AR246186A1 - Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. - Google Patents
Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.Info
- Publication number
- AR246186A1 AR246186A1 AR89315479A AR31547989A AR246186A1 AR 246186 A1 AR246186 A1 AR 246186A1 AR 89315479 A AR89315479 A AR 89315479A AR 31547989 A AR31547989 A AR 31547989A AR 246186 A1 AR246186 A1 AR 246186A1
- Authority
- AR
- Argentina
- Prior art keywords
- estradiol
- procedure
- manufacturing
- aives
- pressure sensitive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PROCEDIMIENTO PARA FABRICAR EL DISPOSITIVO DE ADMINISTRACION DE ESTRADIOL POR VIA TRANSDERMAL, QUE COMPRENDE: A) DEPOSITAR UN REVESTIMIENTO ADHESIVO SENSIBLE A LA PRESION, SOBRE UNA PELICULA FLEXIBLE, RECUBIERTA CON SILICONA, QUE COMPRENDE: A) DEPOSITAR UN REVESTIMIENTO ADHESIVO SENSIBLE A LA PRESION, SOBRE UNA PELICULA FLEXIBLE, RECUBIERTA CON SILICONA, QUE COMPRENDE: UNA COMPOSICION ADHESIVA SENSIBLE A LA PRESION DERMATOLOGICAMENTE ACEPTABLE, EN LA QUE SE ENCUENTRA HOMOGENEAMENTE DISTRIBUIDO ESTRADIOL, COMO AGENTE FARMACOLOGICAMENTE ACTIVO Y UN COMPONENTE BINARIO INCREMENTADOR DE LA VELOCIDAD DE PERMEACION DEL ESTRADIOL, QUE TIENE DE 1 A 20% DE ACIDOS GRASOS NO SATURADOS (C12-C18), O SUS ESTERES DE ALQUILO Y DE 5 A 30% DE GLICERINA O ALQUILEN (C3-C6) 1,2- DIOLES, CORRESPONDIENDO LOS VALORES A PARTES EN PESO POR CADA 100 PARTES DE RECUBRIMIENTO ADHESIVO, ESTANDO EL CONTENIDO DE ESTRADIOL EN EXCESO SOBRE LA CONCENTRACION DE SATURACION EN LA COMPOSICION ADHESIVA:B) CUBRIR EL REVESTI MIENTO CON UNA LAMINA FLEXIBLE; Y C) CORTAR LA ESTRUCTURA DE CARGAS SUPERPUESTAS ASI FORMADA, EN PORCIONES DE FORMA Y DIMENSIONES DETERMINADAS.
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AR89315479A AR246186A1 (es) | 1989-11-17 | 1989-11-17 | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
AT90312435T ATE106753T1 (de) | 1989-11-17 | 1990-11-14 | Gegenstand für die transdermale applikation von estradiol und verfahren zur herstellung eines solchen gegenstandes. |
ES90312435T ES2057442T5 (es) | 1989-11-17 | 1990-11-14 | Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo. |
DK90312435T DK0430491T4 (da) | 1989-11-17 | 1990-11-14 | Transdermalt afgivelsesorgan for estradiol og fremgangsmåde til fremstilling af organet |
DE69009697T DE69009697T3 (de) | 1989-11-17 | 1990-11-14 | Gegenstand für die transdermale Applikation von Estradiol und Verfahren zur Herstellung eines solchen Gegenstandes. |
EP90312435A EP0430491B2 (en) | 1989-11-17 | 1990-11-14 | Transdermal delivery device for estradiol and process for manufacturing said device |
MX023357A MX171907B (es) | 1989-11-17 | 1990-11-16 | Dispositivo para administrar estradiol por via transdermica y procedimiento para fibricar dicho dispositivo |
BR909005908A BR9005908A (pt) | 1989-11-17 | 1990-11-16 | Aparelho transdermico de distribuicao para o estradiol e processo para fabricacao do aparelho |
JP2312573A JPH03227920A (ja) | 1989-11-17 | 1990-11-17 | エストラジオールのための経皮デリバリー装置および該装置の製法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AR89315479A AR246186A1 (es) | 1989-11-17 | 1989-11-17 | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR246186A1 true AR246186A1 (es) | 1994-07-29 |
Family
ID=3478739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR89315479A AR246186A1 (es) | 1989-11-17 | 1989-11-17 | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0430491B2 (es) |
JP (1) | JPH03227920A (es) |
AR (1) | AR246186A1 (es) |
AT (1) | ATE106753T1 (es) |
BR (1) | BR9005908A (es) |
DE (1) | DE69009697T3 (es) |
DK (1) | DK0430491T4 (es) |
ES (1) | ES2057442T5 (es) |
MX (1) | MX171907B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4210165A1 (de) * | 1991-07-30 | 1993-02-04 | Schering Ag | Transdermale therapeutische systeme |
JP2960832B2 (ja) * | 1992-05-08 | 1999-10-12 | ペルマテック テクノロジー アクチェンゲゼルシャフト | エストラジオールの投与システム |
DE4237453C1 (es) * | 1992-11-06 | 1993-08-19 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
DE4400770C1 (de) * | 1994-01-13 | 1995-02-02 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung |
GR1002079B (en) * | 1994-07-26 | 1995-12-05 | Lavipharm A E | System of a special structure and composition for the rapid transdermal administration of oestrogens. |
DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
GB9720470D0 (en) | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
US5968919A (en) * | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
DE19815060A1 (de) * | 1998-04-03 | 1999-10-14 | Jenapharm Gmbh | Pharmazeutische Präparate zur Therapie von Nebenwirkungen während und/oder nach einer GnRHa-Therapie |
SE9801704D0 (sv) | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
DE10003397A1 (de) * | 2000-01-27 | 2001-08-09 | Hartmann Paul Ag | Polyelektrolyt-Feststoffsystem, Verfahren zur Herstellung desselben sowie Wundverband |
DE10019171A1 (de) * | 2000-04-07 | 2001-10-18 | Schering Ag | Zusammensetzungen zur Verwendung als Penetrationsverstärker in transdermalen Formulierungen für hoch lipophile Wirkstoffe |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
US4994267A (en) † | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
WO1990006120A1 (en) * | 1988-12-01 | 1990-06-14 | Schering Corporation | Compositions for transdermal delivery of estradiol |
-
1989
- 1989-11-17 AR AR89315479A patent/AR246186A1/es active
-
1990
- 1990-11-14 DE DE69009697T patent/DE69009697T3/de not_active Expired - Fee Related
- 1990-11-14 ES ES90312435T patent/ES2057442T5/es not_active Expired - Lifetime
- 1990-11-14 DK DK90312435T patent/DK0430491T4/da active
- 1990-11-14 AT AT90312435T patent/ATE106753T1/de not_active IP Right Cessation
- 1990-11-14 EP EP90312435A patent/EP0430491B2/en not_active Expired - Lifetime
- 1990-11-16 BR BR909005908A patent/BR9005908A/pt not_active Application Discontinuation
- 1990-11-16 MX MX023357A patent/MX171907B/es unknown
- 1990-11-17 JP JP2312573A patent/JPH03227920A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69009697T2 (de) | 1994-12-22 |
DE69009697D1 (de) | 1994-07-14 |
DK0430491T4 (da) | 2001-01-02 |
ATE106753T1 (de) | 1994-06-15 |
ES2057442T3 (es) | 1994-10-16 |
EP0430491A2 (en) | 1991-06-05 |
ES2057442T5 (es) | 2001-02-16 |
JPH03227920A (ja) | 1991-10-08 |
DE69009697T3 (de) | 2001-02-22 |
MX171907B (es) | 1993-11-23 |
EP0430491B2 (en) | 2000-10-25 |
EP0430491A3 (en) | 1991-12-27 |
EP0430491B1 (en) | 1994-06-08 |
BR9005908A (pt) | 1991-09-24 |
DK0430491T3 (da) | 1994-09-19 |
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