CA2149147A1 - Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof - Google Patents
Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereofInfo
- Publication number
- CA2149147A1 CA2149147A1 CA002149147A CA2149147A CA2149147A1 CA 2149147 A1 CA2149147 A1 CA 2149147A1 CA 002149147 A CA002149147 A CA 002149147A CA 2149147 A CA2149147 A CA 2149147A CA 2149147 A1 CA2149147 A1 CA 2149147A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- lower alkyl
- processes
- preparation
- pharmacologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LJXQPZWIHJMPQQ-UHFFFAOYSA-N pyrimidin-2-amine Chemical class NC1=NC=CC=N1 LJXQPZWIHJMPQQ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- -1 cyano, carbamoyl Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical class N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Described are N-phenyl-2-pyrimidineamine derivatives of formula (I) wherein R1 is a substituted cyclic radical, the cyclic radical being bonded to a ring carbon atom in each case and being selected from phenyl, pyridyl, pyrazinyl, thiazolyl, pyrimidinyl, pyridazinyl and imidazolyl, and the substituents of the above-mentioned cyclic radical being selected from one or more of the groups halogen, cyano, carbamoyl, -C(=O)-OR3, -C(=O)-R4, -SO2-N(R5)-R6, -N(R7)-R8, -OR9 and fluorine-substituted lower alkyl, wherein R3, R4, R5, R6, R7, R8 and R9 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino; and R2 is selected from halogen, cyano, carbamoyl, -C(=O)-OR10, -C(=O)-R11, -SO2-N(R12)-R13, -N(R14)-R15, -OR16 and fluorine-substituted lower alkyl, wherein R10, R11, R12, R13, R14, R15 and R16 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino. Those compounds can be used, for example, in the treatment of tumour diseases.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2968/93-9 | 1993-10-01 | ||
| CH296893 | 1993-10-01 | ||
| CH2280/94-0 | 1994-07-18 | ||
| CH228094 | 1994-07-18 | ||
| PCT/EP1994/003148 WO1995009851A1 (en) | 1993-10-01 | 1994-09-21 | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2149147A1 true CA2149147A1 (en) | 1995-04-13 |
| CA2149147C CA2149147C (en) | 2006-05-02 |
Family
ID=36283829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002149147A Expired - Fee Related CA2149147C (en) | 1993-10-01 | 1994-09-21 | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2149147C (en) |
-
1994
- 1994-09-21 CA CA002149147A patent/CA2149147C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2149147C (en) | 2006-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |