JPS6348864B2 - - Google Patents

Info

Publication number
JPS6348864B2
JPS6348864B2 JP55016711A JP1671180A JPS6348864B2 JP S6348864 B2 JPS6348864 B2 JP S6348864B2 JP 55016711 A JP55016711 A JP 55016711A JP 1671180 A JP1671180 A JP 1671180A JP S6348864 B2 JPS6348864 B2 JP S6348864B2
Authority
JP
Japan
Prior art keywords
group
hydrogen atom
atom
formula
represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP55016711A
Other languages
English (en)
Japanese (ja)
Other versions
JPS55120559A (en
Inventor
Gunaaru Furiibe Uarutaa
Mihieru Herumuuto
Haintsu Rosu Kaaru
Uiideman Furitsutsu
Baruchu Uorufugangu
Deiitoman Kaaru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of JPS55120559A publication Critical patent/JPS55120559A/ja
Publication of JPS6348864B2 publication Critical patent/JPS6348864B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
JP1671180A 1979-02-16 1980-02-15 Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity Granted JPS55120559A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792905877 DE2905877A1 (de) 1979-02-16 1979-02-16 Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (2)

Publication Number Publication Date
JPS55120559A JPS55120559A (en) 1980-09-17
JPS6348864B2 true JPS6348864B2 (en:Method) 1988-09-30

Family

ID=6063044

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1671180A Granted JPS55120559A (en) 1979-02-16 1980-02-15 Heterocyclic oxypropanolamine derivative*its manufacture and drug containing it and having vasolidating and betaaintercepting activity

Country Status (17)

Country Link
US (1) US4346093A (en:Method)
EP (1) EP0014951B1 (en:Method)
JP (1) JPS55120559A (en:Method)
AT (1) ATE2190T1 (en:Method)
AU (1) AU531282B2 (en:Method)
CA (1) CA1134827A (en:Method)
CS (1) CS227305B2 (en:Method)
DD (1) DD148774A5 (en:Method)
DE (2) DE2905877A1 (en:Method)
DK (1) DK65380A (en:Method)
ES (1) ES488657A1 (en:Method)
FI (1) FI66371C (en:Method)
HK (1) HK4486A (en:Method)
HU (1) HU184719B (en:Method)
IL (1) IL59352A (en:Method)
SU (1) SU1243622A3 (en:Method)
ZA (1) ZA80894B (en:Method)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD150456A5 (de) * 1979-03-01 1981-09-02 Ciba Geigy Ag Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols
SE8003277L (sv) 1979-05-04 1980-11-05 Continental Pharma Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat
EP0034116A3 (en) * 1980-02-11 1981-09-02 Berlex Laboratories, Inc. N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
DE3029980A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indolderivate und verfahren zu ihrer herstellung
DE3030047A1 (de) * 1980-08-08 1982-03-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3131146A1 (de) * 1981-08-06 1983-02-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2523964B1 (fr) * 1982-03-23 1985-09-27 Sanofi Sa Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation
DE3310891A1 (de) * 1983-03-25 1984-09-27 Boehringer Mannheim Gmbh, 6800 Mannheim Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
DE3584560D1 (de) * 1984-04-09 1991-12-05 Du Pont Arzneimittelzusammensetzung geeignet zur behandlung oder prophylaxe von herzstoerungen.
DE3540149A1 (de) * 1985-11-13 1987-05-14 Boehringer Mannheim Gmbh Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten
DE68917024D1 (de) * 1988-05-24 1994-09-01 Kirin Brewery 4(1H)-Chinolonderivate.
CA2091246A1 (en) * 1990-09-13 1992-03-14 Ian Thomson Forbes Indole ureas as 5 ht receptor antagonist
WO1995004047A1 (en) * 1993-07-31 1995-02-09 Smithkline Beecham Plc 2-benzoheterocyclyloxy or thiopropanolamine derivatives with adreno receptor agonist activity
US5741789A (en) 1995-01-17 1998-04-21 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
ES2171839T3 (es) 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
US5808080A (en) 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
FR2756286A1 (fr) * 1996-11-27 1998-05-29 Pf Medicament Amino alcools aromatiques, leur preparation et leurs applications comme medicaments
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
JP2003514801A (ja) * 1999-11-15 2003-04-22 イーライ・リリー・アンド・カンパニー 家畜の生産を改善するためのインダゾリルオキシプロパノールアミン
TW593278B (en) * 2001-01-23 2004-06-21 Wyeth Corp 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands
SE0102640D0 (sv) * 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
US11173144B2 (en) * 2016-05-13 2021-11-16 The Board Of Trustees Of The Leland Stanford Junior University Adrenergic receptor modulating compounds and methods of using the same
GB202213163D0 (en) * 2022-09-08 2022-10-26 Cambridge Entpr Ltd Novel compounds, compositions and therapeutic uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281190A (en:Method) 1961-12-08
CH483423A (de) * 1967-05-29 1969-12-31 Sandoz Ag Verfahren zur Herstellung einer neuen Indolverbindung
CH536839A (de) * 1970-03-24 1973-05-15 Sandoz Ag Verfahren zur Herstellung einer neuen Indolverbindung
US3699123A (en) * 1970-03-24 1972-10-17 Sandoz Ltd 4-(3-amino-2-hydroxy-propoxy) indole derivatives
CH532040A (de) * 1970-03-24 1972-12-31 Sandoz Ag Verfahren zur Herstellung neuer Indolderivate
US3751429A (en) * 1970-03-24 1973-08-07 Sandoz Ltd 4-(3-amino-2-substituted propoxy)indole derivatives
SE379196B (en:Method) 1971-06-24 1975-09-29 Sandoz Ag
DE2508251C2 (de) 1975-02-26 1983-12-29 Boehringer Mannheim Gmbh, 6800 Mannheim Derivate des Indols, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
US4189494A (en) * 1975-11-06 1980-02-19 Sandoz Ltd. Reducing free fatty acid of the blood and suppressing appetite
CH624395A5 (en:Method) * 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2619164C2 (de) 1976-04-30 1985-07-11 Boehringer Mannheim Gmbh, 6800 Mannheim Indazolyl-(4)-oxy-propanolamine, Verfahren zu ihrer Herstellung und deren Verwendung
DE2626890A1 (de) 1976-06-16 1977-12-29 Boehringer Mannheim Gmbh Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel
DE2651574A1 (de) 1976-11-12 1978-05-18 Boehringer Mannheim Gmbh Ein neues aminopropanol-derivat und verfahren zu dessen herstellung
NZ187066A (en) * 1977-05-03 1981-02-11 Hoffmann La Roche 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones)
DE2830211A1 (de) * 1977-07-21 1979-02-01 Sandoz Ag Substituierte indol-derivate, ihre herstellung und verwendung
US4235919A (en) * 1977-07-21 1980-11-25 Sandoz Ltd. 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof
DE2801980A1 (de) * 1978-01-18 1979-07-19 Boehringer Mannheim Gmbh 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
EP0003758A1 (de) * 1978-02-09 1979-09-05 Ciba-Geigy Ag Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate

Also Published As

Publication number Publication date
CS227305B2 (en) 1984-04-16
HK4486A (en) 1986-01-31
SU1243622A3 (ru) 1986-07-07
ES488657A1 (es) 1980-09-16
FI66371B (fi) 1984-06-29
AU5541080A (en) 1980-08-21
JPS55120559A (en) 1980-09-17
ATE2190T1 (de) 1983-01-15
DE2905877A1 (de) 1980-08-28
AU531282B2 (en) 1983-08-18
FI800408A7 (fi) 1980-08-17
FI66371C (fi) 1984-10-10
ZA80894B (en) 1981-09-30
IL59352A0 (en) 1980-05-30
US4346093A (en) 1982-08-24
EP0014951A3 (en) 1981-02-04
IL59352A (en) 1985-01-31
EP0014951A2 (de) 1980-09-03
EP0014951B1 (de) 1983-01-12
HU184719B (en) 1984-10-29
DD148774A5 (de) 1981-06-10
DK65380A (da) 1980-08-17
DE3061555D1 (en) 1983-02-17
CA1134827A (en) 1982-11-02

Similar Documents

Publication Publication Date Title
JPS6348864B2 (en:Method)
FI70406B (fi) Foerfarande foer framstaellning av farmaceutiskt aktiva karbazolyl-(4)-oxi-propanolamin-derivat
EP0549594B1 (en) (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
HRP930508A2 (en) Difenilpropilamina process for the preparation of the novel enylpropylamine derivatives
CA1086740A (en) Piperidinopropyl derivatives and the preparation thereof
FI66370C (fi) Foerfarande foer framstaellning av nya farmakologiskt anvaendbara piperidinopropylderivat
US4229464A (en) Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases
US4143149A (en) Indazolyl-(4)-oxypropanolamine compounds and therapeutic compositions
FI113177B (fi) Uusia 1,3-dioksolo[4,5-h]-, 1,4-dioksano[2,3-h]- ja 1,5-dioksepino[2,3-h] [2,3]bentsodiatsepiinijohdannaisia, niiden valmistus ja käyttö lääkkeenä
PL112154B1 (en) Method of preparation of novel aminopropanol derivatives
FR2643634A1 (fr) Nouveaux derives benzoxazolinoniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
CH633541A5 (en) Pharmacologically active substituted 1,2,4-triazines and medicaments containing these triazines
EP0179428A2 (en) Indoleacetic acid derivative and a pharmaceutical preparation
KR100453981B1 (ko) 아미노피롤린 화합물, 이의 제조 방법 및 이를 함유하는약제 조성물
Baltzly et al. Amines Related to 2, 5-Dimethoxyphenethylamine. 1 I
JPS6345667B2 (en:Method)
JPS6024100B2 (ja) アミノプロパノ−ル−誘導体の製法
FR2611713A1 (fr) Nouveaux derives de l'acide (dihydro-2,3 oxo-2 benzofurannyl-3)-2 acetique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US4438116A (en) Quinoxalinyloxy-amino-propanol compounds with blood pressure lowering and β-blocking properties, their use and pharmaceutical compositions containing them
FR2802532A1 (fr) Derives de 2-phenyl-quinoleine, leur preparation et leur application en therapeutique
HU196170B (en) Process for preparing (/1,3-dioxi-1,3-propane-diil/-diimino)-bis-benzoic acid and its derivatives
PL96042B1 (pl) Sposob wytwarzania nowych aminopochodnych azydofenoli
KR810001891B1 (ko) 페닐 에틸 아민류의 제조방법
JPS6061569A (ja) 新規な３位置換アミン誘導体
JPS6344737B2 (en:Method)