ES2057442T3 - Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo. - Google Patents

Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo.

Info

Publication number
ES2057442T3
ES2057442T3 ES90312435T ES90312435T ES2057442T3 ES 2057442 T3 ES2057442 T3 ES 2057442T3 ES 90312435 T ES90312435 T ES 90312435T ES 90312435 T ES90312435 T ES 90312435T ES 2057442 T3 ES2057442 T3 ES 2057442T3
Authority
ES
Spain
Prior art keywords
sub
estradiol
weight
flexible substrate
supply
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90312435T
Other languages
English (en)
Other versions
ES2057442T5 (es
Inventor
Francisco Jose Evarist Stefano
Jose Adrian Nowogrodski
Dario Norberto Ramon Carrara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beta Pharmaceuticals Co
Original Assignee
Beta Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3478739&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2057442(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beta Pharmaceuticals Co filed Critical Beta Pharmaceuticals Co
Publication of ES2057442T3 publication Critical patent/ES2057442T3/es
Application granted granted Critical
Publication of ES2057442T5 publication Critical patent/ES2057442T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

UN DISPOSITIVO DE LANZAMIENTO TRANSDERMICO PARA ESTRADIOL COMPRENDE UN SUSTRATO FLEXIBLE Y UNA PELICULA PROTECTORA FUNCIONAL. LA SUPERFICIE PROTEGIDA DEL SUSTRATO FLEXIBLE ESTA AL MENOS PARCIALMENTE CUBIERTA CON UN REVESTIMIENTO QUE CONTIENE (A) UN MATERIAL ADHESIVO SENSITIVO PRESURIZADO DERMATOLOGICAMENTE ACEPTABLE PARA ASEGURAR EL DISPOSITIVO A LA PIEL, (B) ESTRADIOL HOMOGENEAMENTE DISTRIBUIDO COMO INGREDIENTE ACTIVO FARMACOLOGICAMENTE Y (C) UN COMPONENTE QUE ELEVA EL PROMEDIO DE PERMEACION DEL ESTRADIOL Y QUE COMPRENDE DE UN 1 A UN 20% POR PESO DE AL MENOS UN PRIMER COMPUESTO SELECCIONADO DE ACIDOS GRASOS NO-SATURADOS (C SUB 12-C18) Y ESTEROS ALKIL DE ESOS, Y DE UN 5 A UN 30% POR PESO DE AL MENOS UN SEGUNDO COMPUESTO SELECCIONADO DE GLICERINA Y (C SUB 3-C SUB 6) ALKILENO 1,2 DIOLOS, LOS PORCENTAJES SE BASAN EN EL PESO TOTAL DEL MENCIONADO REVESTIMIENTO. SE DESCRIBE TAMBIEN UN PROCESO PARA LA MANUFACTURACION DE TAL DISPOSITIVO .
ES90312435T 1989-11-17 1990-11-14 Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo. Expired - Lifetime ES2057442T5 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR89315479A AR246186A1 (es) 1989-11-17 1989-11-17 Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.

Publications (2)

Publication Number Publication Date
ES2057442T3 true ES2057442T3 (es) 1994-10-16
ES2057442T5 ES2057442T5 (es) 2001-02-16

Family

ID=3478739

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90312435T Expired - Lifetime ES2057442T5 (es) 1989-11-17 1990-11-14 Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo.

Country Status (9)

Country Link
EP (1) EP0430491B2 (es)
JP (1) JPH03227920A (es)
AR (1) AR246186A1 (es)
AT (1) ATE106753T1 (es)
BR (1) BR9005908A (es)
DE (1) DE69009697T3 (es)
DK (1) DK0430491T4 (es)
ES (1) ES2057442T5 (es)
MX (1) MX171907B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4210165A1 (de) * 1991-07-30 1993-02-04 Schering Ag Transdermale therapeutische systeme
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
DE4237453C1 (es) * 1992-11-06 1993-08-19 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
GR1002079B (en) * 1994-07-26 1995-12-05 Lavipharm A E System of a special structure and composition for the rapid transdermal administration of oestrogens.
DE4429667C2 (de) * 1994-08-20 1996-07-11 Lohmann Therapie Syst Lts Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
GB9720470D0 (en) 1997-09-25 1997-11-26 Ethical Pharmaceuticals South Inhibition of crystallization in transdermal devices
US5968919A (en) * 1997-10-16 1999-10-19 Macrochem Corporation Hormone replacement therapy drug formulations for topical application to the skin
DE19815060A1 (de) * 1998-04-03 1999-10-14 Jenapharm Gmbh Pharmazeutische Präparate zur Therapie von Nebenwirkungen während und/oder nach einer GnRHa-Therapie
SE9801704D0 (sv) 1998-05-14 1998-05-14 Bioglan Ab Biologically active composition
DE10003397A1 (de) 2000-01-27 2001-08-09 Hartmann Paul Ag Polyelektrolyt-Feststoffsystem, Verfahren zur Herstellung desselben sowie Wundverband
DE10019171A1 (de) * 2000-04-07 2001-10-18 Schering Ag Zusammensetzungen zur Verwendung als Penetrationsverstärker in transdermalen Formulierungen für hoch lipophile Wirkstoffe

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US4908389A (en) * 1986-08-27 1990-03-13 Warner-Lambert Company Penetration enhancement system
US4994267A (en) † 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
AU4745390A (en) * 1988-12-01 1990-06-26 Schering Corporation Compositions for transdermal delivery of estradiol

Also Published As

Publication number Publication date
MX171907B (es) 1993-11-23
EP0430491A3 (en) 1991-12-27
DE69009697T2 (de) 1994-12-22
ATE106753T1 (de) 1994-06-15
DK0430491T4 (da) 2001-01-02
AR246186A1 (es) 1994-07-29
EP0430491A2 (en) 1991-06-05
ES2057442T5 (es) 2001-02-16
EP0430491B1 (en) 1994-06-08
DE69009697T3 (de) 2001-02-22
BR9005908A (pt) 1991-09-24
DK0430491T3 (da) 1994-09-19
DE69009697D1 (de) 1994-07-14
EP0430491B2 (en) 2000-10-25
JPH03227920A (ja) 1991-10-08

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