JPWO2019150305A5 - - Google Patents
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- JPWO2019150305A5 JPWO2019150305A5 JP2020542110A JP2020542110A JPWO2019150305A5 JP WO2019150305 A5 JPWO2019150305 A5 JP WO2019150305A5 JP 2020542110 A JP2020542110 A JP 2020542110A JP 2020542110 A JP2020542110 A JP 2020542110A JP WO2019150305 A5 JPWO2019150305 A5 JP WO2019150305A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- mutant
- pharmaceutical composition
- patient
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862624829P | 2018-02-01 | 2018-02-01 | |
US62/624,829 | 2018-02-01 | ||
US201862685383P | 2018-06-15 | 2018-06-15 | |
US62/685,383 | 2018-06-15 | ||
US201962795062P | 2019-01-22 | 2019-01-22 | |
US62/795,062 | 2019-01-22 | ||
PCT/IB2019/050795 WO2019150305A1 (en) | 2018-02-01 | 2019-01-31 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2021512131A JP2021512131A (ja) | 2021-05-13 |
JPWO2019150305A5 true JPWO2019150305A5 (sr) | 2022-02-08 |
JP7317028B2 JP7317028B2 (ja) | 2023-07-28 |
Family
ID=65685851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020542110A Active JP7317028B2 (ja) | 2018-02-01 | 2019-01-31 | 抗ガン剤として有用な置換キナゾリン誘導体と置換ピリドピリミジン誘導体 |
Country Status (8)
Country | Link |
---|---|
US (1) | US10662204B2 (sr) |
EP (1) | EP3746435B1 (sr) |
JP (1) | JP7317028B2 (sr) |
CA (1) | CA3089936C (sr) |
ES (1) | ES2926373T3 (sr) |
TW (1) | TW201942115A (sr) |
UY (1) | UY38070A (sr) |
WO (1) | WO2019150305A1 (sr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109843856B (zh) | 2016-05-18 | 2023-05-02 | 米拉蒂治疗股份有限公司 | Kras g12c抑制剂 |
KR20200100632A (ko) | 2017-11-15 | 2020-08-26 | 미라티 테라퓨틱스, 인크. | Kras g12c 억제제 |
US10647715B2 (en) | 2017-11-15 | 2020-05-12 | Mirati Therapeutics, Inc. | KRas G12C inhibitors |
TW202012415A (zh) | 2018-05-08 | 2020-04-01 | 瑞典商阿斯特捷利康公司 | 化學化合物 |
IL282916B1 (en) | 2018-11-09 | 2024-05-01 | Hoffmann La Roche | United Cyclic Chemical Compounds and Their Uses in the Treatment of RAS-Mediated Disorders |
CN113382774A (zh) | 2019-02-12 | 2021-09-10 | 诺华股份有限公司 | 包含tno155和krasg12c抑制剂的药物组合 |
CN112390788A (zh) * | 2019-08-13 | 2021-02-23 | 苏州闻天医药科技有限公司 | 一种用于抑制krasg12c突变蛋白的化合物及其制备方法和用途 |
US20220363681A1 (en) * | 2019-08-16 | 2022-11-17 | Genfleet Therapeutics (Shanghai) Inc. | Oxo six-membered cyclopyrimidine compound, preparation method and medical use thereof |
CN112390796B (zh) * | 2019-08-19 | 2023-06-27 | 贝达药业股份有限公司 | Kras g12c抑制剂及其在医药上的应用 |
CN112694475A (zh) * | 2019-10-23 | 2021-04-23 | 苏州泽璟生物制药股份有限公司 | 环烷基类和杂环烷基类抑制剂及其制备方法和应用 |
JP2022553859A (ja) | 2019-11-04 | 2022-12-26 | レボリューション メディシンズ インコーポレイテッド | Ras阻害剤 |
CN115894606A (zh) | 2019-11-04 | 2023-04-04 | 锐新医药公司 | Ras抑制剂 |
BR112022008534A2 (pt) | 2019-11-04 | 2022-08-09 | Revolution Medicines Inc | Compostos, composição farmacêutica, conjugado e métodos para tratar câncer e para tratar um distúrbio relacionado à proteína ras |
CN112851663B (zh) * | 2019-11-12 | 2023-07-18 | 博瑞生物医药(苏州)股份有限公司 | 一种并杂环化合物及其用途 |
JP2023505100A (ja) | 2019-11-27 | 2023-02-08 | レボリューション メディシンズ インコーポレイテッド | 共有ras阻害剤及びその使用 |
CA3163218A1 (en) * | 2019-12-02 | 2021-06-10 | Shanghai Yingli Pharmaceutical Co., Ltd | Oxygen-containing heterocyclic compound, preparation method therefor and use thereof |
CA3163338A1 (en) * | 2019-12-04 | 2021-06-10 | Arcus Biosciences, Inc. | Inhibitors of hif-2alpha |
CN113024544A (zh) * | 2019-12-09 | 2021-06-25 | 武汉誉祥医药科技有限公司 | 一种含氰基并杂环化合物及其用途 |
MX2022009025A (es) | 2020-01-28 | 2022-10-07 | Protego Biopharma Inc | Compuestos, composiciones y métodos para estabilizar la transtiretina e inhibir el plegamiento incorrecto de la transtiretina. |
WO2021169990A1 (zh) * | 2020-02-24 | 2021-09-02 | 泰励生物科技(上海)有限公司 | 用于癌症治疗的kras抑制剂 |
IL295569A (en) | 2020-03-19 | 2022-10-01 | Arcus Biosciences Inc | Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha |
CA3178129A1 (en) * | 2020-04-17 | 2021-10-21 | Dong-A St Co., Ltd. | Pyridopyrimidinone derivatives and their use as aryl hydrocarbon receptor modulators |
IL299131A (en) | 2020-06-18 | 2023-02-01 | Revolution Medicines Inc | Methods for delaying, preventing and treating acquired resistance to RAS inhibitors |
WO2022060583A1 (en) | 2020-09-03 | 2022-03-24 | Revolution Medicines, Inc. | Use of sos1 inhibitors to treat malignancies with shp2 mutations |
US11690915B2 (en) | 2020-09-15 | 2023-07-04 | Revolution Medicines, Inc. | Ras inhibitors |
WO2022133345A1 (en) | 2020-12-18 | 2022-06-23 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
US20240100172A1 (en) | 2020-12-21 | 2024-03-28 | Hangzhou Jijing Pharmaceutical Technology Limited | Methods and compounds for targeted autophagy |
WO2022152313A1 (zh) * | 2021-01-18 | 2022-07-21 | 成都百裕制药股份有限公司 | 嘧啶衍生物及其在医药上的应用 |
CN113072480B (zh) * | 2021-04-13 | 2022-09-30 | 常州佳德医药科技有限公司 | 一种手性(-)-5-氮杂螺[2.4]庚烷-7-醇、制备方法及应用 |
WO2022235870A1 (en) | 2021-05-05 | 2022-11-10 | Revolution Medicines, Inc. | Ras inhibitors for the treatment of cancer |
AR125782A1 (es) | 2021-05-05 | 2023-08-16 | Revolution Medicines Inc | Inhibidores de ras |
KR20240013776A (ko) * | 2021-05-28 | 2024-01-30 | 레드엑스 파마 피엘씨 | Kras 돌연변이 단백질을 억제할 수 있는 피리도[4,3-d]피리미딘 화합물 |
TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途 |
WO2023009585A2 (en) | 2021-07-28 | 2023-02-02 | Protego Biopharma, Inc. | Transthyretin stabilizing compounds |
TW202327569A (zh) | 2021-09-01 | 2023-07-16 | 瑞士商諾華公司 | 包含tead抑制劑的藥物組合及其用於癌症治療之用途 |
US20230143938A1 (en) * | 2021-10-01 | 2023-05-11 | Incyte Corporation | Pyrazoloquinoline kras inhibitors |
AR127308A1 (es) | 2021-10-08 | 2024-01-10 | Revolution Medicines Inc | Inhibidores ras |
WO2023064857A1 (en) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
TW202340214A (zh) | 2021-12-17 | 2023-10-16 | 美商健臻公司 | 做為shp2抑制劑之吡唑并吡𠯤化合物 |
WO2023154124A1 (en) * | 2022-02-09 | 2023-08-17 | Enliven Therapeutics, Inc. | Acylated heterocyclic quinazoline derivatives as inhibitors of erbb2 |
EP4227307A1 (en) | 2022-02-11 | 2023-08-16 | Genzyme Corporation | Pyrazolopyrazine compounds as shp2 inhibitors |
WO2023172940A1 (en) | 2022-03-08 | 2023-09-14 | Revolution Medicines, Inc. | Methods for treating immune refractory lung cancer |
WO2023199180A1 (en) | 2022-04-11 | 2023-10-19 | Novartis Ag | Therapeutic uses of a krasg12c inhibitor |
WO2023205701A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc. | Macrocyclic heterocycles and uses thereof |
WO2023240263A1 (en) | 2022-06-10 | 2023-12-14 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
WO2024006379A1 (en) * | 2022-06-30 | 2024-01-04 | Axonis Therapeutics, Inc. | Methods and compounds for inhibiting mkk7 enzymes |
WO2024040131A1 (en) | 2022-08-17 | 2024-02-22 | Treeline Biosciences, Inc. | Pyridopyrimidine kras inhibitors |
WO2024102421A2 (en) | 2022-11-09 | 2024-05-16 | Revolution Medicines, Inc. | Compounds, complexes, and methods for their preparation and of their use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0166088B1 (ko) | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
WO2000035298A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Chewing gum containing medicament active agents |
GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
DK2780039T3 (en) | 2011-11-17 | 2018-01-15 | Pfizer | Cytotoxic peptides and antibody-drug conjugates thereof |
KR20160076519A (ko) | 2013-10-10 | 2016-06-30 | 아락세스 파마 엘엘씨 | Kras g12c 억제제 |
JP2018513853A (ja) | 2015-04-10 | 2018-05-31 | アラクセス ファーマ エルエルシー | 置換キナゾリン化合物およびその使用方法 |
WO2017015562A1 (en) * | 2015-07-22 | 2017-01-26 | Araxes Pharma Llc | Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins |
EA038635B9 (ru) * | 2015-11-16 | 2021-10-26 | Араксис Фарма Ллк | 2-замещенные соединения хиназолина, содержащие замещенную гетероциклическую группу, и способы их применения |
CN109843856B (zh) * | 2016-05-18 | 2023-05-02 | 米拉蒂治疗股份有限公司 | Kras g12c抑制剂 |
-
2019
- 2019-01-29 TW TW108103302A patent/TW201942115A/zh unknown
- 2019-01-31 ES ES19709113T patent/ES2926373T3/es active Active
- 2019-01-31 US US16/263,185 patent/US10662204B2/en active Active
- 2019-01-31 CA CA3089936A patent/CA3089936C/en active Active
- 2019-01-31 WO PCT/IB2019/050795 patent/WO2019150305A1/en unknown
- 2019-01-31 EP EP19709113.5A patent/EP3746435B1/en active Active
- 2019-01-31 UY UY38070A patent/UY38070A/es unknown
- 2019-01-31 JP JP2020542110A patent/JP7317028B2/ja active Active
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