MX2010003113A - Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. - Google Patents

Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina.

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Publication number
MX2010003113A
MX2010003113A MX2010003113A MX2010003113A MX2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A
Authority
MX
Mexico
Prior art keywords
compounds
receptor antagonists
chemokine receptor
octahydropentalene
conditions
Prior art date
Application number
MX2010003113A
Other languages
English (en)
Inventor
Anna M Ericsson
Dawn M George
Graham K Ansell
Lu Wang
Biqin Li
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2010003113A publication Critical patent/MX2010003113A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

La presente invenci?n est? dirigida a compuestos novedosos de la F?rmula (I), sales farmac?uticamente aceptables de los mismos, prof?rmacos de los mismos, metabolitos biol?gicamente activos de los mismos, is?meros de los mismos o estereois?meros de los mismos, en donde las variables son como se define aqu?. Los compuestos de la F?rmula (I) son ?tiles como antagonistas del receptor de quimiocina y como tales pueden ser ?tiles para tratar ciertas condiciones y enfermedades, especialmente condiciones y enfermedades inflamatorias y trastornos y condiciones proliferativas, por ejemplo, artritis reumatoide, osteoartritis, esclerosis m?ltiple y asma.
MX2010003113A 2007-09-25 2008-09-25 Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. MX2010003113A (es)

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PCT/US2008/011146 WO2009042193A1 (en) 2007-09-25 2008-09-25 Octahydropentalene compounds as chemokine receptor antagonists

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