ITMI922953A1 - Inibitori a doppia attivita' biologica di no sintasi e cicloossigenasi procedimento per la loro preparazione e composizioni terapeutiche che li contengono. - Google Patents
Inibitori a doppia attivita' biologica di no sintasi e cicloossigenasi procedimento per la loro preparazione e composizioni terapeutiche che li contengono.Info
- Publication number
- ITMI922953A1 ITMI922953A1 IT002953A ITMI922953A ITMI922953A1 IT MI922953 A1 ITMI922953 A1 IT MI922953A1 IT 002953 A IT002953 A IT 002953A IT MI922953 A ITMI922953 A IT MI922953A IT MI922953 A1 ITMI922953 A1 IT MI922953A1
- Authority
- IT
- Italy
- Prior art keywords
- synthasis
- cyclooxygenes
- procedure
- contain
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/03—Monoamines
- C07C211/04—Mono-, di- or tri-methylamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
- C07C229/58—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position having the nitrogen atom of at least one of the amino groups further bound to a carbon atom of a six-membered aromatic ring, e.g. N-phenyl-anthranilic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
- C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
- C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929200114A GB9200114D0 (en) | 1992-01-04 | 1992-01-04 | Dual inhibitors of no synthase and cyclooxygenase |
Publications (2)
Publication Number | Publication Date |
---|---|
ITMI922953A1 true ITMI922953A1 (it) | 1994-06-23 |
IT1256761B IT1256761B (it) | 1995-12-15 |
Family
ID=10708115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI922953A IT1256761B (it) | 1992-01-04 | 1992-12-23 | Inibitori a doppia attivita' biologica di no sintasi e cicloossigenasiprocedimento per la loro preparazione e composizioni terapeutiche che li contengono. |
Country Status (34)
Country | Link |
---|---|
US (2) | US5480999A (it) |
JP (1) | JP2984498B2 (it) |
KR (1) | KR100287539B1 (it) |
AT (1) | AT401054B (it) |
AU (1) | AU664399B2 (it) |
BE (1) | BE1006227A3 (it) |
CA (1) | CA2085555C (it) |
CH (1) | CH685629A5 (it) |
DE (1) | DE4244539B4 (it) |
DK (1) | DK157592A (it) |
DZ (1) | DZ1657A1 (it) |
ES (1) | ES2052452B1 (it) |
FI (1) | FI925883A (it) |
FR (2) | FR2685916B1 (it) |
GB (2) | GB9200114D0 (it) |
GR (1) | GR1001443B (it) |
HK (1) | HK22296A (it) |
HU (1) | HU220218B (it) |
IE (1) | IE71675B1 (it) |
IT (1) | IT1256761B (it) |
LU (1) | LU88208A1 (it) |
MA (1) | MA22753A1 (it) |
MY (1) | MY109846A (it) |
NL (1) | NL194889C (it) |
NO (1) | NO302943B1 (it) |
NZ (1) | NZ245499A (it) |
OA (1) | OA10050A (it) |
PL (1) | PL169432B1 (it) |
PT (1) | PT101165B (it) |
RU (1) | RU2104999C1 (it) |
SE (1) | SE511568C2 (it) |
TN (1) | TNSN93001A1 (it) |
TW (1) | TW267152B (it) |
ZA (1) | ZA9210080B (it) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU682768B2 (en) * | 1994-05-07 | 1997-10-16 | Astra Aktiebolag | Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase |
DK0758890T3 (da) | 1994-05-11 | 2005-04-18 | Jes Olesen | Anvendelse af NO indfangere, inhibitorer eller antagonister ved behandling af migræne |
CA2132690A1 (en) * | 1994-09-22 | 1996-03-23 | Dean Willis | Control and modulation of inflammatory response in humans in need of such control and modulation |
US6066333A (en) * | 1994-09-22 | 2000-05-23 | William Harvey Research Limited | Pharmaceutical control of inflammation |
FR2727111B1 (fr) * | 1994-11-21 | 1997-01-17 | Hoechst Lab | Nouveaux analogues soufres d'aminoacides, leur procede de preparation et leurs applications comme medicaments |
PT793646E (pt) | 1994-11-23 | 2002-03-28 | Biovitrum Ab | Carboxilatos de aminoguanidina destinados ao tratamento de diabetes mellitus nao-insulinodependente |
JPH08333258A (ja) | 1994-12-14 | 1996-12-17 | Japan Tobacco Inc | チアジン又はチアゼピン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤 |
ES2096524B1 (es) * | 1994-12-22 | 1997-11-16 | Sanchez Manuel Guerra | Uso de la ng-monometil-l-arginina, para aumentar la capacidad de hacer ejercicio fisico. |
FR2730930B1 (fr) | 1995-02-27 | 1997-04-04 | Oreal | Utilisation d'inhibiteurs de no-synthase pour diminuer l'effet irritant cutane de produits utilises dans le domaine cosmetique ou pharmaceutique |
GB9504350D0 (en) * | 1995-03-04 | 1995-04-26 | Sod Conseils Rech Applic | Arginine derivatives |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
GB9514518D0 (en) * | 1995-07-15 | 1995-09-13 | Sod Conseils Rech Applic | Guanidine salt inhibitors of NO synthase and cyclooxygenase |
WO1997032575A1 (en) * | 1996-03-05 | 1997-09-12 | Children's Hospital Medical Center | Mercapto derivatives as inhibitors of cyclooxygenases |
JP2000511177A (ja) | 1996-05-21 | 2000-08-29 | ファルマシア・アンド・アップジョン・カンパニー | インスリン非依存性糖尿病治療のためのアミノグアニジンカルボキシレート ラクタム類 |
US5872145A (en) * | 1996-08-16 | 1999-02-16 | Pozen, Inc. | Formulation of 5-HT agonist and NSAID for treatment of migraine |
US8022095B2 (en) * | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
IT1301966B1 (it) | 1998-07-30 | 2000-07-20 | Zambon Spa | Composizioni farmaceutiche ad attivita' analgesica |
US6207700B1 (en) * | 1999-01-07 | 2001-03-27 | Vanderbilt University | Amide derivatives for antiangiogenic and/or antitumorigenic use |
US6737427B2 (en) * | 2000-01-31 | 2004-05-18 | Genaera Corporation | Mucin synthesis inhibitors |
US7345051B2 (en) * | 2000-01-31 | 2008-03-18 | Genaera Corporation | Mucin synthesis inhibitors |
US7163958B2 (en) * | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
CA2493156A1 (en) * | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
JP4616009B2 (ja) * | 2002-12-26 | 2011-01-19 | ポーゼン インコーポレイテッド | NSAIDsおよびトリプタンを含有する多層剤型 |
WO2004110492A2 (en) * | 2003-06-06 | 2004-12-23 | Glaxo Group Limited | Composition comprising triptans and nsaids |
CA2530058A1 (en) * | 2003-06-19 | 2004-12-29 | Genaera Corporation | Mucin synthesis inhibitors |
US20050002859A1 (en) * | 2003-06-25 | 2005-01-06 | Vanderbilt University | COX-2-targeted imaging agents |
EP1744747A4 (en) * | 2004-04-26 | 2009-12-02 | Univ Vanderbilt | INDIC ACID AND INDULECTIC ACID DERIVATIVES AS THERAPEUTIC ACTIVITIES WITH REDUCED GASTROINTESTINAL TOXICITY |
US20080139449A1 (en) * | 2005-01-04 | 2008-06-12 | Wolfgang Jahnke | X-Ray Structure of Human Fpps and Use For Selecting Fpps Binding Compounds |
WO2007149456A2 (en) * | 2006-06-19 | 2007-12-27 | Vanderbilt University | Methods and compositions for diagnostic and therapeutic targeting of cox-2 |
WO2013059245A1 (en) | 2011-10-17 | 2013-04-25 | Vanderbilt University | Indomethacin analogs for the treatment of castrate-resistant prostate cancer |
TWM469254U (zh) | 2013-08-29 | 2014-01-01 | J D Components Co Ltd | 自行車之三件式豎管 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR6838M (it) * | 1967-12-08 | 1969-03-31 | ||
ES423794A1 (es) * | 1974-03-01 | 1976-05-01 | Medicinales S A Promesa Prod | Procediemiento de obtencion de una nueva sal soluble de acido acetilsalicilico. |
FR2320759A1 (fr) * | 1975-08-11 | 1977-03-11 | Union Pharma Scient Appl | Solution d'acide acetylsalicylique extemporanee injectable |
IT1127274B (it) * | 1979-12-04 | 1986-05-21 | Selvi & C Spa | Sali dell'acido 5-fluoro-2-metil-1-(p-(metilsulfinil)-benzilidene)-indene-3-acetico |
JPS5781409A (en) * | 1980-11-10 | 1982-05-21 | Toko Yakuhin Kogyo Kk | External plaster |
CA1213888A (en) * | 1983-09-28 | 1986-11-12 | Warner-Lambert Company | L-arginine isoxicamate |
US5081184A (en) * | 1985-08-02 | 1992-01-14 | General Electric Company | Solvent-resistant, compatible blends of polyphenylene ethers and linear polyesters |
JPS6393718A (ja) * | 1986-10-07 | 1988-04-25 | Green Cross Corp:The | 注射剤 |
US5028627A (en) * | 1989-09-13 | 1991-07-02 | Cornell Research Foundation, Inc. | Method of using arginine derivatives to inhibit systemic hypotension associated with nitric oxide production or endothelial derived relaxing factor |
US5059712A (en) * | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
DK0424028T3 (da) * | 1989-10-17 | 1996-01-29 | Merck & Co Inc | S(+)-ibuprofen-L-aminosyre og S(+)-ibuprofen-D-aminosyre som et forbedret smertestillende middel med fremskyndet indtrædelse |
GB8929076D0 (en) * | 1989-12-22 | 1990-02-28 | Scras | Treatment of shock by blocking agents of edrf effect or formation |
US5468476A (en) * | 1994-03-16 | 1995-11-21 | Ahluwalia; Gurpreet S. | Reduction of hair growth |
-
1992
- 1992-01-04 GB GB929200114A patent/GB9200114D0/en active Pending
- 1992-12-14 NO NO924835A patent/NO302943B1/no unknown
- 1992-12-16 CA CA002085555A patent/CA2085555C/en not_active Expired - Fee Related
- 1992-12-17 NZ NZ245499A patent/NZ245499A/en unknown
- 1992-12-18 MY MYPI92002343A patent/MY109846A/en unknown
- 1992-12-18 CH CH3890/92A patent/CH685629A5/fr not_active IP Right Cessation
- 1992-12-18 TW TW081110175A patent/TW267152B/zh active
- 1992-12-18 GR GR920100563A patent/GR1001443B/el not_active IP Right Cessation
- 1992-12-18 SE SE9203825A patent/SE511568C2/sv not_active IP Right Cessation
- 1992-12-22 FR FR9215448A patent/FR2685916B1/fr not_active Expired - Fee Related
- 1992-12-22 FR FR9215447A patent/FR2685869B1/fr not_active Expired - Fee Related
- 1992-12-22 BE BE9201127A patent/BE1006227A3/fr not_active IP Right Cessation
- 1992-12-23 IT ITMI922953A patent/IT1256761B/it active IP Right Grant
- 1992-12-23 US US07/995,792 patent/US5480999A/en not_active Expired - Lifetime
- 1992-12-23 AT AT0256092A patent/AT401054B/de not_active IP Right Cessation
- 1992-12-24 GB GB9227026A patent/GB2263111B/en not_active Expired - Lifetime
- 1992-12-25 MA MA23045A patent/MA22753A1/fr unknown
- 1992-12-28 FI FI925883A patent/FI925883A/fi not_active Application Discontinuation
- 1992-12-29 LU LU88208A patent/LU88208A1/fr unknown
- 1992-12-29 ES ES09202635A patent/ES2052452B1/es not_active Expired - Fee Related
- 1992-12-29 DZ DZ920171A patent/DZ1657A1/fr active
- 1992-12-29 ZA ZA9210080A patent/ZA9210080B/xx unknown
- 1992-12-30 PT PT101165A patent/PT101165B/pt not_active IP Right Cessation
- 1992-12-30 PL PL92297247A patent/PL169432B1/pl not_active IP Right Cessation
- 1992-12-30 DK DK157592A patent/DK157592A/da not_active Application Discontinuation
- 1992-12-30 KR KR1019920026433A patent/KR100287539B1/ko not_active IP Right Cessation
- 1992-12-30 DE DE4244539A patent/DE4244539B4/de not_active Expired - Fee Related
- 1992-12-30 HU HU9204173A patent/HU220218B/hu not_active IP Right Cessation
- 1992-12-31 OA OA60325A patent/OA10050A/fr unknown
- 1992-12-31 RU RU92016217A patent/RU2104999C1/ru not_active IP Right Cessation
- 1992-12-31 AU AU30498/92A patent/AU664399B2/en not_active Ceased
- 1992-12-31 IE IE922954A patent/IE71675B1/en not_active IP Right Cessation
-
1993
- 1993-01-04 NL NL9300001A patent/NL194889C/nl not_active IP Right Cessation
- 1993-01-04 JP JP5000091A patent/JP2984498B2/ja not_active Expired - Fee Related
- 1993-01-04 TN TNTNSN93001A patent/TNSN93001A1/fr unknown
- 1993-09-29 US US08/128,908 patent/US5360925A/en not_active Expired - Lifetime
-
1996
- 1996-02-08 HK HK22296A patent/HK22296A/xx not_active IP Right Cessation
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