JP7689078B2 - オリゴ核酸化合物の製造方法 - Google Patents

オリゴ核酸化合物の製造方法 Download PDF

Info

Publication number
JP7689078B2
JP7689078B2 JP2021556191A JP2021556191A JP7689078B2 JP 7689078 B2 JP7689078 B2 JP 7689078B2 JP 2021556191 A JP2021556191 A JP 2021556191A JP 2021556191 A JP2021556191 A JP 2021556191A JP 7689078 B2 JP7689078 B2 JP 7689078B2
Authority
JP
Japan
Prior art keywords
compound
chloride
reaction
group
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2021556191A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021095874A1 (https=
JPWO2021095874A5 (https=
Inventor
純司 浅田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of JPWO2021095874A1 publication Critical patent/JPWO2021095874A1/ja
Publication of JPWO2021095874A5 publication Critical patent/JPWO2021095874A5/ja
Priority to JP2025087141A priority Critical patent/JP2025128175A/ja
Application granted granted Critical
Publication of JP7689078B2 publication Critical patent/JP7689078B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
JP2021556191A 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法 Active JP7689078B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025087141A JP2025128175A (ja) 2019-11-13 2025-05-26 オリゴ核酸化合物の製造方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019205625 2019-11-13
JP2019205625 2019-11-13
PCT/JP2020/042505 WO2021095874A1 (ja) 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025087141A Division JP2025128175A (ja) 2019-11-13 2025-05-26 オリゴ核酸化合物の製造方法

Publications (3)

Publication Number Publication Date
JPWO2021095874A1 JPWO2021095874A1 (https=) 2021-05-20
JPWO2021095874A5 JPWO2021095874A5 (https=) 2023-11-16
JP7689078B2 true JP7689078B2 (ja) 2025-06-05

Family

ID=75913043

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021556191A Active JP7689078B2 (ja) 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法
JP2025087141A Pending JP2025128175A (ja) 2019-11-13 2025-05-26 オリゴ核酸化合物の製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025087141A Pending JP2025128175A (ja) 2019-11-13 2025-05-26 オリゴ核酸化合物の製造方法

Country Status (7)

Country Link
US (1) US12600743B2 (https=)
EP (1) EP4059944A4 (https=)
JP (2) JP7689078B2 (https=)
KR (1) KR20220098217A (https=)
CN (1) CN114981281A (https=)
CA (1) CA3161586A1 (https=)
WO (1) WO2021095874A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240254158A1 (en) * 2021-04-28 2024-08-01 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
CA3244382A1 (en) * 2021-12-27 2025-02-26 Nippon Shinyaku Co., Ltd. PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002517404A (ja) 1998-06-02 2002-06-18 アイシス・ファーマシューティカルス・インコーポレーテッド オリゴヌクレオチド合成のためのアクチベーター
JP2010527945A (ja) 2007-05-22 2010-08-19 ギリンデュス アクチェンゲゼルシャフト オリゴヌクレオチドの合成

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2130844A5 (https=) 1971-03-23 1972-11-10 Commissariat Energie Atomique
JPS5668388A (en) 1979-11-10 1981-06-09 Norin Suisansyo Shokuhin Sogo Kenkyusho Production of cell body of spirulina algae
JP3398378B2 (ja) 1989-12-20 2003-04-21 アンチビラルス・インコーポレイテツド リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー
JPH10109994A (ja) * 1996-10-03 1998-04-28 Sumitomo Chem Co Ltd アミドチオリン酸エステル誘導体の製造方法
US6313301B1 (en) 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
JPH1180185A (ja) 1997-09-05 1999-03-26 Res Dev Corp Of Japan オリゴヌクレオチドの化学合成法
AU2002328792A1 (en) * 2001-07-12 2003-01-29 Santaris Pharma A/S Method for preparation of lna phosphoramidites
JP2005529957A (ja) 2002-06-13 2005-10-06 ローディア インク． リン・ジアミダイト合成物を生成する工程
US8067571B2 (en) * 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
KR100886139B1 (ko) 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
MX2010004955A (es) 2007-11-15 2010-06-30 Avi Biopharma Inc Metodo de sintesis de oligomeros de morfolina.
JP5548852B2 (ja) 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
RS55610B1 (sr) 2010-09-30 2017-06-30 Nippon Shinyaku Co Ltd Derivat morfolino nukleinske kiseline
JP5979139B2 (ja) 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
EA202090338A1 (ru) 2011-11-18 2021-04-30 Сарепта Терапьютикс, Инк. Функционально-модифицированные олигонуклеотиды и их субъединицы
US10066228B2 (en) 2011-11-30 2018-09-04 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
EP2921499B1 (en) 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
WO2014189142A1 (ja) 2013-05-24 2014-11-27 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
JP6673211B2 (ja) 2014-10-14 2020-03-25 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
EP3266792B1 (en) 2015-03-04 2020-12-30 Jitsubo Co., Ltd. Peptide synthesis method
EP3672601B1 (en) * 2017-09-25 2023-09-13 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers via fast-flow synthesis
CN112384520B (zh) * 2018-05-10 2024-06-11 日本新药株式会社 寡核苷酸化合物的制造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002517404A (ja) 1998-06-02 2002-06-18 アイシス・ファーマシューティカルス・インコーポレーテッド オリゴヌクレオチド合成のためのアクチベーター
JP2010527945A (ja) 2007-05-22 2010-08-19 ギリンデュス アクチェンゲゼルシャフト オリゴヌクレオチドの合成

Also Published As

Publication number Publication date
JP2025128175A (ja) 2025-09-02
EP4059944A4 (en) 2024-04-10
US12600743B2 (en) 2026-04-14
US20230018780A1 (en) 2023-01-19
CN114981281A (zh) 2022-08-30
WO2021095874A1 (ja) 2021-05-20
JPWO2021095874A1 (https=) 2021-05-20
CA3161586A1 (en) 2021-05-20
EP4059944A1 (en) 2022-09-21
KR20220098217A (ko) 2022-07-11

Similar Documents

Publication Publication Date Title
JP7394749B2 (ja) オリゴ核酸化合物の製造方法
JP2025128175A (ja) オリゴ核酸化合物の製造方法
JP5831455B2 (ja) モルホリノ核酸誘導体
EP3263579B1 (en) Precipitation promoter and precipitation method in which same is used
JP2025111536A (ja) オリゴ核酸化合物の製造方法
JP7825613B2 (ja) オリゴ核酸化合物の製造方法
HK40072767A (en) Method for producing oligonucleic acid compound
HK40038624A (en) Method for producing oligonucleic acid compound
HK40081457A (en) Method for producing oligonucleic acid compound
JP7433684B1 (ja) 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
HK40102206A (en) Method for producing oligonucleic acid compound
JP2023179354A (ja) Ｈ－ホスホネート法を用いたモルフォリノ核酸の製造方法
JPWO2024185734A5 (https=)

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20231108

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20231108

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241112

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250110

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250214

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250430

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250526

R150 Certificate of patent or registration of utility model

Ref document number: 7689078

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150