JPWO2021095874A1 - - Google Patents
Info
- Publication number
- JPWO2021095874A1 JPWO2021095874A1 JP2021556191A JP2021556191A JPWO2021095874A1 JP WO2021095874 A1 JPWO2021095874 A1 JP WO2021095874A1 JP 2021556191 A JP2021556191 A JP 2021556191A JP 2021556191 A JP2021556191 A JP 2021556191A JP WO2021095874 A1 JPWO2021095874 A1 JP WO2021095874A1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025087141A JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019205625 | 2019-11-13 | ||
| JP2019205625 | 2019-11-13 | ||
| PCT/JP2020/042505 WO2021095874A1 (ja) | 2019-11-13 | 2020-11-13 | オリゴ核酸化合物の製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025087141A Division JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021095874A1 true JPWO2021095874A1 (https=) | 2021-05-20 |
| JPWO2021095874A5 JPWO2021095874A5 (https=) | 2023-11-16 |
| JP7689078B2 JP7689078B2 (ja) | 2025-06-05 |
Family
ID=75913043
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556191A Active JP7689078B2 (ja) | 2019-11-13 | 2020-11-13 | オリゴ核酸化合物の製造方法 |
| JP2025087141A Pending JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025087141A Pending JP2025128175A (ja) | 2019-11-13 | 2025-05-26 | オリゴ核酸化合物の製造方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12600743B2 (https=) |
| EP (1) | EP4059944A4 (https=) |
| JP (2) | JP7689078B2 (https=) |
| KR (1) | KR20220098217A (https=) |
| CN (1) | CN114981281A (https=) |
| CA (1) | CA3161586A1 (https=) |
| WO (1) | WO2021095874A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20240254158A1 (en) * | 2021-04-28 | 2024-08-01 | Nippon Shinyaku Co., Ltd. | Method for producing oligonucleic acid compound |
| CA3244382A1 (en) * | 2021-12-27 | 2025-02-26 | Nippon Shinyaku Co., Ltd. | PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1180185A (ja) * | 1997-09-05 | 1999-03-26 | Res Dev Corp Of Japan | オリゴヌクレオチドの化学合成法 |
| JP2002517404A (ja) * | 1998-06-02 | 2002-06-18 | アイシス・ファーマシューティカルス・インコーポレーテッド | オリゴヌクレオチド合成のためのアクチベーター |
| WO2003006475A2 (en) * | 2001-07-12 | 2003-01-23 | Santaris Pharma A/S | Method for preparation of lna phosphoramidites |
| JP2010527945A (ja) * | 2007-05-22 | 2010-08-19 | ギリンデュス アクチェンゲゼルシャフト | オリゴヌクレオチドの合成 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2130844A5 (https=) | 1971-03-23 | 1972-11-10 | Commissariat Energie Atomique | |
| JPS5668388A (en) | 1979-11-10 | 1981-06-09 | Norin Suisansyo Shokuhin Sogo Kenkyusho | Production of cell body of spirulina algae |
| JP3398378B2 (ja) | 1989-12-20 | 2003-04-21 | アンチビラルス・インコーポレイテツド | リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー |
| JPH10109994A (ja) * | 1996-10-03 | 1998-04-28 | Sumitomo Chem Co Ltd | アミドチオリン酸エステル誘導体の製造方法 |
| US6313301B1 (en) | 1997-08-13 | 2001-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their intermediates and production thereof |
| JP2005529957A (ja) | 2002-06-13 | 2005-10-06 | ローディア インク． | リン・ジアミダイト合成物を生成する工程 |
| US8067571B2 (en) * | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| KR100886139B1 (ko) | 2007-11-13 | 2009-02-27 | 주식회사 삼천리제약 | 올리고뉴클레오타이드의 제조방법 |
| MX2010004955A (es) | 2007-11-15 | 2010-06-30 | Avi Biopharma Inc | Metodo de sintesis de oligomeros de morfolina. |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| RS55610B1 (sr) | 2010-09-30 | 2017-06-30 | Nippon Shinyaku Co Ltd | Derivat morfolino nukleinske kiseline |
| JP5979139B2 (ja) | 2011-05-17 | 2016-08-24 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| EA202090338A1 (ru) | 2011-11-18 | 2021-04-30 | Сарепта Терапьютикс, Инк. | Функционально-модифицированные олигонуклеотиды и их субъединицы |
| US10066228B2 (en) | 2011-11-30 | 2018-09-04 | Sarepta Therapeutics, Inc. | Oligonucleotides for treating expanded repeat diseases |
| EP2816053B1 (en) | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| EP2921499B1 (en) | 2012-11-14 | 2020-01-22 | Takeda Pharmaceutical Company Limited | Method for liquid-phase synthesis of nucleic acids |
| WO2014189142A1 (ja) | 2013-05-24 | 2014-11-27 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| JP6673211B2 (ja) | 2014-10-14 | 2020-03-25 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| EP3266792B1 (en) | 2015-03-04 | 2020-12-30 | Jitsubo Co., Ltd. | Peptide synthesis method |
| EP3672601B1 (en) * | 2017-09-25 | 2023-09-13 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers via fast-flow synthesis |
| CN112384520B (zh) * | 2018-05-10 | 2024-06-11 | 日本新药株式会社 | 寡核苷酸化合物的制造方法 |
-
2020
- 2020-11-13 CA CA3161586A patent/CA3161586A1/en active Pending
- 2020-11-13 WO PCT/JP2020/042505 patent/WO2021095874A1/ja not_active Ceased
- 2020-11-13 CN CN202080092854.0A patent/CN114981281A/zh active Pending
- 2020-11-13 JP JP2021556191A patent/JP7689078B2/ja active Active
- 2020-11-13 KR KR1020227019550A patent/KR20220098217A/ko active Pending
- 2020-11-13 US US17/776,343 patent/US12600743B2/en active Active
- 2020-11-13 EP EP20886751.5A patent/EP4059944A4/en active Pending
-
2025
- 2025-05-26 JP JP2025087141A patent/JP2025128175A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1180185A (ja) * | 1997-09-05 | 1999-03-26 | Res Dev Corp Of Japan | オリゴヌクレオチドの化学合成法 |
| JP2002517404A (ja) * | 1998-06-02 | 2002-06-18 | アイシス・ファーマシューティカルス・インコーポレーテッド | オリゴヌクレオチド合成のためのアクチベーター |
| WO2003006475A2 (en) * | 2001-07-12 | 2003-01-23 | Santaris Pharma A/S | Method for preparation of lna phosphoramidites |
| JP2010527945A (ja) * | 2007-05-22 | 2010-08-19 | ギリンデュス アクチェンゲゼルシャフト | オリゴヌクレオチドの合成 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2025128175A (ja) | 2025-09-02 |
| EP4059944A4 (en) | 2024-04-10 |
| US12600743B2 (en) | 2026-04-14 |
| US20230018780A1 (en) | 2023-01-19 |
| CN114981281A (zh) | 2022-08-30 |
| JP7689078B2 (ja) | 2025-06-05 |
| WO2021095874A1 (ja) | 2021-05-20 |
| CA3161586A1 (en) | 2021-05-20 |
| EP4059944A1 (en) | 2022-09-21 |
| KR20220098217A (ko) | 2022-07-11 |
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