JPWO2020210613A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020210613A5
JPWO2020210613A5 JP2021559890A JP2021559890A JPWO2020210613A5 JP WO2020210613 A5 JPWO2020210613 A5 JP WO2020210613A5 JP 2021559890 A JP2021559890 A JP 2021559890A JP 2021559890 A JP2021559890 A JP 2021559890A JP WO2020210613 A5 JPWO2020210613 A5 JP WO2020210613A5
Authority
JP
Japan
Prior art keywords
compound
formula
give
acid
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021559890A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022526659A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/027655 external-priority patent/WO2020210613A1/fr
Publication of JP2022526659A publication Critical patent/JP2022526659A/ja
Publication of JPWO2020210613A5 publication Critical patent/JPWO2020210613A5/ja
Pending legal-status Critical Current

Links

JP2021559890A 2019-04-11 2020-04-10 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法 Pending JP2022526659A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962832614P 2019-04-11 2019-04-11
US62/832,614 2019-04-11
PCT/US2020/027655 WO2020210613A1 (fr) 2019-04-11 2020-04-10 Nouvelles options synthétiques pour la fabrication de (6r,10s)-10-{4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl) phényl]-6-oxo-1(6h)-pyrimidinyl}1-(difluorométhyl)-6-méthyl-1,4,7,8,9,10-hexahydro-11,15- (metheno)pyrazolo [4,3-b] [1,7] diazacyclotétradecin-5 (6h)-one

Publications (2)

Publication Number Publication Date
JP2022526659A JP2022526659A (ja) 2022-05-25
JPWO2020210613A5 true JPWO2020210613A5 (fr) 2023-04-12

Family

ID=70457148

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021559890A Pending JP2022526659A (ja) 2019-04-11 2020-04-10 （６ｒ，１０ｓ）－１０－｛４－［５－クロロ－２－（４－クロロ－１ｈ－１，２，３－トリアゾール－１－イル）フェニル］－６－オキソ－１（６ｈ）－ピリミジニル｝－１－（ジフルオロメチル）－６－メチル－１，４，７，８，９，１０－ヘキサヒドロ－１１，１５－（メタノ）ピラゾロ［４，３－ｂ］［１，７］ジアザシクロテトラデシン－５（６ｈ）－オンの製造における新規合成法

Country Status (16)

Country Link
US (1) US20220144836A1 (fr)
EP (2) EP3953334B1 (fr)
JP (1) JP2022526659A (fr)
KR (1) KR20220045105A (fr)
CN (1) CN114375290A (fr)
AR (1) AR118649A1 (fr)
AU (1) AU2020272973A1 (fr)
BR (1) BR112021020368A2 (fr)
CA (1) CA3132365A1 (fr)
EA (1) EA202192807A1 (fr)
ES (1) ES2969253T3 (fr)
IL (1) IL287102A (fr)
MX (1) MX2021012286A (fr)
SG (1) SG11202111132WA (fr)
TW (1) TW202104188A (fr)
WO (1) WO2020210613A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4133064A4 (fr) 2020-04-10 2024-07-24 Codexis Inc Polypeptides de transaminase modifiés
TW202229280A (zh) * 2020-10-12 2022-08-01 美商必治妥美雅史谷比公司 （６ｒ，１０ｓ）－１０－｛４－［５－氯－２－（４－氯－１ｈ－１，２，３－三唑－１－基）苯基］－６－側氧基－１（６ｈ）－嘧啶基｝－１－（二氟甲基）－６－甲基－１，４，７，８，９，１０－六氫－１１，１５－（亞甲橋基）吡唑并［４，３－ｂ］［１，７］二氮雜環十四炔－５（６ｈ）－酮之製備方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2830234A1 (fr) * 2011-03-15 2012-09-20 Abbvie Inc. Modulateurs des recepteurs hormonaux nucleaires
RS57659B1 (sr) 2014-01-31 2018-11-30 Bristol Myers Squibb Co Makrociklusi sa heterocikličnim p2' grupama kao inhibitori faktora xia
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
NO2721243T3 (fr) * 2014-10-01 2018-10-20
CN105294496A (zh) * 2015-09-28 2016-02-03 中山大学 一种西酞普兰中间体的制备方法
CN110062757B (zh) * 2017-01-18 2022-03-04 广东东阳光药业有限公司 凝血因子XIa抑制剂及其用途
AU2020257911B2 (en) * 2019-04-16 2023-01-05 China Resources Biopharmaceutical Company Limited Macrocyclic derivatives acting as XIa factor inhibitor
WO2021013209A1 (fr) * 2019-07-23 2021-01-28 南京明德新药研发有限公司 Dérivés macrocycliques en tant qu'inhibiteurs du facteur xia
IL296983A (en) * 2020-04-10 2022-12-01 Codexis Inc Carboxyesterase polypeptides for kinetic separation

Similar Documents

Publication Publication Date Title
Beak et al. Regioselective, diastereoselective, and enantioselective lithiation− substitution sequences: reaction pathways and synthetic applications
EP2519100B1 (fr) Composés intermédiaires et procédés pour la préparation de tapentadol et de composés apparentés
JPH03503163A (ja) 新規アミン、その使用及び製法
RU2002105496A (ru) Замещенные производные 2-диалкиламиноалкилбифенила
DE60208305T2 (de) Verfahren zur Herstellung von optisch-aktiven Aminalkoholen
JP2005525422A5 (ja) Ｐｍｅａおよびｐｍｐａ環生成合成
CN1768944A (zh) 一种以膦－亚磷酰胺酯为配体的催化剂及制法和应用
JP2003313184A5 (fr)
JPWO2020210613A5 (fr)
JP3867250B2 (ja) テトラヒドロインデノ〔１，２−ｄ〕〔１，３，２〕オキサザボロール及びその鏡像異性体選択性触媒としての使用
KR101354255B1 (ko) 케톤의 비대칭 수소화규소첨가 방법
CN102076634A (zh) 手性胺的合成
JP2002516313A5 (fr)
JPH02289A (ja) 光学活性なアミン−ホウ素系化合物、それを有効成分とする不斉還元剤ならびにそれを用いる光学活性化合物の製造方法
CN1775789A (zh) 一种由脂肪族和苯环连接的双二茂铁膦二亚胺结构的合成方法
JP6173702B2 (ja) 光学活性アミン化合物の製造方法
CA1341025C (fr) Silyl alkylene amine substituees
WO2004011452A1 (fr) Procede de preparation de 3-hydroxy-(2-thienyl)propanamines
FR2915995A1 (fr) Ligands chiraux de type carbenes n-heterocycliques pour la catalyse asymetrique.
Dalmolen et al. Synthesis of Enantiopure 1‐Aryl‐1‐butylamines and 1‐Aryl‐3‐butenylamines by Diastereoselective Addition of Allylzinc Bromide to Imines Derived from (R)‐Phenylglycine Amide
JP2010502632A (ja) スピロボレートエステルを使用するオキシムエーテルのボラン還元を介する第一級アミンの触媒的不斉合成
CN109734611B (zh) 一种手性三级胺类化合物的合成方法及其用途
US5821369A (en) Racemisation process
US4906773A (en) Process for preparing optically active threonine
Demyanovich et al. Effect of intramolecular interactions on circular dichroism of ortho‐substituted 1‐phenethylamines