AU672033B2 - Indole derivative, process for producing the same, and medicinal use thereof - Google Patents

Indole derivative, process for producing the same, and medicinal use thereof Download PDF

Info

Publication number
AU672033B2
AU672033B2 AU48341/93A AU4834193A AU672033B2 AU 672033 B2 AU672033 B2 AU 672033B2 AU 48341/93 A AU48341/93 A AU 48341/93A AU 4834193 A AU4834193 A AU 4834193A AU 672033 B2 AU672033 B2 AU 672033B2
Authority
AU
Australia
Prior art keywords
epoxy
indolomorphinan
didehydro
dihydroxy
allyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU48341/93A
Other languages
English (en)
Other versions
AU4834193A (en
Inventor
Koji Kawai
Akira Mizusuna
Hiroshi Nagase
Izumi Nakatani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Publication of AU4834193A publication Critical patent/AU4834193A/en
Application granted granted Critical
Publication of AU672033B2 publication Critical patent/AU672033B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
AU48341/93A 1992-09-29 1993-09-29 Indole derivative, process for producing the same, and medicinal use thereof Ceased AU672033B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP4-259841 1992-09-29
JP25984192 1992-09-29
PCT/JP1993/001388 WO1994007896A1 (fr) 1992-09-29 1993-09-29 Derive indole, procede pour sa fabrication, et son usage medicinal

Publications (2)

Publication Number Publication Date
AU4834193A AU4834193A (en) 1994-04-26
AU672033B2 true AU672033B2 (en) 1996-09-19

Family

ID=17339733

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48341/93A Ceased AU672033B2 (en) 1992-09-29 1993-09-29 Indole derivative, process for producing the same, and medicinal use thereof

Country Status (14)

Country Link
US (2) US6087369A (enExample)
EP (1) EP0614898B1 (enExample)
JP (1) JP3605825B2 (enExample)
KR (1) KR100301093B1 (enExample)
CN (1) CN1043766C (enExample)
AT (1) ATE239732T1 (enExample)
AU (1) AU672033B2 (enExample)
CA (1) CA2124455C (enExample)
DE (1) DE69332945T2 (enExample)
ES (1) ES2199220T3 (enExample)
FI (1) FI942499L (enExample)
NO (1) NO941977L (enExample)
TW (1) TW271440B (enExample)
WO (1) WO1994007896A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1043766C (zh) 1992-09-29 1999-06-23 东丽株式会社 吲哚衍生物及其制法和它们在制备药物中的应用
US5464841A (en) * 1993-11-08 1995-11-07 Univ Minnesota Use of delta opioid receptor antagonists to treat immunoregulatory disorders
SE9401727D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds I
SE9401728D0 (sv) * 1994-05-18 1994-05-18 Astra Ab New compounds II
US5578725A (en) * 1995-01-30 1996-11-26 Regents Of The University Of Minnesota Delta opioid receptor antagonists
CA2205664C (en) * 1995-09-26 2008-05-20 Toray Industries, Inc. Indole derivatives and medicinal use thereof
US5994327A (en) * 1995-11-17 1999-11-30 Astra Ab Process for the preparation of morphinans
AU706370B2 (en) * 1996-01-10 1999-06-17 Smithkline Beecham Spa Heterocycle-condensed morphinoid derivatives (II)
NZ331769A (en) * 1997-01-16 2000-05-26 Toray Industries Indolomorphinan derivative and agent for curing and preventing cerebral disorder
CA2256336C (en) * 1997-03-31 2008-01-29 Toray Industries, Inc. Quinolinomorphinan derivative and medical use thereof
US5986141A (en) * 1998-09-29 1999-11-16 Eastman Chemical Company Process for the production of cyclopropanemethylamine
CA2383146C (en) * 1999-08-24 2010-11-16 Hiroshi Nagase Therapeutic agent for neuropathic pain and neuropathic pain animal model
US8205237B2 (en) 2000-09-14 2012-06-19 Cox Ingemar J Identifying works, using a sub-linear time search, such as an approximate nearest neighbor search, for initiating a work-based action, such as an action on the internet
US7232829B2 (en) 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
US6809104B2 (en) 2001-05-04 2004-10-26 Tularik Inc. Fused heterocyclic compounds
ES2319619T3 (es) 2001-05-04 2009-05-11 Amgen Inc. Compuestos heterociclicos condensados.
JP2005530685A (ja) * 2002-01-25 2005-10-13 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 選択的鎮痛剤
ZA200503654B (en) 2002-11-06 2006-09-27 Amgen Inc Fused heterocyclic compounds
EP1595541A1 (en) * 2004-05-12 2005-11-16 Alcasynn Pharmaceuticals Gmbh Use of opioid receptor antagonist compounds for the prevention and/or treatment of diseases associated with the target calcineurin
EP3077398B1 (en) 2013-12-05 2020-03-11 The University of Bath Novel opioid compounds and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332818A (en) * 1989-11-28 1994-07-26 Toray Industries, Inc. Immunosuppressive agent and process of producing the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3631829A1 (de) * 1986-09-19 1988-07-28 Hoechst Ag Klonierung und verwendung des transaminase gens-tyrb
US4816586A (en) * 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
JPH04342529A (ja) * 1991-05-21 1992-11-30 Toray Ind Inc 抗アレルギー剤
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5352680A (en) * 1992-07-15 1994-10-04 Regents Of The University Of Minnesota Delta opioid receptor antagonists to block opioid agonist tolerance and dependence
CN1043766C (zh) * 1992-09-29 1999-06-23 东丽株式会社 吲哚衍生物及其制法和它们在制备药物中的应用
US5457208A (en) * 1993-06-21 1995-10-10 Regents Of The University Of Minnesota Kappa opioid receptor antagonists
CA2205664C (en) * 1995-09-26 2008-05-20 Toray Industries, Inc. Indole derivatives and medicinal use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332818A (en) * 1989-11-28 1994-07-26 Toray Industries, Inc. Immunosuppressive agent and process of producing the same

Also Published As

Publication number Publication date
FI942499A7 (fi) 1994-07-27
DE69332945T2 (de) 2004-05-19
US6291470B1 (en) 2001-09-18
EP0614898A1 (en) 1994-09-14
EP0614898A4 (en) 1994-10-12
ES2199220T3 (es) 2004-02-16
CN1043766C (zh) 1999-06-23
CN1092425A (zh) 1994-09-21
CA2124455A1 (en) 1994-04-14
NO941977D0 (no) 1994-05-27
AU4834193A (en) 1994-04-26
NO941977L (no) 1994-07-29
US6087369A (en) 2000-07-11
ATE239732T1 (de) 2003-05-15
JP3605825B2 (ja) 2004-12-22
WO1994007896A1 (fr) 1994-04-14
TW271440B (enExample) 1996-03-01
FI942499A0 (fi) 1994-05-27
KR100301093B1 (ko) 2001-10-22
DE69332945D1 (de) 2003-06-12
FI942499L (fi) 1994-07-27
EP0614898B1 (en) 2003-05-07
CA2124455C (en) 2004-09-14

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