JPWO2021095874A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021095874A5 JPWO2021095874A5 JP2021556191A JP2021556191A JPWO2021095874A5 JP WO2021095874 A5 JPWO2021095874 A5 JP WO2021095874A5 JP 2021556191 A JP2021556191 A JP 2021556191A JP 2021556191 A JP2021556191 A JP 2021556191A JP WO2021095874 A5 JPWO2021095874 A5 JP WO2021095874A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- amino
- group
- chloride
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025087141A JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019205625 | 2019-11-13 | ||
| JP2019205625 | 2019-11-13 | ||
| PCT/JP2020/042505 WO2021095874A1 (ja) | 2019-11-13 | 2020-11-13 | オリゴ核酸化合物の製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025087141A Division JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021095874A1 JPWO2021095874A1 (https=) | 2021-05-20 |
| JPWO2021095874A5 true JPWO2021095874A5 (https=) | 2023-11-16 |
| JP7689078B2 JP7689078B2 (ja) | 2025-06-05 |
Family
ID=75913043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556191A Active JP7689078B2 (ja) | 2019-11-13 | 2020-11-13 | オリゴ核酸化合物の製造方法 |
| JP2025087141A Pending JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025087141A Pending JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12600743B2 (https=) |
| EP (1) | EP4059944A4 (https=) |
| JP (2) | JP7689078B2 (https=) |
| KR (1) | KR20220098217A (https=) |
| CN (1) | CN114981281A (https=) |
| CA (1) | CA3161586A1 (https=) |
| WO (1) | WO2021095874A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7825613B2 (ja) * | 2021-04-28 | 2026-03-06 | 日本新薬株式会社 | オリゴ核酸化合物の製造方法 |
| EP4458833A4 (en) * | 2021-12-27 | 2025-12-31 | Nippon Shinyaku Co Ltd | PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2130844A5 (https=) | 1971-03-23 | 1972-11-10 | Commissariat Energie Atomique | |
| JPS5668388A (en) | 1979-11-10 | 1981-06-09 | Norin Suisansyo Shokuhin Sogo Kenkyusho | Production of cell body of spirulina algae |
| AU655164B2 (en) | 1989-12-20 | 1994-12-08 | Antivirals Inc. | Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages |
| JPH10109994A (ja) * | 1996-10-03 | 1998-04-28 | Sumitomo Chem Co Ltd | アミドチオリン酸エステル誘導体の製造方法 |
| US6313301B1 (en) | 1997-08-13 | 2001-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their intermediates and production thereof |
| JPH1180185A (ja) | 1997-09-05 | 1999-03-26 | Res Dev Corp Of Japan | オリゴヌクレオチドの化学合成法 |
| US6274725B1 (en) | 1998-06-02 | 2001-08-14 | Isis Pharmaceuticals, Inc. | Activators for oligonucleotide synthesis |
| ATE287413T1 (de) * | 2001-07-12 | 2005-02-15 | Santaris Pharma As | Verfahren zur herstellung des lna phosphoramidite |
| CN100338076C (zh) | 2002-06-13 | 2007-09-19 | 罗狄亚公司 | 制备亚磷酰二胺化合物的方法 |
| US8067571B2 (en) * | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| EP2152723A1 (en) * | 2007-05-22 | 2010-02-17 | Girindus AG | Synthesis of oligonucleotides |
| KR100886139B1 (ko) | 2007-11-13 | 2009-02-27 | 주식회사 삼천리제약 | 올리고뉴클레오타이드의 제조방법 |
| RU2606627C2 (ru) | 2007-11-15 | 2017-01-10 | Серепта Терапьютикс,Инк. | Способ синтеза морфолиновых олигомеров |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| ES2607603T3 (es) * | 2010-09-30 | 2017-04-03 | Nippon Shinyaku Co., Ltd. | Derivado de ácido morfolino nucleico |
| DK2711370T3 (en) | 2011-05-17 | 2018-02-26 | Ajinomoto Kk | PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES |
| HK1201514A1 (en) | 2011-11-18 | 2015-09-04 | Sarepta Therapeutics, Inc. | Functionally-modified oligonucleotides and subunits thereof |
| US10066228B2 (en) | 2011-11-30 | 2018-09-04 | Sarepta Therapeutics, Inc. | Oligonucleotides for treating expanded repeat diseases |
| EP2816053B1 (en) | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| US10214555B2 (en) | 2012-11-14 | 2019-02-26 | Takeda Pharmaceutical Company Limitjed | Method for liquid-phase synthesis of nucleic acid |
| DK3015467T3 (da) | 2013-05-24 | 2025-02-10 | Ajinomoto Kk | Morpholino-oligonukleotidfremstillingsfremgangsmåde |
| WO2016060135A1 (ja) | 2014-10-14 | 2016-04-21 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| CN107406480B (zh) | 2015-03-04 | 2022-06-24 | Jitsubo株式会社 | 肽合成方法 |
| WO2019060862A1 (en) * | 2017-09-25 | 2019-03-28 | Sarepta Therapeutics, Inc. | METHODS FOR PREPARING MORPHOLINO PHOSPHORODIAMIDATE OLIGOMERS VIA FAST FLOW SYNTHESIS |
| CA3099778A1 (en) | 2018-05-10 | 2019-11-14 | Nippon Shinyaku Co., Ltd. | Method for preparing oligonucleic acid compound |
-
2020
- 2020-11-13 KR KR1020227019550A patent/KR20220098217A/ko active Pending
- 2020-11-13 CA CA3161586A patent/CA3161586A1/en active Pending
- 2020-11-13 US US17/776,343 patent/US12600743B2/en active Active
- 2020-11-13 CN CN202080092854.0A patent/CN114981281A/zh active Pending
- 2020-11-13 EP EP20886751.5A patent/EP4059944A4/en active Pending
- 2020-11-13 WO PCT/JP2020/042505 patent/WO2021095874A1/ja not_active Ceased
- 2020-11-13 JP JP2021556191A patent/JP7689078B2/ja active Active
-
2025
- 2025-05-26 JP JP2025087141A patent/JP2025128175A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2922859B1 (en) | Phosphonucleosides useful in the treatment of viral disorders | |
| JP3421335B2 (ja) | 鏡像異性的に純粋なβ−Ｄ−（−）−ジオキソラン−ヌクレオシド | |
| AU2018200461B2 (en) | Process methods for phosphatidylinositol 3-kinase inhibitors | |
| US20110021454A1 (en) | Modified 4`-nucleosides as antiviral agents | |
| US6194398B1 (en) | Phosphonate nucleotide compound | |
| JPWO2021095874A5 (https=) | ||
| PT821690E (pt) | Análogos de nucleotídeos para tratamento de infeções virais | |
| US20140275508A1 (en) | Artificial nucleic acids | |
| PT2623507T (pt) | Derivado de ácido morfolino-nucleico | |
| WO2020017085A1 (ja) | アルコキシフェニル誘導体、ヌクレオシド保護体およびヌクレオチド保護体、オリゴヌクレオチド製造方法、ならびに、置換基除去方法 | |
| RU2009104764A (ru) | Производные пурина, как антангонисты a2a | |
| JP2014516923A5 (https=) | ||
| JP2023538524A5 (https=) | ||
| JP2025128175A (ja) | オリゴ核酸化合物の製造方法 | |
| SG191841A1 (en) | Methods of making hiv attachment inhibitor prodrug compound and intermediates | |
| JP2015509836A5 (https=) | ||
| JPH07503453A (ja) | 抗ウイルス性非環式ホスホノメトキシアルキル置換アルケニル及びアルキニルプリン及びピリミジン誘導体 | |
| JPWO2021095875A5 (https=) | ||
| CN1921867B (zh) | 用于治疗hiv感染的膦酸核苷衍生物 | |
| EP0362967B1 (en) | Nucleoside derivatives | |
| JP2011136905A (ja) | ベンゼン化合物及びその医薬用途 | |
| WO2021095875A1 (ja) | オリゴ核酸化合物の製造方法 | |
| JP7825613B2 (ja) | オリゴ核酸化合物の製造方法 | |
| CN1227489A (zh) | 腺嘌呤核苷脱氨酶抑制剂 | |
| JPWO2022230954A5 (https=) |