KR100273937B1 - 4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물 - Google Patents

4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물 Download PDF

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Publication number
KR100273937B1
KR100273937B1 KR1019920026335A KR920026335A KR100273937B1 KR 100273937 B1 KR100273937 B1 KR 100273937B1 KR 1019920026335 A KR1019920026335 A KR 1019920026335A KR 920026335 A KR920026335 A KR 920026335A KR 100273937 B1 KR100273937 B1 KR 100273937B1
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South Korea
Prior art keywords
formula
compound
methyl
dioxabicyclo
alkylation
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Expired - Fee Related
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KR1019920026335A
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English (en)
Korean (ko)
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KR930016436A (ko
Inventor
횔테다그마
프레우스코프울프
에크호우트크리스티안
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독토르 디터 라우어
솔베이 파머슈티컬스 게엠베하
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Publication of KR930016436A publication Critical patent/KR930016436A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
KR1019920026335A 1992-01-07 1992-12-28 4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물 Expired - Fee Related KR100273937B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4200145.5 1992-01-07
DE4200145A DE4200145A1 (de) 1992-01-07 1992-01-07 7,10-epoxy-oxacyclododecan-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
KR930016436A KR930016436A (ko) 1993-08-26
KR100273937B1 true KR100273937B1 (ko) 2000-12-15

Family

ID=6449136

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920026335A Expired - Fee Related KR100273937B1 (ko) 1992-01-07 1992-12-28 4,13-디옥사바이사이클로[8.2.1]트리데세논 유도체와 그의 제조방법 및 이 화합물이 함유된 약학조성물

Country Status (27)

Country Link
US (1) US5418224A (enExample)
EP (1) EP0550895B1 (enExample)
JP (1) JP3300084B2 (enExample)
KR (1) KR100273937B1 (enExample)
CN (1) CN1033646C (enExample)
AT (1) ATE155478T1 (enExample)
AU (1) AU667699B2 (enExample)
CA (1) CA2086811C (enExample)
CZ (1) CZ281773B6 (enExample)
DE (2) DE4200145A1 (enExample)
DK (1) DK0550895T3 (enExample)
DZ (1) DZ1652A1 (enExample)
ES (1) ES2104808T3 (enExample)
FI (1) FI106862B (enExample)
GR (1) GR3024859T3 (enExample)
HU (2) HU212272B (enExample)
IL (1) IL104158A (enExample)
LT (1) LT3015B (enExample)
LV (1) LV10458B (enExample)
MX (1) MX9300045A (enExample)
NO (1) NO179586C (enExample)
PH (1) PH30098A (enExample)
RU (1) RU2107070C1 (enExample)
SK (1) SK279251B6 (enExample)
TW (1) TW238308B (enExample)
UA (1) UA29393C2 (enExample)
ZA (1) ZA9339B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2233541C (en) * 1995-10-13 2002-04-30 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
EP0884322A4 (en) * 1996-03-01 2002-04-24 Takeda Chemical Industries Ltd METHOD FOR PRODUCING ERYTHROMYCIN DERIVATIVES
US6077943A (en) * 1996-03-01 2000-06-20 Takeda Chemical Industries, Ltd. Method of producing erythromycin derivative
DE19644195A1 (de) * 1996-10-24 1998-04-30 Solvay Pharm Gmbh 10,13,15-Trioxatricyclo[9.2.1.1.·9·.·6·]-pentadecanon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
US6165985A (en) * 1998-02-13 2000-12-26 Solvay Pharmaceuticals Gmbh 11-acetyl-12,13-dioxabicyclo[8.2.1]-tridecenone derivatives, processes for their preparation and pharmaceutical compositions comprising them
DE19805822B4 (de) * 1998-02-13 2009-02-05 Solvay Pharmaceuticals Gmbh 11-Acetyl-12,13-dioxabicyclo[8.2.1]tridecenon-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
HRP980496B1 (en) * 1998-09-10 2007-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. New thilozine hydroxy derivatives and a process for the preparation thereof
ES2261224T3 (es) 2000-08-17 2006-11-16 The Kitasato Institute Nuevos derivados de pseudoeritromicina.
JP3944077B2 (ja) * 2000-09-01 2007-07-11 中外製薬株式会社 エリスロマイシン誘導体の製造方法
WO2002092592A1 (de) * 2001-05-10 2002-11-21 Solvay Pharmaceuticals Gmbh Neue 1-amidomethylcarbonyl-piperidinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US20040067896A1 (en) * 2002-07-25 2004-04-08 The Kitasato Institute Novel pseudoerythromycin derivatives
DE602004025569D1 (de) 2003-06-18 2010-04-01 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
US7582611B2 (en) * 2005-05-24 2009-09-01 Pfizer Inc. Motilide compounds
JP2009518396A (ja) * 2005-12-08 2009-05-07 ファイザー・インク エリスロマイシン化合物の３’−ジメチルアミノ基を脱メチルする方法
CA2662897C (en) 2006-09-11 2017-11-07 Tranzyme Pharma, Inc. Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders
MX2009005977A (es) * 2006-12-05 2009-06-17 Pfizer Polimorfos de motilida.
US20080287371A1 (en) * 2007-05-17 2008-11-20 Tranzyme Pharma Inc. Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex
EP2979702A4 (en) * 2013-03-25 2016-11-16 Zeria Pharm Co Ltd GASTROKINETIC POSTPRANDIAL MEDIUM

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
EP0349100A2 (en) * 1988-04-18 1990-01-03 Eli Lilly And Company Macrolide compositions for treating gastro-intestinal motility disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1321581C (en) * 1987-05-26 1993-08-24 Herbert A. Kirst Ring-contracted macrolides
US5106961A (en) * 1987-05-26 1992-04-21 Eli Lilly And Company Erythromycin ring-contracted derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
EP0349100A2 (en) * 1988-04-18 1990-01-03 Eli Lilly And Company Macrolide compositions for treating gastro-intestinal motility disorders

Also Published As

Publication number Publication date
IL104158A (en) 1997-07-13
LV10458A (lv) 1995-02-20
EP0550895B1 (de) 1997-07-16
CZ341492A3 (en) 1993-07-14
NO930029D0 (no) 1993-01-06
LV10458B (en) 1996-02-20
FI930051A0 (fi) 1993-01-07
CA2086811A1 (en) 1993-07-08
ATE155478T1 (de) 1997-08-15
CA2086811C (en) 2003-12-09
US5418224A (en) 1995-05-23
HK1014003A1 (en) 1999-09-17
GR3024859T3 (en) 1998-01-30
EP0550895A1 (de) 1993-07-14
TW238308B (enExample) 1995-01-11
CN1033646C (zh) 1996-12-25
SK341492A3 (en) 1995-05-10
IL104158A0 (en) 1993-05-13
MX9300045A (es) 1993-12-01
HU210216A9 (en) 1995-02-28
PH30098A (en) 1996-12-27
LT3015B (lt) 1994-08-25
CZ281773B6 (cs) 1997-01-15
FI930051L (fi) 1993-07-08
ZA9339B (en) 1993-08-05
NO930029L (no) 1993-07-08
ES2104808T3 (es) 1997-10-16
AU3103693A (en) 1993-07-08
NO179586B (no) 1996-07-29
HU9204076D0 (en) 1993-04-28
DE59208710D1 (de) 1997-08-21
LTIP187A (lt) 1994-03-25
AU667699B2 (en) 1996-04-04
RU2107070C1 (ru) 1998-03-20
SK279251B6 (sk) 1998-08-05
DE4200145A1 (de) 1993-07-08
JP3300084B2 (ja) 2002-07-08
HUT66234A (en) 1994-10-28
KR930016436A (ko) 1993-08-26
FI106862B (fi) 2001-04-30
DZ1652A1 (fr) 2002-02-17
CN1075320A (zh) 1993-08-18
HU212272B (en) 1996-04-29
DK0550895T3 (da) 1997-08-25
UA29393C2 (uk) 2000-11-15
NO179586C (no) 1996-11-06
JPH07247299A (ja) 1995-09-26

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