ES2057442T3 - Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo. - Google Patents
Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo.Info
- Publication number
- ES2057442T3 ES2057442T3 ES90312435T ES90312435T ES2057442T3 ES 2057442 T3 ES2057442 T3 ES 2057442T3 ES 90312435 T ES90312435 T ES 90312435T ES 90312435 T ES90312435 T ES 90312435T ES 2057442 T3 ES2057442 T3 ES 2057442T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- estradiol
- weight
- flexible substrate
- supply
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
UN DISPOSITIVO DE LANZAMIENTO TRANSDERMICO PARA ESTRADIOL COMPRENDE UN SUSTRATO FLEXIBLE Y UNA PELICULA PROTECTORA FUNCIONAL. LA SUPERFICIE PROTEGIDA DEL SUSTRATO FLEXIBLE ESTA AL MENOS PARCIALMENTE CUBIERTA CON UN REVESTIMIENTO QUE CONTIENE (A) UN MATERIAL ADHESIVO SENSITIVO PRESURIZADO DERMATOLOGICAMENTE ACEPTABLE PARA ASEGURAR EL DISPOSITIVO A LA PIEL, (B) ESTRADIOL HOMOGENEAMENTE DISTRIBUIDO COMO INGREDIENTE ACTIVO FARMACOLOGICAMENTE Y (C) UN COMPONENTE QUE ELEVA EL PROMEDIO DE PERMEACION DEL ESTRADIOL Y QUE COMPRENDE DE UN 1 A UN 20% POR PESO DE AL MENOS UN PRIMER COMPUESTO SELECCIONADO DE ACIDOS GRASOS NO-SATURADOS (C SUB 12-C18) Y ESTEROS ALKIL DE ESOS, Y DE UN 5 A UN 30% POR PESO DE AL MENOS UN SEGUNDO COMPUESTO SELECCIONADO DE GLICERINA Y (C SUB 3-C SUB 6) ALKILENO 1,2 DIOLOS, LOS PORCENTAJES SE BASAN EN EL PESO TOTAL DEL MENCIONADO REVESTIMIENTO. SE DESCRIBE TAMBIEN UN PROCESO PARA LA MANUFACTURACION DE TAL DISPOSITIVO .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AR89315479A AR246186A1 (es) | 1989-11-17 | 1989-11-17 | Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2057442T3 true ES2057442T3 (es) | 1994-10-16 |
ES2057442T5 ES2057442T5 (es) | 2001-02-16 |
Family
ID=3478739
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90312435T Expired - Lifetime ES2057442T5 (es) | 1989-11-17 | 1990-11-14 | Dispositivo para el suministro de estradiol por via transdermal y proceso de fabricacion de dicho dispositivo. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0430491B2 (es) |
JP (1) | JPH03227920A (es) |
AR (1) | AR246186A1 (es) |
AT (1) | ATE106753T1 (es) |
BR (1) | BR9005908A (es) |
DE (1) | DE69009697T3 (es) |
DK (1) | DK0430491T4 (es) |
ES (1) | ES2057442T5 (es) |
MX (1) | MX171907B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4210165A1 (de) * | 1991-07-30 | 1993-02-04 | Schering Ag | Transdermale therapeutische systeme |
JP2960832B2 (ja) * | 1992-05-08 | 1999-10-12 | ペルマテック テクノロジー アクチェンゲゼルシャフト | エストラジオールの投与システム |
DE4237453C1 (es) * | 1992-11-06 | 1993-08-19 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
DE4400770C1 (de) * | 1994-01-13 | 1995-02-02 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung |
GR1002079B (en) * | 1994-07-26 | 1995-12-05 | Lavipharm A E | System of a special structure and composition for the rapid transdermal administration of oestrogens. |
DE4429667C2 (de) * | 1994-08-20 | 1996-07-11 | Lohmann Therapie Syst Lts | Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung |
GB9720470D0 (en) | 1997-09-25 | 1997-11-26 | Ethical Pharmaceuticals South | Inhibition of crystallization in transdermal devices |
US5968919A (en) * | 1997-10-16 | 1999-10-19 | Macrochem Corporation | Hormone replacement therapy drug formulations for topical application to the skin |
DE19815060A1 (de) * | 1998-04-03 | 1999-10-14 | Jenapharm Gmbh | Pharmazeutische Präparate zur Therapie von Nebenwirkungen während und/oder nach einer GnRHa-Therapie |
SE9801704D0 (sv) | 1998-05-14 | 1998-05-14 | Bioglan Ab | Biologically active composition |
DE10003397A1 (de) | 2000-01-27 | 2001-08-09 | Hartmann Paul Ag | Polyelektrolyt-Feststoffsystem, Verfahren zur Herstellung desselben sowie Wundverband |
DE10019171A1 (de) * | 2000-04-07 | 2001-10-18 | Schering Ag | Zusammensetzungen zur Verwendung als Penetrationsverstärker in transdermalen Formulierungen für hoch lipophile Wirkstoffe |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
US4994267A (en) † | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Transdermal acrylic multipolymer drug delivery system |
AU4745390A (en) * | 1988-12-01 | 1990-06-26 | Schering Corporation | Compositions for transdermal delivery of estradiol |
-
1989
- 1989-11-17 AR AR89315479A patent/AR246186A1/es active
-
1990
- 1990-11-14 ES ES90312435T patent/ES2057442T5/es not_active Expired - Lifetime
- 1990-11-14 AT AT90312435T patent/ATE106753T1/de not_active IP Right Cessation
- 1990-11-14 DE DE69009697T patent/DE69009697T3/de not_active Expired - Fee Related
- 1990-11-14 EP EP90312435A patent/EP0430491B2/en not_active Expired - Lifetime
- 1990-11-14 DK DK90312435T patent/DK0430491T4/da active
- 1990-11-16 MX MX023357A patent/MX171907B/es unknown
- 1990-11-16 BR BR909005908A patent/BR9005908A/pt not_active Application Discontinuation
- 1990-11-17 JP JP2312573A patent/JPH03227920A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MX171907B (es) | 1993-11-23 |
EP0430491A3 (en) | 1991-12-27 |
DE69009697T2 (de) | 1994-12-22 |
ATE106753T1 (de) | 1994-06-15 |
DK0430491T4 (da) | 2001-01-02 |
AR246186A1 (es) | 1994-07-29 |
EP0430491A2 (en) | 1991-06-05 |
ES2057442T5 (es) | 2001-02-16 |
EP0430491B1 (en) | 1994-06-08 |
DE69009697T3 (de) | 2001-02-22 |
BR9005908A (pt) | 1991-09-24 |
DK0430491T3 (da) | 1994-09-19 |
DE69009697D1 (de) | 1994-07-14 |
EP0430491B2 (en) | 2000-10-25 |
JPH03227920A (ja) | 1991-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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