|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
FR2613935B1
(fr)
|
1987-04-15 |
1989-12-01 |
Roussel Uclaf |
Association renfermant a titre de principes actifs, un analgesique central et la forskoline
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
JPH0688488B2
(ja)
|
1990-10-23 |
1994-11-09 |
豊治 藤本 |
ペルチェ電子素子型の可搬式エアコン及び換気性衣服
|
|
WO1993003054A1
(fr)
|
1991-08-09 |
1993-02-18 |
Teikoku Hormone Mfg. Co., Ltd. |
Nouveau derive de tetrapeptide
|
|
CA2081406C
(en)
|
1991-12-23 |
1997-09-16 |
Chinmoy Bhusan Bose |
Method and apparatus for connected and degraded text recognition
|
|
US5831002A
(en)
|
1992-05-20 |
1998-11-03 |
Basf Aktiengesellschaft |
Antitumor peptides
|
|
CA2136339C
(en)
|
1992-05-20 |
2008-02-05 |
Andreas Haupt |
Derivatives of dolastatin
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
JPH06172397A
(ja)
|
1992-12-11 |
1994-06-21 |
Nippon Kayaku Co Ltd |
新規物質ドラスタチンｃ及びその用途
|
|
PL178766B1
(pl)
|
1992-12-16 |
2000-06-30 |
Basf Ag |
Nowe peptydy
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
EP0731106B1
(en)
|
1993-10-01 |
2004-11-17 |
Teikoku Hormone Mfg. Co., Ltd. |
Dolastatin derivatives
|
|
DE69535243T2
(de)
|
1994-07-13 |
2007-05-10 |
Chugai Seiyaku K.K. |
Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
CN1113066C
(zh)
|
1995-04-21 |
2003-07-02 |
帝国脏器制药株式会社 |
新型肽衍生物
|
|
DE19527575A1
(de)
|
1995-07-28 |
1997-01-30 |
Basf Ag |
Verfahren zur Herstellung von peptidischer Wirkstoffe
|
|
JPH0977791A
(ja)
|
1995-09-08 |
1997-03-25 |
Nippon Kayaku Co Ltd |
ペプチド誘導体及びその用途
|
|
US5816444A
(en)
|
1995-10-23 |
1998-10-06 |
Calico Light Weapon Systems |
Rotor and ratchet assembly
|
|
US5807984A
(en)
|
1995-11-09 |
1998-09-15 |
Basf Aktienegesellschaft |
Oligopeptides, the preparation and use thereof
|
|
US5939527A
(en)
|
1996-07-30 |
1999-08-17 |
Basf Aktiengesellschaft |
Tetrapeptides as antitumor agents
|
|
US5741892A
(en)
|
1996-07-30 |
1998-04-21 |
Basf Aktiengesellschaft |
Pentapeptides as antitumor agents
|
|
WO1998036765A1
(en)
|
1997-02-25 |
1998-08-27 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear and cyclo-depsipeptides dolastatin 16, dolastatin 17, and dolastatin 18
|
|
US5965537A
(en)
|
1997-03-10 |
1999-10-12 |
Basf Aktiengesellschaft |
Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
|
|
US6103698A
(en)
|
1997-03-13 |
2000-08-15 |
Basf Aktiengesellschaft |
Dolastatin-15 derivatives in combination with taxanes
|
|
US6143721A
(en)
|
1997-07-18 |
2000-11-07 |
Basf Aktiengesellschaft |
Dolastatin 15 derivatives
|
|
ATE293638T1
(de)
|
1997-09-24 |
2005-05-15 |
Univ Arizona |
Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
|
|
DK1069185T3
(da)
|
1998-04-03 |
2011-06-27 |
Chugai Pharmaceutical Co Ltd |
Humaniseret antistof mod human vævsfaktor (TF) og fremgangsmåde til at konstruere humaniseret antistof
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
US5985837A
(en)
|
1998-07-08 |
1999-11-16 |
Basf Aktiengesellschaft |
Dolastatin 15 derivatives
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
FR2807767B1
(fr)
|
2000-04-12 |
2005-01-14 |
Lab Francais Du Fractionnement |
Anticorps monoclonaux anti-d
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US7256257B2
(en)
|
2001-04-30 |
2007-08-14 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
US6737409B2
(en)
|
2001-07-19 |
2004-05-18 |
Hoffmann-La Roche Inc. |
Dolastatin 10 derivatives
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
CA2512729C
(en)
|
2003-01-09 |
2014-09-16 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant fc regions and methods of using same
|
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
|
EP2478912B1
(en)
|
2003-11-06 |
2016-08-31 |
Seattle Genetics, Inc. |
Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy
|
|
DE10359795A1
(de)
|
2003-12-19 |
2005-07-21 |
Bayer Technology Services Gmbh |
Strangverdampfervorrichtung
|
|
US8288352B2
(en)
|
2004-11-12 |
2012-10-16 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the N terminus
|
|
JP2008521828A
(ja)
|
2004-11-29 |
2008-06-26 |
シアトル ジェネティックス， インコーポレイテッド |
操作された抗体およびイムノコンジュゲート
|
|
BRPI0519023A2
(pt)
|
2004-12-13 |
2008-12-23 |
Hoffmann La Roche |
composiÇço farmacÊutica contendo pelo menos um derivado de dolastatina 10
|
|
ES2708763T3
(es)
|
2005-07-07 |
2019-04-11 |
Seattle Genetics Inc |
Compuestos de monometilvalina que tienen modificaciones de la cadena lateral de fenilalanina en el extremo C
|
|
BRPI0911926A2
(pt)
|
2008-08-05 |
2020-08-18 |
Toray Industries, Inc |
composições farmacêuticas, anticorpos e usos de um anticorpo ou um fragmento do mesmo.
|
|
EP2711018A1
(en)
|
2009-06-22 |
2014-03-26 |
MedImmune, LLC |
Engineered Fc regions for site-specific conjugation
|
|
EP2480671B8
(en)
|
2009-09-22 |
2015-10-28 |
ProBioGen AG |
Process for producing molecules containing specialized glycan structures
|
|
US9115200B2
(en)
|
2010-02-04 |
2015-08-25 |
Toray Industries, Inc. |
Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1
|
|
RU2603742C2
(ru)
|
2010-02-04 |
2016-11-27 |
Торэй Индастриз, Инк. |
Фармацевтическая композиция для лечения и/или профилактики рака
|
|
CA2788545C
(en)
|
2010-02-04 |
2019-03-26 |
Toray Industries, Inc. |
Pharmaceutical composition for treating and/or preventing cancer
|
|
DK2532680T3
(da)
|
2010-02-04 |
2015-07-20 |
Toray Industries |
Medicinsk sammensætning til behandling og/eller forebyggelse af cancer
|
|
HUE040012T2
(hu)
|
2010-02-04 |
2019-02-28 |
Toray Industries |
Gyógyászati ágens rák kezelésére és/vagy megelõzésére
|
|
DK2532366T3
(da)
|
2010-02-04 |
2017-01-02 |
Toray Industries |
Farmaceutisk sammensætning til behandling og/eller forebyggelse af cancer
|
|
JP2013528357A
(ja)
|
2010-03-29 |
2013-07-11 |
ザイムワークス，インコーポレイテッド |
強化又は抑制されたエフェクター機能を有する抗体
|
|
WO2011154359A1
(de)
|
2010-06-10 |
2011-12-15 |
Bayer Pharma Aktiengesellschaft |
Neue auristatin-derivate und ihre verwendung
|
|
US9029406B2
(en)
|
2011-03-16 |
2015-05-12 |
Seattle Genetics, Inc |
N-carboxyalkylauristatins and use thereof
|
|
BR112013027119A8
(pt)
|
2011-04-21 |
2018-03-06 |
Seattle Genetics Inc |
novos conjugados ligante-droga (adcs) e uso dos mesmos
|
|
WO2012148943A1
(en)
|
2011-04-25 |
2012-11-01 |
Arizona Board Of Regents, For And On Behalf Of, Arizona State University |
Crystal structures of dolastatin 16, dolamethylleuine and dolaphenvaline, and methods for preparing dolamethylleuine and dolaphenvaline
|
|
CN110078789A
(zh)
|
2011-05-27 |
2019-08-02 |
Ambrx 公司 |
含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途
|
|
KR102356286B1
(ko)
|
2011-05-27 |
2022-02-08 |
암브룩스, 인코포레이티드 |
비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
|
|
PL2740793T3
(pl)
|
2011-08-04 |
2018-04-30 |
Toray Industries, Inc. |
Kompozycja leku do leczenia i/lub zapobiegania nowotworowi
|
|
RU2595400C2
(ru)
|
2011-08-04 |
2016-08-27 |
Торэй Индастриз, Инк. |
Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли
|
|
PT2740796T
(pt)
|
2011-08-04 |
2017-07-26 |
Toray Industries |
Composição farmacêutica para o tratamento e/ou profilaxia de cancro
|
|
EP2740794B1
(en)
|
2011-08-04 |
2018-04-04 |
Toray Industries, Inc. |
Pharmaceutical composition for treatment and/or prophylaxis of cancer
|
|
PT2740489T
(pt)
|
2011-08-04 |
2017-01-10 |
Toray Industries |
Composição farmacêutica para o tratamento e/ou a prevenção do cancro pancreático
|
|
US9181348B2
(en)
|
2011-08-04 |
2015-11-10 |
Toray Industries, Inc. |
Pharmaceutical composition for treatment and/or prophylaxis of cancer
|
|
CN108152513B
(zh)
|
2011-09-29 |
2020-07-24 |
西雅图基因公司 |
蛋白偶联的试剂化合物的整体分子量测定
|
|
US9260513B2
(en)
|
2012-02-21 |
2016-02-16 |
Toray Industries, Inc. |
Pharmaceutical composition for treatment and/or prevention of cancer
|
|
WO2013125654A1
(ja)
|
2012-02-21 |
2013-08-29 |
東レ株式会社 |
癌の治療及び／又は予防用医薬組成物
|
|
BR112014021103A2
(pt)
|
2012-02-21 |
2019-10-15 |
Toray Industries, Inc |
Anticorpo, composição farmacêutica, droga de combinação, dna, método de tratamento e uso de anticorpo
|
|
ES2739612T3
(es)
|
2012-02-21 |
2020-02-03 |
Toray Industries |
Composición farmacéutica para el tratamiento de cáncer
|
|
JP6107654B2
(ja)
|
2012-03-30 |
2017-04-05 |
東レ株式会社 |
肝臓癌の治療及び／又は予防用医薬組成物
|
|
WO2013147176A1
(ja)
|
2012-03-30 |
2013-10-03 |
東レ株式会社 |
胆嚢癌の治療及び／又は予防用医薬組成物
|
|
WO2013173337A2
(en)
|
2012-05-15 |
2013-11-21 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
CN112587671A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
|
JP6089108B2
(ja)
|
2012-09-20 |
2017-03-01 |
セルトリオン， インク． |
ドラスタチン１０誘導体、その製造方法およびそれを含む抗癌剤組成物
|
|
FR3005051A1
(fr)
|
2013-04-25 |
2014-10-31 |
Pf Medicament |
Derives de la dolastatine 10 et d'auristatines
|
|
AU2014303375B2
(en)
|
2013-08-09 |
2019-07-04 |
Toray Industries, Inc. |
Pharmaceutical composition for treatment and/or prevention of cancer
|
|
NZ758049A
(en)
|
2013-10-15 |
2024-03-22 |
Seagen Inc |
Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
|
|
KR102442906B1
(ko)
|
2013-12-19 |
2022-09-14 |
씨젠 인크. |
표적화된-약물 컨쥬게이트와 함께 사용되는 메틸렌 카바메이트 링커
|
|
US10562977B2
(en)
*
|
2014-01-29 |
2020-02-18 |
Shanghai Hengrui Pharmaceutical Co., Ltd. |
Ligand-cytotoxic drug conjugate, preparation method thereof, and uses thereof
|
|
CA2937753A1
(en)
|
2014-02-17 |
2015-08-20 |
Seattle Genetics, Inc. |
Hydrophilic antibody-drug conjugates
|
|
CN106279352B
(zh)
|
2015-05-29 |
2020-05-22 |
上海新理念生物医药科技有限公司 |
海兔毒素10的衍生物及其应用
|
|
CN109843919A
(zh)
|
2016-03-25 |
2019-06-04 |
西雅图基因公司 |
用于制备聚乙二醇化的药物-接头及其中间体的方法
|
|
CN108779146B
(zh)
|
2016-03-29 |
2022-03-18 |
东丽株式会社 |
肽衍生物及其用途
|
|
TWI851531B
(zh)
|
2016-08-09 |
2024-08-11 |
美商思進公司 |
具有改善之生理化學性質之具自我穩定連接子之藥物結合物
|
|
CN109890417A
(zh)
*
|
2016-10-28 |
2019-06-14 |
东丽株式会社 |
癌的治疗和/或预防用药物组合物
|
|
JP7244987B2
(ja)
|
2016-12-14 |
2023-03-23 |
シージェン インコーポレイテッド |
多剤抗体薬物コンジュゲート
|
|
IL268959B2
(en)
|
2017-02-28 |
2025-01-01 |
Seagen Inc |
Cystine-mutated antibodies, compositions containing them and uses thereof
|
|
SG11202007540SA
(en)
|
2018-02-20 |
2020-09-29 |
Seattle Genetics Inc |
Hydrophobic auristatin f compounds and conjugates thereof
|
|
CN109796522B
(zh)
|
2019-02-18 |
2021-09-21 |
清远中大创新药物研究中心 |
海兔毒素10环肽衍生物及其制备方法和应用
|
|
US20230000995A1
(en)
|
2019-10-28 |
2023-01-05 |
Ariel Scientific Innovations Ltd. |
Dolastatin 10 analog
|
|
KR20220151166A
(ko)
|
2020-03-09 |
2022-11-14 |
시그마-알드리치 컴퍼니., 엘엘씨 |
중간체 공통 중간체를 통한 돌라스타틴 및 아우리스타틴 유사체의 효율적인 제조
|