JP2013533868A5 - - Google Patents
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- Publication number
- JP2013533868A5 JP2013533868A5 JP2013517018A JP2013517018A JP2013533868A5 JP 2013533868 A5 JP2013533868 A5 JP 2013533868A5 JP 2013517018 A JP2013517018 A JP 2013517018A JP 2013517018 A JP2013517018 A JP 2013517018A JP 2013533868 A5 JP2013533868 A5 JP 2013533868A5
- Authority
- JP
- Japan
- Prior art keywords
- diazaspiro
- pyrrolo
- pyrimidin
- nonan
- methanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 **(CN(*)C1(CC1)CC1)CN1c1c(cc[n]2)c2nc(I)n1 Chemical compound **(CN(*)C1(CC1)CC1)CN1c1c(cc[n]2)c2nc(I)n1 0.000 description 4
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36309510P | 2010-07-09 | 2010-07-09 | |
| US61/363,095 | 2010-07-09 | ||
| PCT/DK2011/000080 WO2012003829A1 (en) | 2010-07-09 | 2011-07-08 | Novel homopiperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533868A JP2013533868A (ja) | 2013-08-29 |
| JP2013533868A5 true JP2013533868A5 (https=) | 2014-08-28 |
Family
ID=44513700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013517018A Pending JP2013533868A (ja) | 2010-07-09 | 2011-07-08 | タンパク質チロシンキナーゼ阻害剤としての新規ホモピペラジン誘導体およびそれらの医薬使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9586961B2 (https=) |
| EP (1) | EP2590981B1 (https=) |
| JP (1) | JP2013533868A (https=) |
| CN (1) | CN102985425A (https=) |
| RU (1) | RU2013105450A (https=) |
| TW (1) | TW201204732A (https=) |
| WO (1) | WO2012003829A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104072499A (zh) * | 2013-03-29 | 2014-10-01 | 黄传满 | 哌嗪取代嘧啶类化合物及其用途 |
| CN103242321A (zh) * | 2013-05-21 | 2013-08-14 | 苏州科捷生物医药有限公司 | 苄基哌嗪类化合物及其抗肿瘤用途 |
| CN103396414B (zh) * | 2013-07-16 | 2015-06-03 | 浙江医药高等专科学校 | 咪唑取代的噻唑并环己烷类化合物、及其抗肿瘤用途 |
| MX368464B (es) * | 2013-12-05 | 2019-10-02 | Pfizer | Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinil o y pirrolo[2,3-d]piridinilo. |
| AR101214A1 (es) * | 2014-07-22 | 2016-11-30 | Bayer Cropscience Ag | Ciano-cicloalquilpenta-2,4-dienos, ciano-cicloalquilpent-2-en-4-inas, ciano-heterociclilpenta-2,4-dienos y ciano-heterociclilpent-2-en-4-inas sustituidos como principios activos contra el estrés abiótico de plantas |
| CN105712998B (zh) * | 2014-12-05 | 2019-12-13 | 上海润诺生物科技有限公司 | 氮杂吲哚类衍生物、其制备方法及其在医药上的应用 |
| CN109689663B (zh) * | 2016-09-14 | 2023-04-14 | 詹森药业有限公司 | Menin-mll相互作用的螺二环抑制剂 |
| CN110291090A (zh) * | 2017-01-20 | 2019-09-27 | 利奥制药有限公司 | 作为新型jak激酶抑制剂的双环胺 |
| CN110248663A (zh) * | 2017-02-03 | 2019-09-17 | 利奥制药有限公司 | 作为新型JAK激酶抑制剂的5-(7H-吡咯并[2,3-d]嘧啶-4-基)-5-氮杂螺[2.5]辛烷-8-甲酸衍生物 |
| CN108069986B (zh) * | 2017-12-08 | 2018-10-02 | 牡丹江医学院 | 一种治疗角膜炎的活性药物及其制备方法 |
| WO2020092015A1 (en) | 2018-11-02 | 2020-05-07 | University Of Rochester | Therapeutic mitigation of epithelial infection |
| CN114599364A (zh) | 2019-09-05 | 2022-06-07 | 因赛特公司 | 用于减少特应性皮炎瘙痒的鲁索替尼制剂 |
| US11992490B2 (en) | 2019-10-16 | 2024-05-28 | Incyte Corporation | Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP) |
| JP7554829B2 (ja) | 2019-12-19 | 2024-09-20 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換直鎖スピロ誘導体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8474101A1 (es) * | 1998-06-19 | 2000-09-29 | Pfizer Prod Inc | Compuestos de pirrolo [2,3-d] pirimidina |
| BR9911365A (pt) * | 1998-06-19 | 2001-03-13 | Pfizer Prod Inc | Compostos pirrolo[2,3-d]pirimidina |
| WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| PL2049529T3 (pl) | 2006-07-14 | 2011-01-31 | Merck Sharp & Dohme | Podstawione związki diazepanowe - antagoniści receptora oreksyny |
| RU2009140319A (ru) * | 2007-04-02 | 2011-05-10 | Палау Фарма С.А. (Es) | Производные пирролпиримидина |
| WO2009017838A2 (en) | 2007-08-01 | 2009-02-05 | Exelixis, Inc. | Combinations of jak-2 inhibitors and other agents |
| EP2188289B1 (en) * | 2007-08-08 | 2015-10-28 | Lexicon Pharmaceuticals, Inc. | (7h-pyrrolo[2,3-d]pyrimidin-4-yl)-piperazines as kinase inhibitors for the treatment of cancer and inflammation |
| UY31631A1 (es) | 2008-02-06 | 2009-09-30 | Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones | |
| NZ588830A (en) | 2008-04-22 | 2012-11-30 | Portola Pharm Inc | Inhibitors of protein kinases |
-
2011
- 2011-07-08 US US13/809,059 patent/US9586961B2/en not_active Expired - Fee Related
- 2011-07-08 RU RU2013105450/04A patent/RU2013105450A/ru not_active Application Discontinuation
- 2011-07-08 TW TW100124316A patent/TW201204732A/zh unknown
- 2011-07-08 JP JP2013517018A patent/JP2013533868A/ja active Pending
- 2011-07-08 WO PCT/DK2011/000080 patent/WO2012003829A1/en not_active Ceased
- 2011-07-08 CN CN2011800339890A patent/CN102985425A/zh active Pending
- 2011-07-08 EP EP11738151.7A patent/EP2590981B1/en not_active Not-in-force
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