JP2021522275A5 - - Google Patents

Info

Publication number
JP2021522275A5
JP2021522275A5 JP2020560277A JP2020560277A JP2021522275A5 JP 2021522275 A5 JP2021522275 A5 JP 2021522275A5 JP 2020560277 A JP2020560277 A JP 2020560277A JP 2020560277 A JP2020560277 A JP 2020560277A JP 2021522275 A5 JP2021522275 A5 JP 2021522275A5
Authority
JP
Japan
Prior art keywords
alkyl
fluoroalkyl
cancer
optionally substituted
aforementioned
Prior art date
Application number
JP2020560277A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019207463A5 (https=
JP7089061B2 (ja
JP2021522275A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2019/053314 external-priority patent/WO2019207463A1/en
Publication of JP2021522275A publication Critical patent/JP2021522275A/ja
Publication of JPWO2019207463A5 publication Critical patent/JPWO2019207463A5/ja
Publication of JP2021522275A5 publication Critical patent/JP2021522275A5/ja
Priority to JP2022093962A priority Critical patent/JP2022120096A/ja
Application granted granted Critical
Publication of JP7089061B2 publication Critical patent/JP7089061B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020560277A 2018-04-26 2019-04-22 サイクリン依存性キナーゼ阻害剤としての2-アミノ-ピリジンまたは2-アミノ-ピリミジン誘導体 Active JP7089061B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022093962A JP2022120096A (ja) 2018-04-26 2022-06-09 サイクリン依存性キナーゼ阻害剤としての2-アミノ-ピリジンまたは2-アミノ-ピリミジン誘導体

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862663096P 2018-04-26 2018-04-26
US62/663,096 2018-04-26
US201862750454P 2018-10-25 2018-10-25
US62/750,454 2018-10-25
US201962826609P 2019-03-29 2019-03-29
US62/826,609 2019-03-29
PCT/IB2019/053314 WO2019207463A1 (en) 2018-04-26 2019-04-22 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022093962A Division JP2022120096A (ja) 2018-04-26 2022-06-09 サイクリン依存性キナーゼ阻害剤としての2-アミノ-ピリジンまたは2-アミノ-ピリミジン誘導体

Publications (4)

Publication Number Publication Date
JP2021522275A JP2021522275A (ja) 2021-08-30
JPWO2019207463A5 JPWO2019207463A5 (https=) 2022-03-01
JP2021522275A5 true JP2021522275A5 (https=) 2022-03-01
JP7089061B2 JP7089061B2 (ja) 2022-06-21

Family

ID=66676856

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020560277A Active JP7089061B2 (ja) 2018-04-26 2019-04-22 サイクリン依存性キナーゼ阻害剤としての2-アミノ-ピリジンまたは2-アミノ-ピリミジン誘導体
JP2022093962A Pending JP2022120096A (ja) 2018-04-26 2022-06-09 サイクリン依存性キナーゼ阻害剤としての2-アミノ-ピリジンまたは2-アミノ-ピリミジン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022093962A Pending JP2022120096A (ja) 2018-04-26 2022-06-09 サイクリン依存性キナーゼ阻害剤としての2-アミノ-ピリジンまたは2-アミノ-ピリミジン誘導体

Country Status (40)

Country Link
US (3) US10766884B2 (https=)
EP (1) EP3784664B1 (https=)
JP (2) JP7089061B2 (https=)
KR (2) KR102661053B1 (https=)
CN (2) CN112313219B (https=)
AU (1) AU2019259653B2 (https=)
BR (1) BR112020021689B1 (https=)
CA (1) CA3098283C (https=)
CL (1) CL2020002748A1 (https=)
CO (1) CO2020013149A2 (https=)
CR (1) CR20200503A (https=)
CU (1) CU20200070A7 (https=)
DK (1) DK3784664T3 (https=)
DO (1) DOP2020000191A (https=)
EC (1) ECSP20067394A (https=)
ES (1) ES3021205T3 (https=)
FI (1) FI3784664T3 (https=)
GE (2) GEP20227433B (https=)
HR (1) HRP20250254T1 (https=)
HU (1) HUE070823T2 (https=)
IL (1) IL278075B2 (https=)
LT (1) LT3784664T (https=)
MA (1) MA52360B1 (https=)
MD (1) MD3784664T2 (https=)
MX (1) MX2020011294A (https=)
NI (1) NI202000072A (https=)
PE (1) PE20201202A1 (https=)
PH (1) PH12020551692A1 (https=)
PL (1) PL3784664T3 (https=)
PT (1) PT3784664T (https=)
PY (1) PY1932509A (https=)
RS (1) RS66650B1 (https=)
RU (1) RU2762557C1 (https=)
SG (1) SG11202009992VA (https=)
SI (1) SI3784664T1 (https=)
TW (1) TWI740135B (https=)
UA (1) UA126177C2 (https=)
UY (1) UY38196A (https=)
WO (1) WO2019207463A1 (https=)
ZA (1) ZA202006944B (https=)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA125650C2 (uk) 2016-09-09 2022-05-11 Інсайт Корпорейшн Регулятори нрk1 на основі похідних піразолопіридину та їх застосування для лікування раку
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
US10800761B2 (en) 2018-02-20 2020-10-13 Incyte Corporation Carboxamide compounds and uses thereof
WO2019164847A1 (en) 2018-02-20 2019-08-29 Incyte Corporation Indazole compounds and uses thereof
MD3784664T2 (ro) * 2018-04-26 2025-06-30 Pfizer Derivați de 2-amino-piridină sau de 2-amino-pirimidină utilizați ca inhibitori de kinaze dependente de cicline
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180959A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
MX2022001562A (es) 2019-08-06 2022-04-26 Incyte Corp Formas solidas de un inhibidor de la cinasa 1 del progenitor hematopoyetico (hpk1).
TW202115024A (zh) 2019-08-14 2021-04-16 美商英塞特公司 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
IL320609A (en) 2019-08-26 2025-07-01 Arvinas Operations Inc Methods for treating breast cancer with a history of tetrahydronaphthalene as estrogen receptor-disrupting agents
US11038699B2 (en) * 2019-08-29 2021-06-15 Advanced New Technologies Co., Ltd. Method and apparatus for performing multi-party secure computing based-on issuing certificate
AU2020364007A1 (en) 2019-10-11 2022-04-28 Incyte Corporation Bicyclic amines as CDK2 inhibitors
TW202216131A (zh) 2020-07-15 2022-05-01 美商輝瑞大藥廠 用於癌症治療之kat6抑制劑方法及組合
CA3188821A1 (en) * 2020-08-13 2022-02-17 Lars ANDERS Combination therapy
CN112028834B (zh) * 2020-09-11 2022-03-29 济南悟通生物科技有限公司 一种阿贝西利的中间体的合成方法
SI4214202T1 (sl) * 2020-09-15 2025-05-30 Pfizer Inc. Trdne oblike inhibitorja cdk4
CN112679522B (zh) * 2020-12-29 2023-02-14 南京正济医药研究有限公司 一种巴洛沙韦中间体的制备方法
WO2022149057A1 (en) * 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors
TW202231282A (zh) * 2021-02-03 2022-08-16 大陸商上海拓界生物醫藥科技有限公司 稠三環類細胞週期蛋白-依賴性激酶抑制劑及其製備方法和醫藥用途
US20240269073A1 (en) * 2021-06-07 2024-08-15 Zerion Pharma ApS Co-amorphous forms for use in cancer therapy
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
IL312650A (en) * 2021-12-02 2024-07-01 Pfizer CDK4 inhibitor for cancer treatment
WO2023100134A1 (en) 2021-12-02 2023-06-08 Pfizer Inc. Methods and dosing regimens comprising a cdk2 inhibitor and a cdk4 inhibitor for treating cancer
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
CN118339157A (zh) * 2021-12-24 2024-07-12 江苏恒瑞医药股份有限公司 氢化吲哚类化合物、其制备方法及其在医药上的应用
US20250163063A1 (en) * 2022-01-25 2025-05-22 Kinnate Biopharma Inc. Inhibitors of cdk4/6 kinase
EP4504709A4 (en) * 2022-04-08 2025-12-24 Biolexis Therapeutics Inc CDK9 inhibitors
JP2025513028A (ja) 2022-04-08 2025-04-22 バイオレクシス セラピューティクス,インコーポレイティド Cdk9阻害剤
KR20250004015A (ko) * 2022-04-29 2025-01-07 베이진 엘티디 사이클린 의존성 키나제 저해제로서의 치환된 7-(피리미딘-4-일)퀴놀린-4(1h)-온 화합물
AR129185A1 (es) * 2022-04-29 2024-07-24 Beigene Ltd Compuestos de 6-(pirimidin-4-il)quinolina sustituidos como inhibidores de la cinasa dependiente de ciclina
WO2024023703A1 (en) 2022-07-29 2024-02-01 Pfizer Inc. Dosing regimens comprising a kat6 inhibitor for the treatment of cancer
WO2024022487A1 (en) * 2022-07-29 2024-02-01 Allorion Therapeutics Inc Aminoheteroaryl kinase inhibitors
WO2024027631A1 (zh) 2022-08-01 2024-02-08 江苏恒瑞医药股份有限公司 一种稠三环类衍生物的晶型及制备方法
CN117645604A (zh) * 2022-09-05 2024-03-05 浙江同源康医药股份有限公司 用作cdk4激酶抑制剂的化合物及其应用
WO2024066986A1 (zh) * 2022-09-30 2024-04-04 楚浦创制(武汉)医药科技有限公司 2-氨基嘧啶类化合物及其应用、药用组合物
WO2024201340A1 (en) 2023-03-30 2024-10-03 Pfizer Inc. Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof
EP4689660A1 (en) 2023-03-30 2026-02-11 Pfizer Inc. Kat6a as a predictive biomarker for treatment with a kat6a inhibitor and methods of treatment thereof
WO2024220866A1 (en) * 2023-04-19 2024-10-24 Accutar Biotechnology Inc. Novel aminopyrimidine derivatives as cyclin-dependent kinase inhibitors
EP4719405A1 (en) 2023-06-02 2026-04-08 Pfizer Inc. Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer
CN121368483A (zh) 2023-06-02 2026-01-20 辉瑞公司 雌激素受体降解剂与cdk4抑制剂的组合
CN120936609A (zh) * 2023-07-19 2025-11-11 浙江同源康医药股份有限公司 用作cdk2/4蛋白激酶抑制剂的化合物及其应用
WO2025024388A1 (en) * 2023-07-21 2025-01-30 Accutar Biotechnology Inc. Aminopyrimidine derivatives as cyclin-dependent kinase inhibitors
CN121127466A (zh) * 2023-09-05 2025-12-12 浙江同源康医药股份有限公司 用作cdk4激酶抑制剂的化合物及其应用
WO2025078995A1 (en) * 2023-10-11 2025-04-17 Beigene Switzerland Gmbh Substituted 6-(pyrimidin-4-yl)quinoline compounds as cyclin dependent kinase inhibitors
WO2025104624A1 (en) 2023-11-14 2025-05-22 Pfizer Inc. Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol
WO2025141469A1 (en) 2023-12-26 2025-07-03 Pfizer Inc. Crystalline form of 2-methoxy-n-{4-methoxy-6-[(1h-pyrazol-1-yl)methyl]-1,2-benzoxazol-3-yl}benzene-1-sulfonamide
WO2025157245A1 (en) * 2024-01-25 2025-07-31 Allorion Therapeutics Inc Aminoheteroaryl kinase inhibitors
WO2025183591A1 (ru) * 2024-02-29 2025-09-04 Федеральное государственное унитарное предприятие "Всероссийский научно-исследовательский институт автоматики им. Н.Л. Духова" (ФГУП "ВНИИА") Производные 2н-[1,4]оксазино- и 2h-[1, 4]тиазино[3,2-c]хинолин-3(4h)-онов в качестве ингибиторов атм и dna-pk киназ
TW202539674A (zh) * 2024-03-05 2025-10-16 大陸商浙江同源康醫藥股份有限公司 用作cdk4蛋白激酶抑制劑的化合物及其應用
WO2025202854A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer
WO2025202871A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor
WO2025202900A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Cdk4 inhibitors for use in the treatment of mantle cell lymphoma
CN118440041B (zh) * 2024-07-02 2024-09-27 苏州凯瑞医药科技有限公司 一种手性4-氨基-3-羟基四氢吡喃的制备方法
WO2026025013A2 (en) 2024-07-26 2026-01-29 Pfizer Inc. Combination therapy using cdk4 inhibitors for cancer treatments
WO2026052020A1 (zh) * 2024-09-04 2026-03-12 浙江同源康医药股份有限公司 用作cdk4蛋白激酶抑制剂的化合物及其应用

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
JP2003509412A (ja) 1999-09-17 2003-03-11 シーオーアール セラピューティクス インコーポレイテッド Xa因子阻害剤
AU2001250783A1 (en) 2000-02-29 2001-09-12 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor xa
US20040171630A1 (en) 2001-06-19 2004-09-02 Yuntae Kim Tyrosine kinase inhibitors
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
PL2256106T3 (pl) 2003-07-22 2015-08-31 Astex Therapeutics Ltd Związki 3,4-pochodne 1h-pirazolu i ich zastosowanie jako kinazy zależne od cyklin (cdk) i modulatory kinazy syntazy glikogenu-3 (gsk-3)
GB0317127D0 (en) * 2003-07-22 2003-08-27 Astex Technology Ltd Pharmaceutical compounds
WO2006038001A1 (en) 2004-10-06 2006-04-13 Celltech R & D Limited Aminopyrimidine derivatives as jnk inhibitors
US7855205B2 (en) * 2004-10-29 2010-12-21 Janssen Pharmaceutica Nv Pyrimidinyl substituted fused-pyrrolyl compounds useful in treating kinase disorders
JP2010501567A (ja) * 2006-08-24 2010-01-21 ノバルティス アクチエンゲゼルシャフト 代謝系、心血管系および他の障害の処置のためのステアロイル−CoA不飽和化酵素(SCD)阻害剤としての2−(ピラジン−2−イル)−チアゾールおよび2−(1H−ピラゾール−3−イル)チアゾール誘導体ならびに関連化合物
US8378387B2 (en) 2008-03-04 2013-02-19 Nec Corporation Field effect transistor and method of manufacturing the same
TWI546290B (zh) 2008-06-27 2016-08-21 賽基艾維洛米斯研究股份有限公司 雜芳基化合物及其用途
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
EP2379527A1 (en) 2008-12-19 2011-10-26 F. Hoffmann-La Roche AG Pyrimidin- 2 -ylamino derivatives and their use to treat inflammation
JO2885B1 (en) 2008-12-22 2015-03-15 ايلي ليلي اند كومباني Protein kinase inhibitors
EP2475667A1 (en) 2009-09-10 2012-07-18 F. Hoffmann-La Roche AG Inhibitors of jak
CA2798325A1 (en) 2010-05-13 2011-11-17 Amgen Inc. Heteroaryloxyheterocyclyl compounds as pde10 inhibitors
WO2012129562A2 (en) 2011-03-24 2012-09-27 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
JO3300B1 (ar) 2012-06-06 2018-09-16 Novartis Ag مركبات وتركيبات لتعديل نشاط egfr
TW201444820A (zh) * 2013-03-13 2014-12-01 Abbvie Inc 吡啶cdk9激酶抑制劑
AR093580A1 (es) 2013-08-30 2015-06-10 Ptc Therapeutics Inc Inhibidores bmi-1 de pirimidina sustituidos
AU2014337067B2 (en) 2013-10-18 2019-01-24 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of proliferative diseases
KR102379517B1 (ko) 2013-12-30 2022-03-25 제넨테크, 인크. 세린/트레오닌 키나아제 억제제
CN106458990B (zh) 2014-04-04 2019-06-07 希洛斯医药品股份有限公司 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
MY187555A (en) 2014-07-24 2021-09-29 Beta Pharma Inc 2-h-indazole derivatives as cyclin-dependent kinase (cdk) inhibitors and therapeutic uses thereof
CN105294655B (zh) 2014-07-26 2019-03-15 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
AU2015367977B9 (en) 2014-12-24 2020-02-06 Lg Chem, Ltd Biaryl derivative as GPR120 agonist
WO2016192630A1 (zh) 2015-06-01 2016-12-08 中国科学院上海药物研究所 一类具有激酶抑制活性的化合物、制备方法和用途
EP3313530B1 (en) * 2015-06-26 2022-10-05 Dana Farber Cancer Institute, Inc. 4,6-pyrimidinylene derivatives and uses thereof
CN105111191B (zh) * 2015-07-21 2018-06-08 上海皓元生物医药科技有限公司 一种用于合成cdk9抑制剂的关键中间体及其制备方法和用途
CN105153119B (zh) * 2015-09-11 2019-01-01 广州必贝特医药技术有限公司 吡啶嘧啶胺类化合物或吡啶吡啶胺类化合物及其应用
CN106928216A (zh) 2015-12-31 2017-07-07 中国科学院上海药物研究所 具有erk激酶抑制活性的化合物、其制备方法和用途
WO2017114512A1 (zh) * 2015-12-31 2017-07-06 上海医药集团股份有限公司 含氮稠杂环化合物、制备方法、中间体、组合物和应用
WO2017133701A1 (en) 2016-02-06 2017-08-10 Shanghai Fochon Pharmaceutical Co., Ltd. Certain protein kinase inhibitors
SG11201900328WA (en) * 2016-07-13 2019-02-27 Jason Marineau Inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2018161033A1 (en) 2017-03-02 2018-09-07 Wright, Adrian Small molecule ire1-alpha inhibitors
EP3686196B1 (en) 2017-09-20 2024-06-12 Hangzhou Innogate Pharma Co., Ltd. Polycyclic compound acting as ido inhibitor and/or ido-hdac dual inhibitor
MD3784664T2 (ro) 2018-04-26 2025-06-30 Pfizer Derivați de 2-amino-piridină sau de 2-amino-pirimidină utilizați ca inhibitori de kinaze dependente de cicline

Similar Documents

Publication Publication Date Title
JP2021522275A5 (https=)
JPWO2019207463A5 (https=)
HRP20250254T1 (hr) Derivati 2‑aminopiridina ili 2‑aminopirimidina kao inhibitori kinaze ovisne o ciklinima
JP2020517616A5 (https=)
JPWO2021245055A5 (https=)
RU2010154105A (ru) Диазакарбазолы и способы применения
JP2010526146A5 (https=)
JP2004511466A5 (https=)
HRP20170352T1 (hr) Spojevi bis(fluroalkil)-1,4-benzodiazepinona kao notch inhibitori
HRP20240055T1 (hr) Derivati piperidinona kao inhibitori mdm2 za liječenje raka
RU2014119339A (ru) 2-КАРБОКСАМИД ЦИКЛОАМИНО ПРОИЗВОДНЫЕ МОЧЕВИНЫ В КОМБИНАЦИИ С ИНГИБИТОРАМИ Hsp90 ДЛЯ ЛЕЧЕНИЯ ПРОЛИФЕРАТИВНЫХ ЗАБОЛЕВАНИЙ
JP2014528464A5 (https=)
JP2012520321A5 (https=)
JP2009536221A5 (https=)
RU2394031C2 (ru) Соли четвертичного аммония в качестве антагонистов м3
JPWO2019214634A5 (https=)
JPWO2020163823A5 (https=)
JP2020531414A5 (https=)
RU2004104329A (ru) Ацилсемикарбазиды как ингибиторы циклинзависимой киназы, полезные в качестве противораковых и противопролиферативных агентов
RU2008106754A (ru) Предотвращающий преждевременную овуляцию агент
JP2012519703A5 (https=)
JP2008510719A5 (https=)
JP2014512362A5 (https=)
JP2021532183A5 (https=)
JP2005531563A5 (https=)