE 59405410D1
Authority
DE
Germany
Prior art keywords
compounds
preparation
medicaments
tetrazole derivatives
gallic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59405410T
Other languages
German (de)
English (en)
Inventor
Alfons Dr Enhsen
Heiner Dr Glombik
Werner Dr Dr Kramer
Guenter Dr Wess
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE59405410T priority Critical patent/DE59405410D1/de
Application granted granted Critical
Publication of DE59405410D1 publication Critical patent/DE59405410D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE59405410T 1993-05-08 1994-05-02 Tetrazolderivate von Gallebnsäuren, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel Expired - Lifetime DE59405410D1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE59405410T DE59405410D1 (de) 1993-05-08 1994-05-02 Tetrazolderivate von Gallebnsäuren, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4315368 1993-05-08
DE59405410T DE59405410D1 (de) 1993-05-08 1994-05-02 Tetrazolderivate von Gallebnsäuren, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel

Publications (1)

Publication Number Publication Date
DE59405410D1 true DE59405410D1 (de) 1998-04-16

Family

ID=6487579

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59405410T Expired - Lifetime DE59405410D1 (de) 1993-05-08 1994-05-02 Tetrazolderivate von Gallebnsäuren, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen als Arzneimittel

Country Status (19)

Country Link
US (1) US5466815A (enExample)
EP (1) EP0624596B1 (enExample)
JP (1) JP3476157B2 (enExample)
KR (1) KR100333149B1 (enExample)
AT (1) ATE163938T1 (enExample)
AU (1) AU666440B2 (enExample)
CA (1) CA2123048C (enExample)
CY (1) CY2119B1 (enExample)
CZ (1) CZ289515B6 (enExample)
DE (1) DE59405410D1 (enExample)
DK (1) DK0624596T3 (enExample)
ES (1) ES2115096T3 (enExample)
FI (1) FI942075L (enExample)
GR (1) GR3026496T3 (enExample)
HU (1) HU217439B (enExample)
IL (1) IL109581A (enExample)
NO (1) NO304795B1 (enExample)
NZ (1) NZ260469A (enExample)
TW (1) TW289757B (enExample)

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EP2459581A4 (en) * 2009-07-29 2012-12-26 Univ Chicago LIVER X-RECEPTOR AGONISTS
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PT4069360T (pt) 2019-12-04 2024-03-06 Albireo Ab Compostos de benzotia(di)azepina e a sua utilização como moduladores de ácido biliar
CN114761018B (zh) 2019-12-04 2025-12-02 阿尔比里奥公司 苯并硫杂二氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
AR120674A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzotiazepina y su uso como ácido biliar
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
CN116157389B (zh) 2020-08-03 2026-02-10 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
JP2023549226A (ja) 2020-11-12 2023-11-22 アルビレオ エービー 進行性家族性肝内胆汁うっ滞症（ｐｆｉｃ）を処置するためのオデビキシバット
WO2022117778A1 (en) 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
JP2025516153A (ja) 2022-04-22 2025-05-27 アルビレオ・アクチボラグ Ａｓｂｔ阻害剤の皮下投与
AU2023285002A1 (en) 2022-06-09 2024-12-05 Albireo Ab Treating hepatitis
KR20250022070A (ko) * 2022-06-09 2025-02-14 산동 루예 파마슈티칼 컴파니 리미티드 19-노르 c3,3-이치환된 c21-아자헤테로고리 치환 스테로이드 및 이의 사용 방법
US20240067617A1 (en) 2022-07-05 2024-02-29 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
US20240207286A1 (en) 2022-12-09 2024-06-27 Albireo Ab Asbt inhibitors in the treatment of renal diseases
WO2025119319A1 (zh) * 2023-12-08 2025-06-12 山东绿叶制药有限公司 一种gabaa受体调节剂的晶型及其制备方法和应用
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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
US5250524A (en) * 1990-12-06 1993-10-05 Hoechst Aktiengesellschaft Bile acid derivatives, process for their preparation and use of these compounds as pharmaceuticals

Also Published As

Publication number Publication date
CZ113594A3 (en) 1994-12-15
HU217439B (hu) 2000-01-28
CY2119B1 (en) 2002-04-26
CA2123048C (en) 2005-11-29
IL109581A (en) 1998-03-10
HUT67390A (en) 1995-04-28
IL109581A0 (en) 1994-08-26
US5466815A (en) 1995-11-14
NO304795B1 (no) 1999-02-15
ATE163938T1 (de) 1998-03-15
NO941677D0 (no) 1994-05-06
AU6194794A (en) 1994-11-10
NZ260469A (en) 1995-03-28
EP0624596A2 (de) 1994-11-17
TW289757B (enExample) 1996-11-01
EP0624596B1 (de) 1998-03-11
FI942075A0 (fi) 1994-05-05
CZ289515B6 (cs) 2002-02-13
NO941677L (no) 1994-11-09
DK0624596T3 (da) 1998-10-07
KR100333149B1 (ko) 2002-09-19
FI942075A7 (fi) 1994-11-09
ES2115096T3 (es) 1998-06-16
JPH06329695A (ja) 1994-11-29
FI942075L (fi) 1994-11-09
HU9401443D0 (en) 1994-08-29
JP3476157B2 (ja) 2003-12-10
CA2123048A1 (en) 1994-11-09
EP0624596A3 (de) 1995-06-07
AU666440B2 (en) 1996-02-08
GR3026496T3 (en) 1998-07-31

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