KR100278857B1 - 신규의 피리미딘 유도체 및 그의 제조방법 - Google Patents

신규의 피리미딘 유도체 및 그의 제조방법 Download PDF

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Publication number
KR100278857B1
KR100278857B1 KR1019980010754A KR19980010754A KR100278857B1 KR 100278857 B1 KR100278857 B1 KR 100278857B1 KR 1019980010754 A KR1019980010754 A KR 1019980010754A KR 19980010754 A KR19980010754 A KR 19980010754A KR 100278857 B1 KR100278857 B1 KR 100278857B1
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KR
South Korea
Prior art keywords
methyl
formula
mmol
pyrimidine
hydrogen
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Expired - Fee Related
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KR1019980010754A
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English (en)
Korean (ko)
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KR19980080789A (ko
Inventor
이종욱
이봉용
김창섭
이승규
송근석
이송진
심우전
황만순
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김선진
주식회사유한양행
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1019980010754A 1997-03-27 1998-03-27 신규의 피리미딘 유도체 및 그의 제조방법 Expired - Fee Related KR100278857B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR1019970010862 1997-03-27
KR19970010863 1997-03-27
KR19970010862 1997-03-27
KR97-10863 1997-03-27
KR1019970010863 1997-03-27
KR97-10862 1997-03-27

Publications (2)

Publication Number Publication Date
KR19980080789A KR19980080789A (ko) 1998-11-25
KR100278857B1 true KR100278857B1 (ko) 2001-01-15

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980010754A Expired - Fee Related KR100278857B1 (ko) 1997-03-27 1998-03-27 신규의 피리미딘 유도체 및 그의 제조방법

Country Status (21)

Country Link
US (1) US6352993B1 (OSRAM)
EP (1) EP1015444B1 (OSRAM)
JP (1) JP3176379B2 (OSRAM)
KR (1) KR100278857B1 (OSRAM)
CN (1) CN1118464C (OSRAM)
AR (1) AR012181A1 (OSRAM)
AT (1) ATE241613T1 (OSRAM)
AU (1) AU720385B2 (OSRAM)
BR (1) BR9808070A (OSRAM)
CA (1) CA2284795C (OSRAM)
DE (1) DE69815126T2 (OSRAM)
DK (1) DK1015444T3 (OSRAM)
ES (1) ES2200324T3 (OSRAM)
HU (1) HUP0000851A3 (OSRAM)
IN (1) IN188411B (OSRAM)
PT (1) PT1015444E (OSRAM)
RU (1) RU2203894C2 (OSRAM)
TR (1) TR199902383T2 (OSRAM)
TW (1) TW542831B (OSRAM)
UY (1) UY24938A1 (OSRAM)
WO (1) WO1998043968A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
TW200302728A (en) 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
US20070161637A1 (en) * 2003-07-22 2007-07-12 Neurogen Corporation Substituted pyridin-2-ylamine analogues
JP4800216B2 (ja) * 2003-10-24 2011-10-26 エグゼリクシス， インコーポレイテッド ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
CN1874772A (zh) 2003-11-03 2006-12-06 阿斯利康(瑞典)有限公司 治疗隐匿性胃食管反流的咪唑并[1,2－a]吡啶衍生物
JP2009511548A (ja) * 2005-10-14 2009-03-19 ノイロサーチ アクティーゼルスカブ 新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
CA2732950C (en) 2008-08-05 2013-10-01 Daiichi Sankyo Company, Limited Imidazopyridin-2-one derivatives
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
WO2012065963A2 (en) 2010-11-15 2012-05-24 Katholieke Universiteit Leuven Novel antiviral compounds
CN103402997B (zh) 2011-02-25 2015-08-26 柳韩洋行 二氨基嘧啶衍生物及其制备方法
CA2864825C (en) * 2012-02-17 2021-01-26 Abbvie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
US9309271B2 (en) 2012-05-29 2016-04-12 Momentive Performance Materials Gmbh Preparation of isocyanato silanes
DK2922828T3 (da) 2012-11-21 2020-08-31 Ptc Therapeutics Inc 4,6-diamino-pyrimidin-derivater som bmi-1-inhibitorer til at behandle cancer
US10035801B2 (en) 2013-03-13 2018-07-31 Genentech, Inc. Pyrazolo compounds and uses thereof
EA034866B1 (ru) 2013-08-30 2020-03-31 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Замещенные пиримидиновые ингибиторы bmi-1
CN104903312B (zh) * 2013-10-07 2019-01-29 卡德门企业有限公司 Rho激酶抑制剂
EP3071553A4 (en) 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
US10370360B2 (en) 2014-10-22 2019-08-06 The Board Of Regents Of The University Of Texas System Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
DK3397622T3 (en) * 2016-01-04 2022-06-07 ObsEva SA Co-administration af alpha-aminoester af hydroxypropylthiazolidincarboxamid-derivat og et tokolytisk middel
EP3606915A1 (de) * 2017-04-05 2020-02-12 Bayer CropScience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidinderivate und deren verwendung zur bekämpfung unerwünschten pflanzenwachstums
BR112021002630A2 (pt) 2018-08-17 2021-05-11 Ptc Therapeutics, Inc. método para tratar câncer pancreático
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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BR9107070A (pt) 1990-11-06 1994-05-31 Pfizer Processo para a preparação de derivados de quinazolina uteis para melhorar a atividade antitumoral.
HUT65177A (en) * 1991-04-17 1994-05-02 Pfizer Process for producing antitumor activity enhancing pyrimidine derivatives and pharmaceutical preparations containing them
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
JPH09501918A (ja) * 1993-08-12 1997-02-25 アストラ・アクチエボラーグ 酸化窒素合成酵素活性を有するアミジン誘導体
DK0640599T3 (da) 1993-08-26 1998-09-28 Ono Pharmaceutical Co 4-Aminopyrimidin-derivater
RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
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PT900214E (pt) * 1996-05-04 2002-03-28 Yuhan Corp Processo para a preparacao de derivados da pirimidina

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
BR9808070A (pt) 2000-03-08
EP1015444B1 (en) 2003-05-28
CA2284795A1 (en) 1998-10-08
CA2284795C (en) 2004-01-20
US6352993B1 (en) 2002-03-05
ES2200324T3 (es) 2004-03-01
CN1251586A (zh) 2000-04-26
DE69815126T2 (de) 2004-04-08
KR19980080789A (ko) 1998-11-25
WO1998043968A1 (en) 1998-10-08
RU2203894C2 (ru) 2003-05-10
TW542831B (en) 2003-07-21
JP3176379B2 (ja) 2001-06-18
HK1026418A1 (en) 2000-12-15
HUP0000851A3 (en) 2002-04-29
HUP0000851A1 (hu) 2001-04-28
UY24938A1 (es) 2001-01-31
DK1015444T3 (da) 2003-08-18
IN188411B (OSRAM) 2002-09-21
DE69815126D1 (de) 2003-07-03
PT1015444E (pt) 2003-10-31
AU6523998A (en) 1998-10-22
EP1015444A1 (en) 2000-07-05
TR199902383T2 (xx) 2000-06-21
JP2000513014A (ja) 2000-10-03
ATE241613T1 (de) 2003-06-15
AU720385B2 (en) 2000-06-01
AR012181A1 (es) 2000-09-27
CN1118464C (zh) 2003-08-20

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