CA2149147A1 - Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof - Google Patents

Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof

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Publication number
CA2149147A1
CA2149147A1 CA002149147A CA2149147A CA2149147A1 CA 2149147 A1 CA2149147 A1 CA 2149147A1 CA 002149147 A CA002149147 A CA 002149147A CA 2149147 A CA2149147 A CA 2149147A CA 2149147 A1 CA2149147 A1 CA 2149147A1
Authority
CA
Canada
Prior art keywords
substituted
lower alkyl
processes
preparation
pharmacologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002149147A
Other languages
French (fr)
Other versions
CA2149147C (en
Inventor
Jurg Zimmermann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/EP1994/003148 external-priority patent/WO1995009851A1/en
Publication of CA2149147A1 publication Critical patent/CA2149147A1/en
Application granted granted Critical
Publication of CA2149147C publication Critical patent/CA2149147C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

Described are N-phenyl-2-pyrimidineamine derivatives of formula (I) wherein R1 is a substituted cyclic radical, the cyclic radical being bonded to a ring carbon atom in each case and being selected from phenyl, pyridyl, pyrazinyl, thiazolyl, pyrimidinyl, pyridazinyl and imidazolyl, and the substituents of the above-mentioned cyclic radical being selected from one or more of the groups halogen, cyano, carbamoyl, -C(=O)-OR3, -C(=O)-R4, -SO2-N(R5)-R6, -N(R7)-R8, -OR9 and fluorine-substituted lower alkyl, wherein R3, R4, R5, R6, R7, R8 and R9 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino; and R2 is selected from halogen, cyano, carbamoyl, -C(=O)-OR10, -C(=O)-R11, -SO2-N(R12)-R13, -N(R14)-R15, -OR16 and fluorine-substituted lower alkyl, wherein R10, R11, R12, R13, R14, R15 and R16 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino. Those compounds can be used, for example, in the treatment of tumour diseases.
CA002149147A 1993-10-01 1994-09-21 Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof Expired - Fee Related CA2149147C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH296893 1993-10-01
CH2968/93-9 1993-10-01
CH2280/94-0 1994-07-18
CH228094 1994-07-18
PCT/EP1994/003148 WO1995009851A1 (en) 1993-10-01 1994-09-21 Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
CA2149147A1 true CA2149147A1 (en) 1995-04-13
CA2149147C CA2149147C (en) 2006-05-02

Family

ID=36283829

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002149147A Expired - Fee Related CA2149147C (en) 1993-10-01 1994-09-21 Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof

Country Status (1)

Country Link
CA (1) CA2149147C (en)

Also Published As

Publication number Publication date
CA2149147C (en) 2006-05-02

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