JP7444797B2 - 老化細胞除去組成物及びその使用 - Google Patents
老化細胞除去組成物及びその使用 Download PDFInfo
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- JP7444797B2 JP7444797B2 JP2020573469A JP2020573469A JP7444797B2 JP 7444797 B2 JP7444797 B2 JP 7444797B2 JP 2020573469 A JP2020573469 A JP 2020573469A JP 2020573469 A JP2020573469 A JP 2020573469A JP 7444797 B2 JP7444797 B2 JP 7444797B2
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024025112A JP2024059789A (ja) | 2018-07-11 | 2024-02-22 | 老化細胞除去組成物及びその使用 |
| JP2025120296A JP2025157418A (ja) | 2018-07-11 | 2025-07-17 | 老化細胞除去組成物及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862696486P | 2018-07-11 | 2018-07-11 | |
| US62/696,486 | 2018-07-11 | ||
| PCT/US2019/041283 WO2020014409A1 (en) | 2018-07-11 | 2019-07-11 | Senolytic compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024025112A Division JP2024059789A (ja) | 2018-07-11 | 2024-02-22 | 老化細胞除去組成物及びその使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021531249A JP2021531249A (ja) | 2021-11-18 |
| JPWO2020014409A5 JPWO2020014409A5 (https=) | 2022-07-19 |
| JP2021531249A5 JP2021531249A5 (https=) | 2022-07-19 |
| JP7444797B2 true JP7444797B2 (ja) | 2024-03-06 |
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| GB202008201D0 (en) | 2020-06-01 | 2020-07-15 | Neophore Ltd | Inhibitor compounds |
| US11857551B1 (en) | 2020-07-10 | 2024-01-02 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
| WO2023039293A1 (en) * | 2021-09-13 | 2023-03-16 | Rubedo Life Sciences, Inc. | Coumarin derivatives of sugar analogs and uses thereof |
| CN118475356A (zh) * | 2021-09-13 | 2024-08-09 | 鲁贝多生命科学公司 | 糖衍生物的药物偶联物及其作为衰老细胞裂解剂的用途 |
| US11897915B2 (en) * | 2021-09-13 | 2024-02-13 | Rubedo Life Sciences, Inc. | Sugar derivatives and uses thereof to prepare novel senolytic agents |
| CN114249782B (zh) * | 2022-01-05 | 2023-06-30 | 湖南大学 | 一种选择性破坏衰老细胞溶酶体的前药及其制备方法与应用 |
| CN118434454A (zh) * | 2022-08-19 | 2024-08-02 | 北京三秀生物医药科技有限公司 | 一种抗衰老相关疾病的前药及其使用方法 |
| CN118496288B (zh) * | 2023-02-06 | 2025-01-10 | 中国科学院微生物研究所 | 一种糖基化喜树碱类化合物Gly-CPTR及其制药用途、药物或前药及制备方法 |
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| WO2025175039A1 (en) * | 2024-02-13 | 2025-08-21 | Luxvitae Therapeutics Inc. | Duocarmycin analogs and applications thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513326A (ja) | 2006-12-19 | 2010-04-30 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ |
| US20170056421A1 (en) | 2014-05-05 | 2017-03-02 | Board Of Trustees Of The University Of Arkansas | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| US20180021323A1 (en) | 2015-01-22 | 2018-01-25 | Bioventures, Llc | Flip - a selective molecular target of senescent cells |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| US6664443B1 (en) | 1998-05-01 | 2003-12-16 | Mayo Foundation For Medical Education And Research | Pathogenic Tau mutations in transgenic mice |
| EA200601252A1 (ru) | 1999-09-08 | 2006-10-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Новый класс веществ, вызывающих дифференцировку клеток и являющихся ингибиторами гистондеацетилазы, и способы их применения |
| CN1257190C (zh) | 2003-04-02 | 2006-05-24 | 郭全太 | 聚葡萄糖生产工艺 |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| MX2010003113A (es) * | 2007-09-25 | 2010-04-01 | Abbott Lab | Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. |
| US20110053991A1 (en) * | 2007-11-19 | 2011-03-03 | Gore Lia | Treatment of Histone Deacetylase Mediated Disorders |
| US8278436B2 (en) * | 2008-07-30 | 2012-10-02 | Wisconsin Alumni Research Foundation | Glycosylated warfarin analogs and uses thereof |
| JP5765239B2 (ja) * | 2009-03-13 | 2015-08-19 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物 |
| US20120005765A1 (en) | 2010-07-01 | 2012-01-05 | Saint Louis University | Animal model for parkinson's disease |
| JP6250394B2 (ja) | 2010-08-19 | 2017-12-20 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | 軽度の認知障害(mci)および関連障害の処置方法 |
| CN103261200B (zh) * | 2010-09-13 | 2016-03-30 | 阿迪维纳斯疗法有限公司 | 作为a2b腺苷受体拮抗剂的前药的嘌呤化合物、它们的制备方法及医药用途 |
| US20140189897A1 (en) | 2011-06-21 | 2014-07-03 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
| KR20140119023A (ko) | 2011-12-13 | 2014-10-08 | 버크 인스티튜트 포 리서치 온 에이징 | 의료 요법을 개선하는 방법 |
| JP6328098B2 (ja) | 2012-03-29 | 2018-05-23 | フィリップス ライティング ホールディング ビー ヴィ | 暖房デバイス及び暖房方法 |
| DK2890981T3 (en) * | 2012-08-28 | 2019-03-04 | Univ Tuebingen Medizinische Fakultaet | Senescence tracers |
| WO2014205244A1 (en) | 2013-06-19 | 2014-12-24 | Demaria Marco | Methods for enhancing effectiveness of medical therapies |
| AU2015211021B2 (en) | 2014-01-28 | 2020-07-02 | Buck Institute For Research On Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
| ES2895174T3 (es) * | 2014-09-29 | 2022-02-17 | Scripps Research Inst | Moduladores del receptor de esfingosina-1-fosfato para el tratamiento de trastornos cardiopulmonares |
| CA2981753A1 (en) * | 2015-02-06 | 2016-08-11 | Unity Biotechnology, Inc. | Compounds and uses in treatment of senescence-associated conditions |
| JP6936498B2 (ja) | 2016-04-21 | 2021-09-15 | バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC | 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用 |
| WO2018146506A1 (en) | 2017-02-10 | 2018-08-16 | Universitat Politècnica De València | Therapeutic derivatives |
-
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-
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- 2024-02-22 JP JP2024025112A patent/JP2024059789A/ja active Pending
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010513326A (ja) | 2006-12-19 | 2010-04-30 | メシルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害薬及びそのプロドラッグ |
| US20170056421A1 (en) | 2014-05-05 | 2017-03-02 | Board Of Trustees Of The University Of Arkansas | COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS |
| US20180021323A1 (en) | 2015-01-22 | 2018-01-25 | Bioventures, Llc | Flip - a selective molecular target of senescent cells |
Non-Patent Citations (5)
| Title |
|---|
| Bioorganic & Medicinal Chemistry Letters,2007年,Vol.17,pp.983-986 |
| Cell Cycle,2013年06月15日,Vol.12, Issue 12,pp.1922-1927 |
| J. Org. Chem.,2007年,Vol.72, No.11,pp.4262-4264 |
| PLoS ONE,2018年01月09日,Vol.13, No.1, e0190374,pp.1-14 |
| Scientific Reports,2017年05月15日,7:1900,pp.1-11 |
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| CA3105982A1 (en) | 2020-01-16 |
| JP2024059789A (ja) | 2024-05-01 |
| KR20210030905A (ko) | 2021-03-18 |
| WO2020014409A1 (en) | 2020-01-16 |
| JP2021531249A (ja) | 2021-11-18 |
| US20200016185A1 (en) | 2020-01-16 |
| IL279755B1 (en) | 2024-06-01 |
| US20230321130A1 (en) | 2023-10-12 |
| JP2025157418A (ja) | 2025-10-15 |
| SG11202012099VA (en) | 2021-01-28 |
| CN112469697B (zh) | 2025-02-14 |
| EP3790861A1 (en) | 2021-03-17 |
| IL279755B2 (en) | 2024-10-01 |
| CN112469697A (zh) | 2021-03-09 |
| IL312612A (en) | 2024-07-01 |
| US11026963B2 (en) | 2021-06-08 |
| IL279755A (en) | 2021-03-01 |
| MX2023009423A (es) | 2023-08-23 |
| US20210299154A1 (en) | 2021-09-30 |
| EP3790861A4 (en) | 2022-03-30 |
| MX2021000395A (es) | 2021-05-12 |
| KR102843318B1 (ko) | 2025-08-05 |
| CN120136941A (zh) | 2025-06-13 |
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