CN114981281A - 寡核苷酸化合物的制造方法 - Google Patents

寡核苷酸化合物的制造方法 Download PDF

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Publication number
CN114981281A
CN114981281A CN202080092854.0A CN202080092854A CN114981281A CN 114981281 A CN114981281 A CN 114981281A CN 202080092854 A CN202080092854 A CN 202080092854A CN 114981281 A CN114981281 A CN 114981281A
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CN
China
Prior art keywords
compound
group
alkyl
amino
chloride
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Pending
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CN202080092854.0A
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English (en)
Chinese (zh)
Inventor
浅田纯司
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Nippon Shinyaku Co Ltd
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Nippon Shinyaku Co Ltd
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Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of CN114981281A publication Critical patent/CN114981281A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
CN202080092854.0A 2019-11-13 2020-11-13 寡核苷酸化合物的制造方法 Pending CN114981281A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019205625 2019-11-13
JP2019-205625 2019-11-13
PCT/JP2020/042505 WO2021095874A1 (ja) 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法

Publications (1)

Publication Number Publication Date
CN114981281A true CN114981281A (zh) 2022-08-30

Family

ID=75913043

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080092854.0A Pending CN114981281A (zh) 2019-11-13 2020-11-13 寡核苷酸化合物的制造方法

Country Status (7)

Country Link
US (1) US12600743B2 (https=)
EP (1) EP4059944A4 (https=)
JP (2) JP7689078B2 (https=)
KR (1) KR20220098217A (https=)
CN (1) CN114981281A (https=)
CA (1) CA3161586A1 (https=)
WO (1) WO2021095874A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240254158A1 (en) * 2021-04-28 2024-08-01 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
CA3244382A1 (en) * 2021-12-27 2025-02-26 Nippon Shinyaku Co., Ltd. PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2130844A5 (https=) 1971-03-23 1972-11-10 Commissariat Energie Atomique
JPS5668388A (en) 1979-11-10 1981-06-09 Norin Suisansyo Shokuhin Sogo Kenkyusho Production of cell body of spirulina algae
JP3398378B2 (ja) 1989-12-20 2003-04-21 アンチビラルス・インコーポレイテツド リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー
JPH10109994A (ja) * 1996-10-03 1998-04-28 Sumitomo Chem Co Ltd アミドチオリン酸エステル誘導体の製造方法
US6313301B1 (en) 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
JPH1180185A (ja) 1997-09-05 1999-03-26 Res Dev Corp Of Japan オリゴヌクレオチドの化学合成法
US6274725B1 (en) * 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
AU2002328792A1 (en) * 2001-07-12 2003-01-29 Santaris Pharma A/S Method for preparation of lna phosphoramidites
JP2005529957A (ja) 2002-06-13 2005-10-06 ローディア インク． リン・ジアミダイト合成物を生成する工程
US8067571B2 (en) * 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
KR20100022470A (ko) * 2007-05-22 2010-03-02 기린두스 아게 올리고뉴클레오타이드의 합성
KR100886139B1 (ko) 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
MX2010004955A (es) 2007-11-15 2010-06-30 Avi Biopharma Inc Metodo de sintesis de oligomeros de morfolina.
JP5548852B2 (ja) 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
RS55610B1 (sr) 2010-09-30 2017-06-30 Nippon Shinyaku Co Ltd Derivat morfolino nukleinske kiseline
JP5979139B2 (ja) 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
EA202090338A1 (ru) 2011-11-18 2021-04-30 Сарепта Терапьютикс, Инк. Функционально-модифицированные олигонуклеотиды и их субъединицы
US10066228B2 (en) 2011-11-30 2018-09-04 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
EP2921499B1 (en) 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
WO2014189142A1 (ja) 2013-05-24 2014-11-27 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
JP6673211B2 (ja) 2014-10-14 2020-03-25 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
EP3266792B1 (en) 2015-03-04 2020-12-30 Jitsubo Co., Ltd. Peptide synthesis method
EP3672601B1 (en) * 2017-09-25 2023-09-13 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers via fast-flow synthesis
CN112384520B (zh) * 2018-05-10 2024-06-11 日本新药株式会社 寡核苷酸化合物的制造方法

Also Published As

Publication number Publication date
JP2025128175A (ja) 2025-09-02
EP4059944A4 (en) 2024-04-10
US12600743B2 (en) 2026-04-14
US20230018780A1 (en) 2023-01-19
JP7689078B2 (ja) 2025-06-05
WO2021095874A1 (ja) 2021-05-20
JPWO2021095874A1 (https=) 2021-05-20
CA3161586A1 (en) 2021-05-20
EP4059944A1 (en) 2022-09-21
KR20220098217A (ko) 2022-07-11

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