JPWO2020097403A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020097403A5
JPWO2020097403A5 JP2021525078A JP2021525078A JPWO2020097403A5 JP WO2020097403 A5 JPWO2020097403 A5 JP WO2020097403A5 JP 2021525078 A JP2021525078 A JP 2021525078A JP 2021525078 A JP2021525078 A JP 2021525078A JP WO2020097403 A5 JPWO2020097403 A5 JP WO2020097403A5
Authority
JP
Japan
Prior art keywords
days
cells
antigen
hours
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021525078A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022512971A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/060367 external-priority patent/WO2020097403A1/en
Publication of JP2022512971A publication Critical patent/JP2022512971A/ja
Publication of JPWO2020097403A5 publication Critical patent/JPWO2020097403A5/ja
Pending legal-status Critical Current

Links

JP2021525078A 2018-11-08 2019-11-07 処置およびt細胞調節のための方法および併用 Pending JP2022512971A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862757755P 2018-11-08 2018-11-08
US62/757,755 2018-11-08
US201962826928P 2019-03-29 2019-03-29
US62/826,928 2019-03-29
PCT/US2019/060367 WO2020097403A1 (en) 2018-11-08 2019-11-07 Methods and combinations for treatment and t cell modulation

Publications (2)

Publication Number Publication Date
JP2022512971A JP2022512971A (ja) 2022-02-07
JPWO2020097403A5 true JPWO2020097403A5 (ko) 2022-11-14

Family

ID=69187891

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021525078A Pending JP2022512971A (ja) 2018-11-08 2019-11-07 処置およびt細胞調節のための方法および併用

Country Status (12)

Country Link
US (1) US20220008477A1 (ko)
EP (1) EP3876958A1 (ko)
JP (1) JP2022512971A (ko)
KR (1) KR20210111247A (ko)
CN (1) CN113573719A (ko)
AU (1) AU2019377854A1 (ko)
BR (1) BR112021008930A2 (ko)
CA (1) CA3117978A1 (ko)
IL (1) IL282886A (ko)
MX (1) MX2021005366A (ko)
SG (1) SG11202104411VA (ko)
WO (1) WO2020097403A1 (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016263808B2 (en) 2015-05-21 2019-01-03 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
JP7090347B2 (ja) 2017-05-12 2022-06-24 ハープーン セラピューティクス,インク. メソテリン結合タンパク質
EA202090739A1 (ru) 2017-10-13 2020-09-07 Харпун Терапьютикс, Инк. Белки, связывающие антиген созревания в-клеток
CA3114038A1 (en) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
EP4054623A1 (en) * 2019-11-07 2022-09-14 Juno Therapeutics, Inc. Combination of a t cell therapy and (s)-3-[4-(4-morpholin-4 ylmethyl-benzyloxy)-l-oxo-l,3-dihydro-isoindol-2-yl]- piperidine-2,6-dione
AU2021263765A1 (en) * 2020-04-28 2022-12-01 Juno Therapeutics, Inc. Combination of BCMA-directed T cell therapy and an immunomodulatory compound
PE20230494A1 (es) 2020-05-08 2023-03-23 Alpine Immune Sciences Inc Proteinas inmunomoduladoras inhibidoras de april y baff y metodos de uso de las mismas
US20220193134A1 (en) * 2020-12-23 2022-06-23 Crispr Therapeutics Ag Co-use of lenalidomide with car-t cells
WO2022137186A1 (en) * 2020-12-23 2022-06-30 Crispr Therapeutics Ag Cancer treatment using cd38 inhibitor and/or lenalidomide and t-cells expressing a chimeric antigen receptor
MX2023008296A (es) 2021-01-13 2023-09-29 Monte Rosa Therapeutics Inc Compuestos de isoindolinona.
EP4308927A1 (en) * 2021-03-17 2024-01-24 Mayo Foundation for Medical Education and Research Methods and materials for identifying myeloma stage and drug sensitivity and treating myeloma
AU2022252220A1 (en) * 2021-03-29 2023-10-12 Juno Therapeutics, Inc. Combination of a car t cell therapy and an immunomodulatory compound for treatment of lymphoma
US20240207310A1 (en) * 2021-04-16 2024-06-27 Celgene Corporation Combination therapies with bcma-directed t cell therapy
EP4331678A1 (en) * 2021-04-27 2024-03-06 Oricell Therapeutics Co., Ltd. Bcma-targeting chimeric antigen receptor and use thereof
WO2022256498A1 (en) * 2021-06-03 2022-12-08 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
EP4412713A1 (en) * 2021-10-05 2024-08-14 GlaxoSmithKline Intellectual Property Development Ltd Combination therapies for treating cancer
CN116338187B (zh) * 2023-05-12 2023-10-03 中国人民解放军军事科学院军事医学研究院 Wtap蛋白作为急性电离辐射损伤标志物的应用

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4690915A (en) 1985-08-08 1987-09-01 The United States Of America As Represented By The Department Of Health And Human Services Adoptive immunotherapy as a treatment modality in humans
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5219740A (en) 1987-02-13 1993-06-15 Fred Hutchinson Cancer Research Center Retroviral gene transfer into diploid fibroblasts for gene therapy
EP0452342B1 (en) 1988-12-28 1994-11-30 MILTENYI, Stefan Methods and materials for high gradient magnetic separation of biological materials
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1996018105A1 (en) 1994-12-06 1996-06-13 The President And Fellows Of Harvard College Single chain t-cell receptor
DE19608753C1 (de) 1996-03-06 1997-06-26 Medigene Gmbh Transduktionssystem und seine Verwendung
WO1997034634A1 (en) 1996-03-20 1997-09-25 Sloan-Kettering Institute For Cancer Research Single chain fv constructs of anti-ganglioside gd2 antibodies
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
ES2339425T3 (es) 1996-07-24 2010-05-20 Celgene Corporation 2-(2,6-dioxopiperidin-3-il)-ftalimidas y -1-oxoisoindolinas sustituidas y procedimiento para reducir los niveles de tnf-alfa.
US5635517B1 (en) 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
US5798368A (en) 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
US6281230B1 (en) 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
JP2001519143A (ja) 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖t細胞レセプタータンパク質
TR200101501T2 (tr) 1998-03-16 2002-06-21 Celgene Corporation 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuar sitokinlerin inhibitörleri olarak kullanımı.
SK17332000A3 (sk) 1998-05-19 2001-06-11 Avidex Limited Preskladaný rekombinantný t bunkový receptor-tcr, sekvencie nukleových kyselín, ktoré kódujú rekombinantné tcr reťazce rekombinantného tcr, a spôsob jeho výroby
JP2002524081A (ja) 1998-09-04 2002-08-06 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 前立腺−特異的膜抗原に特異的な融合受容体およびその使用
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
RU2001121987A (ru) 1999-03-18 2004-02-27 Селджин Корпорейшн (Us) Замещенные 1-оксо- и 1,3-диоксоизоиндолины и их применение в фармацевтических композициях для снижения уровней воспалительных цитокинов
AU2001265346A1 (en) 2000-06-02 2001-12-17 Memorial Sloan-Kettering Cancer Center Artificial antigen presenting cells and methods of use thereof
JP5312721B2 (ja) 2000-11-07 2013-10-09 シティ・オブ・ホープ Cd19特異的再指向免疫細胞
US6458810B1 (en) 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
US7091353B2 (en) 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
US20030045552A1 (en) 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
CA2439410C (en) 2001-02-27 2011-09-06 William D. Figg Analogs of thalidomide as potential angiogenesis inhibitors
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
NZ531208A (en) 2001-08-31 2005-08-26 Avidex Ltd Multivalent soluble T cell receptor (TCR) complexes
US7939059B2 (en) 2001-12-10 2011-05-10 California Institute Of Technology Method for the generation of antigen-specific lymphocytes
US20030170238A1 (en) 2002-03-07 2003-09-11 Gruenberg Micheal L. Re-activated T-cells for adoptive immunotherapy
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
WO2004033685A1 (en) 2002-10-09 2004-04-22 Avidex Ltd Single chain recombinant t cell receptors
US20050129671A1 (en) 2003-03-11 2005-06-16 City Of Hope Mammalian antigen-presenting T cells and bi-specific T cells
ATE475669T1 (de) 2004-06-29 2010-08-15 Immunocore Ltd Einen modifizierten t-zellen-rezeptor exprimierende zellen
US7244759B2 (en) 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
EP2856876B1 (en) 2007-03-30 2018-01-31 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
US7615883B2 (en) 2007-06-06 2009-11-10 Meheen H Joe Wind driven venturi turbine
JP5456689B2 (ja) 2007-12-07 2014-04-02 ミルテンイ バイオテック ゲーエムベーハー 試料を少なくとも2つの成分に分離する遠心分離機
US8479118B2 (en) 2007-12-10 2013-07-02 Microsoft Corporation Switching search providers within a browser search box
US20120164718A1 (en) 2008-05-06 2012-06-28 Innovative Micro Technology Removable/disposable apparatus for MEMS particle sorting device
JP5173594B2 (ja) 2008-05-27 2013-04-03 キヤノン株式会社 管理装置、画像形成装置及びそれらの処理方法
WO2010025177A1 (en) 2008-08-26 2010-03-04 City Of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
LT2406284T (lt) 2009-03-10 2016-10-10 Biogen Ma Inc. Antikūnai prieš b ląstelių subrendimo antigenus
WO2011044186A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
PT2496698T (pt) 2009-11-03 2019-04-18 Hope City Recetor de fator de crescimento epidermal truncado (egfrt) para seleção de células t transduzidas
ES2730763T3 (es) 2010-02-11 2019-11-12 Celgene Corp Derivados de arilmetoxi isoindolina y composiciones que los comprenden y métodos de uso de los mismos
SG190997A1 (en) 2010-12-09 2013-07-31 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
US9987308B2 (en) 2011-03-23 2018-06-05 Fred Hutchinson Cancer Research Center Method and compositions for cellular immunotherapy
US8398282B2 (en) 2011-05-12 2013-03-19 Delphi Technologies, Inc. Vehicle front lighting assembly and systems having a variable tint electrowetting element
CN104080797A (zh) 2011-11-11 2014-10-01 弗雷德哈钦森癌症研究中心 针对癌症的靶向细胞周期蛋白a1的t细胞免疫疗法
AU2013221672B2 (en) 2012-02-13 2017-11-09 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2013126726A1 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Double transgenic t cells comprising a car and a tcr and their methods of use
CN104379179A (zh) 2012-04-11 2015-02-25 美国卫生和人力服务部 靶向b-细胞成熟抗原的嵌合抗原受体
SG11201407175RA (en) 2012-05-03 2014-12-30 Hutchinson Fred Cancer Res Enhanced affinity t cell receptors and methods for making the same
CA2878954C (en) 2012-08-09 2020-12-08 Benjamin M. Cohen Salts and solid forms of (s)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and compositions comprising and methods of using the same
SG11201501259QA (en) 2012-08-20 2015-03-30 Hutchinson Fred Cancer Res Method and compositions for cellular immunotherapy
RU2020124583A (ru) 2012-10-02 2020-08-03 Мемориал Слоан-Кеттеринг Кэнсер Сентер Композиции и способы для иммунотерапии
DE112012007250T5 (de) 2012-12-20 2015-10-08 Mitsubishi Electric Corp. Fahrzeuginterne Vorrichtung und Programm
UY35468A (es) 2013-03-16 2014-10-31 Novartis Ag Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
US9108442B2 (en) 2013-08-20 2015-08-18 Ricoh Company, Ltd. Image forming apparatus
CA3206268A1 (en) 2013-12-06 2015-06-11 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large b-cell lymphoma, multiple myeloma, and myeloid cancers
CA2984484C (en) 2014-05-02 2024-01-23 The Trustees Of The University Of Pennsylvania Compositions and methods of chimeric autoantibody receptor t cells
US20170226216A1 (en) 2014-07-24 2017-08-10 Bluebird Bio, Inc. Bcma chimeric antigen receptors
BR112017005766B1 (pt) 2014-09-22 2022-10-25 Sacmi Cooperativa Meccanici Imola Societa' Cooperativa Linha de produção para a fabricação de produtos, de forma sucessiva e método para a produção de produtos individuais, de forma sucessiva, em ciclo contínuo, em uma linha de produção
SG11201704548PA (en) 2014-12-05 2017-07-28 Memorial Sloan Kettering Cancer Center Antibodies targeting b-cell maturation antigen and methods of use
CN107208047B (zh) 2014-12-05 2021-09-21 纪念斯隆-凯特琳癌症中心 靶向b-细胞成熟抗原的嵌合抗原受体及其用途
ES2895640T3 (es) 2014-12-12 2022-02-22 2Seventy Bio Inc Receptores de antígenos quiméricos de BCMA
US9713375B1 (en) 2015-02-26 2017-07-25 Brett Einar Rahm Collapsible portable table
CN105384825B (zh) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EA201891289A1 (ru) 2015-12-02 2018-11-30 Селджин Корпорейшн Циклическая терапия с применением 3-(5-амино-2-метил-4-оксо-4h-хиназолин-3-ил)пиперидин-2,6-диона
EA201891965A1 (ru) 2016-04-01 2019-04-30 Кайт Фарма, Инк. Химерные рецепторы антигенов и т-клеточные рецепторы и способы их применения
MX2019001184A (es) 2016-07-29 2019-09-26 Juno Therapeutics Inc Anticuerpos anti-idiotípicos y métodos relacionados.
JP7278961B2 (ja) * 2017-03-31 2023-05-22 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー T細胞受容体のシグナル伝達を阻害するまたは調節することによってt細胞の疲弊を治療する方法
FI3618842T3 (fi) * 2017-05-01 2023-12-15 Juno Therapeutics Inc Soluterapian ja immunomodulatorisen yhdisteen yhdistelmä
WO2018223101A1 (en) * 2017-06-02 2018-12-06 Juno Therapeutics, Inc. Articles of manufacture and methods for treatment using adoptive cell therapy
WO2019109053A1 (en) * 2017-12-01 2019-06-06 Juno Therapeutics, Inc. Methods for dosing and for modulation of genetically engineered cells

Similar Documents

Publication Publication Date Title
JPWO2020097403A5 (ko)
CN110475571B (zh) 细胞免疫疗法前细胞毒性预调理的替代
JP2020518591A5 (ko)
Van De Donk et al. Monoclonal antibody-based therapy as a new treatment strategy in multiple myeloma
US20210145977A1 (en) Methods and pharmaceutical composition for the treatment of cancer
US20200038443A1 (en) Multi-function and multi-targeting car system and methods for use thereof
JP2020511462A5 (ko)
JP2019536460A5 (ko)
KR20230156808A (ko) Car-t 세포의 조절 방법
WO2019114762A1 (zh) 免疫效应细胞和辐射联用治疗肿瘤
JP2019532997A5 (ko)
Jung et al. Immunotherapy for the treatment of multiple myeloma
WO2018195348A9 (en) Compositions and methods for treating cancer
Weiner et al. Antibodies and cancer therapy: versatile platforms for cancer immunotherapy
JP2021500878A (ja) 免疫療法のためのt細胞受容体
JP2024507283A (ja) 抗腫瘍薬を調製するための免疫療法薬と併用でのppar-デルタ阻害剤の使用
WO2019114751A1 (zh) 免疫效应细胞和辐射联用治疗肿瘤
TW202345908A (zh) 用於治療trop-2表現性癌症之組合療法
Lu et al. Multiple myeloma: signaling pathways and targeted therapy
Vinay et al. Harnessing immune checkpoints for cancer therapy
JP2020533380A (ja) 癌の組合せ治療
EP4323406A1 (en) Co-inhibition of cd47/sirp? binding and nedd8-activating enzyme e1 regulatory subunit for the treatment of cancer
JPWO2020252218A5 (ko)
CN113316449A (zh) 胍那苄作为免疫疗法的佐剂
WO2019241536A1 (en) Oxabicycloheptanes for enhancing car t cell function