JPWO2020249785A5 - - Google Patents
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- Publication number
- JPWO2020249785A5 JPWO2020249785A5 JP2021573899A JP2021573899A JPWO2020249785A5 JP WO2020249785 A5 JPWO2020249785 A5 JP WO2020249785A5 JP 2021573899 A JP2021573899 A JP 2021573899A JP 2021573899 A JP2021573899 A JP 2021573899A JP WO2020249785 A5 JPWO2020249785 A5 JP WO2020249785A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrazolo
- phenyl
- fluoro
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000003839 salts Chemical class 0.000 claims description 75
- 150000001204 N-oxides Chemical class 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 66
- 239000012453 solvate Substances 0.000 claims description 66
- 230000000155 isotopic effect Effects 0.000 claims description 63
- 150000001875 compounds Chemical class 0.000 claims description 59
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 26
- 201000010099 disease Diseases 0.000 claims description 21
- 208000035475 disorder Diseases 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 20
- 125000001475 halogen functional group Chemical group 0.000 claims description 19
- 108010054200 NR2B NMDA receptor Proteins 0.000 claims description 17
- 230000001404 mediated effect Effects 0.000 claims description 17
- 230000000694 effects Effects 0.000 claims description 16
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 208000020925 Bipolar disease Diseases 0.000 claims description 7
- 208000028552 Treatment-Resistant Depressive disease Diseases 0.000 claims description 7
- 208000024714 major depressive disease Diseases 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 6
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- 125000001544 thienyl group Chemical group 0.000 claims description 5
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- 206010015037 epilepsy Diseases 0.000 claims description 4
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- 201000006474 Brain Ischemia Diseases 0.000 claims description 3
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| SG11202112405VA (en) * | 2019-06-14 | 2021-12-30 | Janssen Pharmaceutica Nv | Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators |
| MX2021015508A (es) | 2019-06-14 | 2022-01-31 | Janssen Pharmaceutica Nv | Carbamatos de piridina y su uso como moduladores del receptor glun2b. |
| CN113950357A (zh) | 2019-06-14 | 2022-01-18 | 詹森药业有限公司 | 吡嗪氨基甲酸酯及其作为GluN2B受体调节剂的用途 |
| AU2020293642A1 (en) | 2019-06-14 | 2022-01-20 | Janssen Pharmaceutica Nv | Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators |
| KR20220024403A (ko) | 2019-06-14 | 2022-03-03 | 얀센 파마슈티카 엔.브이. | 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도 |
| CN113993868A (zh) | 2019-06-14 | 2022-01-28 | 詹森药业有限公司 | 取代的吡唑并吡啶酰胺以及它们作为glun2b受体调节剂的用途 |
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2020
- 2020-06-12 SG SG11202112405VA patent/SG11202112405VA/en unknown
- 2020-06-12 TW TW109119836A patent/TW202115054A/zh unknown
- 2020-06-12 JP JP2021573899A patent/JP2022536424A/ja active Pending
- 2020-06-12 MX MX2021015503A patent/MX2021015503A/es unknown
- 2020-06-12 CA CA3143276A patent/CA3143276A1/en active Pending
- 2020-06-12 CR CR20210615A patent/CR20210615A/es unknown
- 2020-06-12 BR BR112021025141A patent/BR112021025141A2/pt unknown
- 2020-06-12 PE PE2021002072A patent/PE20220806A1/es unknown
- 2020-06-12 US US16/899,829 patent/US11530210B2/en active Active
- 2020-06-12 EP EP20733713.0A patent/EP3982958A1/en not_active Withdrawn
- 2020-06-12 WO PCT/EP2020/066384 patent/WO2020249785A1/en not_active Ceased
- 2020-06-12 MA MA056183A patent/MA56183A/fr unknown
- 2020-06-12 KR KR1020227001097A patent/KR20220024512A/ko not_active Withdrawn
- 2020-06-12 CN CN202080043611.8A patent/CN114007610A/zh active Pending
- 2020-06-12 AU AU2020291188A patent/AU2020291188A1/en not_active Abandoned
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2021
- 2021-12-02 DO DO2021000250A patent/DOP2021000250A/es unknown
- 2021-12-07 CL CL2021003257A patent/CL2021003257A1/es unknown
- 2021-12-09 IL IL288858A patent/IL288858A/en unknown
- 2021-12-13 CO CONC2021/0016860A patent/CO2021016860A2/es unknown
- 2021-12-14 JO JOP/2021/0330A patent/JOP20210330A1/ar unknown
- 2021-12-14 EC ECSENADI202190450A patent/ECSP21090450A/es unknown
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2022
- 2022-09-12 US US17/942,829 patent/US20230045960A1/en not_active Abandoned
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