KR100287539B1 - No신타제및시클로옥시게나제의이중억제제,이들의제조방법및이들을함유하는치료조성물 - Google Patents

No신타제및시클로옥시게나제의이중억제제,이들의제조방법및이들을함유하는치료조성물 Download PDF

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KR100287539B1
KR100287539B1 KR1019920026433A KR920026433A KR100287539B1 KR 100287539 B1 KR100287539 B1 KR 100287539B1 KR 1019920026433 A KR1019920026433 A KR 1019920026433A KR 920026433 A KR920026433 A KR 920026433A KR 100287539 B1 KR100287539 B1 KR 100287539B1
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South Korea
Prior art keywords
compound
general formula
formula
salicylic acid
cyclooxygenase
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Expired - Fee Related
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KR1019920026433A
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English (en)
Korean (ko)
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KR930016389A (ko
Inventor
삐에르-에띠엔샤브리에르드라소니에르
삐에르브라께
꼴레뜨브로께
세르즈오벵
Original Assignee
앙드레 부귄
소시에떼 드 꽁세이으 드 르세르세 에 따블리까시옹 시앙띠피끄 (에스세.에르.아.에스.)
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Publication of KR930016389A publication Critical patent/KR930016389A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/03—Monoamines
    • C07C211/04—Mono-, di- or tri-methylamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
    • C07C279/32—N-nitroguanidines
    • C07C279/36—Substituted N-nitroguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019920026433A 1992-01-04 1992-12-30 No신타제및시클로옥시게나제의이중억제제,이들의제조방법및이들을함유하는치료조성물 Expired - Fee Related KR100287539B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929200114A GB9200114D0 (en) 1992-01-04 1992-01-04 Dual inhibitors of no synthase and cyclooxygenase
GB9200114.8 1992-01-04
FR9200114.8 1992-01-04

Publications (2)

Publication Number Publication Date
KR930016389A KR930016389A (ko) 1993-08-26
KR100287539B1 true KR100287539B1 (ko) 2001-04-16

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KR1019920026433A Expired - Fee Related KR100287539B1 (ko) 1992-01-04 1992-12-30 No신타제및시클로옥시게나제의이중억제제,이들의제조방법및이들을함유하는치료조성물

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Publication number Publication date
KR930016389A (ko) 1993-08-26
DE4244539B4 (de) 2006-10-26
MA22753A1 (fr) 1993-07-01
AT401054B (de) 1996-06-25
DK157592D0 (da) 1992-12-30
IT1256761B (it) 1995-12-15
FR2685869B1 (fr) 1995-06-09
AU3049892A (en) 1993-07-08
PT101165A (pt) 1994-02-28
JPH05286916A (ja) 1993-11-02
IE922954A1 (en) 1993-07-14
SE9203825L (sv) 1993-07-05
FI925883L (fi) 1993-07-05
GB9200114D0 (en) 1992-02-26
CA2085555A1 (en) 1993-07-05
TNSN93001A1 (fr) 1994-03-17
US5360925A (en) 1994-11-01
ITMI922953A1 (it) 1994-06-23
GB9227026D0 (en) 1993-02-17
NO924835D0 (no) 1992-12-14
GR1001443B (el) 1993-12-30
JP2984498B2 (ja) 1999-11-29
SE511568C2 (sv) 1999-10-18
FI925883A0 (fi) 1992-12-28
TW267152B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1996-01-01
DZ1657A1 (fr) 2002-02-17
NL194889B (nl) 2003-02-03
HU220218B (hu) 2001-11-28
CA2085555C (en) 2004-07-20
LU88208A1 (fr) 1993-04-15
US5480999A (en) 1996-01-02
ES2052452B1 (es) 1995-02-01
HU9204173D0 (en) 1993-04-28
FR2685916A1 (fr) 1993-07-09
GB2263111B (en) 1995-08-16
PT101165B (pt) 1999-09-30
DK157592A (da) 1993-07-05
SE9203825D0 (sv) 1992-12-18
PL169432B1 (pl) 1996-07-31
ZA9210080B (en) 1993-08-02
MY109846A (en) 1997-08-30
FR2685869A1 (fr) 1993-07-09
PL297247A1 (en) 1993-09-06
NO302943B1 (no) 1998-05-11
NL9300001A (nl) 1993-08-02
NO924835L (no) 1993-07-05
DE4244539A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-07-08
ATA256092A (de) 1995-10-15
FR2685916B1 (fr) 2001-09-28
NL194889C (nl) 2003-06-04
RU2104999C1 (ru) 1998-02-20
HK22296A (en) 1996-02-16
FI925883A7 (fi) 1993-07-05
BE1006227A3 (fr) 1994-06-14
AU664399B2 (en) 1995-11-16
ES2052452A1 (es) 1994-07-01
HUT64047A (en) 1993-11-29
GB2263111A (en) 1993-07-14
NZ245499A (en) 1995-07-26
OA10050A (fr) 1996-10-14
CH685629A5 (fr) 1995-08-31
IE71675B1 (en) 1997-02-26

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