JPS6350332B2 - - Google Patents

Info

Publication number
JPS6350332B2
JPS6350332B2 JP54144561A JP14456179A JPS6350332B2 JP S6350332 B2 JPS6350332 B2 JP S6350332B2 JP 54144561 A JP54144561 A JP 54144561A JP 14456179 A JP14456179 A JP 14456179A JP S6350332 B2 JPS6350332 B2 JP S6350332B2
Authority
JP
Japan
Prior art keywords
detergent
solution
neisseria meningitidis
minutes
sodium desoxycholate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54144561A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5566519A (en
Inventor
Beruteiru Heruteingu Torusuten
Guteerurain Geruharuto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of JPS5566519A publication Critical patent/JPS5566519A/ja
Publication of JPS6350332B2 publication Critical patent/JPS6350332B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP14456179A 1978-11-11 1979-11-09 Manufacture of membrane protein and vaccine containing it Granted JPS5566519A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782848965 DE2848965A1 (de) 1978-11-11 1978-11-11 Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine

Publications (2)

Publication Number Publication Date
JPS5566519A JPS5566519A (en) 1980-05-20
JPS6350332B2 true JPS6350332B2 (esLanguage) 1988-10-07

Family

ID=6054405

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14456179A Granted JPS5566519A (en) 1978-11-11 1979-11-09 Manufacture of membrane protein and vaccine containing it

Country Status (9)

Country Link
EP (1) EP0011243B1 (esLanguage)
JP (1) JPS5566519A (esLanguage)
AT (1) ATE857T1 (esLanguage)
AU (1) AU533386B2 (esLanguage)
CA (1) CA1142083A (esLanguage)
DE (2) DE2848965A1 (esLanguage)
DK (1) DK154841C (esLanguage)
ES (1) ES485715A1 (esLanguage)
IL (1) IL58673A (esLanguage)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4317811A (en) 1980-09-11 1982-03-02 Merck & Co., Inc. Herpes simplex type 1 subunit vaccine
CA1221626A (en) * 1982-12-02 1987-05-12 Milan Blake Iga binding protein
US7118757B1 (en) 1988-12-19 2006-10-10 Wyeth Holdings Corporation Meningococcal class 1 outer-membrane protein vaccine
DE69934225T2 (de) 1998-05-29 2007-09-27 Novartis Vaccines and Diagnostics, Inc., Emeryville Kombinierte meningitis b/c impfstoffe
ES2563650T3 (es) 1999-05-19 2016-03-15 Glaxosmithkline Biologicals Sa Composiciones de combinaciones de Neisseria
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
PT1248647E (pt) 2000-01-17 2010-11-18 Novartis Vaccines & Diagnostics Srl Vacina de vesícula da membrana externa (omv) compreendendo proteínas de membrana externa de n. meningitidis do serogrupo b
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
EP1524992B1 (en) 2002-08-02 2015-03-04 GlaxoSmithKline Biologicals s.a. Vaccine compositions comprising l2 and/or l3 immunotype lipooligosaccharides from lgtb- neisseria menigitidis
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
CU23313A1 (es) 2002-11-27 2008-09-25 Inst Finlay Ct De Investigacia Mã0/00todo de obtenciã"n de estructuras cocleares. composiciones vacunales y adyuvantes basados en estructuras cocleares y sus intermediarios
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
CA2550927A1 (en) * 2003-12-23 2005-07-14 Glaxosmithkline Biologicals S.A. A gram negative bacterium with reduced lps level in the outer membrane and use thereof for treating gram negative bacterial infection
GB0419627D0 (en) 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
GB0424092D0 (en) 2004-10-29 2004-12-01 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
US20090123499A1 (en) 2006-06-12 2009-05-14 Nathalie Devos Vaccine
BR122016015627A2 (pt) 2007-10-19 2018-10-30 Novartis Ag kit, composição antigênica liofilizada e método para preparação de uma composição imunogênica
CA2716212A1 (en) 2008-02-21 2009-08-27 Novartis Ag Meningococcal fhbp polypeptides
GB0822634D0 (en) 2008-12-11 2009-01-21 Novartis Ag Meningitis vaccines
WO2010070453A2 (en) 2008-12-17 2010-06-24 Novartis Ag Meningococcal vaccines including hemoglobin receptor
US9517263B2 (en) 2009-06-10 2016-12-13 Glaxosmithkline Biologicals Sa Benzonaphthyridine-containing vaccines
EP3017828A1 (en) 2009-08-27 2016-05-11 GlaxoSmithKline Biologicals SA Hybrid polypeptides including meningococcal fhbp sequences
EP2470205A1 (en) 2009-08-27 2012-07-04 Novartis AG Adjuvant comprising aluminium, oligonucleotide and polycation
TWI445708B (zh) 2009-09-02 2014-07-21 Irm Llc 作為ｔｌｒ活性調節劑之化合物及組合物
GB0917003D0 (en) 2009-09-28 2009-11-11 Novartis Vaccines Inst For Global Health Srl Purification of bacterial vesicles
EP2483390A2 (en) 2009-09-30 2012-08-08 Novartis AG Expression of meningococcal fhbp polypeptides
CN102917730A (zh) 2009-10-27 2013-02-06 诺华有限公司 修饰的脑膜炎球菌fHBP多肽
WO2011057148A1 (en) 2009-11-05 2011-05-12 Irm Llc Compounds and compositions as tlr-7 activity modulators
CN102762206A (zh) 2009-12-15 2012-10-31 诺华有限公司 免疫增强化合物的均匀悬液及其用途
US20130004530A1 (en) 2010-03-10 2013-01-03 Jan Poolman Vaccine composition
WO2012020326A1 (en) 2010-03-18 2012-02-16 Novartis Ag Adjuvanted vaccines for serogroup b meningococcus
EA023725B1 (ru) 2010-03-23 2016-07-29 Новартис Аг Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний
GB201015132D0 (en) 2010-09-10 2010-10-27 Univ Bristol Vaccine composition
AU2011300418B2 (en) 2010-09-10 2016-05-12 Glaxosmithkline Biologicals Sa Meningococcus overexpressing NadA and/or NHBA and outer membrane vesicles derived therefrom
WO2012153302A1 (en) 2011-05-12 2012-11-15 Novartis Ag Antipyretics to enhance tolerability of vesicle-based vaccines
ES2654613T3 (es) 2012-02-02 2018-02-14 Glaxosmithkline Biologicals Sa Promotores para una expresión aumentada de proteínas en meningococos
JP2015517089A (ja) 2012-03-08 2015-06-18 ノバルティス アーゲー タンパク質ベースの髄膜炎菌ワクチンのためのインビトロ有効性アッセイ
NZ630133A (en) 2012-06-14 2016-10-28 Novartis Ag Vaccines for serogroup x meningococcus
CA2882619A1 (en) 2012-09-06 2014-03-13 Novartis Ag Combination vaccines with serogroup b meningococcus and d/t/p
JP6283674B2 (ja) 2012-09-18 2018-02-21 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 外膜小胞
RS61246B1 (sr) 2014-02-28 2021-01-29 Glaxosmithkline Biologicals Sa Modifikovani meningokokni fhbp polipeptidi
US12161707B2 (en) 2016-09-02 2024-12-10 Glaxosmithkline Biologicals Sa Vaccines for Neisseria gonorrhoeae
AU2018330322A1 (en) 2017-09-08 2020-03-19 Evelo Biosciences, Inc. Bacterial extracellular vesicles
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
CA3117867A1 (en) 2018-11-06 2020-05-14 Glaxosmithkline Biologicals Sa Immunogenic compositions
EP3799884A1 (en) 2019-10-01 2021-04-07 GlaxoSmithKline Biologicals S.A. Immunogenic compositions
GB202115072D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Assay
GB202115077D0 (en) 2021-10-21 2021-12-08 Glaxosmithkline Biologicals Sa Assay
GB202211033D0 (en) 2022-07-28 2022-09-14 Glaxosmithkline Biologicals Sa Purification process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.BACTEVIOL=1978 *

Also Published As

Publication number Publication date
IL58673A (en) 1983-02-23
IL58673A0 (en) 1980-02-29
EP0011243A1 (de) 1980-05-28
DK475779A (da) 1980-05-12
CA1142083A (en) 1983-03-01
DK154841B (da) 1988-12-27
JPS5566519A (en) 1980-05-20
DE2848965A1 (de) 1980-05-22
DK154841C (da) 1989-06-05
AU5268279A (en) 1980-05-15
ATE857T1 (de) 1982-04-15
AU533386B2 (en) 1983-11-24
EP0011243B1 (de) 1982-04-14
DE2962526D1 (en) 1982-05-27
ES485715A1 (es) 1980-05-16

Similar Documents

Publication Publication Date Title
JPS6350332B2 (esLanguage)
US4271147A (en) Process for the isolation of membrane proteins from Neisseria meningitidis and vaccines containing same
JP4827196B2 (ja) 髄膜炎菌類タンパク質ｎｍｂ１８７０のドメインおよびエピトープ
US6355253B1 (en) Preparation and uses of LOS-depleted outer membrane proteins of gram-negative cocci
US4220717A (en) Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b.
JP5960055B2 (ja) 改変髄膜炎菌ｆＨＢＰポリペプチド
US9707286B2 (en) Process for detergent-free production of outer membrane vesicles of a gram-negative bacterium
JP2015110653A (ja) 髄膜炎菌ｆＨＢＰ配列を含むハイブリッドポリペプチド
KR102779223B1 (ko) 변형된 수막구균 fhbp 폴리펩티드
KR102626831B1 (ko) 수막구균 백신
JPH09500538A (ja) ナイセリア・メニンギチジス外膜グループｂポーリンタンパク質の高レベル発現、精製および再生
JPS61186400A (ja) 細菌由来中性多糖類と免疫原性タン白との安定な、共有結合された多糖―タンパク質結合体、該結合体の製造方法並びに該結合体を含む医薬組成物
US4196192A (en) Combined Haemophilus influenzae type b and pertussis vaccine
Holland et al. Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b
HK8097A (en) Process for removing bacterial endotoxin from gram-negative polysaccharides
JPH03502881A (ja) 淋菌ｐｉタンパク質およびワクチンの製造
KR20220070279A (ko) 면역원성 조성물
EP0400569B1 (en) Method for preparing a vaccine from Streptococcus mutans for dental caries and vaccinal compositions for dental caries used as nasal drops
CN110891597B (zh) 防治家禽滑膜霉浆菌感染的组合物
CN113354742A (zh) 一种布鲁氏杆菌基因工程亚单位疫苗及其制备方法和应用
JP2889923B2 (ja) 百日咳トキソイドワクチン
RU2407792C1 (ru) СПОСОБ ПОЛУЧЕНИЯ IgAl-ПРОТЕАЗЫ ИЗ КУЛЬТУРЫ NEISSERIA MENINGITIDIS СЕРОГРУППЫ А И ИММУНОГЕННЫЙ ПРЕПАРАТ НА ЕЕ ОСНОВЕ
NZ188211A (en) Isolation of polyribosyl ribitol phosphate(prp)from haemophilus influenzae type b;vaccine comprising prp and bordetellapertussis antigens
RU2401304C2 (ru) РЕКОМБИНАНТНАЯ ПЛАЗМИДА pD5spGBD, ШТАММ Escherichia coli - ПРОДУЦЕНТ РЕКОМБИНАНТНОГО БЕЛКА D5-GBD, РЕКОМБИНАНТНЫЙ БЕЛОК D5-GBD И СПОСОБ ЕГО ПОЛУЧЕНИЯ, СПОСОБ ИССЛЕДОВАНИЯ СВЯЗЫВАНИЯ БЕЛКА D5-GBD С АНТИТЕЛАМИ СЫВОРОТОК БОЛЬНЫХ, СПОСОБ ПОЛУЧЕНИЯ СПЕЦИФИЧЕСКИХ АНТИТЕЛ К БЕЛКУ D5-GBD
RU2296560C2 (ru) Суппозитории для иммунопрофилактики вирусных инфекций