JP2012520321A5 - - Google Patents
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- Publication number
- JP2012520321A5 JP2012520321A5 JP2011554220A JP2011554220A JP2012520321A5 JP 2012520321 A5 JP2012520321 A5 JP 2012520321A5 JP 2011554220 A JP2011554220 A JP 2011554220A JP 2011554220 A JP2011554220 A JP 2011554220A JP 2012520321 A5 JP2012520321 A5 JP 2012520321A5
- Authority
- JP
- Japan
- Prior art keywords
- effective amount
- therapeutically effective
- difluoro
- pharmaceutical composition
- iodophenylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- RDSACQWTXKSHJT-NSHDSACASA-N n-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2s)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide Chemical compound C1CC1(C[C@H](O)CO)S(=O)(=O)NC=1C(OC)=CC(F)=C(F)C=1NC1=CC=C(I)C=C1F RDSACQWTXKSHJT-NSHDSACASA-N 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 24
- 239000011885 synergistic combination Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 14
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 8
- -1 6,7-bis (2-methoxyethoxy) quinazolin-4-ylamino Chemical group 0.000 claims 6
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 claims 5
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 4
- 201000002510 thyroid cancer Diseases 0.000 claims 4
- DYPIHQVLLQBLGP-UHFFFAOYSA-N 2-(3-morpholin-4-ylpropoxy)quinazolin-4-amine Chemical compound N=1C2=CC=CC=C2C(N)=NC=1OCCCN1CCOCC1 DYPIHQVLLQBLGP-UHFFFAOYSA-N 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 239000004593 Epoxy Substances 0.000 claims 3
- UWYXLGUQQFPJRI-UHFFFAOYSA-N n-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.CC1=CC=C(S(O)(=O)=O)C=C1.O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 UWYXLGUQQFPJRI-UHFFFAOYSA-N 0.000 claims 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 238000011374 additional therapy Methods 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- QJIHCROKGYMFNF-UHFFFAOYSA-N 3-[[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amino]benzonitrile Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#N)=C1 QJIHCROKGYMFNF-UHFFFAOYSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- AKWHREAVLKZDDE-UHFFFAOYSA-N hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone Chemical compound CCCCCCCC=CC=CC=CCCCC(=O)CCC=CCC(=O)CCCC(=O)CCCCCCC(=O)C(C)=O AKWHREAVLKZDDE-UHFFFAOYSA-N 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 claims 1
- RFRJWGMOFBZAKC-DWCOZBPGSA-N CCC(/C=C\N([C@@H](C1(F)F)O[C@H](CO)C1O)C(N)=O)N Chemical compound CCC(/C=C\N([C@@H](C1(F)F)O[C@H](CO)C1O)C(N)=O)N RFRJWGMOFBZAKC-DWCOZBPGSA-N 0.000 description 1
- SSEZZHCCCUDIHL-UHFFFAOYSA-N CN(C([n]1c(N)c(C(N)=O)nc1)=O)N Chemical compound CN(C([n]1c(N)c(C(N)=O)nc1)=O)N SSEZZHCCCUDIHL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15940309P | 2009-03-11 | 2009-03-11 | |
| US61/159,403 | 2009-03-11 | ||
| PCT/US2010/027060 WO2010105110A1 (en) | 2009-03-11 | 2010-03-11 | Pharmaceutical combinations comprising rdea119/bay 869766 for the treatment of specific cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014180216A Division JP5911929B2 (ja) | 2009-03-11 | 2014-09-04 | 特定の癌の治療のためのｒｄｅａ１１９／ｂａｙ８６９７６６を含む組み合わせ医薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012520321A JP2012520321A (ja) | 2012-09-06 |
| JP2012520321A5 true JP2012520321A5 (https=) | 2013-04-04 |
| JP5767122B2 JP5767122B2 (ja) | 2015-08-19 |
Family
ID=42135921
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554220A Expired - Fee Related JP5767122B2 (ja) | 2009-03-11 | 2010-03-11 | 特定の癌の治療のためのｒｄｅａ１１９／ｂａｙ８６９７６６を含む組み合わせ医薬 |
| JP2014180216A Expired - Fee Related JP5911929B2 (ja) | 2009-03-11 | 2014-09-04 | 特定の癌の治療のためのｒｄｅａ１１９／ｂａｙ８６９７６６を含む組み合わせ医薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014180216A Expired - Fee Related JP5911929B2 (ja) | 2009-03-11 | 2014-09-04 | 特定の癌の治療のためのｒｄｅａ１１９／ｂａｙ８６９７６６を含む組み合わせ医薬 |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8673876B2 (https=) |
| EP (1) | EP2405908B1 (https=) |
| JP (2) | JP5767122B2 (https=) |
| KR (1) | KR20110132371A (https=) |
| CN (2) | CN103948600A (https=) |
| AU (1) | AU2010224044A1 (https=) |
| BR (1) | BRPI1009448A2 (https=) |
| CA (2) | CA2972379A1 (https=) |
| CL (1) | CL2011002233A1 (https=) |
| CO (1) | CO6430423A2 (https=) |
| CR (1) | CR20110479A (https=) |
| CU (1) | CU20110170A7 (https=) |
| DO (1) | DOP2011000282A (https=) |
| EA (1) | EA201101302A1 (https=) |
| EC (1) | ECSP11011314A (https=) |
| HK (1) | HK1199710A1 (https=) |
| IL (1) | IL214749A0 (https=) |
| MA (1) | MA33091B1 (https=) |
| MX (1) | MX2011009498A (https=) |
| PE (1) | PE20120105A1 (https=) |
| SG (1) | SG174272A1 (https=) |
| TN (1) | TN2011000455A1 (https=) |
| WO (1) | WO2010105110A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| SG190568A1 (en) | 2008-09-26 | 2013-06-28 | Oncomed Pharm Inc | Frizzled-binding agents and uses thereof |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| WO2013001372A2 (en) * | 2011-06-30 | 2013-01-03 | University Of Oslo | Methods and compositions for inhibition of activation of regulatory t cells |
| EP2788378A4 (en) * | 2011-12-09 | 2015-09-09 | Oncomed Pharm Inc | COMBINATION THERAPY FOR CANCER TREATMENT |
| US20150265679A1 (en) | 2012-11-02 | 2015-09-24 | The United States Of America, As Represented By Secretary, Department Of Health And Human Services | Method of reducing adverse effects in a cancer patient undregoing treatment with a mek inhibitor |
| AU2014212081A1 (en) | 2013-02-04 | 2015-08-13 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
| EP3043778B1 (en) * | 2013-09-13 | 2017-09-06 | Bayer Pharma Aktiengesellschaft | Pharmaceutical compositions containing refametinib |
| EP2848246A1 (en) * | 2013-09-13 | 2015-03-18 | Bayer Pharma Aktiengesellschaft | Pharmaceutical compositions containing refametinib |
| US20170114323A1 (en) | 2014-06-19 | 2017-04-27 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9925958D0 (en) * | 1999-11-02 | 1999-12-29 | Bundred Nigel J | Therapeutic use |
| WO2002039958A2 (en) * | 2000-11-03 | 2002-05-23 | Tularik Inc. | Combination therapy using pentafluorobenzenesulfonamides and antineoplastic agents |
| AU2002340139A1 (en) * | 2001-10-09 | 2003-04-22 | The University Of Cincinnati | Inhibitors of the egf receptor for the treatment of thyroid cancer |
| KR20060022647A (ko) * | 2003-04-25 | 2006-03-10 | 길리애드 사이언시즈, 인코포레이티드 | 키나아제 억제 포스포네이트 유사체 |
| WO2006066267A2 (en) * | 2004-12-17 | 2006-06-22 | Smithkline Beecham (Cork) Limited | Cancer treatment method |
| WO2006076463A2 (en) * | 2005-01-12 | 2006-07-20 | Amgen Inc. | Kinase-directed, activity-based probes |
| JP5106098B2 (ja) * | 2005-02-28 | 2012-12-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホンアミド化合物の抗癌剤との新規併用 |
| CA2618218C (en) * | 2005-07-21 | 2015-06-30 | Ardea Biosciences, Inc. | N-(arylamino)-sulfonamide inhibitors of mek |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| US8329421B2 (en) | 2007-07-13 | 2012-12-11 | Ventana Medical Systems, Inc. | Methods of predicting response of a neoplasm to an EGFR inhibitor and detecting interactions between EGFR and an EGFR regulatory protein |
| EA032294B1 (ru) | 2007-07-30 | 2019-05-31 | Арди Байосайенсиз, Инк. | Способ получения полиморфной формы производного n-(ариламино)сульфонамида, фармацевтическая композиция, содержащая указанное производное, и способ лечения с помощью указанного производного |
| CA2924436A1 (en) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Pharmaceutical combinations of n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide as inhibitors of mek and methods of use |
| US8044240B2 (en) * | 2008-03-06 | 2011-10-25 | Ardea Biosciences Inc. | Polymorphic form of N-(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and uses thereof |
| DE102008031039A1 (de) * | 2008-06-30 | 2009-12-31 | Dömling, Alexander, Priv.-Doz. Dr. | Tarceva zur Anwendung in der Organtransplantation. |
-
2010
- 2010-03-11 WO PCT/US2010/027060 patent/WO2010105110A1/en not_active Ceased
- 2010-03-11 KR KR1020117021234A patent/KR20110132371A/ko not_active Withdrawn
- 2010-03-11 CN CN201310462579.9A patent/CN103948600A/zh active Pending
- 2010-03-11 CN CN2010800209977A patent/CN102421427B/zh not_active Expired - Fee Related
- 2010-03-11 SG SG2011064300A patent/SG174272A1/en unknown
- 2010-03-11 CA CA2972379A patent/CA2972379A1/en not_active Abandoned
- 2010-03-11 EP EP10709139.9A patent/EP2405908B1/en active Active
- 2010-03-11 AU AU2010224044A patent/AU2010224044A1/en not_active Abandoned
- 2010-03-11 US US13/255,278 patent/US8673876B2/en not_active Expired - Fee Related
- 2010-03-11 JP JP2011554220A patent/JP5767122B2/ja not_active Expired - Fee Related
- 2010-03-11 EA EA201101302A patent/EA201101302A1/ru unknown
- 2010-03-11 BR BRPI1009448A patent/BRPI1009448A2/pt not_active IP Right Cessation
- 2010-03-11 PE PE2011001622A patent/PE20120105A1/es not_active Application Discontinuation
- 2010-03-11 MA MA34134A patent/MA33091B1/fr unknown
- 2010-03-11 CA CA2754913A patent/CA2754913C/en not_active Expired - Fee Related
- 2010-03-11 MX MX2011009498A patent/MX2011009498A/es not_active Application Discontinuation
-
2011
- 2011-08-18 IL IL214749A patent/IL214749A0/en unknown
- 2011-09-09 DO DO2011000282A patent/DOP2011000282A/es unknown
- 2011-09-09 CO CO11116967A patent/CO6430423A2/es not_active Application Discontinuation
- 2011-09-09 TN TN2011000455A patent/TN2011000455A1/fr unknown
- 2011-09-09 CL CL2011002233A patent/CL2011002233A1/es unknown
- 2011-09-09 EC EC2011011314A patent/ECSP11011314A/es unknown
- 2011-09-09 CR CR20110479A patent/CR20110479A/es unknown
- 2011-09-09 CU CU20110170A patent/CU20110170A7/es unknown
-
2013
- 2013-11-18 US US14/082,681 patent/US9220696B2/en not_active Expired - Fee Related
-
2014
- 2014-09-04 JP JP2014180216A patent/JP5911929B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-08 HK HK15100195.6A patent/HK1199710A1/xx unknown
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