JPWO2021173930A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021173930A5 JPWO2021173930A5 JP2022551290A JP2022551290A JPWO2021173930A5 JP WO2021173930 A5 JPWO2021173930 A5 JP WO2021173930A5 JP 2022551290 A JP2022551290 A JP 2022551290A JP 2022551290 A JP2022551290 A JP 2022551290A JP WO2021173930 A5 JPWO2021173930 A5 JP WO2021173930A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- epilepsy
- cycloalkyl
- compound
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062982804P | 2020-02-28 | 2020-02-28 | |
| US202062982830P | 2020-02-28 | 2020-02-28 | |
| US202062982838P | 2020-02-28 | 2020-02-28 | |
| US62/982,830 | 2020-02-28 | ||
| US62/982,804 | 2020-02-28 | ||
| US62/982,838 | 2020-02-28 | ||
| PCT/US2021/019814 WO2021173930A1 (en) | 2020-02-28 | 2021-02-26 | Kcnt1 inhibitors and methods of use |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023515576A JP2023515576A (ja) | 2023-04-13 |
| JP2023515576A5 JP2023515576A5 (https=) | 2024-03-04 |
| JPWO2021173930A5 true JPWO2021173930A5 (https=) | 2024-03-04 |
| JP7699836B2 JP7699836B2 (ja) | 2025-06-30 |
Family
ID=77492026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022551290A Active JP7699836B2 (ja) | 2020-02-28 | 2021-02-26 | Ｋｃｎｔ１阻害剤、および使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12583849B2 (https=) |
| EP (2) | EP4110317B1 (https=) |
| JP (1) | JP7699836B2 (https=) |
| KR (1) | KR20230005813A (https=) |
| CN (1) | CN115443129A (https=) |
| BR (1) | BR112022017191A2 (https=) |
| CA (1) | CA3169779A1 (https=) |
| IL (1) | IL295940A (https=) |
| MX (1) | MX2022010625A (https=) |
| WO (1) | WO2021173930A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250172745A (ko) * | 2019-05-03 | 2025-12-09 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| KR20220016086A (ko) * | 2019-05-03 | 2022-02-08 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| EP4329735B1 (en) * | 2021-04-29 | 2026-02-25 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
| US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| TWI243164B (en) | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| GB0127547D0 (en) | 2001-11-16 | 2002-01-09 | Astrazeneca Ab | Chemical compounds |
| TW200301698A (en) | 2001-12-21 | 2003-07-16 | Bristol Myers Squibb Co | Acridone inhibitors of IMPDH enzyme |
| US6995144B2 (en) * | 2002-03-14 | 2006-02-07 | Eisai Co., Ltd. | Nitrogen containing heterocyclic compounds and medicines containing the same |
| JP2005060255A (ja) | 2003-08-20 | 2005-03-10 | Nippon Nohyaku Co Ltd | カルボキサミド類及びこれを有効成分とする有害生物防除剤 |
| US7585881B2 (en) | 2004-02-18 | 2009-09-08 | Astrazeneca Ab | Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| KR20070030196A (ko) * | 2004-04-13 | 2007-03-15 | 이카겐, 인코포레이티드 | 칼륨 이온 채널 조절제로서의 폴리시클릭 피리딘 |
| EP2044061A2 (en) | 2006-07-20 | 2009-04-08 | Mehmet Kahraman | Benzothiophene inhibitors of rho kinase |
| US20080269241A1 (en) | 2007-02-15 | 2008-10-30 | Darin Allen | Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
| US8445686B2 (en) * | 2007-08-27 | 2013-05-21 | Abbvie Inc. | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators |
| US9321727B2 (en) | 2011-06-10 | 2016-04-26 | Hoffmann-La Roche Inc. | Pyridine derivatives as agonists of the CB2 receptor |
| EP2970240B1 (en) | 2013-03-14 | 2018-01-10 | Novartis AG | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| NZ725860A (en) * | 2014-04-04 | 2019-08-30 | Iomet Pharma Ltd | Indole derivatives for use in medicine |
| TW201642855A (zh) | 2015-03-10 | 2016-12-16 | 健臻公司 | 用於治療蛋白質病變之方法 |
| EP3275440B1 (en) | 2015-03-25 | 2022-05-04 | National Center for Geriatrics and Gerontology | Novel oxadiazole derivative and pharmaceutical containing same |
| JPWO2017170826A1 (ja) | 2016-03-30 | 2019-02-14 | 味の素株式会社 | グルカゴン様ペプチド−１受容体作用増強活性を有する化合物 |
| WO2018187480A1 (en) | 2017-04-04 | 2018-10-11 | Praxis Precision Medicines, Inc. | Compounds and their methods of use |
| CN114364693A (zh) | 2019-05-03 | 2022-04-15 | 新加坡保健服务私人有限公司 | 代谢性疾病的治疗和预防 |
| KR20220016086A (ko) | 2019-05-03 | 2022-02-08 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| KR20250172745A (ko) | 2019-05-03 | 2025-12-09 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| KR20230005168A (ko) | 2020-03-23 | 2023-01-09 | 프락시스 프리시젼 메디신즈, 인크. | Kcnt1 억제제 및 사용 방법 |
| CA3188825A1 (en) | 2020-07-06 | 2022-01-13 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| US11773088B2 (en) | 2020-11-02 | 2023-10-03 | Praxis Precision Medicines, Inc. | KCNT1 inhibitors and methods of use |
| WO2022140547A2 (en) | 2020-12-22 | 2022-06-30 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| EP4329735B1 (en) | 2021-04-29 | 2026-02-25 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors and methods of use |
| US20250360117A1 (en) | 2022-06-08 | 2025-11-27 | Praxis Precision Medicines, Inc. | Kcnt1 inhibitors comprising an isoxazole or oxadiazole core and methods of use |
-
2021
- 2021-02-26 JP JP2022551290A patent/JP7699836B2/ja active Active
- 2021-02-26 EP EP21760026.1A patent/EP4110317B1/en active Active
- 2021-02-26 WO PCT/US2021/019814 patent/WO2021173930A1/en not_active Ceased
- 2021-02-26 BR BR112022017191A patent/BR112022017191A2/pt unknown
- 2021-02-26 EP EP25207650.0A patent/EP4692069A3/en active Pending
- 2021-02-26 MX MX2022010625A patent/MX2022010625A/es unknown
- 2021-02-26 US US17/904,963 patent/US12583849B2/en active Active
- 2021-02-26 CN CN202180028764.XA patent/CN115443129A/zh active Pending
- 2021-02-26 KR KR1020227033876A patent/KR20230005813A/ko active Pending
- 2021-02-26 IL IL295940A patent/IL295940A/en unknown
- 2021-02-26 CA CA3169779A patent/CA3169779A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102943760B1 (ko) | 피리다진 유도체 억제제, 및 그의 제조 방법 및 용도 | |
| EP4143195B1 (en) | Imidazopyridazines as modulators of il-17 | |
| JP2021105002A5 (https=) | ||
| JP6377068B2 (ja) | ピラゾロピリミジン化合物 | |
| JP2006513268A5 (ja) | アンタゴニスト活性を有するベンゾアゾリルピペラジン誘導体 | |
| KR101717872B1 (ko) | 소아 간질 및 간질-관련 증후군의 예방 또는 치료용 페닐카바메이트 화합물 | |
| JP2012532112A5 (https=) | ||
| RU2015101532A (ru) | Замещенные бициклические алкокси-пиразольные аналоги в качестве аллостерических модуляторов рецепторов mglur5 | |
| JP2021523200A5 (https=) | ||
| JP2007508358A5 (https=) | ||
| RU2015101512A (ru) | Замещенные бициклические алкокси-пиразольные аналоги в качестве аллостерических модуляторов рецепторов mglur5 | |
| JP2021534106A5 (https=) | ||
| RU2008119692A (ru) | Новые 1-азабициклоалкилпроизводные для лечения психических растройств | |
| KR20160004260A (ko) | 페닐카바메이트 화합물 및 이를 포함하는 신경보호용 조성물 | |
| JP2024160326A (ja) | Ｅａａｔ２活性化因子およびその使用方法 | |
| JPWO2021173930A5 (https=) | ||
| JPWO2020227097A5 (https=) | ||
| JP2010530002A5 (https=) | ||
| DE60122484T2 (de) | Verbindungen für die modulation der proliferation von zellen | |
| JPWO2020069322A5 (https=) | ||
| JPWO2020227101A5 (https=) | ||
| DE3422876A1 (de) | (3-amino-1h-pyrazol-4-yl)-(aryl)-methanone | |
| JPWO2021195066A5 (https=) | ||
| RU2005125919A (ru) | Альфа-аминоамидные производные, применимые в качестве антимигренозных средств | |
| RU96102574A (ru) | Новые производные /1-фенил-1-гетероциклил/алкана и их применение в качестве нейрозащитных агентов |