KE3833A - Indoles - Google Patents

Indoles

Info

Publication number
KE3833A
KE3833A KE3833A KE383388A KE3833A KE 3833 A KE3833 A KE 3833A KE 3833 A KE3833 A KE 3833A KE 383388 A KE383388 A KE 383388A KE 3833 A KE3833 A KE 3833A
Authority
KE
Kenya
Prior art keywords
indoles
Prior art date
Application number
KE3833A
Other languages
English (en)
Inventor
Dennis Dowle Michael
Harold Coates Ian
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10530876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KE3833(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of KE3833A publication Critical patent/KE3833A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16Tryptamines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KE3833A 1982-06-07 1988-09-30 Indoles KE3833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216526 1982-06-07

Publications (1)

Publication Number Publication Date
KE3833A true KE3833A (en) 1988-11-18

Family

ID=10530876

Family Applications (1)

Application Number Title Priority Date Filing Date
KE3833A KE3833A (en) 1982-06-07 1988-09-30 Indoles

Country Status (33)

Country Link
US (1) US4816470A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
JP (1) JPS5942366A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
KR (1) KR900006681B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
AT (1) AT381933B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
AU (1) AU566149B2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
BE (1) BE896986A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CA (1) CA1199643A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CH (1) CH657359A5 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CY (1) CY1458A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
CZ (1) CZ280529B6 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
DE (2) DE19375045I2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
DK (1) DK260183D0 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
DO (1) DOP1989476000A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
ES (3) ES523039A0 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
FI (1) FI79530C (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
FR (1) FR2530625B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
GB (1) GB2124210B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
GR (1) GR79215B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
HK (1) HK14789A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
IE (1) IE55358B1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
IL (1) IL68913A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
IT (1) IT1170387B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
KE (1) KE3833A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
LU (1) LU84852A1 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
MX (1) MX9202623A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
MY (1) MY8700179A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
NL (1) NL193694C (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
NZ (1) NZ204482A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
PH (1) PH19908A (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
PT (1) PT76830B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
SE (1) SE452459B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
SK (1) SK404091A3 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)
ZA (1) ZA834110B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html)

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US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8601959D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Indole derivatives
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ATE92057T1 (de) * 1987-08-13 1993-08-15 Glaxo Group Ltd Indol-derivate.
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
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US5155218A (en) * 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
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GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
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GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
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CA2084531A1 (en) 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
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ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
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RU2108326C1 (ru) * 1993-02-26 1998-04-10 Вита-Инвест С.А. Способ получения 2-карбокси-3-[2-(диметиламино)этил]-n-метил-1h-индол-5-метансульфонамида или его сложных эфиров
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FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
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US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
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GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
AU2001285156A1 (en) * 2000-08-23 2002-03-04 Bristol-Myers Squibb Company Combination therapy for the treatment of migraine
US6951654B2 (en) * 2001-03-27 2005-10-04 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
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US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
US7645886B2 (en) 2002-12-20 2010-01-12 Ciba Specialty Corporation Synthesis of amines and intermediates for the synthesis thereof
ATE546134T1 (de) 2002-12-26 2012-03-15 Pozen Inc Mehrschichtige dosierformen enthaltend naproxen und triptane
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
KR20060015641A (ko) * 2003-06-06 2006-02-17 글락소 그룹 리미티드 트립탄 및 nsaid를 포함하는 조성물
CA2529528A1 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Topical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
CN1897924B (zh) * 2003-09-26 2011-09-21 阿尔扎公司 能提供高载药量的药物包衣和提供它的方法
MXPA06003454A (es) * 2003-09-26 2006-08-31 Johnson & Johnson Formulaciones de liberacion controlada de analgesicos opioides y no opiodes.
DE602004032149D1 (de) * 2003-09-26 2011-05-19 Alza Corp Oros-push-stick für die kontrollierte abgabe von wirkstoffen
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US20060002989A1 (en) * 2004-06-10 2006-01-05 Ahmed Salah U Formulations of sumatriptan for absorption across biological membranes, and methods of making and using the same
US8541026B2 (en) * 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
DK1883451T3 (da) * 2005-04-13 2011-03-14 Neuraxon Inc Substituerede indolforbindelser med NOS-hæmmende virkning
US20070166336A1 (en) * 2005-12-13 2007-07-19 David Delmarre Stable and palatable oral liquid sumatriptan compositions
AU2007240078B2 (en) * 2006-04-13 2013-07-25 Neuraxon, Inc. 1,5 and 3,6- substituted indole compounds having NOS inhibitory activity
JP2010507585A (ja) * 2006-10-19 2010-03-11 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換インドール
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US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
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CA2729346A1 (en) * 2008-06-30 2010-01-14 Afgin Pharma, Llc Topical regional neuro-affective therapy
US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
RU2012116452A (ru) 2009-09-25 2013-10-27 Др. Редди'С Лабораторис Лимитед Композиции, содержащие триптановые соединения
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
HK1244715A1 (zh) 2015-03-02 2018-08-17 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10537554B2 (en) 2015-08-05 2020-01-21 Upsher-Smith Laboratories, Llc Pharmaceutical composition for treating migraine
CA3010568C (en) 2016-01-27 2023-10-17 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
DK157920C (da) * 1980-08-12 1990-08-06 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af indolderivater
IT1171450B (it) * 1980-08-12 1987-06-10 Glaxo Group Ltd Composti eterociclici indolici, procedimento per produrli e composizioni farmaceutiche che li contengono

Also Published As

Publication number Publication date
AU566149B2 (en) 1987-10-08
SE452459B (sv) 1987-11-30
DE19375045I2 (de) 2002-09-05
SE8303208D0 (sv) 1983-06-07
HK14789A (en) 1989-02-24
ES8601880A1 (es) 1985-11-16
CH657359A5 (fr) 1986-08-29
FI832035L (fi) 1983-12-08
ES8407473A1 (es) 1984-10-01
KR840005095A (ko) 1984-11-03
IT1170387B (it) 1987-06-03
GB2124210A (en) 1984-02-15
PH19908A (en) 1986-08-13
IE831335L (en) 1983-12-07
CY1458A (en) 1989-07-21
DOP1989476000A (es) 1996-02-03
AT381933B (de) 1986-12-10
PT76830B (en) 1986-04-21
FR2530625A1 (fr) 1984-01-27
FI79530B (fi) 1989-09-29
DE3320521A1 (de) 1983-12-08
DK260183D0 (da) 1983-06-06
SE8303208L (sv) 1983-12-08
FI832035A0 (fi) 1983-06-07
KR900006681B1 (ko) 1990-09-17
JPH0329069B2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 1991-04-23
US4816470A (en) 1989-03-28
BE896986A (fr) 1983-12-07
AU1544183A (en) 1983-12-15
CZ404091A3 (en) 1993-04-14
DE3320521C2 (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 1992-06-25
MX9202623A (es) 1992-06-30
ES523039A0 (es) 1984-10-01
LU84852A1 (fr) 1985-03-29
ES544281A0 (es) 1986-07-16
SK277877B6 (en) 1995-06-07
SK404091A3 (en) 1995-06-07
ES529802A0 (es) 1985-11-16
IE55358B1 (en) 1990-08-29
PT76830A (en) 1983-07-01
MY8700179A (en) 1987-12-31
GR79215B (c_deeref_Disk_and_Scratch_Disk_Pools_and_Their_Defaults.html) 1984-10-22
CZ280529B6 (cs) 1996-02-14
NL193694B (nl) 2000-03-01
NL8302031A (nl) 1984-01-02
GB2124210B (en) 1985-11-13
FI79530C (fi) 1990-01-10
NL193694C (nl) 2000-07-04
NZ204482A (en) 1986-09-10
GB8315564D0 (en) 1983-07-13
ES8609247A1 (es) 1986-07-16
IL68913A0 (en) 1983-10-31
IL68913A (en) 1987-08-31
FR2530625B1 (fr) 1986-04-18
JPS5942366A (ja) 1984-03-08
ZA834110B (en) 1985-01-30
IT8348422A0 (it) 1983-06-03
CA1199643A (en) 1986-01-21
ATA208483A (de) 1986-05-15

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