ES2969253T3 - Las opciones sintéticas novedosas hacia la fabricación de (6R,10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6H)-ona - Google Patents
Las opciones sintéticas novedosas hacia la fabricación de (6R,10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6H)-ona Download PDFInfo
- Publication number
- ES2969253T3 ES2969253T3 ES20721374T ES20721374T ES2969253T3 ES 2969253 T3 ES2969253 T3 ES 2969253T3 ES 20721374 T ES20721374 T ES 20721374T ES 20721374 T ES20721374 T ES 20721374T ES 2969253 T3 ES2969253 T3 ES 2969253T3
- Authority
- ES
- Spain
- Prior art keywords
- chloro
- diazacyclotetradecin
- methene
- pyrazolo
- hexahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se proporcionan métodos altamente eficientes para preparar intermedios clave en la síntesis del Compuesto (I), que son ampliamente aplicables y pueden proporcionar componentes seleccionados que tienen una variedad de grupos sustituyentes. (Traducción automática con Google Translate, sin valor legal)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962832614P | 2019-04-11 | 2019-04-11 | |
PCT/US2020/027655 WO2020210613A1 (en) | 2019-04-11 | 2020-04-10 | Novel synthetic options towards the manufacture of (6r,10s)-10- {4-[5-chloro-2-(4-chloro-1h-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6h)- pyrimidinyl}- 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15 -(metheno)pyrazolo [4,3-b] [1,7] diazacyclotetradecin-5(6h)-one |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2969253T3 true ES2969253T3 (es) | 2024-05-17 |
Family
ID=70457148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES20721374T Active ES2969253T3 (es) | 2019-04-11 | 2020-04-10 | Las opciones sintéticas novedosas hacia la fabricación de (6R,10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6H)-ona |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220144836A1 (es) |
EP (2) | EP3953334B1 (es) |
JP (1) | JP2022526659A (es) |
KR (1) | KR20220045105A (es) |
CN (1) | CN114375290A (es) |
AR (1) | AR118649A1 (es) |
AU (1) | AU2020272973A1 (es) |
BR (1) | BR112021020368A2 (es) |
CA (1) | CA3132365A1 (es) |
EA (1) | EA202192807A1 (es) |
ES (1) | ES2969253T3 (es) |
IL (1) | IL287102A (es) |
MX (1) | MX2021012286A (es) |
SG (1) | SG11202111132WA (es) |
TW (1) | TW202104188A (es) |
WO (1) | WO2020210613A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4133064A2 (en) | 2020-04-10 | 2023-02-15 | Codexis, Inc. | Engineered transaminase polypeptides |
TW202229280A (zh) * | 2020-10-12 | 2022-08-01 | 美商必治妥美雅史谷比公司 | (6r,10s)-10-{4-[5-氯-2-(4-氯-1h-1,2,3-三唑-1-基)苯基]-6-側氧基-1(6h)-嘧啶基}-1-(二氟甲基)-6-甲基-1,4,7,8,9,10-六氫-11,15-(亞甲橋基)吡唑并[4,3-b][1,7]二氮雜環十四炔-5(6h)-酮之製備方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2830234A1 (en) * | 2011-03-15 | 2012-09-20 | Abbvie Inc. | Nuclear hormone receptor modulators |
WO2015116886A1 (en) | 2014-01-31 | 2015-08-06 | Bristol-Myers Squibb Company | Macrocycles with hetrocyclic p2' groups as factor xia inhibitors |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
NO2721243T3 (es) * | 2014-10-01 | 2018-10-20 | ||
CN105294496A (zh) * | 2015-09-28 | 2016-02-03 | 中山大学 | 一种西酞普兰中间体的制备方法 |
WO2018133793A1 (zh) * | 2017-01-18 | 2018-07-26 | 广东东阳光药业有限公司 | 凝血因子XIa抑制剂及其用途 |
EP3957638A4 (en) * | 2019-04-16 | 2023-01-11 | China Resources Biopharmaceutical Company Limited | MACROCYCLIC DERIVATIVES ACTING AS FACTOR XIA INHIBITORS |
WO2021013209A1 (zh) * | 2019-07-23 | 2021-01-28 | 南京明德新药研发有限公司 | 作为XIa因子抑制剂的大环衍生物 |
EP4133065A1 (en) * | 2020-04-10 | 2023-02-15 | Codexis, Inc. | Carboxyesterase polypeptides for kinetic resolution |
-
2020
- 2020-04-10 EP EP20721374.5A patent/EP3953334B1/en active Active
- 2020-04-10 EP EP23169596.6A patent/EP4234555A3/en active Pending
- 2020-04-10 JP JP2021559890A patent/JP2022526659A/ja active Pending
- 2020-04-10 KR KR1020217036807A patent/KR20220045105A/ko unknown
- 2020-04-10 TW TW109112263A patent/TW202104188A/zh unknown
- 2020-04-10 WO PCT/US2020/027655 patent/WO2020210613A1/en unknown
- 2020-04-10 AU AU2020272973A patent/AU2020272973A1/en active Pending
- 2020-04-10 EA EA202192807A patent/EA202192807A1/ru unknown
- 2020-04-10 ES ES20721374T patent/ES2969253T3/es active Active
- 2020-04-10 MX MX2021012286A patent/MX2021012286A/es unknown
- 2020-04-10 SG SG11202111132WA patent/SG11202111132WA/en unknown
- 2020-04-10 CN CN202080041935.8A patent/CN114375290A/zh active Pending
- 2020-04-10 CA CA3132365A patent/CA3132365A1/en active Pending
- 2020-04-10 BR BR112021020368A patent/BR112021020368A2/pt unknown
- 2020-04-10 US US17/602,059 patent/US20220144836A1/en active Pending
- 2020-04-13 AR ARP200101024A patent/AR118649A1/es unknown
-
2021
- 2021-10-07 IL IL287102A patent/IL287102A/en unknown
Also Published As
Publication number | Publication date |
---|---|
US20220144836A1 (en) | 2022-05-12 |
EP4234555A2 (en) | 2023-08-30 |
CN114375290A (zh) | 2022-04-19 |
EA202192807A1 (ru) | 2022-02-24 |
JP2022526659A (ja) | 2022-05-25 |
SG11202111132WA (en) | 2021-11-29 |
WO2020210613A1 (en) | 2020-10-15 |
AR118649A1 (es) | 2021-10-20 |
MX2021012286A (es) | 2022-04-06 |
CA3132365A1 (en) | 2020-10-15 |
EP4234555A3 (en) | 2024-01-03 |
EP3953334A1 (en) | 2022-02-16 |
BR112021020368A2 (pt) | 2021-12-07 |
TW202104188A (zh) | 2021-02-01 |
EP3953334B1 (en) | 2023-11-22 |
IL287102A (en) | 2021-12-01 |
AU2020272973A1 (en) | 2021-12-02 |
KR20220045105A (ko) | 2022-04-12 |
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