MX2020011294A - Derivados de 2-amino-piridina o 2-amino-pirimidina como inhibidores de cinasa dependientes de ciclina. - Google Patents
Derivados de 2-amino-piridina o 2-amino-pirimidina como inhibidores de cinasa dependientes de ciclina.Info
- Publication number
- MX2020011294A MX2020011294A MX2020011294A MX2020011294A MX2020011294A MX 2020011294 A MX2020011294 A MX 2020011294A MX 2020011294 A MX2020011294 A MX 2020011294A MX 2020011294 A MX2020011294 A MX 2020011294A MX 2020011294 A MX2020011294 A MX 2020011294A
- Authority
- MX
- Mexico
- Prior art keywords
- amino
- pyridine
- kinase inhibitors
- dependent kinase
- pyrimidine derivatives
- Prior art date
Links
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical compound NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 title 2
- 150000005006 2-aminopyrimidines Chemical class 0.000 title 1
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title 1
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Esta invención se relaciona con compuestos de la Fórmula (I) (ver Fórmula), o una sal farmacéuticamente aceptable del mismo, en la cual los grupos-R R1 a R23, A, Q, U, V, W, X, Y, Z, n, p y q son como se definen en la presente, con composiciones farmacéuticas que comprenden tales compuestos y sales, y con métodos para utilizar tales compuestos, sales y composiciones para el tratamiento de crecimiento celular anormal, que incluye cáncer, en un sujeto.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862663096P | 2018-04-26 | 2018-04-26 | |
| US201862750454P | 2018-10-25 | 2018-10-25 | |
| US201962826609P | 2019-03-29 | 2019-03-29 | |
| PCT/IB2019/053314 WO2019207463A1 (en) | 2018-04-26 | 2019-04-22 | 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020011294A true MX2020011294A (es) | 2020-11-18 |
Family
ID=66676856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020011294A MX2020011294A (es) | 2018-04-26 | 2019-04-22 | Derivados de 2-amino-piridina o 2-amino-pirimidina como inhibidores de cinasa dependientes de ciclina. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10766884B2 (es) |
| EP (1) | EP3784664A1 (es) |
| JP (2) | JP7089061B2 (es) |
| KR (1) | KR102596598B1 (es) |
| AU (1) | AU2019259653B2 (es) |
| BR (1) | BR112020021689B1 (es) |
| CA (1) | CA3098283C (es) |
| CL (1) | CL2020002748A1 (es) |
| CO (1) | CO2020013149A2 (es) |
| CR (1) | CR20200503A (es) |
| CU (1) | CU20200070A7 (es) |
| DO (1) | DOP2020000191A (es) |
| EC (1) | ECSP20067394A (es) |
| GE (1) | GEP20227433B (es) |
| IL (1) | IL278075B2 (es) |
| MA (1) | MA52360A (es) |
| MX (1) | MX2020011294A (es) |
| NI (1) | NI202000072A (es) |
| PE (1) | PE20201202A1 (es) |
| PH (1) | PH12020551692A1 (es) |
| RU (1) | RU2762557C1 (es) |
| SG (1) | SG11202009992VA (es) |
| TW (1) | TWI740135B (es) |
| UA (1) | UA126177C2 (es) |
| UY (1) | UY38196A (es) |
| WO (1) | WO2019207463A1 (es) |
| ZA (1) | ZA202006944B (es) |
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| EP4119558A1 (en) | 2016-09-09 | 2023-01-18 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| TW201811799A (zh) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | 吡唑并嘧啶化合物及其用途 |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| LT3755703T (lt) | 2018-02-20 | 2022-10-10 | Incyte Corporation | N-(fenil)-2-(fenil)pirimidin-4-karboksamido dariniai ir susiję junginiai, kaip hpk1 inhibitoriai, skirti vėžio gydymui |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| UA126177C2 (uk) | 2018-04-26 | 2022-08-25 | Пфайзер Інк. | Похідні 2-амінопіридину або 2-амінопіримідину як інгібітори циклінзалежної кінази |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| JP2022543155A (ja) | 2019-08-06 | 2022-10-07 | インサイト・コーポレイション | Ｈｐｋ１阻害剤の固体形態 |
| CN116348458A (zh) | 2019-08-14 | 2023-06-27 | 因赛特公司 | 作为cdk2抑制剂的咪唑基嘧啶基胺化合物 |
| US11038699B2 (en) | 2019-08-29 | 2021-06-15 | Advanced New Technologies Co., Ltd. | Method and apparatus for performing multi-party secure computing based-on issuing certificate |
| US11851426B2 (en) | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| BR112023000687A2 (pt) | 2020-07-15 | 2023-02-07 | Pfizer | Métodos e combinações de inibidores de kat6 para o tratamento de câncer |
| CA3188821A1 (en) | 2020-08-13 | 2022-02-17 | Lars ANDERS | Combination therapy |
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| JP7260606B2 (ja) * | 2020-09-15 | 2023-04-18 | ファイザー・インク | 固体形態のｃｄｋ４阻害薬 |
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| WO2022149057A1 (en) * | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
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| CN109843872B (zh) | 2017-09-20 | 2022-08-30 | 杭州英创医药科技有限公司 | 作为ido抑制剂和/或ido-hdac双重抑制剂的多环化合物 |
| UA126177C2 (uk) | 2018-04-26 | 2022-08-25 | Пфайзер Інк. | Похідні 2-амінопіридину або 2-амінопіримідину як інгібітори циклінзалежної кінази |
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2019
- 2019-04-22 UA UAA202006733A patent/UA126177C2/uk unknown
- 2019-04-22 RU RU2020134811A patent/RU2762557C1/ru active
- 2019-04-22 CA CA3098283A patent/CA3098283C/en active Active
- 2019-04-22 AU AU2019259653A patent/AU2019259653B2/en active Active
- 2019-04-22 PE PE2020001635A patent/PE20201202A1/es unknown
- 2019-04-22 KR KR1020207033931A patent/KR102596598B1/ko active Application Filing
- 2019-04-22 JP JP2020560277A patent/JP7089061B2/ja active Active
- 2019-04-22 BR BR112020021689-5A patent/BR112020021689B1/pt active IP Right Grant
- 2019-04-22 EP EP19727502.7A patent/EP3784664A1/en active Pending
- 2019-04-22 CU CU2020000070A patent/CU20200070A7/es unknown
- 2019-04-22 WO PCT/IB2019/053314 patent/WO2019207463A1/en active Application Filing
- 2019-04-22 GE GEAP201915475A patent/GEP20227433B/en unknown
- 2019-04-22 MX MX2020011294A patent/MX2020011294A/es unknown
- 2019-04-22 CR CR20200503A patent/CR20200503A/es unknown
- 2019-04-22 SG SG11202009992VA patent/SG11202009992VA/en unknown
- 2019-04-22 MA MA052360A patent/MA52360A/fr unknown
- 2019-04-23 TW TW108114112A patent/TWI740135B/zh active
- 2019-04-23 US US16/391,836 patent/US10766884B2/en active Active
- 2019-04-24 UY UY0001038196A patent/UY38196A/es unknown
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2020
- 2020-07-29 US US16/942,209 patent/US11220494B2/en active Active
- 2020-10-13 PH PH12020551692A patent/PH12020551692A1/en unknown
- 2020-10-15 IL IL278075A patent/IL278075B2/en unknown
- 2020-10-21 CO CONC2020/0013149A patent/CO2020013149A2/es unknown
- 2020-10-21 EC ECSENADI202067394A patent/ECSP20067394A/es unknown
- 2020-10-22 NI NI202000072A patent/NI202000072A/es unknown
- 2020-10-23 CL CL2020002748A patent/CL2020002748A1/es unknown
- 2020-10-23 DO DO2020000191A patent/DOP2020000191A/es unknown
- 2020-11-06 ZA ZA2020/06944A patent/ZA202006944B/en unknown
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2021
- 2021-12-07 US US17/544,303 patent/US20220089580A1/en active Pending
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2022
- 2022-06-09 JP JP2022093962A patent/JP2022120096A/ja active Pending
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