|
MY125533A
(en)
*
|
1999-12-06 |
2006-08-30 |
Bristol Myers Squibb Co |
Heterocyclic dihydropyrimidine compounds
|
|
AU2002311919B8
(en)
|
2001-05-11 |
2007-03-22 |
Ludwig Institute For Cancer Research Ltd |
Specific binding proteins and uses thereof
|
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
|
TW200307539A
(en)
*
|
2002-02-01 |
2003-12-16 |
Bristol Myers Squibb Co |
Cycloalkyl inhibitors of potassium channel function
|
|
GB0205176D0
(en)
*
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
TW200403058A
(en)
*
|
2002-04-19 |
2004-03-01 |
Bristol Myers Squibb Co |
Heterocyclo inhibitors of potassium channel function
|
|
WO2004035571A1
(en)
*
|
2002-10-15 |
2004-04-29 |
Rigel Pharmaceuticals, Inc. |
Substituted indoles and their use as hcv inhibitors
|
|
US7208491B2
(en)
|
2003-02-07 |
2007-04-24 |
Hoffmann-La Roche Inc. |
N-monoacylated o-phenylenediamines
|
|
US7078419B2
(en)
|
2003-03-10 |
2006-07-18 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Cytokine inhibitors
|
|
WO2005032594A2
(en)
*
|
2003-10-03 |
2005-04-14 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Alkylators linked to polyamides as dna binding agents
|
|
KR101274524B1
(ko)
*
|
2004-03-16 |
2013-06-19 |
온코노바 테라퓨틱스, 인코포레이티드 |
증식성 질병 치료용 치환 페녹시- 및 페닐티오- 유도체
|
|
WO2006055463A2
(en)
*
|
2004-11-15 |
2006-05-26 |
Bristol-Myers Squibb Company |
2-amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
|
|
WO2006053274A2
(en)
*
|
2004-11-15 |
2006-05-18 |
Bristol-Myers Squibb Company |
2-amino-1-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
|
|
US7226942B2
(en)
|
2004-11-15 |
2007-06-05 |
Bristol-Myers Squibb Company |
2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
|
|
US7223786B2
(en)
*
|
2004-11-15 |
2007-05-29 |
Bristol-Myers Squibb Company |
2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
|
|
US8782706B2
(en)
|
2005-12-29 |
2014-07-15 |
United Video Properties |
Systems and methods for providing channel groups in an interactive media guidance application
|
|
MX352516B
(es)
|
2006-07-05 |
2017-04-06 |
Fibrotech Therapeutics Pty Ltd |
Compuestos terapeuticos.
|
|
GB0619325D0
(en)
*
|
2006-09-30 |
2006-11-08 |
Univ Strathclyde |
New compounds
|
|
AR063311A1
(es)
*
|
2006-10-18 |
2009-01-21 |
Novartis Ag |
Compuestos organicos
|
|
WO2008050140A2
(en)
*
|
2006-10-27 |
2008-05-02 |
Spirogen Limited |
Compounds for treatment of parasitic infection
|
|
US9090693B2
(en)
|
2007-01-25 |
2015-07-28 |
Dana-Farber Cancer Institute |
Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
|
|
CA2680854C
(en)
|
2007-03-15 |
2017-02-14 |
Ludwig Institute For Cancer Research |
Treatment method using egfr antibodies and src inhibitors and related formulations
|
|
US9901567B2
(en)
|
2007-08-01 |
2018-02-27 |
Syntarga B.V. |
Substituted CC-1065 analogs and their conjugates
|
|
CN108424454B
(zh)
|
2007-08-14 |
2022-05-31 |
路德维格癌症研究所有限公司 |
靶向egf受体的单克隆抗体175及其衍生物和用途
|
|
GB0819095D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
ES2647317T3
(es)
|
2008-11-03 |
2017-12-20 |
Syntarga B.V. |
Análogos de CC-1065 y sus conjugados
|
|
US20110076232A1
(en)
*
|
2009-09-29 |
2011-03-31 |
Ludwig Institute For Cancer Research |
Specific binding proteins and uses thereof
|
|
CN102574843B
(zh)
|
2009-10-22 |
2015-06-17 |
法博太科制药有限公司 |
抗纤维化剂的稠环类似物
|
|
JP5875083B2
(ja)
|
2010-04-15 |
2016-03-02 |
メディミューン リミテッド |
増殖性疾患治療用ピロロベンゾジアゼピン
|
|
CA2795349C
(en)
|
2010-04-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Targeted pyrrolobenzodiazepine conjugates
|
|
PT3056203T
(pt)
|
2010-04-21 |
2018-02-15 |
Syntarga Bv |
Conjugados de análogos de cc-1065 e ligantes bifuncionais
|
|
WO2012171020A1
(en)
|
2011-06-10 |
2012-12-13 |
Mersana Therapeutics, Inc. |
Protein-polymer-drug conjugates
|
|
SG11201400770SA
(en)
|
2011-09-20 |
2014-04-28 |
Spirogen Sarl |
Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates
|
|
CA2850373C
(en)
|
2011-10-14 |
2019-07-16 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
EP2751111B1
(en)
|
2011-10-14 |
2017-04-26 |
MedImmune Limited |
Asymmetrical bis-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-5-one) derivatives for the treatment of proliferative or autoimmune diseases
|
|
AU2012322932B2
(en)
|
2011-10-14 |
2016-11-10 |
Medimmune Limited |
Pyrrolobenzodiazepines
|
|
CN103997893B
(zh)
|
2011-10-14 |
2019-04-12 |
西雅图基因公司 |
吡咯并苯并二氮杂卓和靶向结合物
|
|
CN102827061A
(zh)
*
|
2012-09-19 |
2012-12-19 |
兰州大学 |
5,6,7-三甲氧基吲哚类衍生物、制备方法及用途
|
|
HRP20190366T1
(hr)
|
2012-10-12 |
2019-04-19 |
Medimmune Limited |
Pirolobenzodiazepini i njihovi konjugati
|
|
EP2906249B1
(en)
|
2012-10-12 |
2018-06-27 |
MedImmune Limited |
Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
|
|
JP6392765B2
(ja)
|
2012-10-12 |
2018-09-19 |
エイディーシー・セラピューティクス・エス・アーＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａ |
ピロロベンゾジアゼピン−抗体結合体
|
|
EP2906297B1
(en)
|
2012-10-12 |
2017-12-06 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP2906296B1
(en)
|
2012-10-12 |
2018-03-21 |
ADC Therapeutics SA |
Pyrrolobenzodiazepine-antibody conjugates
|
|
MX338711B
(es)
|
2012-10-12 |
2016-04-28 |
Medimmune Ltd |
Pirrolobenzodiazepinas y conjugados de las mismas.
|
|
ES2680153T3
(es)
|
2012-10-12 |
2018-09-04 |
Adc Therapeutics Sa |
Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
|
|
RS57694B1
(sr)
|
2012-10-12 |
2018-11-30 |
Adc Therapeutics Sa |
Pirolobenzodiazepin - anti-psma konjugati antitela
|
|
HRP20182129T1
(hr)
|
2012-10-12 |
2019-02-08 |
Adc Therapeutics Sa |
Konjugati protutijelo - pirolobenzodiazepin
|
|
CA2892863C
(en)
|
2012-12-10 |
2022-03-15 |
Mersana Therapeutics, Inc. |
Polymeric scaffold based on phf for targeted drug delivery
|
|
WO2014093640A1
(en)
|
2012-12-12 |
2014-06-19 |
Mersana Therapeutics,Inc. |
Hydroxy-polmer-drug-protein conjugates
|
|
CN105189507A
(zh)
|
2012-12-21 |
2015-12-23 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
CN110627797A
(zh)
|
2012-12-21 |
2019-12-31 |
麦迪穆有限责任公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
AU2014229529B2
(en)
|
2013-03-13 |
2018-02-15 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
TWI680766B
(zh)
|
2013-03-13 |
2020-01-01 |
英商梅迪繆思有限公司 |
吡咯并苯并二氮呯及其共軛物
|
|
KR102087850B1
(ko)
|
2013-10-11 |
2020-03-12 |
메르사나 테라퓨틱스, 인코포레이티드 |
단백질-고분자-약물 접합체
|
|
WO2015052535A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
EP3054983B1
(en)
|
2013-10-11 |
2019-03-20 |
Medimmune Limited |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
WO2015052534A1
(en)
|
2013-10-11 |
2015-04-16 |
Spirogen Sàrl |
Pyrrolobenzodiazepine-antibody conjugates
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
ES2754397T3
(es)
|
2013-10-11 |
2020-04-17 |
Asana Biosciences Llc |
Conjugados de proteína-polímero-fármaco
|
|
RU2686085C2
(ru)
|
2014-01-10 |
2019-04-24 |
Синтон Байофармасьютикалс Б. В. |
Конъюгаты антитело-лекарственное средство (adc) с дуокармицином, применяемые для лечения рака эндометрия
|
|
CA2935433C
(en)
|
2014-01-10 |
2019-04-02 |
Synthon Biopharmaceuticals B.V. |
Duocarmycin anti-her2 antibody drug conjucates with activity against her2 expressing malignancies
|
|
RU2680404C2
(ru)
|
2014-01-10 |
2019-02-21 |
Синтон Байофармасьютикалс Б. В. |
Способ очистки cys-связанных конъюгатов антитело-лекарственное средство
|
|
GB201416112D0
(en)
|
2014-09-12 |
2014-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CN107148285B
(zh)
|
2014-11-25 |
2022-01-04 |
Adc治疗股份有限公司 |
吡咯并苯并二氮杂䓬-抗体缀合物
|
|
GB201506411D0
(en)
|
2015-04-15 |
2015-05-27 |
Bergenbio As |
Humanized anti-axl antibodies
|
|
GB201506402D0
(en)
|
2015-04-15 |
2015-05-27 |
Berkel Patricius H C Van And Howard Philip W |
Site-specific antibody-drug conjugates
|
|
DE102016105449A1
(de)
*
|
2015-10-29 |
2017-05-04 |
Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts |
Bifunktionale Prodrugs
|
|
GB201601431D0
(en)
|
2016-01-26 |
2016-03-09 |
Medimmune Ltd |
Pyrrolobenzodiazepines
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
WO2018004338A1
(en)
|
2016-06-27 |
2018-01-04 |
Tagworks Pharmaceuticals B.V. |
Cleavable tetrazine used in bio-orthogonal drug activation
|
|
GB201617466D0
(en)
|
2016-10-14 |
2016-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepine conjugates
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
JP7185631B2
(ja)
|
2017-02-03 |
2022-12-07 |
サータ セラピューティクス プロプライエタリー リミテッド |
抗線維化化合物
|
|
GB201702031D0
(en)
|
2017-02-08 |
2017-03-22 |
Medlmmune Ltd |
Pyrrolobenzodiazepine-antibody conjugates
|
|
RS61795B1
(sr)
|
2017-02-08 |
2021-06-30 |
Adc Therapeutics Sa |
Konjugati pirolobenzodiazepin antitela
|
|
CN110582505B
(zh)
|
2017-04-18 |
2021-04-02 |
免疫医疗有限公司 |
吡咯并苯并二氮杂*缀合物
|
|
WO2018193102A1
(en)
|
2017-04-20 |
2018-10-25 |
Adc Therapeutics Sa |
Combination therapy with an anti-axl antibody-drug conjugate
|
|
CA3064804A1
(en)
|
2017-06-14 |
2018-12-20 |
Adc Therapeutics Sa |
Dosage regimes for the administration of an anti-cd19 adc
|
|
AU2018290330A1
(en)
|
2017-06-22 |
2020-01-02 |
Mersana Therapeutics, Inc. |
Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
|
|
KR102270107B1
(ko)
|
2017-08-18 |
2021-06-30 |
메디뮨 리미티드 |
피롤로벤조디아제핀 컨쥬게이트
|
|
GB201803342D0
(en)
|
2018-03-01 |
2018-04-18 |
Medimmune Ltd |
Methods
|
|
GB201806022D0
(en)
|
2018-04-12 |
2018-05-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
AU2019262520B2
(en)
|
2018-05-04 |
2025-07-10 |
Tagworks Pharmaceuticals B.V. |
Tetrazines for high click conjugation yield in vivo and high click release yield
|
|
CA3099421C
(en)
|
2018-05-04 |
2025-05-06 |
Tagworks Pharmaceuticals B.V. |
COMPOUNDS INCLUDING A BINDER TO INCREASE TRANSCYCLOOCTENE STABILITY
|
|
CN113365664A
(zh)
|
2018-10-29 |
2021-09-07 |
梅尔莎纳医疗公司 |
具有含肽接头的半胱氨酸工程化的抗体-药物缀合物
|
|
CN113631560B
(zh)
|
2019-03-15 |
2025-02-18 |
麦迪穆有限责任公司 |
氮杂环丁烷并苯并二氮杂䓬二聚体和用于治疗癌症的包含它们的缀合物
|
|
DK3983363T3
(da)
|
2019-06-17 |
2024-06-24 |
Tagworks Pharmaceuticals B V |
Forbindelser til hurtig og effektiv klikfrigivelse
|
|
IL289094A
(en)
|
2019-06-17 |
2022-02-01 |
Tagworks Pharmaceuticals B V |
Tetrazines for increasing the speed and yield of the "click release" reaction
|
|
WO2021040393A1
(ko)
*
|
2019-08-26 |
2021-03-04 |
국제약품 주식회사 |
인돌 카복사미드 유도체 및 그를 포함하는 약제학적 조성물
|
|
US20250327057A1
(en)
|
2021-09-06 |
2025-10-23 |
Veraxa Biotech Gmbh |
Novel aminoacyl-trna synthetase variants for genetic code expansion in eukaryotes
|
|
WO2023094525A1
(en)
|
2021-11-25 |
2023-06-01 |
Veraxa Biotech Gmbh |
Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
|
|
DK4186529T3
(da)
|
2021-11-25 |
2025-08-25 |
Veraxa Biotech Gmbh |
Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse
|
|
US20250135011A1
(en)
|
2021-12-08 |
2025-05-01 |
European Molecular Biology Laboratory |
Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
|
|
US20250114489A1
(en)
|
2022-02-15 |
2025-04-10 |
Tagworks Pharmaceuticals B.V. |
Masked il12 protein
|
|
CA3261603A1
(en)
|
2022-07-15 |
2024-01-18 |
Pheon Therapeutics Ltd |
ANTIBODY-DRUG CONJUGATES
|
|
WO2024080872A1
(en)
|
2022-10-12 |
2024-04-18 |
Tagworks Pharmaceuticals B.V. |
Strained bicyclononenes
|
|
WO2024153789A1
(en)
|
2023-01-20 |
2024-07-25 |
Basf Se |
Stabilized biopolymer composition, their manufacture and use
|
|
WO2024191293A1
(en)
|
2023-03-10 |
2024-09-19 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctene with improved t-linker
|
|
KR20260046464A
(ko)
|
2023-07-27 |
2026-04-07 |
베락사 바이오테크 게엠베하 |
친수성 트랜스-시클로옥텐(hyTCO) 화합물, 이를 포함하는 구조체 및 접합체
|
|
WO2025056807A1
(en)
|
2023-09-15 |
2025-03-20 |
Basf Se |
Stabilized biopolymer composition, their manufacture and use
|
|
WO2025149667A1
(en)
|
2024-01-12 |
2025-07-17 |
Pheon Therapeutics Ltd |
Antibody drug conjugates and uses thereof
|
|
WO2025174248A1
(en)
|
2024-02-16 |
2025-08-21 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctenes with "or gate" release
|
|
WO2026043376A1
(en)
|
2024-08-22 |
2026-02-26 |
Tagworks Pharmaceuticals B.V. |
Trans-cyclooctene formulations
|
|
WO2026078060A1
(en)
|
2024-10-08 |
2026-04-16 |
Basf Se |
Tocopherol alkoxylates for biopolymer stabilization
|