JP2007523208A5 - - Google Patents
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- Publication number
- JP2007523208A5 JP2007523208A5 JP2007500152A JP2007500152A JP2007523208A5 JP 2007523208 A5 JP2007523208 A5 JP 2007523208A5 JP 2007500152 A JP2007500152 A JP 2007500152A JP 2007500152 A JP2007500152 A JP 2007500152A JP 2007523208 A5 JP2007523208 A5 JP 2007523208A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- azabicyclo
- thio
- propyl
- triazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 15
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 8
- 229960003638 dopamine Drugs 0.000 claims description 4
- -1 2-pyrrolidinonyl Chemical group 0.000 claims 50
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 36
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 31
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 15
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 11
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 9
- PUMREIFKTMLCAF-UHFFFAOYSA-N 4-methyl-1,3-oxazole Chemical compound CC1=COC=N1 PUMREIFKTMLCAF-UHFFFAOYSA-N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 7
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 6
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 6
- 208000028017 Psychotic disease Diseases 0.000 claims 6
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000004076 pyridyl group Chemical group 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 4
- 201000009032 substance abuse Diseases 0.000 claims 4
- 231100000736 substance abuse Toxicity 0.000 claims 4
- 208000011117 substance-related disease Diseases 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 3
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 3
- GLSJOAMLOIMSGI-KMDAROACSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]butylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound C([C@]1(C[C@H]1C1)C=2C=CC(=CC=2)C(F)(F)F)N1C(C)CCSC(N1C)=NN=C1C=1OC=NC=1C GLSJOAMLOIMSGI-KMDAROACSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 3
- 230000009286 beneficial effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- PSAASTBVOYWQMI-CJAUYULYSA-N 1-[2-methoxy-5-[(1r,5s)-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]propan-1-one Chemical compound C1=C(OC)C(C(=O)CC)=CC([C@]23[C@H](C2)CN(CCCSC=2N(C(C4=C(N=CO4)C)=NN=2)C)C3)=C1 PSAASTBVOYWQMI-CJAUYULYSA-N 0.000 claims 2
- HMMLWDCQIVJIHP-KDYSTLNUSA-N 2-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-phenyl-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]quinoline Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=CC=C1 HMMLWDCQIVJIHP-KDYSTLNUSA-N 0.000 claims 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 2
- ZZLCFHIKESPLTH-UHFFFAOYSA-N 4-Methylbiphenyl Chemical compound C1=CC(C)=CC=C1C1=CC=CC=C1 ZZLCFHIKESPLTH-UHFFFAOYSA-N 0.000 claims 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 2
- UAOBDKREOZMZJQ-HXOBKFHXSA-N 4-methyl-5-[4-methyl-5-[3-[(1r,5s)-1-(2-methyl-1,3-benzothiazol-5-yl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound C([C@H]1C[C@]1(C1)C=2C=C3N=C(SC3=CC=2)C)N1CCCSC(N1C)=NN=C1C=1OC=NC=1C UAOBDKREOZMZJQ-HXOBKFHXSA-N 0.000 claims 2
- MLHRKLZCJRKSHO-UTKZUKDTSA-N 4-methyl-5-[4-methyl-5-[3-[(1r,5s)-1-[3-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@@]4(C[C@@H]4C3)C=3C=C(C=CC=3)C(F)(F)F)=NN=2)C)=C1C MLHRKLZCJRKSHO-UTKZUKDTSA-N 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 2
- RDNMLFUSVMBDDY-FGZHOGPDSA-N 5-[5-[3-[(1r,5s)-1-(3-chlorophenyl)-5-methyl-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@]4(C)C3)C=3C=C(Cl)C=CC=3)=NN=2)C)=C1C RDNMLFUSVMBDDY-FGZHOGPDSA-N 0.000 claims 2
- VUFRFPUOFHXBBM-HRFSGMKKSA-N 5-[5-[3-[(1r,5s)-1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1([C@@]23C[C@@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C(Br)C=C1 VUFRFPUOFHXBBM-HRFSGMKKSA-N 0.000 claims 2
- NKIUMOVWDJZMRB-PIKZIKFNSA-N 5-[5-[3-[(1r,5s)-1-(4-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1=CC(OC)=CC=C1[C@]1(CN(CCCSC=2N(C(C=3C4=CC=C(C)N=C4C=CC=3)=NN=2)C)C2)[C@@H]2C1 NKIUMOVWDJZMRB-PIKZIKFNSA-N 0.000 claims 2
- DRKUAUJUSZGTGW-XJFCNFDWSA-N 5-[5-[3-[(1r,5s)-1-(4-tert-butylphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1([C@@]23C[C@@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C(C(C)(C)C)C=C1 DRKUAUJUSZGTGW-XJFCNFDWSA-N 0.000 claims 2
- URICTYNITRPTLS-UZTOHYMASA-N 5-[5-[3-[(1s,5r)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C(Cl)C(Cl)=C1 URICTYNITRPTLS-UZTOHYMASA-N 0.000 claims 2
- VUFRFPUOFHXBBM-CCLHPLFOSA-N 5-[5-[3-[(1s,5r)-1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C(Br)C=C1 VUFRFPUOFHXBBM-CCLHPLFOSA-N 0.000 claims 2
- NKIUMOVWDJZMRB-RBTNQOKQSA-N 5-[5-[3-[(1s,5r)-1-(4-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1=CC(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C=3C4=CC=C(C)N=C4C=CC=3)=NN=2)C)C2)[C@H]2C1 NKIUMOVWDJZMRB-RBTNQOKQSA-N 0.000 claims 2
- DRKUAUJUSZGTGW-QXNWPYRLSA-N 5-[5-[3-[(1s,5r)-1-(4-tert-butylphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methylquinoline Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C(C(C)(C)C)C=C1 DRKUAUJUSZGTGW-QXNWPYRLSA-N 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 2
- 125000002619 bicyclic group Chemical group 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 2
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- GKACMWQTMKXQPT-WMZHIEFXSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[(4-ethyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NC=CC=2)CC)=CC=C(Br)C=C1 GKACMWQTMKXQPT-WMZHIEFXSA-N 0.000 claims 1
- POPJUDCEQMELRU-LAUBAEHRSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[(4-methyl-5-pyridazin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NN=CC=2)C)=CC=C(Br)C=C1 POPJUDCEQMELRU-LAUBAEHRSA-N 0.000 claims 1
- HTPVMIVXLCGVPI-PGRDOPGGSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[(4-methyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NC=CC=2)C)=CC=C(Br)C=C1 HTPVMIVXLCGVPI-PGRDOPGGSA-N 0.000 claims 1
- ZUWBWKOPWGGXEZ-LAUBAEHRSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[(4-methyl-5-pyrimidin-5-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NC=NC=2)C)=CC=C(Br)C=C1 ZUWBWKOPWGGXEZ-LAUBAEHRSA-N 0.000 claims 1
- SZFGGKSIQQDFKO-MGPUTAFESA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(1-methyltriazol-4-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound N1=NN(C)C=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 SZFGGKSIQQDFKO-MGPUTAFESA-N 0.000 claims 1
- ZOVUVPBEDQGAEY-HRAATJIYSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(2-methylpyrazol-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CN1N=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 ZOVUVPBEDQGAEY-HRAATJIYSA-N 0.000 claims 1
- CAFSAVHFADPFEJ-FDDCHVKYSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(2-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=NC=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 CAFSAVHFADPFEJ-FDDCHVKYSA-N 0.000 claims 1
- WCOFNBHSYDWYKP-HTAPYJJXSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(3-methylfuran-2-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Br)=CC=3)=NN=2)C)=C1C WCOFNBHSYDWYKP-HTAPYJJXSA-N 0.000 claims 1
- XPYNDTGYDNWMBS-FDDCHVKYSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(3-methylpyridin-2-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=CC=CN=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 XPYNDTGYDNWMBS-FDDCHVKYSA-N 0.000 claims 1
- TVOWXONSXDBYAG-WMZHIEFXSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(5-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=CN=CC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Br)=CC=3)=NN=2)C)=C1 TVOWXONSXDBYAG-WMZHIEFXSA-N 0.000 claims 1
- XWYQMRGVVCAGPL-WMZHIEFXSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(6-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NC(C)=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 XWYQMRGVVCAGPL-WMZHIEFXSA-N 0.000 claims 1
- ACTJTIJRIQDHEB-PGRDOPGGSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-(oxan-4-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C2CCOCC2)C)=CC=C(Br)C=C1 ACTJTIJRIQDHEB-PGRDOPGGSA-N 0.000 claims 1
- GIWTTYIZASKYKT-YCRPNKLZSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound FC(F)(F)C1=NN(C)C=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 GIWTTYIZASKYKT-YCRPNKLZSA-N 0.000 claims 1
- NVNFYUKRFGJWDM-GAJHUEQPSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-[2-methyl-6-(trifluoromethyl)pyridin-3-yl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=NC(C(F)(F)F)=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 NVNFYUKRFGJWDM-GAJHUEQPSA-N 0.000 claims 1
- AIEYZNFNEQHWKO-WMZHIEFXSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[4-methyl-5-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=CC(=CC=2)C(F)(F)F)C)=CC=C(Br)C=C1 AIEYZNFNEQHWKO-WMZHIEFXSA-N 0.000 claims 1
- BUNMQAXAYZRBJI-HTAPYJJXSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[5-(1,5-dimethylpyrazol-4-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NN(C)C(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 BUNMQAXAYZRBJI-HTAPYJJXSA-N 0.000 claims 1
- DHPMGQUNTCQWHG-FDDCHVKYSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[5-(2,5-dimethylfuran-3-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound O1C(C)=CC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Br)=CC=3)=NN=2)C)=C1C DHPMGQUNTCQWHG-FDDCHVKYSA-N 0.000 claims 1
- BCASKIBJIZNNHQ-GAJHUEQPSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[5-(3,4-difluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=C(F)C(F)=CC=2)C)=CC=C(Br)C=C1 BCASKIBJIZNNHQ-GAJHUEQPSA-N 0.000 claims 1
- ICMWFZOZUUSQNF-YCRPNKLZSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[5-(5-chloro-1-methylpyrazol-4-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CN1N=CC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Br)=CC=3)=NN=2)C)=C1Cl ICMWFZOZUUSQNF-YCRPNKLZSA-N 0.000 claims 1
- HRNYFPHZFKDZFM-YCRPNKLZSA-N (1s,5r)-1-(4-bromophenyl)-3-[3-[[5-(5-chlorothiophen-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2SC(Cl)=CC=2)C)=CC=C(Br)C=C1 HRNYFPHZFKDZFM-YCRPNKLZSA-N 0.000 claims 1
- JJASSNLYKBIBDB-KKSFZXQISA-N (1s,5r)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[(4-methyl-5-pyridazin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NN=CC=2)C)=CC=C(C(F)(F)F)C=C1F JJASSNLYKBIBDB-KKSFZXQISA-N 0.000 claims 1
- JCQGGPNAPQZIIU-KKSFZXQISA-N (1s,5r)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[(4-methyl-5-pyrimidin-5-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NC=NC=2)C)=CC=C(C(F)(F)F)C=C1F JCQGGPNAPQZIIU-KKSFZXQISA-N 0.000 claims 1
- IIBPCCLUIAWPNP-SBUREZEXSA-N (1s,5r)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(2-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=NC=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C(=CC(=CC=3)C(F)(F)F)F)C[C@H]2C1 IIBPCCLUIAWPNP-SBUREZEXSA-N 0.000 claims 1
- XMDQXTSZWZHIQV-AOMKIAJQSA-N (1s,5r)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-(5-methylpyrazin-2-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NC(C)=CN=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C(=CC(=CC=3)C(F)(F)F)F)C[C@H]2C1 XMDQXTSZWZHIQV-AOMKIAJQSA-N 0.000 claims 1
- SWSAZAYWDBMULB-MBSDFSHPSA-N (1s,5r)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-[3-[[4-methyl-5-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=CC(=CC=2)C(F)(F)F)C)=CC=C(C(F)(F)F)C=C1F SWSAZAYWDBMULB-MBSDFSHPSA-N 0.000 claims 1
- WXNXGSDVKPBNGU-PGRDOPGGSA-N (1s,5r)-3-[3-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]propyl]-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=CC=CC=2)C)=CC=C(C(F)(F)F)N=C1 WXNXGSDVKPBNGU-PGRDOPGGSA-N 0.000 claims 1
- OTKZOEOQKWTXMD-GHTZIAJQSA-N (1s,5r)-3-[3-[(4-methyl-5-pyridazin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NN=CC=2)C)=CC=C(C(F)(F)F)C=C1 OTKZOEOQKWTXMD-GHTZIAJQSA-N 0.000 claims 1
- ZUBZEOWJXKKPSY-GHTZIAJQSA-N (1s,5r)-3-[3-[(4-methyl-5-pyrimidin-5-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=NC=NC=2)C)=CC=C(C(F)(F)F)C=C1 ZUBZEOWJXKKPSY-GHTZIAJQSA-N 0.000 claims 1
- WHGLFZPJAYDODK-WMZHIEFXSA-N (1s,5r)-3-[3-[[4-methyl-5-(2-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=NC=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(=CC=3)C(F)(F)F)C[C@H]2C1 WHGLFZPJAYDODK-WMZHIEFXSA-N 0.000 claims 1
- VCUZSEOWZWQCDM-HTAPYJJXSA-N (1s,5r)-3-[3-[[4-methyl-5-(2-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexane Chemical compound CC1=NC=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=NC(=CC=3)C(F)(F)F)C[C@H]2C1 VCUZSEOWZWQCDM-HTAPYJJXSA-N 0.000 claims 1
- AEXFOTSQBUVBKJ-PGRDOPGGSA-N (1s,5r)-3-[3-[[4-methyl-5-(5-methylpyrazin-2-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NC(C)=CN=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(=CC=3)C(F)(F)F)C[C@H]2C1 AEXFOTSQBUVBKJ-PGRDOPGGSA-N 0.000 claims 1
- GXTDRNOVSQHWKB-HRAATJIYSA-N (1s,5r)-3-[3-[[4-methyl-5-(5-methylpyrazin-2-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NC(C)=CN=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=NC(=CC=3)C(F)(F)F)C[C@H]2C1 GXTDRNOVSQHWKB-HRAATJIYSA-N 0.000 claims 1
- CCJLDYTVWAENSM-NZQKXSOJSA-N (1s,5r)-3-[3-[[4-methyl-5-(6-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NC(C)=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(=CC=3)C(F)(F)F)C[C@H]2C1 CCJLDYTVWAENSM-NZQKXSOJSA-N 0.000 claims 1
- RUIZWYILWQFWPT-PGRDOPGGSA-N (1s,5r)-3-[3-[[4-methyl-5-(6-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NC(C)=CC=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=NC(=CC=3)C(F)(F)F)C[C@H]2C1 RUIZWYILWQFWPT-PGRDOPGGSA-N 0.000 claims 1
- KZBPRKVXUYDFQJ-PGRDOPGGSA-N (1s,5r)-3-[3-[[4-methyl-5-(oxan-4-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[4-(trifluoromethoxy)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C2CCOCC2)C)=CC=C(OC(F)(F)F)C=C1 KZBPRKVXUYDFQJ-PGRDOPGGSA-N 0.000 claims 1
- HJAJGYFKFFRJEC-SIKLNZKXSA-N (1s,5r)-3-[3-[[4-methyl-5-(oxan-4-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C2CCOCC2)C)=CC=C(C(F)(F)F)C=C1 HJAJGYFKFFRJEC-SIKLNZKXSA-N 0.000 claims 1
- PTRHJEYSWXFORZ-PGRDOPGGSA-N (1s,5r)-3-[3-[[4-methyl-5-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexane Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC=2N(C(=NN=2)C=2C=CC(=CC=2)C(F)(F)F)C)=CC=C(C(F)(F)F)N=C1 PTRHJEYSWXFORZ-PGRDOPGGSA-N 0.000 claims 1
- SYCYUYFGTJYLJB-PGRDOPGGSA-N (1s,5r)-3-[3-[[5-(1,5-dimethylpyrazol-4-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane Chemical compound C1=NN(C)C(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(=CC=3)C(F)(F)F)C[C@H]2C1 SYCYUYFGTJYLJB-PGRDOPGGSA-N 0.000 claims 1
- HSORSBPOHUZXNY-KCWXNJEJSA-N 1-[2-hydroxy-5-[(1s,5r)-3-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(O)C(C(=O)C)=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C=4C5=CC=C(C)N=C5C=CC=4)=NN=2)C)C3)=C1 HSORSBPOHUZXNY-KCWXNJEJSA-N 0.000 claims 1
- KHWKHOXPNILXFK-NBGIEHNGSA-N 1-[2-hydroxy-5-[(1s,5r)-3-[3-[[4-methyl-5-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(O)C(C(=O)C)=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C=4C=CC(=CC=4)C(F)(F)F)=NN=2)C)C3)=C1 KHWKHOXPNILXFK-NBGIEHNGSA-N 0.000 claims 1
- OOUUSTJOZYKIFZ-MHECFPHRSA-N 1-[2-methoxy-4-[(1s,5r)-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C4=C(N=CO4)C)=NN=2)C)C3)=C1 OOUUSTJOZYKIFZ-MHECFPHRSA-N 0.000 claims 1
- GHYALLPUTLGENT-AVRWGWEMSA-N 1-[2-methoxy-4-[(1s,5r)-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]propan-1-one Chemical compound C1=C(OC)C(C(=O)CC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C3=C(N=CO3)C)=NN=2)C)C2)[C@H]2C1 GHYALLPUTLGENT-AVRWGWEMSA-N 0.000 claims 1
- WUXMBXJSTUXONL-NBGIEHNGSA-N 1-[2-methoxy-5-[(1s,5r)-3-[3-[(4-methyl-5-pyridin-3-yl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C=3C=NC=CC=3)=NN=2)C)C2)[C@H]2C1 WUXMBXJSTUXONL-NBGIEHNGSA-N 0.000 claims 1
- WWMANSPKRWDTJQ-SMSORMJASA-N 1-[2-methoxy-5-[(1s,5r)-3-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C=3C4=CC=C(C)N=C4C=CC=3)=NN=2)C)C2)[C@H]2C1 WWMANSPKRWDTJQ-SMSORMJASA-N 0.000 claims 1
- YQNWPSNHRUBNBO-MHECFPHRSA-N 1-[2-methoxy-5-[(1s,5r)-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C3=C(N=CO3)C)=NN=2)C)C2)[C@H]2C1 YQNWPSNHRUBNBO-MHECFPHRSA-N 0.000 claims 1
- PSAASTBVOYWQMI-AVRWGWEMSA-N 1-[2-methoxy-5-[(1s,5r)-3-[3-[[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]propan-1-one Chemical compound C1=C(OC)C(C(=O)CC)=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C4=C(N=CO4)C)=NN=2)C)C3)=C1 PSAASTBVOYWQMI-AVRWGWEMSA-N 0.000 claims 1
- SIWHEXWKLXJQML-NBGIEHNGSA-N 1-[2-methoxy-5-[(1s,5r)-3-[3-[[4-methyl-5-(oxan-4-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C3CCOCC3)=NN=2)C)C2)[C@H]2C1 SIWHEXWKLXJQML-NBGIEHNGSA-N 0.000 claims 1
- XHXOKGKTIICKOZ-HFZDXXHNSA-N 1-[2-methoxy-5-[(1s,5r)-3-[3-[[4-methyl-5-[4-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C=3C=CC(=CC=3)C(F)(F)F)=NN=2)C)C2)[C@H]2C1 XHXOKGKTIICKOZ-HFZDXXHNSA-N 0.000 claims 1
- CDTMYUYGZNHOPV-GTYOFVGBSA-N 1-[4-[(1s,5r)-3-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]phenyl]pyrrolidin-2-one Chemical compound C1=CC([C@]23C[C@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C1N1CCCC1=O CDTMYUYGZNHOPV-GTYOFVGBSA-N 0.000 claims 1
- ZKGLMIMJGUYTID-AVRWGWEMSA-N 1-[5-[(1s,5r)-3-[3-[[5-(3,4-difluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]-2-hydroxyphenyl]ethanone Chemical compound C1=C(O)C(C(=O)C)=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C=4C=C(F)C(F)=CC=4)=NN=2)C)C3)=C1 ZKGLMIMJGUYTID-AVRWGWEMSA-N 0.000 claims 1
- DBHVXGHVYLHGTG-AFMDSPMNSA-N 1-[5-[(1s,5r)-3-[3-[[5-(3,4-difluorophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]-2-methoxyphenyl]ethanone Chemical compound C1=C(C(C)=O)C(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C=3C=C(F)C(F)=CC=3)=NN=2)C)C2)[C@H]2C1 DBHVXGHVYLHGTG-AFMDSPMNSA-N 0.000 claims 1
- WGSXKYXKAARAKD-UHFFFAOYSA-N 1-fluoro-3-isocyanato-5-(trifluoromethyl)benzene Chemical group FC1=CC(N=C=O)=CC(C(F)(F)F)=C1 WGSXKYXKAARAKD-UHFFFAOYSA-N 0.000 claims 1
- ODIJMXCJWMOZFJ-PGRDOPGGSA-N 2,4-dimethyl-5-[4-methyl-5-[3-[(1s,5r)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-thiazole Chemical compound S1C(C)=NC(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(=CC=3)C(F)(F)F)C[C@H]2C1 ODIJMXCJWMOZFJ-PGRDOPGGSA-N 0.000 claims 1
- QGHRENZJUREQGK-HRAATJIYSA-N 2,4-dimethyl-5-[4-methyl-5-[3-[(1s,5r)-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-thiazole Chemical compound S1C(C)=NC(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=NC(=CC=3)C(F)(F)F)C[C@H]2C1 QGHRENZJUREQGK-HRAATJIYSA-N 0.000 claims 1
- PNKRTTBCLUZVBM-NBGIEHNGSA-N 2-methyl-5-[(1s,5r)-3-[3-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]-1,3-benzothiazole Chemical compound C([C@@H]1C[C@@]1(C1)C=2C=C3N=C(SC3=CC=2)C)N1CCCSC(N1C)=NN=C1C1=CC=CC=C1 PNKRTTBCLUZVBM-NBGIEHNGSA-N 0.000 claims 1
- CKQJENKLIZUINM-MHECFPHRSA-N 2-methyl-5-[(1s,5r)-3-[3-[[4-methyl-5-(5-methylpyrazin-2-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]-1,3-benzothiazole Chemical compound C([C@@H]1C[C@@]1(C1)C=2C=C3N=C(SC3=CC=2)C)N1CCCSC(N1C)=NN=C1C1=CN=C(C)C=N1 CKQJENKLIZUINM-MHECFPHRSA-N 0.000 claims 1
- DRBBHLNQSPVHLL-NBGIEHNGSA-N 2-methyl-5-[(1s,5r)-3-[3-[[4-methyl-5-(6-methylpyridin-3-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]-1,3-benzothiazole Chemical compound C([C@@H]1C[C@@]1(C1)C=2C=C3N=C(SC3=CC=2)C)N1CCCSC(N1C)=NN=C1C1=CC=C(C)N=C1 DRBBHLNQSPVHLL-NBGIEHNGSA-N 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- CLLQEXUCEWAACY-RBISFHTESA-N 4-[(1s,5r)-3-[3-[[4-methyl-5-(2-methylquinolin-5-yl)-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]benzonitrile Chemical compound C1([C@]23C[C@H]2CN(C3)CCCSC2=NN=C(N2C)C=2C3=CC=C(N=C3C=CC=2)C)=CC=C(C#N)C=C1 CLLQEXUCEWAACY-RBISFHTESA-N 0.000 claims 1
- SQHSACZAZLANKD-YCRPNKLZSA-N 4-[5-[3-[(1s,5r)-1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2-methyl-5-(trifluoromethyl)-1,3-oxazole Chemical compound O1C(C)=NC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Br)=CC=3)=NN=2)C)=C1C(F)(F)F SQHSACZAZLANKD-YCRPNKLZSA-N 0.000 claims 1
- FPFPTUKYJWTWPY-YWZLYKJASA-N 4-methyl-5-[4-methyl-5-[3-[(1r,5r)-1-[5-(trifluoromethyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3N=CC(=CC=3)C(F)(F)F)=NN=2)C)=C1C FPFPTUKYJWTWPY-YWZLYKJASA-N 0.000 claims 1
- JWUUYXCKKOYVDZ-XOBRGWDASA-N 4-methyl-5-[4-methyl-5-[3-[(1r,5r)-1-[6-(trifluoromethyl)pyridin-2-yl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3N=C(C=CC=3)C(F)(F)F)=NN=2)C)=C1C JWUUYXCKKOYVDZ-XOBRGWDASA-N 0.000 claims 1
- LEUDJRMEBMLZBI-FDDCHVKYSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-(1-methylindazol-5-yl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=C4C=NN(C)C4=CC=3)=NN=2)C)=C1C LEUDJRMEBMLZBI-FDDCHVKYSA-N 0.000 claims 1
- UAOBDKREOZMZJQ-GAJHUEQPSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-(2-methyl-1,3-benzothiazol-5-yl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound C([C@@H]1C[C@@]1(C1)C=2C=C3N=C(SC3=CC=2)C)N1CCCSC(N1C)=NN=C1C=1OC=NC=1C UAOBDKREOZMZJQ-GAJHUEQPSA-N 0.000 claims 1
- OIERNJOFVGMUEF-GAJHUEQPSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-(2-methyl-1,3-benzothiazol-6-yl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound C([C@@H]1C[C@@]1(C1)C2=CC=C3N=C(SC3=C2)C)N1CCCSC(N1C)=NN=C1C=1OC=NC=1C OIERNJOFVGMUEF-GAJHUEQPSA-N 0.000 claims 1
- KYPWROFHQUYOCS-BTYIYWSLSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[2-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C(=CC=CC=3)C(F)(F)F)=NN=2)C)=C1C KYPWROFHQUYOCS-BTYIYWSLSA-N 0.000 claims 1
- KFCVKULFYARZLT-JTSKRJEESA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[2-methyl-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C(=CC(=CC=3)C(F)(F)F)C)=NN=2)C)=C1C KFCVKULFYARZLT-JTSKRJEESA-N 0.000 claims 1
- FKRBBYMVCAJBHR-HFZDXXHNSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[3-(5-methylthiophen-2-yl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound S1C(C)=CC=C1C1=CC=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C4=C(N=CO4)C)=NN=2)C)C3)=C1 FKRBBYMVCAJBHR-HFZDXXHNSA-N 0.000 claims 1
- MLHRKLZCJRKSHO-LAUBAEHRSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[3-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=C(C=CC=3)C(F)(F)F)=NN=2)C)=C1C MLHRKLZCJRKSHO-LAUBAEHRSA-N 0.000 claims 1
- SRVOWVHRVJSZKO-HRAATJIYSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[4-(trifluoromethoxy)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(OC(F)(F)F)=CC=3)=NN=2)C)=C1C SRVOWVHRVJSZKO-HRAATJIYSA-N 0.000 claims 1
- HIRZFMOIKMLUHF-LAUBAEHRSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(=CC=3)C(F)(F)F)=NN=2)C)=C1C HIRZFMOIKMLUHF-LAUBAEHRSA-N 0.000 claims 1
- STMFIEJAIJCUPM-RXFWQSSRSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[4-[6-(trifluoromethyl)pyridin-2-yl]phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(=CC=3)C=3N=C(C=CC=3)C(F)(F)F)=NN=2)C)=C1C STMFIEJAIJCUPM-RXFWQSSRSA-N 0.000 claims 1
- QWTAGVPLIGQGIW-MGPUTAFESA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-[6-(trifluoromethyl)pyridin-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=NC(=CC=3)C(F)(F)F)=NN=2)C)=C1C QWTAGVPLIGQGIW-MGPUTAFESA-N 0.000 claims 1
- YYLVZNFHPHPLKB-LAUBAEHRSA-N 4-methyl-5-[4-methyl-5-[3-[(1s,5r)-1-phenyl-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-1,2,4-triazol-3-yl]-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC=CC=3)=NN=2)C)=C1C YYLVZNFHPHPLKB-LAUBAEHRSA-N 0.000 claims 1
- UXBIDSXSMDZFKR-MHECFPHRSA-N 5-[(1s,5r)-3-[3-[[5-(2,4-dimethyl-1,3-thiazol-5-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]propyl]-3-azabicyclo[3.1.0]hexan-1-yl]-2-methyl-1,3-benzothiazole Chemical compound S1C(C)=NC(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=C4N=C(C)SC4=CC=3)C[C@H]2C1 UXBIDSXSMDZFKR-MHECFPHRSA-N 0.000 claims 1
- MHDWNZWHPYKUAY-UJPJHGMFSA-N 5-[5-[1-[(1s,5r)-1-(2-chloro-4-methylphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propan-2-ylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound C1([C@]23C[C@H]2CN(C3)CC(C)SC=2N(C(C3=C(N=CO3)C)=NN=2)C)=CC=C(C)C=C1Cl MHDWNZWHPYKUAY-UJPJHGMFSA-N 0.000 claims 1
- NRBWMTGEADXYFF-VQBJLOOESA-N 5-[5-[1-[(1s,5r)-1-(3-chloro-4-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propan-2-ylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound C1=C(Cl)C(OC)=CC=C1[C@@]1(CN(CC(C)SC=2N(C(C3=C(N=CO3)C)=NN=2)C)C2)[C@H]2C1 NRBWMTGEADXYFF-VQBJLOOESA-N 0.000 claims 1
- YFAACACUMCZFCU-HRAATJIYSA-N 5-[5-[3-[(1s,5r)-1-(3-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=C(Br)C=CC=3)=NN=2)C)=C1C YFAACACUMCZFCU-HRAATJIYSA-N 0.000 claims 1
- RDNMLFUSVMBDDY-VXKWHMMOSA-N 5-[5-[3-[(1s,5r)-1-(3-chlorophenyl)-5-methyl-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@@]4(C[C@@]4(C)C3)C=3C=C(Cl)C=CC=3)=NN=2)C)=C1C RDNMLFUSVMBDDY-VXKWHMMOSA-N 0.000 claims 1
- JEBLLBOUXXZBPR-HRAATJIYSA-N 5-[5-[3-[(1s,5r)-1-(3-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=C(F)C=CC=3)=NN=2)C)=C1C JEBLLBOUXXZBPR-HRAATJIYSA-N 0.000 claims 1
- VSHFJDFDEHUHMG-HTAPYJJXSA-N 5-[5-[3-[(1s,5r)-1-(3-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound COC1=CC=CC([C@@]23[C@@H](C2)CN(CCCSC=2N(C(C4=C(N=CO4)C)=NN=2)C)C3)=C1 VSHFJDFDEHUHMG-HTAPYJJXSA-N 0.000 claims 1
- QYIGIFAPYBZLOA-HTAPYJJXSA-N 5-[5-[3-[(1s,5r)-1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2,4-dimethyl-1,3-thiazole Chemical compound S1C(C)=NC(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 QYIGIFAPYBZLOA-HTAPYJJXSA-N 0.000 claims 1
- RWAAUSOBGQKJNX-HRAATJIYSA-N 5-[5-[3-[(1s,5r)-1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-3-methyl-1,2-oxazole Chemical compound O1N=C(C)C=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C=CC(Br)=CC=3)C[C@H]2C1 RWAAUSOBGQKJNX-HRAATJIYSA-N 0.000 claims 1
- TXPWWEBUZHUGQI-HRAATJIYSA-N 5-[5-[3-[(1s,5r)-1-(4-bromophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Br)=CC=3)=NN=2)C)=C1C TXPWWEBUZHUGQI-HRAATJIYSA-N 0.000 claims 1
- JASDXILVHIDXCQ-HRAATJIYSA-N 5-[5-[3-[(1s,5r)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(Cl)=CC=3)=NN=2)C)=C1C JASDXILVHIDXCQ-HRAATJIYSA-N 0.000 claims 1
- QLOCSQXNJJSRQH-HRAATJIYSA-N 5-[5-[3-[(1s,5r)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(F)=CC=3)=NN=2)C)=C1C QLOCSQXNJJSRQH-HRAATJIYSA-N 0.000 claims 1
- AVTONHYDPSFOLQ-HTAPYJJXSA-N 5-[5-[3-[(1s,5r)-1-(4-methoxyphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound C1=CC(OC)=CC=C1[C@@]1(CN(CCCSC=2N(C(C3=C(N=CO3)C)=NN=2)C)C2)[C@H]2C1 AVTONHYDPSFOLQ-HTAPYJJXSA-N 0.000 claims 1
- KBYDKOYJEQUBOE-NBGIEHNGSA-N 5-[5-[3-[(1s,5r)-1-(4-tert-butylphenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3C[C@]4(C[C@H]4C3)C=3C=CC(=CC=3)C(C)(C)C)=NN=2)C)=C1C KBYDKOYJEQUBOE-NBGIEHNGSA-N 0.000 claims 1
- CRZBMVVRCINCBG-AOMKIAJQSA-N 5-[5-[3-[(1s,5r)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-2,4-dimethyl-1,3-thiazole Chemical compound S1C(C)=NC(C)=C1C(N1C)=NN=C1SCCCN1C[C@@]2(C=3C(=CC(=CC=3)C(F)(F)F)F)C[C@H]2C1 CRZBMVVRCINCBG-AOMKIAJQSA-N 0.000 claims 1
- JASDXILVHIDXCQ-UHFFFAOYSA-N 5-[5-[3-[1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexan-3-yl]propylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]-4-methyl-1,3-oxazole Chemical compound N1=COC(C=2N(C(SCCCN3CC4(CC4C3)C=3C=CC(Cl)=CC=3)=NN=2)C)=C1C JASDXILVHIDXCQ-UHFFFAOYSA-N 0.000 claims 1
- QRDSDKAGXMWBID-UHFFFAOYSA-N 5-azabicyclo[3.1.0]hexane Chemical compound C1CCN2CC21 QRDSDKAGXMWBID-UHFFFAOYSA-N 0.000 claims 1
- GLDGSDYGUWBOSJ-NPMXOYFQSA-N BrC1=CC=C(C=C1)[C@]12CN(C[C@@H]2C1)CCCSC=1N(C(=NN=1)C1=CSC=2N(N=C(C=21)C(F)(F)F)C)C Chemical compound BrC1=CC=C(C=C1)[C@]12CN(C[C@@H]2C1)CCCSC=1N(C(=NN=1)C1=CSC=2N(N=C(C=21)C(F)(F)F)C)C GLDGSDYGUWBOSJ-NPMXOYFQSA-N 0.000 claims 1
- RPONDORJJYDDEO-UHFFFAOYSA-N CN1C(SCCCC2(C3)C3CNC2)=NN=C1C1=CN=NC=C1 Chemical compound CN1C(SCCCC2(C3)C3CNC2)=NN=C1C1=CN=NC=C1 RPONDORJJYDDEO-UHFFFAOYSA-N 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
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- 238000000034 method Methods 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
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| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
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| WO2007006117A1 (en) * | 2005-07-13 | 2007-01-18 | Nicogen Inc. | Novel cyp2a6 inhibitors |
| NZ592836A (en) * | 2005-07-27 | 2013-01-25 | Dov Pharmaceutical Inc | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
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| WO2007022933A1 (en) * | 2005-08-22 | 2007-03-01 | Glaxo Group Limited | Triazole derivatives as modulators of dopamine d3 receptors |
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| AR060237A1 (es) * | 2006-04-03 | 2008-06-04 | Glaxo Group Ltd | Compuesto de 3-azabiciclo[3.1.0]hexano como moduladores del receptor de dopamina d3, su uso para la preparacion de un medicamento para el tratamiento de afecciones psicoticas y composicion farmaceutica que lo comprende. |
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| US8222266B2 (en) * | 2006-04-03 | 2012-07-17 | Glaxo Group Limited | Azabicyclo [3.1.0] hexyl derivatives as modulators of dopamine D3 receptors |
| US8163927B2 (en) * | 2006-04-03 | 2012-04-24 | Glaxo Group Limited | Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors |
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| US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| GB0616574D0 (en) * | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
| US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| US20090069374A1 (en) * | 2007-06-06 | 2009-03-12 | Phil Skolnick | Novel 1-Heteroaryl-3-Azabicyclo[3.1.0]Hexanes, Methods For Their Preparation And Their Use As Medicaments |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| GB0719235D0 (en) * | 2007-10-02 | 2007-11-14 | Glaxo Group Ltd | Novel compounds |
| GB0719234D0 (en) * | 2007-10-02 | 2007-11-14 | Glaxo Group Ltd | Novel compounds |
| CN102816106A (zh) | 2008-06-24 | 2012-12-12 | 默沙东公司 | 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法 |
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| BR112012000657A2 (pt) | 2009-06-26 | 2016-11-16 | Panacea Biotec Ltd | novos azabicilohexanos |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| US20160279098A1 (en) * | 2013-11-11 | 2016-09-29 | Euthymics Bioscience, Inc. | Novel methods |
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| JP7250405B2 (ja) | 2018-01-26 | 2023-04-03 | 塩野義製薬株式会社 | ドーパミンｄ３受容体拮抗作用を有する環式化合物 |
| CN116113627B (zh) | 2020-06-22 | 2025-06-03 | 科赛普特治疗公司 | 季吲哚糖皮质激素受体拮抗剂 |
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| TWI274750B (en) * | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
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| GB0507602D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
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| GB0517175D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
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