PT1745040E - Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina - Google Patents
Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina Download PDFInfo
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- PT1745040E PT1745040E PT05707610T PT05707610T PT1745040E PT 1745040 E PT1745040 E PT 1745040E PT 05707610 T PT05707610 T PT 05707610T PT 05707610 T PT05707610 T PT 05707610T PT 1745040 E PT1745040 E PT 1745040E
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- Prior art keywords
- compound
- formula
- methyl
- phenyl
- trifluoromethyl
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- 102000004073 Dopamine D3 Receptors Human genes 0.000 title claims description 10
- 108090000525 Dopamine D3 Receptors Proteins 0.000 title claims description 10
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Classifications
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB0403990A GB0403990D0 (en) | 2004-02-23 | 2004-02-23 | Compounds |
| GB0404083A GB0404083D0 (en) | 2004-02-24 | 2004-02-24 | Compounds |
| GB0417120A GB0417120D0 (en) | 2004-07-30 | 2004-07-30 | Compounds |
Publications (1)
| Publication Number | Publication Date |
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| PT1745040E true PT1745040E (pt) | 2010-03-08 |
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Family Applications (3)
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| PT05707610T PT1745040E (pt) | 2004-02-23 | 2005-02-21 | Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina |
| PT08169934T PT2070922E (pt) | 2004-02-23 | 2005-02-21 | Derivados de azabiciclo(3.1.0)hexano úteis como moduladores dos receptores d3 da dopamina |
| PT08169935T PT2060570E (pt) | 2004-02-23 | 2005-02-21 | Derivados de azabiciclo(3.1.0)-hexano úteis como moduladores dos receptores d3 da dopamina |
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| Application Number | Title | Priority Date | Filing Date |
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| PT08169934T PT2070922E (pt) | 2004-02-23 | 2005-02-21 | Derivados de azabiciclo(3.1.0)hexano úteis como moduladores dos receptores d3 da dopamina |
| PT08169935T PT2060570E (pt) | 2004-02-23 | 2005-02-21 | Derivados de azabiciclo(3.1.0)-hexano úteis como moduladores dos receptores d3 da dopamina |
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|---|---|
| US (3) | US7855298B2 (https=) |
| EP (3) | EP2060570B1 (https=) |
| JP (1) | JP4960217B2 (https=) |
| KR (1) | KR101143718B1 (https=) |
| CN (1) | CN1946714B (https=) |
| AR (1) | AR047890A1 (https=) |
| AT (3) | ATE451364T1 (https=) |
| AU (2) | AU2005215918C1 (https=) |
| BR (1) | BRPI0507945A (https=) |
| CA (1) | CA2557115C (https=) |
| CY (3) | CY1109854T1 (https=) |
| DE (1) | DE602005018190D1 (https=) |
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| ES (2) | ES2380990T3 (https=) |
| HR (3) | HRP20100114T1 (https=) |
| IL (1) | IL177184A0 (https=) |
| MA (1) | MA28438B1 (https=) |
| NO (1) | NO20064309L (https=) |
| PE (1) | PE20051173A1 (https=) |
| PL (3) | PL2060570T3 (https=) |
| PT (3) | PT1745040E (https=) |
| RU (1) | RU2434011C2 (https=) |
| SI (3) | SI1745040T1 (https=) |
| TW (1) | TW200538113A (https=) |
| WO (1) | WO2005080382A1 (https=) |
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| PT1745040E (pt) * | 2004-02-23 | 2010-03-08 | Glaxo Group Ltd | Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina |
| US20070043100A1 (en) | 2005-08-16 | 2007-02-22 | Hagen Eric J | Novel polymorphs of azabicyclohexane |
| GB0507601D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507602D0 (en) | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507680D0 (en) | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| EP1891056B1 (en) | 2005-06-14 | 2010-10-13 | Glaxo Group Limited | Novel compounds |
| WO2007006117A1 (en) * | 2005-07-13 | 2007-01-18 | Nicogen Inc. | Novel cyp2a6 inhibitors |
| EP1915146A4 (en) | 2005-07-27 | 2010-06-02 | Dov Pharmaceutical Inc | NOVEL 1-ARYL-3-AZABICYCLO [3.1.0] HEXANEES. PREPARATION AND USE FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES |
| GB0517175D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517187D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517193D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
| US7799815B2 (en) * | 2005-08-22 | 2010-09-21 | Glaxo Group Limited | Triazole derivatives as modulators of dopamine D3 receptors |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| EA200870404A1 (ru) | 2006-04-03 | 2009-04-28 | Глэксо Груп Лимитед | Производные азабицикло[3.1.0.]гексила в качестве модуляторов рецепторов допамина d3 |
| GB0607899D0 (en) * | 2006-04-03 | 2006-05-31 | Glaxo Group Ltd | Process for preparing heterocyclic derivatives |
| GB0703387D0 (en) * | 2007-02-21 | 2007-03-28 | Glaxo Group Ltd | Novel compounds |
| WO2007113258A1 (en) * | 2006-04-03 | 2007-10-11 | Glaxo Group Limited | Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors |
| EP2007751B1 (en) * | 2006-04-03 | 2013-08-21 | Glaxo Group Limited | Azabicyclo [3. 1. o] hexyl derivatives as modulators of dopamine d3 receptors |
| GB0608452D0 (en) * | 2006-04-27 | 2006-06-07 | Glaxo Group Ltd | Novel compounds |
| US20080045725A1 (en) | 2006-04-28 | 2008-02-21 | Murry Jerry A | Process For The Synthesis of (+) And (-)-1-(3,4-Dichlorophenyl)-3-Azabicyclo[3.1.0]Hexane |
| GB0616574D0 (en) * | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
| US8138377B2 (en) | 2006-11-07 | 2012-03-20 | Dov Pharmaceutical, Inc. | Arylbicyclo[3.1.0]hexylamines and methods and compositions for their preparation and use |
| EP2167083B1 (en) * | 2007-06-06 | 2015-10-28 | Euthymics Bioscience, Inc. | 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| US9133159B2 (en) | 2007-06-06 | 2015-09-15 | Neurovance, Inc. | 1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments |
| GB0719235D0 (en) | 2007-10-02 | 2007-11-14 | Glaxo Group Ltd | Novel compounds |
| GB0719234D0 (en) * | 2007-10-02 | 2007-11-14 | Glaxo Group Ltd | Novel compounds |
| MX2010014500A (es) | 2008-06-24 | 2011-05-30 | Codexis Inc | Procedimientos biocataliticos para la preparacion de compuestos de prolina biciclica fusionada sustancialmente estereomericamente puros. |
| US8536185B2 (en) * | 2008-09-22 | 2013-09-17 | Cayman Chemical Company, Incorporated | Multiheteroaryl compounds as inhibitors of H-PGDS and their use for treating prostaglandin D2 mediated diseases |
| KR20120106697A (ko) * | 2009-06-26 | 2012-09-26 | 파나세아 바이오테크 리미티드 | 신규 아자비시클로헥산 |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| EP3068226A4 (en) * | 2013-11-11 | 2017-05-17 | Euthymics Bioscience, Inc. | Novel methods |
| ES2821896T3 (es) | 2015-08-05 | 2021-04-28 | Indivior Uk Ltd | Antagonistas del receptor de dopamina D3 que tienen una unidad estructural biciclo |
| US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| AU2021296163B2 (en) | 2020-06-22 | 2024-07-04 | Corcept Therapeutics Incorporated | Quaternary indazole glucocorticoid receptor antagonists |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| IL313663A (en) | 2021-12-21 | 2024-08-01 | Corcept Therapeutics Inc | Piperazine indazole glucocorticoid receptor antagonists |
| KR20240125035A (ko) | 2021-12-21 | 2024-08-19 | 코어셉트 쎄라퓨틱스 인코포레이티드 | 이환 인다졸 글루코코르티코이드 수용체 길항제 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI274750B (en) * | 1999-01-12 | 2007-03-01 | Abbott Gmbh & Co Kg | Triazole compounds showing high affinity to dopamine D3 receptor and pharmaceutical composition comprising the same |
| GB0015562D0 (en) * | 2000-06-23 | 2000-08-16 | Pfizer Ltd | Heterocycles |
| EP1335915B1 (en) | 2000-11-14 | 2008-01-02 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
| EA006708B1 (ru) * | 2001-10-22 | 2006-02-24 | Пфайзер Продактс Инк. | Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора |
| WO2004014881A2 (en) * | 2002-08-09 | 2004-02-19 | Astra Zeneca Ab | '1,2,4'oxadiazoles as modulators of metabotropic glutamate receptor-5 |
| PT1745040E (pt) * | 2004-02-23 | 2010-03-08 | Glaxo Group Ltd | Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina |
| GB0507601D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507602D0 (en) | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| EP1891056B1 (en) | 2005-06-14 | 2010-10-13 | Glaxo Group Limited | Novel compounds |
| GB0517175D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| US7799815B2 (en) * | 2005-08-22 | 2010-09-21 | Glaxo Group Limited | Triazole derivatives as modulators of dopamine D3 receptors |
| GB0517187D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517193D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
| EA200870404A1 (ru) | 2006-04-03 | 2009-04-28 | Глэксо Груп Лимитед | Производные азабицикло[3.1.0.]гексила в качестве модуляторов рецепторов допамина d3 |
| GB0616574D0 (en) * | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
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2005
- 2005-02-21 PT PT05707610T patent/PT1745040E/pt unknown
- 2005-02-21 ES ES08169935T patent/ES2380990T3/es not_active Expired - Lifetime
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- 2005-02-21 DK DK05707610.1T patent/DK1745040T3/da active
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- 2005-02-21 EP EP08169934A patent/EP2070922B1/en not_active Expired - Lifetime
- 2005-02-21 SI SI200530923T patent/SI1745040T1/sl unknown
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- 2005-02-21 KR KR1020067016833A patent/KR101143718B1/ko not_active Expired - Fee Related
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- 2005-02-21 JP JP2007500152A patent/JP4960217B2/ja not_active Expired - Fee Related
- 2005-02-21 TW TW094105108A patent/TW200538113A/zh unknown
- 2005-02-21 AU AU2005215918A patent/AU2005215918C1/en not_active Ceased
- 2005-02-21 PL PL05707610T patent/PL1745040T3/pl unknown
- 2005-02-21 AT AT08169935T patent/ATE542816T1/de active
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- 2005-02-21 CN CN2005800126155A patent/CN1946714B/zh not_active Expired - Fee Related
- 2005-02-21 PT PT08169934T patent/PT2070922E/pt unknown
- 2005-02-21 PL PL08169934T patent/PL2070922T3/pl unknown
- 2005-02-21 SI SI200531398T patent/SI2070922T1/sl unknown
- 2005-02-21 BR BRPI0507945-4A patent/BRPI0507945A/pt active Search and Examination
- 2005-02-21 WO PCT/EP2005/001940 patent/WO2005080382A1/en not_active Ceased
- 2005-02-21 ES ES05707610T patent/ES2337590T3/es not_active Expired - Lifetime
- 2005-02-21 HR HR20100114T patent/HRP20100114T1/hr unknown
- 2005-02-21 RU RU2006133909/04A patent/RU2434011C2/ru not_active IP Right Cessation
- 2005-02-21 PT PT08169935T patent/PT2060570E/pt unknown
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- 2006-08-22 MA MA29286A patent/MA28438B1/fr unknown
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- 2009-12-16 US US12/639,282 patent/US8283474B2/en not_active Expired - Fee Related
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