JPWO2020014409A5 - - Google Patents
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- Publication number
- JPWO2020014409A5 JPWO2020014409A5 JP2020573469A JP2020573469A JPWO2020014409A5 JP WO2020014409 A5 JPWO2020014409 A5 JP WO2020014409A5 JP 2020573469 A JP2020573469 A JP 2020573469A JP 2020573469 A JP2020573469 A JP 2020573469A JP WO2020014409 A5 JPWO2020014409 A5 JP WO2020014409A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound according
- formula
- compound
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 3
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- -1 placenostat Chemical compound 0.000 claims 2
- MAUCONCHVWBMHK-UHFFFAOYSA-N 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide Chemical compound O1C2=CC=CC=C2C(CN(C)C)=C1C(=O)NCCOC1=CC=C(C(=O)NO)C=C1 MAUCONCHVWBMHK-UHFFFAOYSA-N 0.000 claims 1
- PLIVFNIUGLLCEK-UHFFFAOYSA-N 7-[4-(3-ethynylanilino)-7-methoxyquinazolin-6-yl]oxy-n-hydroxyheptanamide Chemical compound C=12C=C(OCCCCCCC(=O)NO)C(OC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 PLIVFNIUGLLCEK-UHFFFAOYSA-N 0.000 claims 1
- 241001550224 Apha Species 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- PTJGLFIIZFVFJV-UHFFFAOYSA-N N'-hydroxy-N-(3-pyridinyl)octanediamide Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CN=C1 PTJGLFIIZFVFJV-UHFFFAOYSA-N 0.000 claims 1
- 229950008805 abexinostat Drugs 0.000 claims 1
- NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 claims 1
- 229960003094 belinostat Drugs 0.000 claims 1
- WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 claims 1
- JOWXJLIFIIOYMS-UHFFFAOYSA-N n-hydroxy-2-[[2-(6-methoxypyridin-3-yl)-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-yl]methyl-methylamino]pyrimidine-5-carboxamide Chemical compound C1=NC(OC)=CC=C1C1=NC(N2CCOCC2)=C(SC(CN(C)C=2N=CC(=CN=2)C(=O)NO)=C2)C2=N1 JOWXJLIFIIOYMS-UHFFFAOYSA-N 0.000 claims 1
- CHQWLWFOYFRJDY-UHFFFAOYSA-N n-phenylheptanamide Chemical group CCCCCCC(=O)NC1=CC=CC=C1 CHQWLWFOYFRJDY-UHFFFAOYSA-N 0.000 claims 1
- 229960005184 panobinostat Drugs 0.000 claims 1
- FWZRWHZDXBDTFK-ZHACJKMWSA-N panobinostat Chemical group CC1=NC2=CC=C[CH]C2=C1CCNCC1=CC=C(\C=C\C(=O)NO)C=C1 FWZRWHZDXBDTFK-ZHACJKMWSA-N 0.000 claims 1
- 150000003214 pyranose derivatives Chemical group 0.000 claims 1
- FECGNJPYVFEKOD-VMPITWQZSA-N resminostat Chemical compound C1=CC(CN(C)C)=CC=C1S(=O)(=O)N1C=C(\C=C\C(=O)NO)C=C1 FECGNJPYVFEKOD-VMPITWQZSA-N 0.000 claims 1
- 229950002821 resminostat Drugs 0.000 claims 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- 229960000237 vorinostat Drugs 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024025112A JP2024059789A (ja) | 2018-07-11 | 2024-02-22 | 老化細胞除去組成物及びその使用 |
| JP2025120296A JP2025157418A (ja) | 2018-07-11 | 2025-07-17 | 老化細胞除去組成物及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696486P | 2018-07-11 | 2018-07-11 | |
| US62/696,486 | 2018-07-11 | ||
| PCT/US2019/041283 WO2020014409A1 (en) | 2018-07-11 | 2019-07-11 | Senolytic compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024025112A Division JP2024059789A (ja) | 2018-07-11 | 2024-02-22 | 老化細胞除去組成物及びその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021531249A JP2021531249A (ja) | 2021-11-18 |
| JPWO2020014409A5 true JPWO2020014409A5 (https=) | 2022-07-19 |
| JP2021531249A5 JP2021531249A5 (https=) | 2022-07-19 |
| JP7444797B2 JP7444797B2 (ja) | 2024-03-06 |
Family
ID=69140375
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020573469A Active JP7444797B2 (ja) | 2018-07-11 | 2019-07-11 | 老化細胞除去組成物及びその使用 |
| JP2024025112A Pending JP2024059789A (ja) | 2018-07-11 | 2024-02-22 | 老化細胞除去組成物及びその使用 |
| JP2025120296A Pending JP2025157418A (ja) | 2018-07-11 | 2025-07-17 | 老化細胞除去組成物及びその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024025112A Pending JP2024059789A (ja) | 2018-07-11 | 2024-02-22 | 老化細胞除去組成物及びその使用 |
| JP2025120296A Pending JP2025157418A (ja) | 2018-07-11 | 2025-07-17 | 老化細胞除去組成物及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11026963B2 (https=) |
| EP (1) | EP3790861A4 (https=) |
| JP (3) | JP7444797B2 (https=) |
| KR (1) | KR102843318B1 (https=) |
| CN (2) | CN120136941A (https=) |
| IL (2) | IL312612A (https=) |
| MX (2) | MX2021000395A (https=) |
| SG (1) | SG11202012099VA (https=) |
| WO (1) | WO2020014409A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| CN115397811B (zh) | 2020-01-20 | 2025-05-23 | 奈奥芬莱有限公司 | 与atp结合位点结合的异吲哚啉衍生物 |
| JP2023527869A (ja) * | 2020-06-01 | 2023-06-30 | エイチシーダブリュー バイオロジックス インコーポレイテッド | 加齢関連障害の治療法 |
| GB202008201D0 (en) | 2020-06-01 | 2020-07-15 | Neophore Ltd | Inhibitor compounds |
| US11857551B1 (en) | 2020-07-10 | 2024-01-02 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
| WO2023039293A1 (en) * | 2021-09-13 | 2023-03-16 | Rubedo Life Sciences, Inc. | Coumarin derivatives of sugar analogs and uses thereof |
| CN118475356A (zh) * | 2021-09-13 | 2024-08-09 | 鲁贝多生命科学公司 | 糖衍生物的药物偶联物及其作为衰老细胞裂解剂的用途 |
| US11897915B2 (en) * | 2021-09-13 | 2024-02-13 | Rubedo Life Sciences, Inc. | Sugar derivatives and uses thereof to prepare novel senolytic agents |
| CN114249782B (zh) * | 2022-01-05 | 2023-06-30 | 湖南大学 | 一种选择性破坏衰老细胞溶酶体的前药及其制备方法与应用 |
| CN118434454A (zh) * | 2022-08-19 | 2024-08-02 | 北京三秀生物医药科技有限公司 | 一种抗衰老相关疾病的前药及其使用方法 |
| CN118496288B (zh) * | 2023-02-06 | 2025-01-10 | 中国科学院微生物研究所 | 一种糖基化喜树碱类化合物Gly-CPTR及其制药用途、药物或前药及制备方法 |
| EP4687893A1 (en) * | 2023-04-06 | 2026-02-11 | Integrated Biosciences, Inc. | Compounds and uses thereof |
| CN116688159A (zh) * | 2023-06-19 | 2023-09-05 | 江西德上制药股份有限公司 | 一种基于mRNA技术治疗阿尔茨海默病的药物组合物及制备方法 |
| CN116942653A (zh) * | 2023-08-25 | 2023-10-27 | 徐诺药业(南京)有限公司 | 艾贝司他用于制备防治细胞因子风暴相关疾病药物的用途 |
| WO2025175039A1 (en) * | 2024-02-13 | 2025-08-21 | Luxvitae Therapeutics Inc. | Duocarmycin analogs and applications thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| US6664443B1 (en) | 1998-05-01 | 2003-12-16 | Mayo Foundation For Medical Education And Research | Pathogenic Tau mutations in transgenic mice |
| EA200601252A1 (ru) | 1999-09-08 | 2006-10-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Новый класс веществ, вызывающих дифференцировку клеток и являющихся ингибиторами гистондеацетилазы, и способы их применения |
| CN1257190C (zh) | 2003-04-02 | 2006-05-24 | 郭全太 | 聚葡萄糖生产工艺 |
| EP1973872A4 (en) | 2006-12-19 | 2012-05-09 | Methylgene Inc | HISTONDEACETYLASE HEMMER AND PROPHARMAKA THEREOF |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| MX2010003113A (es) * | 2007-09-25 | 2010-04-01 | Abbott Lab | Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. |
| US20110053991A1 (en) * | 2007-11-19 | 2011-03-03 | Gore Lia | Treatment of Histone Deacetylase Mediated Disorders |
| US8278436B2 (en) * | 2008-07-30 | 2012-10-02 | Wisconsin Alumni Research Foundation | Glycosylated warfarin analogs and uses thereof |
| JP5765239B2 (ja) * | 2009-03-13 | 2015-08-19 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物 |
| US20120005765A1 (en) | 2010-07-01 | 2012-01-05 | Saint Louis University | Animal model for parkinson's disease |
| JP6250394B2 (ja) | 2010-08-19 | 2017-12-20 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | 軽度の認知障害（ｍｃｉ）および関連障害の処置方法 |
| CN103261200B (zh) * | 2010-09-13 | 2016-03-30 | 阿迪维纳斯疗法有限公司 | 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途 |
| US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| KR20140119023A (ko) | 2011-12-13 | 2014-10-08 | 버크 인스티튜트 포 리서치 온 에이징 | 의료 요법을 개선하는 방법 |
| JP6328098B2 (ja) | 2012-03-29 | 2018-05-23 | フィリップス ライティング ホールディング ビー ヴィ | 暖房デバイス及び暖房方法 |
| DK2890981T3 (en) * | 2012-08-28 | 2019-03-04 | Univ Tuebingen Medizinische Fakultaet | Senescence tracers |
| WO2014205244A1 (en) | 2013-06-19 | 2014-12-24 | Demaria Marco | Methods for enhancing effectiveness of medical therapies |
| AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| EP3139942B1 (en) | 2014-05-05 | 2019-12-18 | Bioventures, Llc | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| ES2895174T3 (es) * | 2014-09-29 | 2022-02-17 | Scripps Research Inst | Moduladores del receptor de esfingosina-1-fosfato para el tratamiento de trastornos cardiopulmonares |
| WO2016118859A1 (en) | 2015-01-22 | 2016-07-28 | Board Of Trustees Of The University Of Arkansas | Compositions and methods for selectively depleting senescent cells comprising flip |
| CA2981753A1 (en) * | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditions |
| JP6936498B2 (ja) | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーＢｉｏＶｅｎｔｕｒｅｓ， ＬＬＣ | 抗アポトーシス性Ｂｃｌ−２ファミリータンパク質の分解を誘導する化合物及びその使用 |
| WO2018146506A1 (en) | 2017-02-10 | 2018-08-16 | Universitat Politècnica De València | Therapeutic derivatives |
-
2019
- 2019-07-11 IL IL312612A patent/IL312612A/en unknown
- 2019-07-11 KR KR1020207036831A patent/KR102843318B1/ko active Active
- 2019-07-11 EP EP19834078.8A patent/EP3790861A4/en active Pending
- 2019-07-11 WO PCT/US2019/041283 patent/WO2020014409A1/en not_active Ceased
- 2019-07-11 IL IL279755A patent/IL279755B2/en unknown
- 2019-07-11 US US16/508,477 patent/US11026963B2/en active Active
- 2019-07-11 SG SG11202012099VA patent/SG11202012099VA/en unknown
- 2019-07-11 CN CN202510137110.0A patent/CN120136941A/zh active Pending
- 2019-07-11 JP JP2020573469A patent/JP7444797B2/ja active Active
- 2019-07-11 MX MX2021000395A patent/MX2021000395A/es unknown
- 2019-07-11 CN CN201980046447.3A patent/CN112469697B/zh active Active
-
2021
- 2021-01-11 MX MX2023009423A patent/MX2023009423A/es unknown
- 2021-05-04 US US17/307,047 patent/US20210299154A1/en not_active Abandoned
-
2023
- 2023-04-17 US US18/301,874 patent/US20230321130A1/en not_active Abandoned
-
2024
- 2024-02-22 JP JP2024025112A patent/JP2024059789A/ja active Pending
-
2025
- 2025-07-17 JP JP2025120296A patent/JP2025157418A/ja active Pending
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