KR100301093B1 - 인돌유도체,그제조방법및그의약용도 - Google Patents

인돌유도체,그제조방법및그의약용도 Download PDF

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Publication number
KR100301093B1
KR100301093B1 KR1019940701818A KR19940701818A KR100301093B1 KR 100301093 B1 KR100301093 B1 KR 100301093B1 KR 1019940701818 A KR1019940701818 A KR 1019940701818A KR 19940701818 A KR19940701818 A KR 19940701818A KR 100301093 B1 KR100301093 B1 KR 100301093B1
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KR
South Korea
Prior art keywords
epoxy
dihydroxy
didehydro
cyclopropylmethyl
hydroxy
Prior art date
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Expired - Fee Related
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KR1019940701818A
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English (en)
Korean (ko)
Inventor
나가세히로시
마주수나아키라
카와이코오지
나카타니이주미
Original Assignee
히라이 가쯔히꼬
도레이 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KR1019940701818A 1992-09-29 1993-09-29 인돌유도체,그제조방법및그의약용도 Expired - Fee Related KR100301093B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25984192 1992-09-29
JP92-259841 1992-09-29
PCT/JP1993/001388 WO1994007896A1 (fr) 1992-09-29 1993-09-29 Derive indole, procede pour sa fabrication, et son usage medicinal

Publications (1)

Publication Number Publication Date
KR100301093B1 true KR100301093B1 (ko) 2001-10-22

Family

ID=17339733

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940701818A Expired - Fee Related KR100301093B1 (ko) 1992-09-29 1993-09-29 인돌유도체,그제조방법및그의약용도

Country Status (14)

Country Link
US (2) US6087369A (enExample)
EP (1) EP0614898B1 (enExample)
JP (1) JP3605825B2 (enExample)
KR (1) KR100301093B1 (enExample)
CN (1) CN1043766C (enExample)
AT (1) ATE239732T1 (enExample)
AU (1) AU672033B2 (enExample)
CA (1) CA2124455C (enExample)
DE (1) DE69332945T2 (enExample)
ES (1) ES2199220T3 (enExample)
FI (1) FI942499A7 (enExample)
NO (1) NO941977L (enExample)
TW (1) TW271440B (enExample)
WO (1) WO1994007896A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2124455C (en) 1992-09-29 2004-09-14 Hiroshi Nagase Indole derivatives, process for producing the same and medicinal uses of the same
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
EP0805157B1 (en) * 1995-09-26 2003-06-04 Toray Industries, Inc. Indole derivatives and medicinal use thereof
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
EP0880526B1 (en) 1996-01-10 2002-12-18 GlaxoSmithKline S.p.A. Heterocycle-condensed morphinoid derivatives (ii)
KR100557804B1 (ko) * 1997-01-16 2006-06-20 도레이 가부시끼가이샤 인돌로모르피난유도체및뇌장해치료·예방제
CA2256336C (en) * 1997-03-31 2008-01-29 Toray Industries, Inc. Quinolinomorphinan derivative and medical use thereof
US5986141A (en) * 1998-09-29 1999-11-16 Eastman Chemical Company Process for the production of cyclopropanemethylamine
CN1204139C (zh) * 1999-08-24 2005-06-01 东丽株式会社 神经性疼痛治疗剂
US8205237B2 (en) 2000-09-14 2012-06-19 Cox Ingemar J Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
ATE422887T1 (de) 2001-05-04 2009-03-15 Amgen Inc Kondensierte heterozyklische verbindungen
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
JP2005530685A (ja) * 2002-01-25 2005-10-13 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 選択的鎮痛剤
ZA200503654B (en) 2002-11-06 2006-09-27 Amgen Inc Fused heterocyclic compounds
EP1595541A1 (en) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
US9969746B2 (en) 2013-12-05 2018-05-15 The University Of Bath Opioid compounds and their uses

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631829A1 (de) * 1986-09-19 1988-07-28 Hoechst Ag Klonierung und verwendung des transaminase gens-tyrb
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JP2906654B2 (ja) * 1989-11-28 1999-06-21 東レ株式会社 免疫抑制剤及びその製造方法
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
CA2124455C (en) * 1992-09-29 2004-09-14 Hiroshi Nagase Indole derivatives, process for producing the same and medicinal uses of the same
US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
EP0805157B1 (en) * 1995-09-26 2003-06-04 Toray Industries, Inc. Indole derivatives and medicinal use thereof

Also Published As

Publication number Publication date
AU4834193A (en) 1994-04-26
US6291470B1 (en) 2001-09-18
EP0614898A4 (en) 1994-10-12
FI942499L (fi) 1994-07-27
CA2124455C (en) 2004-09-14
JP3605825B2 (ja) 2004-12-22
CN1043766C (zh) 1999-06-23
EP0614898A1 (en) 1994-09-14
FI942499A7 (fi) 1994-07-27
FI942499A0 (fi) 1994-05-27
WO1994007896A1 (fr) 1994-04-14
TW271440B (enExample) 1996-03-01
NO941977D0 (no) 1994-05-27
NO941977L (no) 1994-07-29
AU672033B2 (en) 1996-09-19
EP0614898B1 (en) 2003-05-07
ATE239732T1 (de) 2003-05-15
CN1092425A (zh) 1994-09-21
ES2199220T3 (es) 2004-02-16
DE69332945T2 (de) 2004-05-19
DE69332945D1 (de) 2003-06-12
CA2124455A1 (en) 1994-04-14
US6087369A (en) 2000-07-11

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