CN114007610A - 取代的杂芳族吡唑并吡啶以及它们作为glun2b受体调节剂的用途 - Google Patents

取代的杂芳族吡唑并吡啶以及它们作为glun2b受体调节剂的用途 Download PDF

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Publication number
CN114007610A
CN114007610A CN202080043611.8A CN202080043611A CN114007610A CN 114007610 A CN114007610 A CN 114007610A CN 202080043611 A CN202080043611 A CN 202080043611A CN 114007610 A CN114007610 A CN 114007610A
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China
Prior art keywords
methyl
pyrazolo
phenyl
pyridine
fluoro
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Pending
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CN202080043611.8A
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English (en)
Chinese (zh)
Inventor
A·希斯科
B·斯坦纳
C·克罗维亚
C·格林
A·萨曼特
M·A·莱特威克
C·德沃夏克
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN114007610A publication Critical patent/CN114007610A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202080043611.8A 2019-06-14 2020-06-12 取代的杂芳族吡唑并吡啶以及它们作为glun2b受体调节剂的用途 Pending CN114007610A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962861665P 2019-06-14 2019-06-14
US62/861665 2019-06-14
PK34920 2020-06-03
PK349/2020 2020-06-03
PCT/EP2020/066384 WO2020249785A1 (en) 2019-06-14 2020-06-12 Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators

Publications (1)

Publication Number Publication Date
CN114007610A true CN114007610A (zh) 2022-02-01

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CN202080043611.8A Pending CN114007610A (zh) 2019-06-14 2020-06-12 取代的杂芳族吡唑并吡啶以及它们作为glun2b受体调节剂的用途

Country Status (21)

Country Link
US (2) US11530210B2 (https=)
EP (1) EP3982958A1 (https=)
JP (1) JP2022536424A (https=)
KR (1) KR20220024512A (https=)
CN (1) CN114007610A (https=)
AU (1) AU2020291188A1 (https=)
BR (1) BR112021025141A2 (https=)
CA (1) CA3143276A1 (https=)
CL (1) CL2021003257A1 (https=)
CO (1) CO2021016860A2 (https=)
CR (1) CR20210615A (https=)
DO (1) DOP2021000250A (https=)
EC (1) ECSP21090450A (https=)
IL (1) IL288858A (https=)
JO (1) JOP20210330A1 (https=)
MA (1) MA56183A (https=)
MX (1) MX2021015503A (https=)
PE (1) PE20220806A1 (https=)
SG (1) SG11202112405VA (https=)
TW (1) TW202115054A (https=)
WO (1) WO2020249785A1 (https=)

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TW201819376A (zh) 2016-10-06 2018-06-01 比利時商健生藥品公司 經取代之１Ｈ－咪唑並［４，５－ｂ］吡啶－２（３Ｈ）－酮及其作為ＧＬＵＮ２Ｂ受體調節劑之用途
CN113993868A (zh) 2019-06-14 2022-01-28 詹森药业有限公司 取代的吡唑并吡啶酰胺以及它们作为glun2b受体调节剂的用途
AU2020293642A1 (en) 2019-06-14 2022-01-20 Janssen Pharmaceutica Nv Substituted pyrazolo[4,3-b]pyridines and their use as GluN2B receptor modulators
MX2021015508A (es) 2019-06-14 2022-01-31 Janssen Pharmaceutica Nv Carbamatos de piridina y su uso como moduladores del receptor glun2b.
KR20220024403A (ko) 2019-06-14 2022-03-03 얀센 파마슈티카 엔.브이. 치환된 피라졸로-피라진 및 이들의 glun2b 수용체 조절제로서의 용도
CN113950357A (zh) 2019-06-14 2022-01-18 詹森药业有限公司 吡嗪氨基甲酸酯及其作为GluN2B受体调节剂的用途
SG11202112405VA (en) 2019-06-14 2021-12-30 Janssen Pharmaceutica Nv Substituted heteroaromatic pyrazolo-pyridines and their use as glun2b receptor modulators
JP7667097B2 (ja) 2019-06-14 2025-04-22 ヤンセン ファーマシューティカ エヌ．ベー． 置換ピラゾロ－ピリジンアミド及びｇｌｕｎ２ｂ受容体調節因子としてのその使用
CN114149425A (zh) * 2021-11-16 2022-03-08 上海应用技术大学 5-氟甲基吡啶衍生物和18-f同位素标记的5-氟甲基吡啶衍生物及其制备与应用

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EP3982958A1 (en) 2022-04-20
MA56183A (fr) 2022-04-20
ECSP21090450A (es) 2022-01-31
SG11202112405VA (en) 2021-12-30
TW202115054A (zh) 2021-04-16
KR20220024512A (ko) 2022-03-03
CO2021016860A2 (es) 2022-01-17
JP2022536424A (ja) 2022-08-16
IL288858A (en) 2022-02-01
JOP20210330A1 (ar) 2023-01-30
BR112021025141A2 (pt) 2022-01-25
PE20220806A1 (es) 2022-05-20
WO2020249785A1 (en) 2020-12-17
CL2021003257A1 (es) 2022-08-19
US20210017169A1 (en) 2021-01-21
CA3143276A1 (en) 2020-12-17
DOP2021000250A (es) 2022-03-31
CR20210615A (es) 2022-01-31
AU2020291188A1 (en) 2022-01-20
MX2021015503A (es) 2022-04-20
US20230045960A1 (en) 2023-02-16
US11530210B2 (en) 2022-12-20

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