KR20220098217A - 올리고 핵산 화합물의 제조 방법 - Google Patents

올리고 핵산 화합물의 제조 방법 Download PDF

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Publication number
KR20220098217A
KR20220098217A KR1020227019550A KR20227019550A KR20220098217A KR 20220098217 A KR20220098217 A KR 20220098217A KR 1020227019550 A KR1020227019550 A KR 1020227019550A KR 20227019550 A KR20227019550 A KR 20227019550A KR 20220098217 A KR20220098217 A KR 20220098217A
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KR
South Korea
Prior art keywords
compound
alkyl
amino
chloride
formula
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Pending
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KR1020227019550A
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English (en)
Korean (ko)
Inventor
쥰시 아사다
Original Assignee
니뽄 신야쿠 가부시키가이샤
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Application filed by 니뽄 신야쿠 가부시키가이샤 filed Critical 니뽄 신야쿠 가부시키가이샤
Publication of KR20220098217A publication Critical patent/KR20220098217A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
KR1020227019550A 2019-11-13 2020-11-13 올리고 핵산 화합물의 제조 방법 Pending KR20220098217A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2019205625 2019-11-13
JPJP-P-2019-205625 2019-11-13
PCT/JP2020/042505 WO2021095874A1 (ja) 2019-11-13 2020-11-13 オリゴ核酸化合物の製造方法

Publications (1)

Publication Number Publication Date
KR20220098217A true KR20220098217A (ko) 2022-07-11

Family

ID=75913043

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227019550A Pending KR20220098217A (ko) 2019-11-13 2020-11-13 올리고 핵산 화합물의 제조 방법

Country Status (7)

Country Link
US (1) US12600743B2 (https=)
EP (1) EP4059944A4 (https=)
JP (2) JP7689078B2 (https=)
KR (1) KR20220098217A (https=)
CN (1) CN114981281A (https=)
CA (1) CA3161586A1 (https=)
WO (1) WO2021095874A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7825613B2 (ja) * 2021-04-28 2026-03-06 日本新薬株式会社 オリゴ核酸化合物の製造方法
EP4458833A4 (en) * 2021-12-27 2025-12-31 Nippon Shinyaku Co Ltd PROCESS FOR THE PRODUCTION OF OLIGONUCLEIC ACID COMPOUNDS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5548852B1 (https=) 1971-03-23 1980-12-09
WO1991009033A1 (en) 1989-12-20 1991-06-27 Anti-Gene Development Group Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages
WO2013122236A1 (ja) 2012-02-17 2013-08-22 味の素株式会社 塩基部保護オリゴヌクレオチド
WO2014077292A1 (ja) 2012-11-14 2014-05-22 武田薬品工業株式会社 核酸の液相合成方法
WO2016060135A1 (ja) 2014-10-14 2016-04-21 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法

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Publication number Priority date Publication date Assignee Title
JPS5668388A (en) 1979-11-10 1981-06-09 Norin Suisansyo Shokuhin Sogo Kenkyusho Production of cell body of spirulina algae
JPH10109994A (ja) * 1996-10-03 1998-04-28 Sumitomo Chem Co Ltd アミドチオリン酸エステル誘導体の製造方法
US6313301B1 (en) 1997-08-13 2001-11-06 Takeda Chemical Industries, Ltd. Thienopyridine derivatives, their intermediates and production thereof
JPH1180185A (ja) 1997-09-05 1999-03-26 Res Dev Corp Of Japan オリゴヌクレオチドの化学合成法
US6274725B1 (en) 1998-06-02 2001-08-14 Isis Pharmaceuticals, Inc. Activators for oligonucleotide synthesis
ATE287413T1 (de) * 2001-07-12 2005-02-15 Santaris Pharma As Verfahren zur herstellung des lna phosphoramidite
CN100338076C (zh) 2002-06-13 2007-09-19 罗狄亚公司 制备亚磷酰二胺化合物的方法
US8067571B2 (en) * 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
EP2152723A1 (en) * 2007-05-22 2010-02-17 Girindus AG Synthesis of oligonucleotides
KR100886139B1 (ko) 2007-11-13 2009-02-27 주식회사 삼천리제약 올리고뉴클레오타이드의 제조방법
RU2606627C2 (ru) 2007-11-15 2017-01-10 Серепта Терапьютикс,Инк. Способ синтеза морфолиновых олигомеров
JP5548852B2 (ja) 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
ES2607603T3 (es) * 2010-09-30 2017-04-03 Nippon Shinyaku Co., Ltd. Derivado de ácido morfolino nucleico
DK2711370T3 (en) 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
HK1201514A1 (en) 2011-11-18 2015-09-04 Sarepta Therapeutics, Inc. Functionally-modified oligonucleotides and subunits thereof
US10066228B2 (en) 2011-11-30 2018-09-04 Sarepta Therapeutics, Inc. Oligonucleotides for treating expanded repeat diseases
DK3015467T3 (da) 2013-05-24 2025-02-10 Ajinomoto Kk Morpholino-oligonukleotidfremstillingsfremgangsmåde
CN107406480B (zh) 2015-03-04 2022-06-24 Jitsubo株式会社 肽合成方法
WO2019060862A1 (en) * 2017-09-25 2019-03-28 Sarepta Therapeutics, Inc. METHODS FOR PREPARING MORPHOLINO PHOSPHORODIAMIDATE OLIGOMERS VIA FAST FLOW SYNTHESIS
CA3099778A1 (en) 2018-05-10 2019-11-14 Nippon Shinyaku Co., Ltd. Method for preparing oligonucleic acid compound

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5548852B1 (https=) 1971-03-23 1980-12-09
WO1991009033A1 (en) 1989-12-20 1991-06-27 Anti-Gene Development Group Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages
WO2013122236A1 (ja) 2012-02-17 2013-08-22 味の素株式会社 塩基部保護オリゴヌクレオチド
WO2014077292A1 (ja) 2012-11-14 2014-05-22 武田薬品工業株式会社 核酸の液相合成方法
WO2016060135A1 (ja) 2014-10-14 2016-04-21 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Acc.Chem.Res., Vol. 24, 278-284, 1991

Also Published As

Publication number Publication date
CN114981281A (zh) 2022-08-30
WO2021095874A1 (ja) 2021-05-20
US12600743B2 (en) 2026-04-14
US20230018780A1 (en) 2023-01-19
EP4059944A1 (en) 2022-09-21
JP2025128175A (ja) 2025-09-02
CA3161586A1 (en) 2021-05-20
JP7689078B2 (ja) 2025-06-05
JPWO2021095874A1 (https=) 2021-05-20
EP4059944A4 (en) 2024-04-10

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