KR100306946B1 - 17-b-에스트라디올방출용경피치료시스템및이것의제조방법 - Google Patents

17-b-에스트라디올방출용경피치료시스템및이것의제조방법 Download PDF

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Publication number
KR100306946B1
KR100306946B1 KR1019950701791A KR19950701791A KR100306946B1 KR 100306946 B1 KR100306946 B1 KR 100306946B1 KR 1019950701791 A KR1019950701791 A KR 1019950701791A KR 19950701791 A KR19950701791 A KR 19950701791A KR 100306946 B1 KR100306946 B1 KR 100306946B1
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KR
South Korea
Prior art keywords
estradiol
layer
relative humidity
matrix
active ingredient
Prior art date
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Expired - Lifetime
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KR1019950701791A
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English (en)
Korean (ko)
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KR950703940A (ko
Inventor
미하엘호르스트만
질피아한
라인홀트메코니
로베르트-페터클라인
Original Assignee
베어 프랑크, 베슬링 베르너
에르테에스 로만 테라피-시스테메 게엠베하 운트 코.카게
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6472230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100306946(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 베어 프랑크, 베슬링 베르너, 에르테에스 로만 테라피-시스테메 게엠베하 운트 코.카게 filed Critical 베어 프랑크, 베슬링 베르너
Publication of KR950703940A publication Critical patent/KR950703940A/ko
Application granted granted Critical
Publication of KR100306946B1 publication Critical patent/KR100306946B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
KR1019950701791A 1992-11-06 1993-10-27 17-b-에스트라디올방출용경피치료시스템및이것의제조방법 Expired - Lifetime KR100306946B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP4237453.7 1992-11-06
DE4237453A DE4237453C1 (enExample) 1992-11-06 1992-11-06
PCT/EP1993/002971 WO1994010984A1 (de) 1992-11-06 1993-10-27 TRANSDERMALES THERAPEUTISCHES SYSTEM ZUR ABGABE VON 17-β-ESTRADIOL UND VERFAHREN ZU SEINER HERSTELLUNG

Publications (2)

Publication Number Publication Date
KR950703940A KR950703940A (ko) 1995-11-17
KR100306946B1 true KR100306946B1 (ko) 2002-04-24

Family

ID=6472230

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019950701791A Expired - Lifetime KR100306946B1 (ko) 1992-11-06 1993-10-27 17-b-에스트라디올방출용경피치료시스템및이것의제조방법

Country Status (24)

Country Link
US (1) US5912008A (enExample)
EP (1) EP0716599B1 (enExample)
JP (1) JP3237016B2 (enExample)
KR (1) KR100306946B1 (enExample)
AT (1) ATE164516T1 (enExample)
AU (1) AU678408B2 (enExample)
CA (1) CA2147172C (enExample)
CZ (1) CZ286907B6 (enExample)
DE (2) DE4237453C1 (enExample)
DK (1) DK0716599T3 (enExample)
ES (1) ES2117152T3 (enExample)
FI (1) FI113339B (enExample)
HR (1) HRP931360B1 (enExample)
HU (1) HU221847B1 (enExample)
IL (1) IL107395A (enExample)
MY (1) MY118171A (enExample)
NO (1) NO311783B1 (enExample)
NZ (1) NZ257137A (enExample)
PL (1) PL174604B1 (enExample)
SI (1) SI9300581A (enExample)
SK (1) SK279911B6 (enExample)
WO (1) WO1994010984A1 (enExample)
YU (1) YU69693A (enExample)
ZA (1) ZA938257B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69003632T2 (de) * 1989-02-28 1994-02-17 Teijin Ltd Pflaster sowie dessen herstellung.
ATE163262T1 (de) * 1993-04-20 1998-03-15 Hexal Ag Wirkstoffplaster
DE4429664C2 (de) * 1994-08-20 1997-09-11 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
US5906830A (en) * 1995-09-08 1999-05-25 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
DE19600347A1 (de) * 1996-01-08 1997-07-10 Lohmann Therapie Syst Lts Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus
DE19701949A1 (de) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
DE19827732A1 (de) * 1998-06-22 1999-12-23 Rottapharm Bv Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie
JP4399044B2 (ja) * 1998-10-14 2010-01-13 久光製薬株式会社 吸収促進剤及び該吸収促進剤を有してなる経皮吸収製剤
US6631186B1 (en) * 1999-04-09 2003-10-07 Sbc Technology Resources, Inc. System and method for implementing and accessing call forwarding services
DE19925613A1 (de) * 1999-06-04 2000-12-07 Lohmann Therapie Syst Lts Verbundlaminat und Verfahren zu seiner Herstellung
ITRM20060440A1 (it) * 2006-08-10 2008-02-11 Carmine Antropoli Uso della nifedipina per il trattamento antirughe
US20100087768A1 (en) * 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
DE102010026903A1 (de) 2010-07-12 2012-01-12 Amw Gmbh Transdermales therapeutisches System mit Avocadoöl oder Palmöl als Hilfsstoff
ES2804263T3 (es) 2011-07-05 2021-02-05 Novan Inc Composiciones tópicas
WO2013006613A1 (en) 2011-07-05 2013-01-10 Novan, Inc. Methods of manufacturing topical compositions and apparatus for same
DE102012000369A1 (de) 2012-01-11 2013-07-11 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Transdermales therapeutisches System mit Cholinesterase-Hemmer
US9855211B2 (en) 2013-02-28 2018-01-02 Novan, Inc. Topical compositions and methods of using the same
US10322082B2 (en) 2014-07-11 2019-06-18 Novan, Inc. Topical antiviral compositions and methods of using the same
JP6651499B2 (ja) 2014-07-11 2020-02-19 ノヴァン，インコーポレイテッド 局所用抗ウイルス薬組成物及びこれを使用する方法
EP3442502A4 (en) 2016-04-13 2019-11-06 Novan, Inc. COMPOSITIONS, SYSTEMS, KITS AND METHODS FOR TREATING INFECTIONS
DE102017127433A1 (de) 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag TTS auf Basis von klebenden Weichmacher-Polymer-Matrices

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421454A2 (de) * 1989-10-06 1991-04-10 LTS Lohmann Therapie-Systeme GmbH & Co. KG Oestrogenhaltiges Wirkstoffpflaster

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FR527450A (fr) * 1919-12-04 1921-10-25 Gilbert Mahaut Système et dispositif pour la combustion des huiles lourdes dans les foyers industriels et autres
US4435180A (en) * 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
GB2138286B (en) * 1983-04-19 1986-10-08 Dr Christopher Harry Mortimer Pharmaceutical composition for the treatment of hair loss
DE3587616D1 (de) * 1984-12-22 1993-11-11 Sanol Arznei Schwarz Gmbh Wirkstoffpflaster.
US5145682A (en) * 1986-05-30 1992-09-08 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration
US5023084A (en) * 1986-12-29 1991-06-11 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
FR2612785A1 (fr) * 1987-03-25 1988-09-30 Lhd Lab Hygiene Dietetique Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee
US4863738A (en) * 1987-11-23 1989-09-05 Alza Corporation Skin permeation enhancer compositions using glycerol monooleate
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
DE69003632T2 (de) * 1989-02-28 1994-02-17 Teijin Ltd Pflaster sowie dessen herstellung.
AU6712090A (en) * 1989-10-13 1991-05-16 Watson Laboratories, Inc. Drug delivery systems and matrix therefor
AR246186A1 (es) * 1989-11-17 1994-07-29 Beta Pharm Co Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.
DE4002281A1 (de) * 1990-01-26 1991-08-01 Lohmann Therapie Syst Lts Transdermales therapeutisches system mit dem wirkstoff tulobuterol
AU633733B2 (en) * 1990-05-17 1993-02-04 Hisamitsu Pharmaceutical Co., Inc. Percutaneous preparation containing estradiol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0421454A2 (de) * 1989-10-06 1991-04-10 LTS Lohmann Therapie-Systeme GmbH & Co. KG Oestrogenhaltiges Wirkstoffpflaster

Also Published As

Publication number Publication date
CA2147172A1 (en) 1994-05-26
DE59308360D1 (de) 1998-05-07
EP0716599B1 (de) 1998-04-01
SI9300581A (en) 1994-06-30
NO311783B1 (no) 2002-01-28
HUT71681A (en) 1996-01-29
FI952115A0 (fi) 1995-05-03
PL308532A1 (en) 1995-08-21
FI113339B (fi) 2004-04-15
PL174604B1 (pl) 1998-08-31
CZ286907B6 (en) 2000-08-16
WO1994010984A1 (de) 1994-05-26
SK58095A3 (en) 1995-11-08
AU5338694A (en) 1994-06-08
HU221847B1 (hu) 2003-02-28
NO951765L (no) 1995-05-05
IL107395A (en) 1997-08-14
HRP931360B1 (en) 1999-12-31
ES2117152T3 (es) 1998-08-01
MY118171A (en) 2004-09-30
NZ257137A (en) 1996-09-25
EP0716599A1 (de) 1996-06-19
AU678408B2 (en) 1997-05-29
CZ116295A3 (en) 1995-12-13
HU9501318D0 (en) 1995-06-28
US5912008A (en) 1999-06-15
FI952115L (fi) 1995-05-03
SK279911B6 (sk) 1999-05-07
YU69693A (sh) 1997-07-31
JP3237016B2 (ja) 2001-12-10
IL107395A0 (en) 1994-01-25
CA2147172C (en) 2003-12-23
HRP931360A2 (en) 1995-02-28
KR950703940A (ko) 1995-11-17
DK0716599T3 (da) 1999-01-11
ZA938257B (en) 1994-06-08
DE4237453C1 (enExample) 1993-08-19
ATE164516T1 (de) 1998-04-15
JPH08502987A (ja) 1996-04-02
NO951765D0 (no) 1995-05-05

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EXPY Expiration of term
PC1801 Expiration of term

Termination date: 20140427

Termination category: Expiration of duration