JPWO2020264499A5 - - Google Patents
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- JPWO2020264499A5 JPWO2020264499A5 JP2021577410A JP2021577410A JPWO2020264499A5 JP WO2020264499 A5 JPWO2020264499 A5 JP WO2020264499A5 JP 2021577410 A JP2021577410 A JP 2021577410A JP 2021577410 A JP2021577410 A JP 2021577410A JP WO2020264499 A5 JPWO2020264499 A5 JP WO2020264499A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- ring
- membered
- oxygen
- sulfur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962868609P | 2019-06-28 | 2019-06-28 | |
| US62/868,609 | 2019-06-28 | ||
| US201962875407P | 2019-07-17 | 2019-07-17 | |
| US62/875,407 | 2019-07-17 | ||
| US201962908153P | 2019-09-30 | 2019-09-30 | |
| US62/908,153 | 2019-09-30 | ||
| US201962944834P | 2019-12-06 | 2019-12-06 | |
| US62/944,834 | 2019-12-06 | ||
| US201962948968P | 2019-12-17 | 2019-12-17 | |
| US62/948,968 | 2019-12-17 | ||
| US202062958980P | 2020-01-09 | 2020-01-09 | |
| US62/958,980 | 2020-01-09 | ||
| US202062964955P | 2020-01-23 | 2020-01-23 | |
| US62/964,955 | 2020-01-23 | ||
| US202063040891P | 2020-06-18 | 2020-06-18 | |
| US63/040,891 | 2020-06-18 | ||
| PCT/US2020/040125 WO2020264499A1 (en) | 2019-06-28 | 2020-06-29 | Irak degraders and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022538192A JP2022538192A (ja) | 2022-08-31 |
| JPWO2020264499A5 true JPWO2020264499A5 (de) | 2023-07-05 |
Family
ID=74060700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021577410A Pending JP2022538192A (ja) | 2019-06-28 | 2020-06-29 | Ｉｒａｋ分解剤およびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230069104A1 (de) |
| EP (1) | EP3989966A4 (de) |
| JP (1) | JP2022538192A (de) |
| KR (1) | KR20220032063A (de) |
| CN (1) | CN114502158A (de) |
| AU (1) | AU2020302118A1 (de) |
| BR (1) | BR112021026517A2 (de) |
| CA (1) | CA3144805A1 (de) |
| CO (1) | CO2021017893A2 (de) |
| IL (1) | IL289267A (de) |
| MX (1) | MX2021015995A (de) |
| WO (1) | WO2020264499A1 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | IRAK joints and used in them |
| MX2021006154A (es) | 2018-11-30 | 2021-08-24 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. |
| US11485750B1 (en) | 2019-04-05 | 2022-11-01 | Kymera Therapeutics, Inc. | STAT degraders and uses thereof |
| KR20220145325A (ko) * | 2019-12-17 | 2022-10-28 | 카이메라 쎄라퓨틱스 인코포레이티드 | Irak 분해제 및 이의 용도 |
| US11591332B2 (en) | 2019-12-17 | 2023-02-28 | Kymera Therapeutics, Inc. | IRAK degraders and uses thereof |
| TW202210483A (zh) | 2020-06-03 | 2022-03-16 | 美商凱麥拉醫療公司 | Irak降解劑之結晶型 |
| BR112023001638A2 (pt) | 2020-07-30 | 2023-02-23 | Kymera Therapeutics Inc | Métodos de tratamento de linfomas mutantes |
| JP7474527B2 (ja) * | 2020-10-26 | 2024-04-25 | シャンハイ リーディングタック ファーマシューティカル カンパニー，リミテッド | インダゾール誘導体ならびにその調製方法および応用 |
| WO2022161414A1 (zh) * | 2021-01-26 | 2022-08-04 | 成都茵创园医药科技有限公司 | 芳香化合物、含其的药物组合物及其应用 |
| CN112724079A (zh) * | 2021-02-04 | 2021-04-30 | 康化（上海）新药研发有限公司 | 一种6-甲氧基吡啶甲酸甲酯的合成方法 |
| AU2022228710A1 (en) * | 2021-03-01 | 2023-09-07 | Orion Corporation | Process for the preparation of a cyp11a1 inhibitor and intermediates thereof |
| CN117120054A (zh) * | 2021-04-08 | 2023-11-24 | 柯里斯公司 | 治疗癌症的组合疗法 |
| TW202309030A (zh) | 2021-05-07 | 2023-03-01 | 美商凱麥拉醫療公司 | Cdk2降解劑及其用途 |
| WO2022257152A1 (en) * | 2021-06-11 | 2022-12-15 | Dsm Ip Assets B.V. | Process for producing biotin intermediate |
| US20230099344A1 (en) * | 2021-06-15 | 2023-03-30 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of irak-4 |
| WO2023283372A1 (en) * | 2021-07-07 | 2023-01-12 | Biogen Ma Inc. | Compounds for targeting degradation of irak4 proteins |
| EP4137485A1 (de) * | 2021-08-20 | 2023-02-22 | Henkel AG & Co. KGaA | Vinylether |
| CA3229646A1 (en) * | 2021-08-23 | 2023-03-02 | Zhengqing YE | Irak4 degradation agent, and preparation method therefor and use thereof |
| JP2024536872A (ja) * | 2021-09-26 | 2024-10-08 | メッドシャイン ディスカバリー インコーポレイテッド | ２，６－ピペリジンジオン系化合物とその使用 |
| EP4434981A1 (de) * | 2021-12-23 | 2024-09-25 | Hangzhou Polymed Biopharmaceuticals, Inc. | Fünf- und sechsgliedrige verbindung und herstellungsverfahren dafür sowie pharmazeutische zusammensetzung und verwendung davon |
| CN118076595A (zh) * | 2021-12-23 | 2024-05-24 | 杭州多域生物技术有限公司 | 一种五元并六元化合物、制备方法、药物组合物和应用 |
| TW202333670A (zh) | 2022-01-04 | 2023-09-01 | 大陸商海思科醫藥集團股份有限公司 | 抑制並降解irak4的化合物及其藥物组合物和藥學上的應用 |
| CN118525021A (zh) * | 2022-01-28 | 2024-08-20 | 上海齐鲁制药研究中心有限公司 | 靶向malt1的蛋白降解化合物 |
| AU2023214044A1 (en) | 2022-01-31 | 2024-08-08 | Kymera Therapeutics, Inc. | Irak degraders and uses thereof |
| WO2023178323A1 (en) * | 2022-03-18 | 2023-09-21 | Henry Ford Health System | Therapeutic inhibition of cd38 to treat hidradenitis suppurativa |
| AR129567A1 (es) * | 2022-06-09 | 2024-09-04 | Beigene Ltd | Degradación de irak4 por medio de una conjugación de inhibidores de irak4 con el ligando de ligasa e3 y métodos de uso |
| WO2023237116A1 (en) * | 2022-06-10 | 2023-12-14 | Zhuhai Yufan Biotechnologies Co., Ltd. | Protein degraders and uses thereof |
| TW202413345A (zh) * | 2022-06-15 | 2024-04-01 | 大陸商杭州多域生物技術有限公司 | 一種五元并六元化合物、製備方法、藥物組合物和應用 |
| WO2024020522A1 (en) * | 2022-07-22 | 2024-01-25 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of irak-4 |
| CN117777126A (zh) * | 2022-09-29 | 2024-03-29 | 武汉人福创新药物研发中心有限公司 | 作为irak4降解剂的咪唑并吡啶类化合物及其用途 |
| WO2024126617A1 (en) | 2022-12-14 | 2024-06-20 | Crossfire Oncology Holding B.V. | Bifunctional compounds for degrading kinases via ubiquitin proteosome pathway |
| CN115974703A (zh) * | 2022-12-21 | 2023-04-18 | 上海泰坦科技股份有限公司 | 一种羟甲基取代的n,n-二甲基脂环胺的制备方法 |
| WO2024183650A1 (zh) * | 2023-03-03 | 2024-09-12 | 上海齐鲁制药研究中心有限公司 | Irak4降解剂及其应用 |
| WO2024199147A1 (zh) * | 2023-03-24 | 2024-10-03 | 漳州片仔癀药业股份有限公司 | 2,6-哌啶二酮类化合物的晶型、制备方法及其应用 |
| WO2024199135A1 (zh) * | 2023-03-24 | 2024-10-03 | 漳州片仔癀药业股份有限公司 | 2,6-哌啶二酮类化合物盐型和晶型的制备方法及其应用 |
| WO2024209044A1 (en) | 2023-04-07 | 2024-10-10 | Astrazeneca Ab | Irak4 protacs |
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| US4650750A (en) | 1982-02-01 | 1987-03-17 | Giese Roger W | Method of chemical analysis employing molecular release tag compounds |
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| US5516931A (en) | 1982-02-01 | 1996-05-14 | Northeastern University | Release tag compounds producing ketone signal groups |
| JP3545461B2 (ja) | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
| US7041298B2 (en) | 2000-09-08 | 2006-05-09 | California Institute Of Technology | Proteolysis targeting chimeric pharmaceutical |
| PT1966130E (pt) | 2005-12-23 | 2014-01-30 | Zealand Pharma As | Compostos miméticos de lisina modificados |
| US9765019B2 (en) | 2010-06-30 | 2017-09-19 | Brandeis University | Small-molecule-targeted protein degradation |
| WO2012078559A2 (en) | 2010-12-07 | 2012-06-14 | Yale University | Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same |
| CA2863259A1 (en) * | 2012-01-10 | 2013-07-18 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| CN117736134A (zh) | 2012-01-12 | 2024-03-22 | 耶鲁大学 | 通过e3泛素连接酶增强靶蛋白质及其他多肽降解的化合物和方法 |
| WO2013106646A2 (en) | 2012-01-12 | 2013-07-18 | Yale University | Compounds and methods for the inhibition of vcb e3 ubiquitin ligase |
| MX2015003188A (es) | 2012-09-19 | 2015-07-17 | Hoffmann La Roche | 2-oxo-2,3,4,5-tetrahidro-1 h-benzo[b]diazepinas y su uso en el tratamiento de cancer. |
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| GB201311910D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel Compounds |
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| KR20220101015A (ko) | 2014-04-14 | 2022-07-18 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법 |
| KR20160145803A (ko) * | 2014-04-22 | 2016-12-20 | 님버스 아이리스 인코포레이티드 | Irak 억제제 및 이의 용도 |
| US20160022642A1 (en) | 2014-07-25 | 2016-01-28 | Yale University | Compounds Useful for Promoting Protein Degradation and Methods Using Same |
| CN107257800B (zh) | 2014-12-23 | 2020-06-30 | 达纳-法伯癌症研究所股份有限公司 | 通过双功能分子诱导靶蛋白降解的方法 |
| US20170327469A1 (en) | 2015-01-20 | 2017-11-16 | Arvinas, Inc. | Compounds and methods for the targeted degradation of androgen receptor |
| BR112017015497A2 (pt) | 2015-01-20 | 2018-01-30 | Arvinas, Inc. | composto, e, composição |
| KR20230175343A (ko) | 2015-03-18 | 2023-12-29 | 아비나스 오퍼레이션스, 인코포레이티드 | 타겟화된 단백질들의 향상된 분해를 위한 화합물들 및 방법들 |
| GB201506871D0 (en) | 2015-04-22 | 2015-06-03 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
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| WO2017108744A1 (de) | 2015-12-22 | 2017-06-29 | Bayer Pharma Aktiengesellschaft | Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
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| US20210276996A1 (en) | 2018-07-20 | 2021-09-09 | Dana-Farber Cancer Institute, Inc. | Degraders that target proteins via keap1 |
| MX2021006154A (es) * | 2018-11-30 | 2021-08-24 | Kymera Therapeutics Inc | Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos. |
-
2020
- 2020-06-29 CN CN202080059563.1A patent/CN114502158A/zh active Pending
- 2020-06-29 MX MX2021015995A patent/MX2021015995A/es unknown
- 2020-06-29 BR BR112021026517A patent/BR112021026517A2/pt unknown
- 2020-06-29 WO PCT/US2020/040125 patent/WO2020264499A1/en active Application Filing
- 2020-06-29 JP JP2021577410A patent/JP2022538192A/ja active Pending
- 2020-06-29 CA CA3144805A patent/CA3144805A1/en active Pending
- 2020-06-29 KR KR1020227003218A patent/KR20220032063A/ko unknown
- 2020-06-29 AU AU2020302118A patent/AU2020302118A1/en active Pending
- 2020-06-29 EP EP20833679.2A patent/EP3989966A4/de active Pending
- 2020-06-29 US US17/597,165 patent/US20230069104A1/en active Pending
-
2021
- 2021-12-22 IL IL289267A patent/IL289267A/en unknown
- 2021-12-27 CO CONC2021/0017893A patent/CO2021017893A2/es unknown
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