JPWO2020247160A5 - - Google Patents
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- JPWO2020247160A5 JPWO2020247160A5 JP2021567819A JP2021567819A JPWO2020247160A5 JP WO2020247160 A5 JPWO2020247160 A5 JP WO2020247160A5 JP 2021567819 A JP2021567819 A JP 2021567819A JP 2021567819 A JP2021567819 A JP 2021567819A JP WO2020247160 A5 JPWO2020247160 A5 JP WO2020247160A5
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- Japan
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962847562P | 2019-05-14 | 2019-05-14 | |
| US62/847,562 | 2019-05-14 | ||
| US202063004813P | 2020-04-03 | 2020-04-03 | |
| US63/004,813 | 2020-04-03 | ||
| PCT/US2020/032832 WO2020247160A1 (en) | 2019-05-14 | 2020-05-14 | Condensed tryciclic pyrroles as alpha-1 antitrypsin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022532340A JP2022532340A (ja) | 2022-07-14 |
| JPWO2020247160A5 true JPWO2020247160A5 (ko) | 2023-05-15 |
Family
ID=72644864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021567819A Pending JP2022532340A (ja) | 2019-05-14 | 2020-05-14 | α－１抗トリプシンモジュレーターとしての縮合三環系ピロール |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US11884672B2 (ko) |
| EP (1) | EP3969440A1 (ko) |
| JP (1) | JP2022532340A (ko) |
| KR (1) | KR20220023987A (ko) |
| CN (1) | CN114096542B (ko) |
| AU (1) | AU2020286424A1 (ko) |
| BR (1) | BR112021022832A2 (ko) |
| CA (1) | CA3140039A1 (ko) |
| CL (1) | CL2021002964A1 (ko) |
| CO (1) | CO2021016594A2 (ko) |
| CR (1) | CR20210608A (ko) |
| DO (1) | DOP2021000234A (ko) |
| EC (1) | ECSP21085481A (ko) |
| IL (1) | IL287878A (ko) |
| JO (1) | JOP20210301A1 (ko) |
| MA (1) | MA55971A (ko) |
| MX (1) | MX2021013993A (ko) |
| PE (1) | PE20220905A1 (ko) |
| SG (1) | SG11202112414UA (ko) |
| TW (1) | TW202108588A (ko) |
| UY (1) | UY38696A (ko) |
| WO (1) | WO2020247160A1 (ko) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022512588A (ja) * | 2018-10-05 | 2022-02-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ１アンチトリプシンのモジュレーター |
| UY38696A (es) * | 2019-05-14 | 2020-11-30 | Vertex Pharma | Moduladores de alfa-1 antitripsina |
| GB201918416D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
| GB201918413D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
| GB201918414D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency |
| GB201918410D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
| GB201918404D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of aplha1-antitrypsin deficiency |
| TW202139997A (zh) * | 2020-01-30 | 2021-11-01 | 美商維泰克斯製藥公司 | α－１抗胰蛋白酶缺乏之治療方法 |
| CN115776984A (zh) * | 2020-04-03 | 2023-03-10 | 弗特克斯药品有限公司 | 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1-抗胰蛋白酶调节剂的吡咯并[2,3-f]吲唑和2,4,5,10-四氮杂三环[7.3.0.03,7]十二碳-1,3(7),5,8,11-五烯衍生物 |
| WO2022026372A2 (en) | 2020-07-27 | 2022-02-03 | Vertex Pharmaceuticals Incorporated | Processes for preparing modulators of alpha-1 antitrypsin |
| US20240012010A1 (en) | 2020-11-12 | 2024-01-11 | Vertex Pharmaceuticals Incorporated | Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat |
| EP4247490A2 (en) | 2020-11-17 | 2023-09-27 | Vertex Pharmaceuticals Incorporated | Solid forms of 4-(5-(4-fluorophenyl)-6-tetrahydro-2h-pyran-4-yl)- 1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid |
| GB202108523D0 (en) | 2021-06-15 | 2021-07-28 | Z Factor Ltd | Compositions and their use for the treatment of alpha1-antitrypsin deficiency |
| WO2024054624A1 (en) | 2022-09-09 | 2024-03-14 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK158590D0 (da) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | Indolderivater |
| US20020017295A1 (en) | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| JP2000072751A (ja) | 1998-08-26 | 2000-03-07 | Tanabe Seiyaku Co Ltd | イソキノリノン誘導体 |
| JP2000281654A (ja) | 1999-03-26 | 2000-10-10 | Tanabe Seiyaku Co Ltd | イソキノリン誘導体 |
| GB9913083D0 (en) | 1999-06-04 | 1999-08-04 | Novartis Ag | Organic compounds |
| FR2802532A1 (fr) | 1999-12-17 | 2001-06-22 | Sanofi Synthelabo | Derives de 2-phenyl-quinoleine, leur preparation et leur application en therapeutique |
| US6638929B2 (en) | 1999-12-29 | 2003-10-28 | Wyeth | Tricyclic protein kinase inhibitors |
| MXPA03000708A (es) | 2000-07-26 | 2003-06-04 | Smithkline Beecham Plc | Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana. |
| US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| JPWO2002094790A1 (ja) | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| CN1612866A (zh) | 2001-11-14 | 2005-05-04 | 特瓦制药工业有限公司 | 无定形和结晶形的氯沙坦钾及其制备方法 |
| US7208601B2 (en) | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| DE102008022521A1 (de) * | 2008-05-07 | 2009-11-12 | Bayer Schering Pharma Aktiengesellschaft | 1,4-Diaryl-pyrimidopyridazin-2,5-dione und ihre Verwendung |
| WO2011056222A1 (en) | 2009-11-05 | 2011-05-12 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods of treating disorders associated with protein aggregation |
| US20110224229A1 (en) | 2010-03-10 | 2011-09-15 | Astrazeneca Ab | Novel Crystalline Form |
| NZ700556A (en) | 2010-03-25 | 2016-04-29 | Vertex Pharma | Solid forms of (r)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide |
| CA2811706C (en) | 2010-09-24 | 2017-03-28 | Grifols Therapeutics Inc. | Immunochromatography devices, methods, and kits |
| US9572794B2 (en) | 2014-08-06 | 2017-02-21 | Vanderbilt University | Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists |
| WO2016154051A1 (en) | 2015-03-20 | 2016-09-29 | University Of Florida Research Foundation, Inc. | Combination therapy for treating infections diseases |
| AU2017263574B2 (en) | 2016-05-12 | 2022-11-17 | The Regents Of The University Of Michigan | ASH1L inhibitors and methods of treatment therewith |
| JOP20180008A1 (ar) * | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| JP2020537669A (ja) | 2017-10-19 | 2020-12-24 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | ピラゾリル基を含む三環式誘導体、その製造方法及び用途 |
| TW201922722A (zh) | 2017-11-01 | 2019-06-16 | 美商必治妥美雅史谷比公司 | 作為法尼醇x受體調節劑之橋聯雙環化合物 |
| CN107698505A (zh) | 2017-11-20 | 2018-02-16 | 孙婷婷 | 一种诺得司他的制备方法 |
| BR112020011746A2 (pt) | 2017-12-13 | 2020-11-17 | Lupin Limited | compostos heterocíclicos bicíclicos substituídos atuando como inibidores de prmt5 |
| EP3746431A1 (en) | 2018-01-31 | 2020-12-09 | Merck Patent GmbH | Quinoline compounds as irak inhibitors and uses thereof |
| EP3810131A1 (en) | 2018-06-22 | 2021-04-28 | UCL Business Ltd | Novel compounds |
| US20220363707A1 (en) | 2018-08-07 | 2022-11-17 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| JP2022512588A (ja) | 2018-10-05 | 2022-02-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ１アンチトリプシンのモジュレーター |
| CN110776459B (zh) | 2019-03-19 | 2023-01-24 | 江苏知原药业股份有限公司 | 7-羟基-2-喹诺酮-二硫代氨基甲酸酯类胆碱酯酶抑制剂 |
| UY38696A (es) | 2019-05-14 | 2020-11-30 | Vertex Pharma | Moduladores de alfa-1 antitripsina |
| TW202116303A (zh) | 2019-10-02 | 2021-05-01 | 美商維泰克斯製藥公司 | α—１抗胰蛋白酶缺乏症之治療方法 |
| TW202139997A (zh) | 2020-01-30 | 2021-11-01 | 美商維泰克斯製藥公司 | α－１抗胰蛋白酶缺乏之治療方法 |
| JP2023520396A (ja) | 2020-04-03 | 2023-05-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ１－アンチトリプシンのモジュレーター |
| CN115776984A (zh) | 2020-04-03 | 2023-03-10 | 弗特克斯药品有限公司 | 作为用于治疗α-1抗胰蛋白酶缺乏症(AATD)的α-1-抗胰蛋白酶调节剂的吡咯并[2,3-f]吲唑和2,4,5,10-四氮杂三环[7.3.0.03,7]十二碳-1,3(7),5,8,11-五烯衍生物 |
| AU2021246527A1 (en) | 2020-04-03 | 2022-10-27 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
| WO2021203025A1 (en) | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | 1 h-pyrazolo[4,3-g]isoquinoline and 1 h-pyrazolo[4,3-g]quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| AU2021246526A1 (en) | 2020-04-03 | 2022-11-03 | Vertex Pharmaceuticals Incorporated | Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (AATD) |
| US20240012010A1 (en) | 2020-11-12 | 2024-01-11 | Vertex Pharmaceuticals Incorporated | Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat |
| EP4247490A2 (en) | 2020-11-17 | 2023-09-27 | Vertex Pharmaceuticals Incorporated | Solid forms of 4-(5-(4-fluorophenyl)-6-tetrahydro-2h-pyran-4-yl)- 1,5-dihydropyrrolo[2,3-f]indazol-7-yl)benzoic acid |
-
2020
- 2020-05-13 UY UY0001038696A patent/UY38696A/es unknown
- 2020-05-13 US US15/931,256 patent/US11884672B2/en active Active
- 2020-05-14 JP JP2021567819A patent/JP2022532340A/ja active Pending
- 2020-05-14 MA MA055971A patent/MA55971A/fr unknown
- 2020-05-14 BR BR112021022832A patent/BR112021022832A2/pt unknown
- 2020-05-14 EP EP20780387.5A patent/EP3969440A1/en active Pending
- 2020-05-14 SG SG11202112414UA patent/SG11202112414UA/en unknown
- 2020-05-14 WO PCT/US2020/032832 patent/WO2020247160A1/en active Application Filing
- 2020-05-14 KR KR1020217040417A patent/KR20220023987A/ko unknown
- 2020-05-14 AU AU2020286424A patent/AU2020286424A1/en active Pending
- 2020-05-14 PE PE2021001895A patent/PE20220905A1/es unknown
- 2020-05-14 MX MX2021013993A patent/MX2021013993A/es unknown
- 2020-05-14 JO JOP/2021/0301A patent/JOP20210301A1/ar unknown
- 2020-05-14 CN CN202080050991.8A patent/CN114096542B/zh active Active
- 2020-05-14 CA CA3140039A patent/CA3140039A1/en active Pending
- 2020-05-14 CR CR20210608A patent/CR20210608A/es unknown
- 2020-05-14 TW TW109116114A patent/TW202108588A/zh unknown
-
2021
- 2021-11-07 IL IL287878A patent/IL287878A/en unknown
- 2021-11-09 CL CL2021002964A patent/CL2021002964A1/es unknown
- 2021-11-12 DO DO2021000234A patent/DOP2021000234A/es unknown
- 2021-11-25 EC ECSENADI202185481A patent/ECSP21085481A/es unknown
- 2021-12-07 CO CONC2021/0016594A patent/CO2021016594A2/es unknown
-
2023
- 2023-10-16 US US18/487,690 patent/US20240336614A1/en active Pending
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