CA2149147A1 - Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof - Google Patents
Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereofInfo
- Publication number
- CA2149147A1 CA2149147A1 CA002149147A CA2149147A CA2149147A1 CA 2149147 A1 CA2149147 A1 CA 2149147A1 CA 002149147 A CA002149147 A CA 002149147A CA 2149147 A CA2149147 A CA 2149147A CA 2149147 A1 CA2149147 A1 CA 2149147A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- lower alkyl
- processes
- preparation
- pharmacologically active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Described are N-phenyl-2-pyrimidineamine derivatives of formula (I) wherein R1 is a substituted cyclic radical, the cyclic radical being bonded to a ring carbon atom in each case and being selected from phenyl, pyridyl, pyrazinyl, thiazolyl, pyrimidinyl, pyridazinyl and imidazolyl, and the substituents of the above-mentioned cyclic radical being selected from one or more of the groups halogen, cyano, carbamoyl, -C(=O)-OR3, -C(=O)-R4, -SO2-N(R5)-R6, -N(R7)-R8, -OR9 and fluorine-substituted lower alkyl, wherein R3, R4, R5, R6, R7, R8 and R9 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino; and R2 is selected from halogen, cyano, carbamoyl, -C(=O)-OR10, -C(=O)-R11, -SO2-N(R12)-R13, -N(R14)-R15, -OR16 and fluorine-substituted lower alkyl, wherein R10, R11, R12, R13, R14, R15 and R16 are each independently of the others hydrogen or lower alkyl that is unsubstituted or substituted by mono- or di-lower alkylamino. Those compounds can be used, for example, in the treatment of tumour diseases.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH296893 | 1993-10-01 | ||
CH2968/93-9 | 1993-10-01 | ||
CH2280/94-0 | 1994-07-18 | ||
CH228094 | 1994-07-18 | ||
PCT/EP1994/003148 WO1995009851A1 (en) | 1993-10-01 | 1994-09-21 | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2149147A1 true CA2149147A1 (en) | 1995-04-13 |
CA2149147C CA2149147C (en) | 2006-05-02 |
Family
ID=36283829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002149147A Expired - Fee Related CA2149147C (en) | 1993-10-01 | 1994-09-21 | Pharmacologically active pyrimidineamine derivatives and processes for the preparation thereof |
Country Status (1)
Country | Link |
---|---|
CA (1) | CA2149147C (en) |
-
1994
- 1994-09-21 CA CA002149147A patent/CA2149147C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2149147C (en) | 2006-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |