BR112021025141A2 - Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b - Google Patents

Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b

Info

Publication number
BR112021025141A2
BR112021025141A2 BR112021025141A BR112021025141A BR112021025141A2 BR 112021025141 A2 BR112021025141 A2 BR 112021025141A2 BR 112021025141 A BR112021025141 A BR 112021025141A BR 112021025141 A BR112021025141 A BR 112021025141A BR 112021025141 A2 BR112021025141 A2 BR 112021025141A2
Authority
BR
Brazil
Prior art keywords
pyridines
glun2b receptor
receptor modulators
substituted pyrazole
glun2b
Prior art date
Application number
BR112021025141A
Other languages
English (en)
Portuguese (pt)
Inventor
Afton Hiscox
Andrew Samant
Brice Stenne
Christa Chrovian
Christine Gelin
Curt Dvorak
A Letavic Michael
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112021025141A2 publication Critical patent/BR112021025141A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112021025141A 2019-06-14 2020-06-12 Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b BR112021025141A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962861665P 2019-06-14 2019-06-14
PK34920 2020-06-03
PCT/EP2020/066384 WO2020249785A1 (en) 2019-06-14 2020-06-12 Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators

Publications (1)

Publication Number Publication Date
BR112021025141A2 true BR112021025141A2 (pt) 2022-01-25

Family

ID=73781827

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025141A BR112021025141A2 (pt) 2019-06-14 2020-06-12 Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b

Country Status (21)

Country Link
US (2) US11530210B2 (https=)
EP (1) EP3982958A1 (https=)
JP (1) JP2022536424A (https=)
KR (1) KR20220024512A (https=)
CN (1) CN114007610A (https=)
AU (1) AU2020291188A1 (https=)
BR (1) BR112021025141A2 (https=)
CA (1) CA3143276A1 (https=)
CL (1) CL2021003257A1 (https=)
CO (1) CO2021016860A2 (https=)
CR (1) CR20210615A (https=)
DO (1) DOP2021000250A (https=)
EC (1) ECSP21090450A (https=)
IL (1) IL288858A (https=)
JO (1) JOP20210330A1 (https=)
MA (1) MA56183A (https=)
MX (1) MX2021015503A (https=)
PE (1) PE20220806A1 (https=)
SG (1) SG11202112405VA (https=)
TW (1) TW202115054A (https=)
WO (1) WO2020249785A1 (https=)

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CN113993868A (zh) 2019-06-14 2022-01-28 詹森药业有限公司 取代的吡唑并吡啶酰胺以及它们作为glun2b受体调节剂的用途
AU2020293642A1 (en) 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
MX2021015508A (es) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Carbamatos de piridina y su uso como moduladores del receptor glun2b.
KR20220024403A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
CN113950357A (zh) 2019-06-14 2022-01-18 詹森药业有限公司 吡嗪氨基甲酸酯及其作为GluN2B受体调节剂的用途
SG11202112405VA (en) 2019-06-14 2021-12-30 Janssen Pharmaceutica Nv Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
CN114149425A (zh) * 2021-11-16 2022-03-08 上海应用技术大学 5-氟甲基吡啶衍生物和18-f同位素标记的5-氟甲基吡啶衍生物及其制备与应用

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Also Published As

Publication number Publication date
EP3982958A1 (en) 2022-04-20
MA56183A (fr) 2022-04-20
ECSP21090450A (es) 2022-01-31
SG11202112405VA (en) 2021-12-30
TW202115054A (zh) 2021-04-16
CN114007610A (zh) 2022-02-01
KR20220024512A (ko) 2022-03-03
CO2021016860A2 (es) 2022-01-17
JP2022536424A (ja) 2022-08-16
IL288858A (en) 2022-02-01
JOP20210330A1 (ar) 2023-01-30
PE20220806A1 (es) 2022-05-20
WO2020249785A1 (en) 2020-12-17
CL2021003257A1 (es) 2022-08-19
US20210017169A1 (en) 2021-01-21
CA3143276A1 (en) 2020-12-17
DOP2021000250A (es) 2022-03-31
CR20210615A (es) 2022-01-31
AU2020291188A1 (en) 2022-01-20
MX2021015503A (es) 2022-04-20
US20230045960A1 (en) 2023-02-16
US11530210B2 (en) 2022-12-20

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