ATE2190T1 - Heterocyclische oxypropanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. - Google Patents
Heterocyclische oxypropanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.Info
- Publication number
- ATE2190T1 ATE2190T1 AT80100719T AT80100719T ATE2190T1 AT E2190 T1 ATE2190 T1 AT E2190T1 AT 80100719 T AT80100719 T AT 80100719T AT 80100719 T AT80100719 T AT 80100719T AT E2190 T1 ATE2190 T1 AT E2190T1
- Authority
- AT
- Austria
- Prior art keywords
- radical
- radicals
- lower alkyl
- hydrogen atom
- atom
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 alkanoyl radical Chemical class 0.000 abstract 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- HZVOZRGWRWCICA-UHFFFAOYSA-N methanediyl Chemical compound [CH2] HZVOZRGWRWCICA-UHFFFAOYSA-N 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792905877 DE2905877A1 (de) | 1979-02-16 | 1979-02-16 | Neue aminopropanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| EP80100719A EP0014951B1 (de) | 1979-02-16 | 1980-02-13 | Heterocyclische Oxypropanolamin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE2190T1 true ATE2190T1 (de) | 1983-01-15 |
Family
ID=6063044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80100719T ATE2190T1 (de) | 1979-02-16 | 1980-02-13 | Heterocyclische oxypropanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4346093A (en:Method) |
| EP (1) | EP0014951B1 (en:Method) |
| JP (1) | JPS55120559A (en:Method) |
| AT (1) | ATE2190T1 (en:Method) |
| AU (1) | AU531282B2 (en:Method) |
| CA (1) | CA1134827A (en:Method) |
| CS (1) | CS227305B2 (en:Method) |
| DD (1) | DD148774A5 (en:Method) |
| DE (2) | DE2905877A1 (en:Method) |
| DK (1) | DK65380A (en:Method) |
| ES (1) | ES488657A1 (en:Method) |
| FI (1) | FI66371C (en:Method) |
| HK (1) | HK4486A (en:Method) |
| HU (1) | HU184719B (en:Method) |
| IL (1) | IL59352A (en:Method) |
| SU (1) | SU1243622A3 (en:Method) |
| ZA (1) | ZA80894B (en:Method) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
| SE8003277L (sv) | 1979-05-04 | 1980-11-05 | Continental Pharma | Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat |
| EP0034116A3 (en) * | 1980-02-11 | 1981-09-02 | Berlex Laboratories, Inc. | N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines |
| DE3029980A1 (de) * | 1980-08-08 | 1982-03-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indolderivate und verfahren zu ihrer herstellung |
| DE3030047A1 (de) * | 1980-08-08 | 1982-03-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue aminopropanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3131146A1 (de) * | 1981-08-06 | 1983-02-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue heteroaryloxypropanolamine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| FR2523964B1 (fr) * | 1982-03-23 | 1985-09-27 | Sanofi Sa | Nouveaux derives de la tryptamine actifs notamment sur le systeme cardiovasculaire et procede pour leur preparation |
| DE3310891A1 (de) * | 1983-03-25 | 1984-09-27 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue indolinon-(2)-derivate, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und zwischenprodukte |
| US4562200A (en) * | 1983-06-30 | 1985-12-31 | American Home Products Corporation | 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives |
| DE3584560D1 (de) * | 1984-04-09 | 1991-12-05 | Du Pont | Arzneimittelzusammensetzung geeignet zur behandlung oder prophylaxe von herzstoerungen. |
| DE3540149A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten |
| DE68917024D1 (de) * | 1988-05-24 | 1994-09-01 | Kirin Brewery | 4(1H)-Chinolonderivate. |
| CA2091246A1 (en) * | 1990-09-13 | 1992-03-14 | Ian Thomson Forbes | Indole ureas as 5 ht receptor antagonist |
| WO1995004047A1 (en) * | 1993-07-31 | 1995-02-09 | Smithkline Beecham Plc | 2-benzoheterocyclyloxy or thiopropanolamine derivatives with adreno receptor agonist activity |
| US5741789A (en) | 1995-01-17 | 1998-04-21 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| US5576321A (en) * | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
| ES2171839T3 (es) | 1996-09-05 | 2002-09-16 | Lilly Co Eli | Analogos de carbazol como agonistas adrenergicos selectivos de beta3. |
| US5808080A (en) | 1996-09-05 | 1998-09-15 | Eli Lilly And Company | Selective β3 adrenergic agonists |
| FR2756286A1 (fr) * | 1996-11-27 | 1998-05-29 | Pf Medicament | Amino alcools aromatiques, leur preparation et leurs applications comme medicaments |
| CO5011072A1 (es) | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
| JP2003514801A (ja) * | 1999-11-15 | 2003-04-22 | イーライ・リリー・アンド・カンパニー | 家畜の生産を改善するためのインダゾリルオキシプロパノールアミン |
| TW593278B (en) * | 2001-01-23 | 2004-06-21 | Wyeth Corp | 1-aryl-or 1-alkylsulfonylbenzazole derivatives as 5-hydroxytryptamine-6 ligands |
| SE0102640D0 (sv) * | 2001-07-31 | 2001-07-31 | Astrazeneca Ab | Novel compounds |
| US11173144B2 (en) * | 2016-05-13 | 2021-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adrenergic receptor modulating compounds and methods of using the same |
| GB202213163D0 (en) * | 2022-09-08 | 2022-10-26 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL281190A (en:Method) | 1961-12-08 | |||
| CH483423A (de) * | 1967-05-29 | 1969-12-31 | Sandoz Ag | Verfahren zur Herstellung einer neuen Indolverbindung |
| CH536839A (de) * | 1970-03-24 | 1973-05-15 | Sandoz Ag | Verfahren zur Herstellung einer neuen Indolverbindung |
| US3699123A (en) * | 1970-03-24 | 1972-10-17 | Sandoz Ltd | 4-(3-amino-2-hydroxy-propoxy) indole derivatives |
| CH532040A (de) * | 1970-03-24 | 1972-12-31 | Sandoz Ag | Verfahren zur Herstellung neuer Indolderivate |
| US3751429A (en) * | 1970-03-24 | 1973-08-07 | Sandoz Ltd | 4-(3-amino-2-substituted propoxy)indole derivatives |
| SE379196B (en:Method) | 1971-06-24 | 1975-09-29 | Sandoz Ag | |
| DE2508251C2 (de) | 1975-02-26 | 1983-12-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Derivate des Indols, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel |
| US4189494A (en) * | 1975-11-06 | 1980-02-19 | Sandoz Ltd. | Reducing free fatty acid of the blood and suppressing appetite |
| CH624395A5 (en:Method) * | 1976-01-08 | 1981-07-31 | Ciba Geigy Ag | |
| DE2619164C2 (de) | 1976-04-30 | 1985-07-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indazolyl-(4)-oxy-propanolamine, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2626890A1 (de) | 1976-06-16 | 1977-12-29 | Boehringer Mannheim Gmbh | Neue derivate des indols, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
| DE2651574A1 (de) | 1976-11-12 | 1978-05-18 | Boehringer Mannheim Gmbh | Ein neues aminopropanol-derivat und verfahren zu dessen herstellung |
| NZ187066A (en) * | 1977-05-03 | 1981-02-11 | Hoffmann La Roche | 4-(3-substitutedamino-2-hydroxypropoxy)-benzimidazolidin-2-(ones or thiones) |
| DE2830211A1 (de) * | 1977-07-21 | 1979-02-01 | Sandoz Ag | Substituierte indol-derivate, ihre herstellung und verwendung |
| US4235919A (en) * | 1977-07-21 | 1980-11-25 | Sandoz Ltd. | 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof |
| DE2801980A1 (de) * | 1978-01-18 | 1979-07-19 | Boehringer Mannheim Gmbh | 4-hydroxy-2-benzimidazolin-thion- derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
| EP0003758A1 (de) * | 1978-02-09 | 1979-09-05 | Ciba-Geigy Ag | Verätherte Hydroxy-benzodiheterocyclen und ihre Säureadditionssalze, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Präparate |
-
1979
- 1979-02-16 DE DE19792905877 patent/DE2905877A1/de not_active Withdrawn
-
1980
- 1980-01-31 US US06/117,190 patent/US4346093A/en not_active Expired - Lifetime
- 1980-02-05 CA CA000345099A patent/CA1134827A/en not_active Expired
- 1980-02-10 IL IL59352A patent/IL59352A/xx unknown
- 1980-02-11 FI FI800408A patent/FI66371C/fi not_active IP Right Cessation
- 1980-02-11 SU SU802878004A patent/SU1243622A3/ru active
- 1980-02-11 AU AU55410/80A patent/AU531282B2/en not_active Ceased
- 1980-02-13 EP EP80100719A patent/EP0014951B1/de not_active Expired
- 1980-02-13 AT AT80100719T patent/ATE2190T1/de not_active IP Right Cessation
- 1980-02-13 DD DD80219037A patent/DD148774A5/de not_active IP Right Cessation
- 1980-02-13 DE DE8080100719T patent/DE3061555D1/de not_active Expired
- 1980-02-15 DK DK65380A patent/DK65380A/da not_active Application Discontinuation
- 1980-02-15 HU HU80350A patent/HU184719B/hu not_active IP Right Cessation
- 1980-02-15 ES ES488657A patent/ES488657A1/es not_active Expired
- 1980-02-15 ZA ZA00800894A patent/ZA80894B/xx unknown
- 1980-02-15 JP JP1671180A patent/JPS55120559A/ja active Granted
- 1980-02-15 CS CS801055A patent/CS227305B2/cs unknown
-
1986
- 1986-01-23 HK HK44/86A patent/HK4486A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CS227305B2 (en) | 1984-04-16 |
| HK4486A (en) | 1986-01-31 |
| SU1243622A3 (ru) | 1986-07-07 |
| ES488657A1 (es) | 1980-09-16 |
| JPS6348864B2 (en:Method) | 1988-09-30 |
| FI66371B (fi) | 1984-06-29 |
| AU5541080A (en) | 1980-08-21 |
| JPS55120559A (en) | 1980-09-17 |
| DE2905877A1 (de) | 1980-08-28 |
| AU531282B2 (en) | 1983-08-18 |
| FI800408A7 (fi) | 1980-08-17 |
| FI66371C (fi) | 1984-10-10 |
| ZA80894B (en) | 1981-09-30 |
| IL59352A0 (en) | 1980-05-30 |
| US4346093A (en) | 1982-08-24 |
| EP0014951A3 (en) | 1981-02-04 |
| IL59352A (en) | 1985-01-31 |
| EP0014951A2 (de) | 1980-09-03 |
| EP0014951B1 (de) | 1983-01-12 |
| HU184719B (en) | 1984-10-29 |
| DD148774A5 (de) | 1981-06-10 |
| DK65380A (da) | 1980-08-17 |
| DE3061555D1 (en) | 1983-02-17 |
| CA1134827A (en) | 1982-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |