JPWO2019207463A5 - - Google Patents
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- JPWO2019207463A5 JPWO2019207463A5 JP2020560277A JP2020560277A JPWO2019207463A5 JP WO2019207463 A5 JPWO2019207463 A5 JP WO2019207463A5 JP 2020560277 A JP2020560277 A JP 2020560277A JP 2020560277 A JP2020560277 A JP 2020560277A JP WO2019207463 A5 JPWO2019207463 A5 JP WO2019207463A5
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- JP
- Japan
- Prior art keywords
- alkyl
- fluoroalkyl
- cancer
- fluoroalkoxy
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 15
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 6
- 208000026310 Breast neoplasm Diseases 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 229940119564 Selective estrogen receptor downregulator Drugs 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- KSCSDVHAZVSGAW-XHBKTUGNSA-N (3R,4R)-4-[[5-chloro-4-[7-fluoro-2-[(1R)-1-hydroxyethyl]-3-propan-2-ylbenzimidazol-5-yl]pyrimidin-2-yl]amino]-1-methylsulfonylpiperidin-3-ol Chemical compound ClC=1C(=NC(=NC=1)N[C@H]1[C@@H](CN(CC1)S(=O)(=O)C)O)C=1C=C(C2=C(N(C(=N2)[C@@H](C)O)C(C)C)C=1)F KSCSDVHAZVSGAW-XHBKTUGNSA-N 0.000 claims 1
- 229940122815 Aromatase inhibitor Drugs 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 1
- 208000017891 HER2 positive breast carcinoma Diseases 0.000 claims 1
- 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 claims 1
- 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000003886 aromatase inhibitor Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 102000015694 estrogen receptors Human genes 0.000 claims 1
- 108010038795 estrogen receptors Proteins 0.000 claims 1
- 229960002258 fulvestrant Drugs 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000004653 inflammatory breast carcinoma Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 229960003881 letrozole Drugs 0.000 claims 1
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical group C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- -1 {5-chloro-4- [4-fluoro-2- (2-hydroxypropane-2-yl) -1- (propane-2-yl) -1H-benz Imidazole-6-yl] pyrimidine-2-yl} amino Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022093962A JP2022120096A (ja) | 2018-04-26 | 2022-06-09 | サイクリン依存性キナーゼ阻害剤としての２－アミノ－ピリジンまたは２－アミノ－ピリミジン誘導体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663096P | 2018-04-26 | 2018-04-26 | |
| US62/663,096 | 2018-04-26 | ||
| US201862750454P | 2018-10-25 | 2018-10-25 | |
| US62/750,454 | 2018-10-25 | ||
| US201962826609P | 2019-03-29 | 2019-03-29 | |
| US62/826,609 | 2019-03-29 | ||
| PCT/IB2019/053314 WO2019207463A1 (en) | 2018-04-26 | 2019-04-22 | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022093962A Division JP2022120096A (ja) | 2018-04-26 | 2022-06-09 | サイクリン依存性キナーゼ阻害剤としての２－アミノ－ピリジンまたは２－アミノ－ピリミジン誘導体 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021522275A JP2021522275A (ja) | 2021-08-30 |
| JPWO2019207463A5 true JPWO2019207463A5 (https=) | 2022-03-01 |
| JP2021522275A5 JP2021522275A5 (https=) | 2022-03-01 |
| JP7089061B2 JP7089061B2 (ja) | 2022-06-21 |
Family
ID=66676856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020560277A Active JP7089061B2 (ja) | 2018-04-26 | 2019-04-22 | サイクリン依存性キナーゼ阻害剤としての２－アミノ－ピリジンまたは２－アミノ－ピリミジン誘導体 |
| JP2022093962A Pending JP2022120096A (ja) | 2018-04-26 | 2022-06-09 | サイクリン依存性キナーゼ阻害剤としての２－アミノ－ピリジンまたは２－アミノ－ピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022093962A Pending JP2022120096A (ja) | 2018-04-26 | 2022-06-09 | サイクリン依存性キナーゼ阻害剤としての２－アミノ－ピリジンまたは２－アミノ－ピリミジン誘導体 |
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