JP2018511613A5 - - Google Patents
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- Publication number
- JP2018511613A5 JP2018511613A5 JP2017552060A JP2017552060A JP2018511613A5 JP 2018511613 A5 JP2018511613 A5 JP 2018511613A5 JP 2017552060 A JP2017552060 A JP 2017552060A JP 2017552060 A JP2017552060 A JP 2017552060A JP 2018511613 A5 JP2018511613 A5 JP 2018511613A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- cancer
- diazaspiro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- AUYJRJPTGVBQLV-LHEWISCISA-N CC(C)Oc(nc1)ccc1-c1n[nH]c(cc2)c1cc2N(CC[C@]12CN(CC(N(CC3)CC=C3c(cc3)ccc3-c3c[n](C)nn3)=O)CC1)C2=O Chemical compound CC(C)Oc(nc1)ccc1-c1n[nH]c(cc2)c1cc2N(CC[C@]12CN(CC(N(CC3)CC=C3c(cc3)ccc3-c3c[n](C)nn3)=O)CC1)C2=O AUYJRJPTGVBQLV-LHEWISCISA-N 0.000 description 1
- XTTJGAWTXBNCAU-LHEWISCISA-N CC(C)Oc(nc1)ccc1-c1n[nH]c(cc2)c1cc2N(CC[C@]12CN(CC(N(CC3)CCC3c(cc3)ccc3-c3n[n](C)cn3)=O)CC1)C2=O Chemical compound CC(C)Oc(nc1)ccc1-c1n[nH]c(cc2)c1cc2N(CC[C@]12CN(CC(N(CC3)CCC3c(cc3)ccc3-c3n[n](C)cn3)=O)CC1)C2=O XTTJGAWTXBNCAU-LHEWISCISA-N 0.000 description 1
- CCMWYGFUITYBRG-UHFFFAOYSA-O CC(C)Oc(nc1)ccc1C(c(cc(cc1)N(CCC23CN(CC(N(CC4)CC=C4c(cc4)ccc4-c4n[n](C)cn4)=O)C2)C3=O)c1N)=[NH2+] Chemical compound CC(C)Oc(nc1)ccc1C(c(cc(cc1)N(CCC23CN(CC(N(CC4)CC=C4c(cc4)ccc4-c4n[n](C)cn4)=O)C2)C3=O)c1N)=[NH2+] CCMWYGFUITYBRG-UHFFFAOYSA-O 0.000 description 1
- RMVSQGMQXWDXOS-UHFFFAOYSA-P CC(C)Oc(nc1)ccc1C(c(cc(cc1)N(CCC23CN(CC(N(CC4)CC=C4c(cc4)ccc4N4[NH2+]NC=C4)=O)CC2)C3=O)c1N)=[NH2+] Chemical compound CC(C)Oc(nc1)ccc1C(c(cc(cc1)N(CCC23CN(CC(N(CC4)CC=C4c(cc4)ccc4N4[NH2+]NC=C4)=O)CC2)C3=O)c1N)=[NH2+] RMVSQGMQXWDXOS-UHFFFAOYSA-P 0.000 description 1
- YCJYGYBAUYCFCU-LHEWISCISA-O CC(C)Oc(nc1)ccc1C(c(cc(cc1)N(CC[C@]23CN(CC(N(CC4)CC=C4c(cc4)ccc4-c4nnc(C)[o]4)=O)CC2)C3=O)c1N)=[NH2+] Chemical compound CC(C)Oc(nc1)ccc1C(c(cc(cc1)N(CC[C@]23CN(CC(N(CC4)CC=C4c(cc4)ccc4-c4nnc(C)[o]4)=O)CC2)C3=O)c1N)=[NH2+] YCJYGYBAUYCFCU-LHEWISCISA-O 0.000 description 1
- OBQBSLOTUAAHHD-KDXMTYKHSA-N CCNc1nnc(-c(cc2)ccc2C(CC2)=CCN2C(CN(CC2)C[C@]2(CCN2c(cc3)cc4c3[nH]nc4-c(cn3)ccc3OC(C)C)C2=O)=O)[o]1 Chemical compound CCNc1nnc(-c(cc2)ccc2C(CC2)=CCN2C(CN(CC2)C[C@]2(CCN2c(cc3)cc4c3[nH]nc4-c(cn3)ccc3OC(C)C)C2=O)=O)[o]1 OBQBSLOTUAAHHD-KDXMTYKHSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562142946P | 2015-04-03 | 2015-04-03 | |
| US62/142,946 | 2015-04-03 | ||
| PCT/US2016/025345 WO2016161160A1 (en) | 2015-04-03 | 2016-03-31 | Spirocyclic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018511613A JP2018511613A (ja) | 2018-04-26 |
| JP2018511613A5 true JP2018511613A5 (https=) | 2019-05-09 |
| JP6737533B2 JP6737533B2 (ja) | 2020-08-12 |
Family
ID=57007413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552060A Expired - Fee Related JP6737533B2 (ja) | 2015-04-03 | 2016-03-31 | スピロ環式化合物 |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10525036B2 (https=) |
| EP (1) | EP3277690B1 (https=) |
| JP (1) | JP6737533B2 (https=) |
| KR (1) | KR20170132307A (https=) |
| CN (1) | CN107849053B (https=) |
| AU (1) | AU2016242940B2 (https=) |
| BR (1) | BR112017021194A2 (https=) |
| CA (1) | CA2981055A1 (https=) |
| CY (1) | CY1123019T1 (https=) |
| DK (1) | DK3277690T3 (https=) |
| ES (1) | ES2788160T3 (https=) |
| HR (1) | HRP20200805T1 (https=) |
| HU (1) | HUE049481T2 (https=) |
| IL (1) | IL254662B (https=) |
| LT (1) | LT3277690T (https=) |
| MX (1) | MX379622B (https=) |
| PL (1) | PL3277690T3 (https=) |
| PT (1) | PT3277690T (https=) |
| RS (1) | RS60340B1 (https=) |
| RU (1) | RU2745069C2 (https=) |
| SG (1) | SG11201707911VA (https=) |
| SI (1) | SI3277690T1 (https=) |
| SM (1) | SMT202000279T1 (https=) |
| TW (1) | TWI705067B (https=) |
| WO (1) | WO2016161160A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10308609B2 (en) * | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
| MX379622B (es) | 2015-04-03 | 2025-03-11 | Recurium Ip Holdings Llc | Compuestos espirociclicos |
| AU2017339890A1 (en) * | 2016-10-05 | 2019-04-11 | Recurium Ip Holdings, Llc | Spirocyclic compounds |
| KR20190087622A (ko) | 2016-12-08 | 2019-07-24 | 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 | 질환 치료를 위한 이중 류신 지퍼 (dlk) 키나아제의 바이시클로[1.1.1]펜탄 억제제 |
| PE20211455A1 (es) * | 2018-01-31 | 2021-08-05 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactama y usos de los mismos |
| CA3137152A1 (en) | 2019-04-18 | 2020-10-22 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-[1,2,4]triazolo[1,5a] pyridine derivatives and use thereof |
| US11560366B2 (en) | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
| AU2021362678A1 (en) | 2020-10-13 | 2023-05-04 | The Johns Hopkins University | SUBSTITUTED 4-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)THIOPHENE-2-CARBOXAMIDE DERIVATIVES AND USE THEREOF |
| CN115124542A (zh) * | 2022-07-08 | 2022-09-30 | 河南师范大学 | 羟基苯取代吡唑酮并吲唑[螺]吡唑酮类化合物的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| US8546404B2 (en) * | 2005-12-13 | 2013-10-01 | Merck Sharp & Dohme | Compounds that are ERK inhibitors |
| WO2008063609A2 (en) | 2006-11-17 | 2008-05-29 | Polyera Corporation | Diimide-based semiconductor materials and methods of preparing and using the same |
| US8716483B2 (en) | 2008-02-21 | 2014-05-06 | Merck Sharp & Dohme Corp. | Compounds that are ERK inhibitors |
| EP2318388A2 (en) | 2008-07-23 | 2011-05-11 | Schering Corporation | Tricyclic spirocycle derivatives and methods of use thereof |
| JP2013506669A (ja) * | 2009-09-30 | 2013-02-28 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｅｒｋ阻害剤である新規化合物 |
| EP3296398A1 (en) | 2009-12-07 | 2018-03-21 | Arbutus Biopharma Corporation | Compositions for nucleic acid delivery |
| US8664213B2 (en) | 2011-08-29 | 2014-03-04 | Bristol-Myers Squibb Company | Spiro bicyclic diamine derivatives as HIV attachment inhibitors |
| CN103130775B (zh) | 2011-11-22 | 2015-09-30 | 山东亨利医药科技有限责任公司 | 作为酪氨酸激酶抑制剂的吲哚满酮衍生物 |
| US8987264B2 (en) | 2012-11-09 | 2015-03-24 | Bristol-Myers Squibb Company | 1,3,5-triazine derivatives of spiro bicyclic oxalamide-compounds for treatment of hepatitis C |
| US9447026B2 (en) | 2013-03-14 | 2016-09-20 | Kalyra Pharmaceuticals, Inc. | Bicyclic analgesic compounds |
| CN105732636B (zh) | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| MX379622B (es) | 2015-04-03 | 2025-03-11 | Recurium Ip Holdings Llc | Compuestos espirociclicos |
| AU2017339890A1 (en) | 2016-10-05 | 2019-04-11 | Recurium Ip Holdings, Llc | Spirocyclic compounds |
-
2016
- 2016-03-31 MX MX2017012553A patent/MX379622B/es unknown
- 2016-03-31 WO PCT/US2016/025345 patent/WO2016161160A1/en not_active Ceased
- 2016-03-31 AU AU2016242940A patent/AU2016242940B2/en not_active Ceased
- 2016-03-31 PT PT167742329T patent/PT3277690T/pt unknown
- 2016-03-31 DK DK16774232.9T patent/DK3277690T3/da active
- 2016-03-31 KR KR1020177031578A patent/KR20170132307A/ko not_active Ceased
- 2016-03-31 SI SI201630764T patent/SI3277690T1/sl unknown
- 2016-03-31 SM SM20200279T patent/SMT202000279T1/it unknown
- 2016-03-31 SG SG11201707911VA patent/SG11201707911VA/en unknown
- 2016-03-31 PL PL16774232T patent/PL3277690T3/pl unknown
- 2016-03-31 JP JP2017552060A patent/JP6737533B2/ja not_active Expired - Fee Related
- 2016-03-31 EP EP16774232.9A patent/EP3277690B1/en active Active
- 2016-03-31 RS RS20200577A patent/RS60340B1/sr unknown
- 2016-03-31 CA CA2981055A patent/CA2981055A1/en not_active Abandoned
- 2016-03-31 ES ES16774232T patent/ES2788160T3/es active Active
- 2016-03-31 BR BR112017021194A patent/BR112017021194A2/pt not_active IP Right Cessation
- 2016-03-31 HU HUE16774232A patent/HUE049481T2/hu unknown
- 2016-03-31 RU RU2017133973A patent/RU2745069C2/ru active
- 2016-03-31 HR HRP20200805TT patent/HRP20200805T1/hr unknown
- 2016-03-31 US US15/563,926 patent/US10525036B2/en not_active Expired - Fee Related
- 2016-03-31 CN CN201680028591.0A patent/CN107849053B/zh not_active Expired - Fee Related
- 2016-03-31 LT LTEP16774232.9T patent/LT3277690T/lt unknown
- 2016-04-01 TW TW105110691A patent/TWI705067B/zh not_active IP Right Cessation
-
2017
- 2017-09-25 IL IL254662A patent/IL254662B/en active IP Right Grant
-
2019
- 2019-03-15 US US16/354,949 patent/US10493060B2/en not_active Expired - Fee Related
-
2020
- 2020-01-06 US US16/734,857 patent/US20200268714A1/en not_active Abandoned
- 2020-04-10 CY CY20201100356T patent/CY1123019T1/el unknown
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