ES2070401T3 - Preparacion para la administracion transdermica de farmacos. - Google Patents

Preparacion para la administracion transdermica de farmacos.

Info

Publication number
ES2070401T3
ES2070401T3 ES91120100T ES91120100T ES2070401T3 ES 2070401 T3 ES2070401 T3 ES 2070401T3 ES 91120100 T ES91120100 T ES 91120100T ES 91120100 T ES91120100 T ES 91120100T ES 2070401 T3 ES2070401 T3 ES 2070401T3
Authority
ES
Spain
Prior art keywords
skin
adhesive layer
preparation
pressure
proportion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91120100T
Other languages
English (en)
Inventor
Sunami Masaki
Maruyama C O Nitto Denko Koji
Hori C O Nitto Denko Mitsuhiko
Tokuda C O Nitto Denko Shoichi
Saito C O Nitto Denk Kenichiro
Kishi Ikuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Japan Inc
Nitto Denko Corp
Original Assignee
Lederle Japan Ltd
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd, Nitto Denko Corp filed Critical Lederle Japan Ltd
Application granted granted Critical
Publication of ES2070401T3 publication Critical patent/ES2070401T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN PREPARADO PARA ADMINISTRAR UNA DROGA A TRAVES DE LA PIEL QUE COMPRENDE UNA CAPA DE SOPORTE FLEXIBLE Y OTRA CAPA ADHESIVA SENSIBLE A LA PRESION QUE CONTIENE UN ANESTESICO LOCAL EN UNA PROPORCION DEL 40 AL 65% DE SU PESO. YA QUE LA PROPORCION DE LA CANTIDAD DE ANESTESICO LOCAL NO DISUELTO (AC) A AQUEL ANESTESICO LOCAL DISUELTO (AS), AC/AS, EN LA CAPA ADHESIVA SENSIBLE A LA PRESION SE DETERMINA PARA QUE ESTE EN LA GAMA DE 0.1 A 1.8, EL PREPARADO PARA LA ADMINISTRACION DE DROGAS A TRAVES DE LA PIEL DE LA INVENCION ACTUAL ES SUPERIOR EN AUTO-ADHESIVIDAD Y NO DEJA RESTOS DE MATERIAL ADHESIVO UNA VEZ QUE SE RETIRA DE LA PIEL. ADEMAS, LA RETIRADA RAPIDA DE LA DROGA NO DISUELTA DE LA CAPA ADHESIVA SENSIBLE A LA PRESION INMEDIATAMENTE DESPUES DE SU APLICACION A LA PIEL PERMITE LA RAPIDA APARICION DE LOS EFECTOS DE LA ANESTESIA, QUE PERMITEN APLICACIONES CLINICAS AMPLIAS DE LOS PREPARADOS DE LA INVENCION ACTUAL
ES91120100T 1990-11-30 1991-11-26 Preparacion para la administracion transdermica de farmacos. Expired - Lifetime ES2070401T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2338885A JP2849950B2 (ja) 1990-11-30 1990-11-30 経皮吸収製剤

Publications (1)

Publication Number Publication Date
ES2070401T3 true ES2070401T3 (es) 1995-06-01

Family

ID=18322294

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91120100T Expired - Lifetime ES2070401T3 (es) 1990-11-30 1991-11-26 Preparacion para la administracion transdermica de farmacos.

Country Status (10)

Country Link
US (1) US5368860A (es)
EP (1) EP0488137B1 (es)
JP (1) JP2849950B2 (es)
KR (1) KR0185715B1 (es)
AT (1) ATE120642T1 (es)
CA (1) CA2056653C (es)
DE (1) DE69108683T2 (es)
DK (1) DK0488137T3 (es)
ES (1) ES2070401T3 (es)
TW (1) TW198692B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3970993A (en) * 1992-03-30 1993-11-08 Alza Corporation Polymer system containing a partially soluble compound
WO1996008229A2 (en) 1994-09-14 1996-03-21 Minnesota Mining And Manufacturing Company Matrix for transdermal drug delivery
US5573778A (en) * 1995-03-17 1996-11-12 Adhesives Research, Inc. Drug flux enhancer-tolerant pressure sensitive adhesive composition
DE19524691A1 (de) * 1995-07-06 1997-01-09 Liedtke Pharmed Gmbh Methode und Zusammensetzung einer topischen Therapie von Innenohr und Labyrinth-Symptomen
US5667799A (en) * 1995-10-30 1997-09-16 Caldwell; Larry J. Method for treating headache pain with topical local anesthetic compositions
DE19546159A1 (de) * 1995-12-11 1997-06-12 Liedtke Pharmed Gmbh Methode und Zusammensetzung einer topisch wirksamen Therapie postoperativer und posttraumatischer Wundschmerzen
US5985317A (en) * 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
US6365178B1 (en) * 1996-09-06 2002-04-02 Watson Pharmaceuticals, Inc. Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions
US6103771A (en) * 1998-03-20 2000-08-15 Caldwell Galer Incorporated Method of treating neuroma pain
WO2000024386A1 (en) * 1998-09-08 2000-05-04 Theratech, Inc. Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs
WO2001064149A1 (en) * 2000-02-29 2001-09-07 Jie Zhang Improved transdermal drug patch
US7842007B2 (en) 2004-04-30 2010-11-30 Clawson Burrell E Apparatus and methods for isolating human body areas for localized cooling
US7666914B2 (en) * 2004-06-03 2010-02-23 Richlin David M Topical preparation and method for transdermal delivery and localization of therapeutic agents
WO2006037047A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The r-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
WO2006036936A2 (en) * 2004-09-27 2006-04-06 Bridge Pharma, Inc. The s-isomer of 2-{2-[n-(2-indanyl)-n-phenylamino]ethyl}piperidine and other dermal anesthetic agents
JP2006248996A (ja) * 2005-03-10 2006-09-21 Nitto Denko Corp 経皮吸収型貼付剤
CA2655809C (en) * 2006-07-21 2013-10-01 Bridge Pharma, Inc. Dermal anesthetic compounds
PT2117521E (pt) 2006-11-03 2012-09-10 Durect Corp Sistemas de administração transdérmica que compreendem bupivacaína
AU2009298411B2 (en) 2008-10-02 2013-06-06 Mylan Inc. Method of making a multilayer adhesive laminate
KR101080380B1 (ko) 2009-08-14 2011-11-04 한국수력원자력 주식회사 접착력이 향상된 수화겔 접착용 필름 및 이의 제조방법
AU2016259348B9 (en) * 2010-04-13 2018-11-29 Relmada Therapeutics, Inc. Dermal pharmaceutical compositions of 1-Methyl-2',6' pipecoloxylidide and method of use
JP5927506B2 (ja) * 2010-04-13 2016-06-01 レルマダ セラピューティクス、インク． １−メチル−２’，６’−ピペコロキシリダイドの皮膚医薬組成物および使用方法
DE102011100619A1 (de) 2010-05-05 2012-01-05 Amw Gmbh Transdermales therapeutisches System (TTS) mit einem Gehalt an einem Opiod-Analgetikum
CN106714827A (zh) * 2014-10-02 2017-05-24 日东电工株式会社 经皮给药用疫苗药物组合物
CN109316469B (zh) * 2018-10-09 2022-02-22 北京德默高科医药技术有限公司 一种稳定的高载药利多卡因透皮贴剂及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58148815A (ja) * 1982-02-26 1983-09-05 Nitto Electric Ind Co Ltd 複合医薬製剤の製法
ATE42901T1 (de) * 1984-03-05 1989-05-15 Nitto Denko Corp Haftendes arzneimittelpraeparat fuer perkutane absorption.
US4655768A (en) * 1984-07-06 1987-04-07 Avery International Corporation Bandage for sustained delivery of drugs
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
EP0331392A3 (en) * 1988-03-01 1990-02-14 Alza Corporation Anesthesia and antisepsis of the skin
AU611307B2 (en) * 1988-06-09 1991-06-06 Alza Corporation Permeation enhancer comprising ethanol and glycerol monooleate
US5120325A (en) * 1991-06-12 1992-06-09 Fleshtones Products Co., Inc. Color-matched sterile adhesive bandages containing melanin-like pigment composition

Also Published As

Publication number Publication date
CA2056653C (en) 2000-08-08
KR0185715B1 (ko) 1999-05-01
CA2056653A1 (en) 1992-05-31
EP0488137A3 (en) 1993-02-03
DE69108683D1 (de) 1995-05-11
JP2849950B2 (ja) 1999-01-27
US5368860A (en) 1994-11-29
KR920009387A (ko) 1992-06-25
JPH04208229A (ja) 1992-07-29
TW198692B (es) 1993-01-21
EP0488137B1 (en) 1995-04-05
DK0488137T3 (da) 1995-08-28
DE69108683T2 (de) 1995-10-05
ATE120642T1 (de) 1995-04-15
EP0488137A2 (en) 1992-06-03

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