JPWO2020103815A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020103815A5
JPWO2020103815A5 JP2021529110A JP2021529110A JPWO2020103815A5 JP WO2020103815 A5 JPWO2020103815 A5 JP WO2020103815A5 JP 2021529110 A JP2021529110 A JP 2021529110A JP 2021529110 A JP2021529110 A JP 2021529110A JP WO2020103815 A5 JPWO2020103815 A5 JP WO2020103815A5
Authority
JP
Japan
Prior art keywords
alkyl
halogen
saturated
alkoxy
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021529110A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022508203A (ja
JP2022508203A5 (https=
JP7664156B2 (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2019/119373 external-priority patent/WO2020103815A1/en
Publication of JP2022508203A publication Critical patent/JP2022508203A/ja
Publication of JPWO2020103815A5 publication Critical patent/JPWO2020103815A5/ja
Publication of JP2022508203A5 publication Critical patent/JP2022508203A5/ja
Application granted granted Critical
Publication of JP7664156B2 publication Critical patent/JP7664156B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021529110A 2018-11-22 2019-11-19 Glp-1rアゴニスト及びその使用 Active JP7664156B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018117047 2018-11-22
CNPCT/CN2018/117047 2018-11-22
PCT/CN2019/119373 WO2020103815A1 (en) 2018-11-22 2019-11-19 Glp-1r agonists and uses thereof

Publications (4)

Publication Number Publication Date
JP2022508203A JP2022508203A (ja) 2022-01-19
JPWO2020103815A5 true JPWO2020103815A5 (https=) 2022-11-24
JP2022508203A5 JP2022508203A5 (https=) 2022-11-24
JP7664156B2 JP7664156B2 (ja) 2025-04-17

Family

ID=70774321

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021529110A Active JP7664156B2 (ja) 2018-11-22 2019-11-19 Glp-1rアゴニスト及びその使用

Country Status (23)

Country Link
US (3) US12365670B2 (https=)
EP (1) EP3883928A4 (https=)
JP (1) JP7664156B2 (https=)
KR (1) KR102904955B1 (https=)
CN (1) CN113227068B (https=)
AU (1) AU2019382642B2 (https=)
BR (1) BR112021009877A2 (https=)
CA (1) CA3120499A1 (https=)
CL (1) CL2021001332A1 (https=)
CO (1) CO2021008089A2 (https=)
CR (1) CR20210341A (https=)
CU (1) CU20210042A7 (https=)
EA (1) EA202191432A1 (https=)
IL (1) IL283322B2 (https=)
MA (1) MA54555A (https=)
MX (1) MX2021006034A (https=)
PE (1) PE20211871A1 (https=)
PH (1) PH12021551165A1 (https=)
SA (1) SA521422068B1 (https=)
SG (1) SG11202105241YA (https=)
TW (1) TWI839416B (https=)
UA (1) UA130273C2 (https=)
WO (1) WO2020103815A1 (https=)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2943510T3 (es) * 2018-06-15 2023-06-13 Pfizer Agonistas del receptor GLP-1 y usos del mismo
ES2986417T3 (es) 2018-08-13 2024-11-11 Hoffmann La Roche Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa
CR20210341A (es) 2018-11-22 2021-11-25 Qilu Regor Therapeutics Inc Agonistas de glp-ir y usos de los mismos
AU2020256647B2 (en) * 2019-04-12 2025-07-31 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
TWI751585B (zh) * 2019-06-28 2022-01-01 美商美國禮來大藥廠 類升糖素肽1受體促效劑
WO2021018023A1 (zh) * 2019-08-01 2021-02-04 济南泰达领创医药技术有限公司 小分子glp-1受体调节剂
EP4028403B1 (en) 2019-09-12 2023-11-22 F. Hoffmann-La Roche AG 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
CA3157525A1 (en) * 2019-10-25 2021-04-29 Gilead Sciences, Inc. Glp-1r modulating compounds
JP7386997B2 (ja) 2019-11-15 2023-11-27 イルドン ファーマシューティカル カンパニー リミテッド Glp-1受容体アゴニストおよびその使用
WO2021154796A1 (en) 2020-01-29 2021-08-05 Gilead Sciences, Inc. Glp-1r modulating compounds
CN119841865A (zh) 2020-02-07 2025-04-18 加舒布鲁姆生物公司 杂环glp-1激动剂
WO2021160127A1 (en) * 2020-02-13 2021-08-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
TW202144340A (zh) * 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
FI4143183T3 (fi) 2020-04-29 2026-01-07 Gasherbrum Bio Inc Heterosyklisiä glp-1-agonisteja
FI4157832T3 (fi) * 2020-05-27 2024-08-29 Qilu Regor Therapeutics Inc Glp-1r-agonistien suola- ja kidemuotoja ja niiden käyttötarkoituksia
PH12022553313A1 (en) * 2020-06-04 2023-04-12 Hangzhou Sciwind Biosciences Co Ltd Five-membered heteroaromatic imidazole compound and use thereof
CN117645601A (zh) * 2020-06-10 2024-03-05 重庆康丁医药技术有限公司 一种具有心血管益处的glp-1小分子
CN113816948B (zh) * 2020-06-19 2023-08-11 江苏恒瑞医药股份有限公司 稠合咪唑类衍生物、其制备方法及其在医药上的应用
WO2021259309A1 (zh) * 2020-06-24 2021-12-30 广州市恒诺康医药科技有限公司 Glp-1受体激动剂及其药物组合物和用途
PE20231181A1 (es) 2020-08-06 2023-08-11 Gasherbrum Bio Inc Agonistas del glp-1 heterociclicos
TW202214622A (zh) * 2020-08-06 2022-04-16 大陸商上海齊魯銳格醫藥研發有限公司 Glp-1r促效劑及其用途
PE20231206A1 (es) * 2020-08-21 2023-08-17 Terns Pharmaceuticals Inc Compuestos como agonistas de glp-1r
WO2022042691A1 (en) * 2020-08-28 2022-03-03 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
AU2021306414B2 (en) * 2020-09-01 2026-01-29 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Fused imidazole derivative, preparation method therefor, and medical use thereof
WO2022051317A1 (en) * 2020-09-03 2022-03-10 Amgen Inc. Diol desymmetrization by nucleophilic aromatic substitution
EP4211139A4 (en) 2020-09-10 2024-12-18 Gasherbrum Bio, Inc. HETEROCYCLIC GLP-1 AGONISTS
WO2022068772A1 (zh) * 2020-09-29 2022-04-07 深圳信立泰药业股份有限公司 一种苯并咪唑类衍生物及其制备方法和医药用途
EP4227299A4 (en) * 2020-10-12 2025-04-09 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. GLP-1 RECEPTOR AGONIST, BENZIMIDAZOLONE AND ITS USE
EP4229050A4 (en) * 2020-10-13 2024-12-11 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
JP2023546054A (ja) * 2020-10-13 2023-11-01 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環glp-1アゴニスト
TWI912388B (zh) * 2020-10-14 2026-01-21 大陸商上海齊魯銳格醫藥研發有限公司 Glp-1r促效劑的晶型及其用途
CN114478497B (zh) * 2020-11-12 2023-10-20 杭州中美华东制药有限公司 芳基烷基酸类glp-1受体激动剂及其用途
EP4247804A1 (en) 2020-11-20 2023-09-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
US20240246959A1 (en) * 2020-11-27 2024-07-25 Shenzhen Salubris Pharmaceuticals Co., Ltd. Benzimidazole derivative and preparation method therefor and medical use thereof
CN114591308B (zh) * 2020-12-03 2024-03-08 苏州闻泰医药科技有限公司 一类glp-1r受体激动剂化合物及其用途
WO2022135572A1 (zh) * 2020-12-25 2022-06-30 四川海思科制药有限公司 一种五并五元环衍生物及其在医药上的应用
CA3209593A1 (en) * 2021-01-28 2022-08-04 Carmot Therapeutics, Inc. Gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use
CN117043154A (zh) * 2021-01-28 2023-11-10 卡莫特医疗有限公司 Gpcr受体激动剂、包含其的药物组合物以及它们的使用方法
CN114907351A (zh) * 2021-02-07 2022-08-16 杭州中美华东制药有限公司 三环类glp-1受体激动剂及其用途
WO2022184849A1 (en) 2021-03-04 2022-09-09 Les Laboratoires Servier Glp-1r agonists, uses and pharmaceutical compositions thereof
EP4304711A1 (en) * 2021-03-11 2024-01-17 Gilead Sciences, Inc. Glp-1r modulating compounds
WO2022192430A1 (en) * 2021-03-11 2022-09-15 Gilead Sciences, Inc. Glp-1r modulating compounds
CN116940561A (zh) * 2021-03-22 2023-10-24 杭州中美华东制药有限公司 噻吩类glp-1受体激动剂及其用途
WO2022202864A1 (ja) 2021-03-24 2022-09-29 塩野義製薬株式会社 縮合環を有するglp-1受容体作動薬を含有する医薬組成物
PH12023552860A1 (en) 2021-04-21 2024-05-20 Gilead Sciences Inc Carboxy-benzimidazole glp-1r modulating compounds
WO2022228490A1 (zh) * 2021-04-30 2022-11-03 上海翰森生物医药科技有限公司 多环类衍生物调节剂、其制备方法和应用
WO2022235717A1 (en) * 2021-05-03 2022-11-10 Carmot Therapeutics, Inc. Benzimidazoyl glp-1 receptor agonists, pharmaceutical compositions comprising the same, and methods for their use
TWI843104B (zh) 2021-05-20 2024-05-21 美商美國禮來大藥廠 類升糖素肽1受體促效劑
WO2022268152A1 (zh) 2021-06-24 2022-12-29 杭州中美华东制药有限公司 Glp-1受体激动剂及其组合物和用途
WO2023001237A1 (en) * 2021-07-21 2023-01-26 Hepagene Therapeutics (HK) Limited Glucagon-like peptide-1 receptor modulators and uses thereof
CN113480534B (zh) * 2021-07-23 2022-05-13 广州必贝特医药股份有限公司 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用
EP4382525A4 (en) * 2021-08-04 2025-07-16 Shanghai Hansoh Biomedical Co Ltd CYCLOALKENE DERIVATIVE REGULATOR, PREPARATION METHOD AND USE THEREOF
IL310377A (en) * 2021-08-30 2024-03-01 Mindrank Ai Ltd Novel aryl ether substituted heterocyclic compound as glp1r agonist
WO2023038039A1 (ja) 2021-09-08 2023-03-16 塩野義製薬株式会社 抗肥満作用の関与する疾患の予防及び治療用医薬
KR20240068737A (ko) 2021-09-27 2024-05-17 테른스 파마슈티칼스, 인크. Glp-1r 효능제로서의 벤즈이미다졸 카복실산
WO2023057414A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
WO2023057429A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
AU2022358915A1 (en) 2021-10-05 2024-05-09 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes as glp-1 receptor modulators
TWI843243B (zh) * 2021-10-22 2024-05-21 大陸商盛世泰科生物醫藥技術(蘇州)股份有限公司 作為glp-1受體激動劑的化合物、包含其的藥物組成物及其用途
AU2022375634A1 (en) 2021-10-25 2024-06-06 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
CN115850296B (zh) * 2021-12-03 2025-03-11 杭州先为达生物科技股份有限公司 一种噻吩并咪唑类化合物的晶型及其制备方法
CN114163438A (zh) * 2021-12-13 2022-03-11 无锡捷化医药科技有限公司 一种2-甲基-3-羰基吡唑并[4,3-c]吡啶-7-羧酸盐酸盐的制备方法
US20250066338A1 (en) 2021-12-16 2025-02-27 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
WO2023111145A1 (en) 2021-12-16 2023-06-22 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
US20250049777A1 (en) * 2021-12-23 2025-02-13 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutically acceptable salt and crystalline form of glp-1 receptor agonist and preparation method therefor
CN116354945B (zh) * 2021-12-27 2024-08-30 长春金赛药业有限责任公司 一种稠合咪唑羧酸类化合物及其制备方法和应用
CN118613476A (zh) * 2022-01-10 2024-09-06 西藏海思科制药有限公司 一种glp-1激动剂盐及其晶型及在医药上的应用
WO2023151575A1 (en) * 2022-02-09 2023-08-17 Gasherbrum Bio Inc. Heterocyclic glp-1 agonists
KR20240150488A (ko) 2022-02-23 2024-10-15 테른스 파마슈티칼스, 인크. Glp-1r 작용제로서의 화합물
WO2023169436A1 (zh) 2022-03-08 2023-09-14 广州市联瑞制药有限公司 苯并双环类化合物及其制备方法和应用
CN119137124A (zh) * 2022-03-09 2024-12-13 加舒布鲁姆生物公司 杂环glp-1激动剂
WO2023198140A1 (en) * 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
US20250136584A1 (en) * 2022-05-20 2025-05-01 Chengdu Di'ao Jiuhong Pharmaceutical Factory Benzimidazole Or Azabenzimidazole Compound, Preparation Method Therefor And Use Thereof
CN117362282B (zh) * 2022-07-07 2026-04-21 杭州德睿智药科技有限公司 Glp-1r激动剂的盐及其制备方法和应用
CN119923395A (zh) * 2022-07-27 2025-05-02 卡莫特医疗有限公司 N-杂环gpcr受体激动剂、包含其的药物组合物和其使用方法
IL319453A (en) * 2022-09-06 2025-05-01 Mindrank Therapeutics Suzhou New Drug Res And Development Co Ltd Polymorph of a GLP-1R agonist compound, method of preparation thereof and use thereof
US20260097037A1 (en) 2022-09-22 2026-04-09 Shionogi & Co., Ltd. Fused ring compound having glp-1 receptor agonist effect
CN116102543B (zh) * 2022-10-21 2025-07-22 江南大学 一种glp-1r激动剂、合成方法及其用途
WO2024102625A1 (en) 2022-11-11 2024-05-16 Eli Lilly And Company Glucagon-like peptide 1 receptor agonists
IL320810A (en) 2022-11-16 2025-07-01 Lilly Co Eli Glucagon-like peptide 1 receptor agonists
CN120530106A (zh) * 2022-12-13 2025-08-22 杭州中美华东制药有限公司 Glp-1受体激动剂的新晶型和制备方法及其药物组合物和用途
TW202440556A (zh) * 2022-12-13 2024-10-16 中國大陸商杭州中美華東製藥有限公司 鹽型的glp-1受體激動劑、其晶型和製備方法及其藥物組合物和用途
EP4652167A1 (en) * 2023-01-17 2025-11-26 Fochon Biosciences, Ltd. Glp-1r agonists and uses thereof
EP4660194A1 (en) * 2023-02-02 2025-12-10 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Salt and crystal form of cycloalkene compound, and preparation method therefor and use thereof
AU2024222719A1 (en) 2023-02-16 2025-08-21 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
US20240398794A1 (en) 2023-04-07 2024-12-05 Terns Pharmaceuticals, Inc. COMBINATIONS OF GLP-1R AND THRß AGONISTS AND METHODS OF USE THEREOF
WO2024212742A1 (zh) * 2023-04-10 2024-10-17 上海研健新药研发有限公司 一种glp-1r激动剂,其制备方法和应用
TW202504600A (zh) * 2023-07-04 2025-02-01 大陸商杭州中美華東製藥有限公司 Glp1r激動劑及其中間體的製備方法
TW202521533A (zh) 2023-09-14 2025-06-01 香港商歌禮製藥(中國)有限公司 Glp-1r 激動劑及其治療方法
US12291530B1 (en) 2023-11-24 2025-05-06 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof
WO2025158275A1 (en) 2024-01-24 2025-07-31 Pfizer Inc. Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds
WO2025189141A1 (en) 2024-03-08 2025-09-12 Annapurna Bio, Inc. Methods for treating obesity and increasing weight loss
WO2026059341A1 (ko) * 2024-09-11 2026-03-19 한미약품 주식회사 Glp-1 수용체 작용제 및 이의 용도

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US20040127504A1 (en) 2002-09-06 2004-07-01 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
MXPA05011539A (es) 2003-04-30 2006-01-23 Inst For Pharm Discovery Inc Acidos carboxilicos sustituidos con heterociclo como inhibidores de la proteina tirosina-fosfatasa-1b.
EP1790637B1 (en) 2004-09-13 2014-01-29 Ono Pharmaceutical Co., Ltd. Derivatives of N-4-piperidyl urea and medicaments containing them as active ingredient
AU2005307718A1 (en) 2004-11-18 2006-05-26 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids for the treatment of diabetes
EP1976873A2 (en) 2006-01-11 2008-10-08 Brystol-Myers Squibb Company Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions
US7727983B2 (en) 2008-03-07 2010-06-01 Transtech Pharma, Inc. Oxadiazoanthracene compounds for the treatment of diabetes
US8765920B2 (en) 2009-12-23 2014-07-01 The Scripps Research Institute Tyrosine bioconjugation through aqueous Ene-like reactions
MA34300B1 (fr) * 2010-05-13 2013-06-01 Amgen Inc Composés azotés hétérocycliques convenant comme inhibiteurs de la pde10
US8501982B2 (en) 2010-06-09 2013-08-06 Receptos, Inc. GLP-1 receptor stabilizers and modulators
BR112013021236B1 (pt) 2011-02-25 2021-05-25 Merck Sharp & Dohme Corp composto derivado de benzimidazol, e, composição
WO2012129562A2 (en) 2011-03-24 2012-09-27 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
AU2012352349B2 (en) 2011-12-12 2017-08-17 Receptos Llc Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes
DK3240785T3 (da) 2014-12-29 2021-09-27 Us Health Småmolekylede hæmmere af laktasedehydrogenase og fremgangsmåder til brug deraf
CN109152784B (zh) 2016-03-16 2021-12-28 库拉肿瘤学公司 经取代的menin-mll抑制剂及使用方法
EP3555064B9 (en) * 2016-12-16 2023-03-01 Pfizer Inc. Glp-1 receptor agonists and uses thereof
CA3045644C (en) * 2018-06-13 2024-01-16 Pfizer Inc. Glp-1 receptor agonists and uses thereof
ES2943510T3 (es) * 2018-06-15 2023-06-13 Pfizer Agonistas del receptor GLP-1 y usos del mismo
US11945803B2 (en) 2018-08-07 2024-04-02 Tosk, Inc. Modulators of RAS GTPase
CR20210110A (es) 2018-08-31 2021-05-13 Pfizer Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas
CR20210341A (es) 2018-11-22 2021-11-25 Qilu Regor Therapeutics Inc Agonistas de glp-ir y usos de los mismos
AU2020256647B2 (en) 2019-04-12 2025-07-31 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
TWI751585B (zh) 2019-06-28 2022-01-01 美商美國禮來大藥廠 類升糖素肽1受體促效劑
WO2021018023A1 (zh) 2019-08-01 2021-02-04 济南泰达领创医药技术有限公司 小分子glp-1受体调节剂
CA3157525A1 (en) 2019-10-25 2021-04-29 Gilead Sciences, Inc. Glp-1r modulating compounds
KR20210069000A (ko) 2019-12-02 2021-06-10 현대약품 주식회사 Glp-1 수용체 작용제
MX2022007105A (es) 2019-12-10 2022-07-11 Pfizer Formas solidas de sal de 1,3-dihidroxi-2-(hidroximetil)propan-2-am ina de acido 2-((4-((s)-2-(5-cloropiridin-2-il)-2-metilbenzo[d][1, 3] dioxol-4-il)piperidin-1-il)metil)-1-(((s)-oxetan-2-il) metil)-1h- benzo[d]imidazol-6-carboxilico.
WO2021154796A1 (en) 2020-01-29 2021-08-05 Gilead Sciences, Inc. Glp-1r modulating compounds
CN119841865A (zh) 2020-02-07 2025-04-18 加舒布鲁姆生物公司 杂环glp-1激动剂
WO2021160127A1 (en) 2020-02-13 2021-08-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
EP4125896B1 (en) 2020-03-27 2025-05-07 Pfizer Inc. Treatment of type 2 diabetes with 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl} piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof
US12459954B2 (en) 2020-04-01 2025-11-04 Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. Crystalline form a of GLP-1 receptor agonist and preparation method therefor
WO2021196951A1 (zh) 2020-04-01 2021-10-07 杭州中美华东制药有限公司 Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法
TW202144340A (zh) 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
CN113493447B (zh) 2020-04-03 2024-06-11 轩竹(北京)医药科技有限公司 Glp-1受体激动剂
FI4157832T3 (fi) * 2020-05-27 2024-08-29 Qilu Regor Therapeutics Inc Glp-1r-agonistien suola- ja kidemuotoja ja niiden käyttötarkoituksia

Similar Documents

Publication Publication Date Title
JPWO2020103815A5 (https=)
JP2021091683A5 (https=)
JP2024050527A5 (https=)
CN115244056A (zh) 稠合咪唑类衍生物、其制备方法及其在医药上的应用
JP5487202B2 (ja) 新規甲状腺ホルモンβ受容体作動薬
JP2016500063A5 (https=)
JP5847533B2 (ja) 新規甲状腺ホルモンβ受容体作動薬
JP2007502264A5 (https=)
JP2019531320A5 (https=)
CN112955448A (zh) 芳环或芳杂环类化合物及其制备方法和医药用途
TWI439464B (zh) 二胺衍生物之製造方法
JP2005539000A5 (https=)
JP2014521700A5 (https=)
JP2017514856A5 (https=)
JP2011513367A5 (https=)
JP2010516702A5 (https=)
JP2019131544A5 (https=)
JPWO2008016175A1 (ja) ペルオキシソーム増殖剤活性化受容体の活性化剤
JP2021512114A5 (https=)
JP2019081782A (ja) トロンビン阻害剤としてのハロゲノピラゾール
JP2010504322A5 (https=)
JP2017514865A5 (https=)
JP2016508152A (ja) Cracチャネル阻害薬としての、ピラゾリルをベースとするカルボキサミド類i
JPWO2022078352A5 (https=)
JPWO2019213470A5 (https=)