FR2323383A1 - (2)-Alkyl (5)-thiazole-methyl-amines - with antilipolytic and hypoglycaemic activity - Google Patents

(2)-Alkyl (5)-thiazole-methyl-amines - with antilipolytic and hypoglycaemic activity

Info

Publication number
FR2323383A1
FR2323383A1 FR7528095A FR7528095A FR2323383A1 FR 2323383 A1 FR2323383 A1 FR 2323383A1 FR 7528095 A FR7528095 A FR 7528095A FR 7528095 A FR7528095 A FR 7528095A FR 2323383 A1 FR2323383 A1 FR 2323383A1
Authority
FR
France
Prior art keywords
alkyl
methyl
thiazole
antilipolytic
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7528095A
Other languages
French (fr)
Other versions
FR2323383B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7528095A priority Critical patent/FR2323383A1/en
Priority to SE7609666A priority patent/SE7609666L/en
Priority to ZA765294A priority patent/ZA765294B/en
Priority to US05/721,370 priority patent/US4108994A/en
Priority to BE170510A priority patent/BE846059A/en
Priority to LU75764A priority patent/LU75764A1/xx
Priority to DK408176A priority patent/DK408176A/en
Priority to NL7610062A priority patent/NL7610062A/en
Priority to CH1157176A priority patent/CH613958A5/en
Priority to JP51107981A priority patent/JPS5236664A/en
Priority to CA261,119A priority patent/CA1082716A/en
Priority to AU17630/76A priority patent/AU499425B2/en
Priority to ES451466A priority patent/ES451466A1/en
Priority to GB37770/76A priority patent/GB1526038A/en
Priority to DE19762641129 priority patent/DE2641129A1/en
Priority to IE2042/76A priority patent/IE44294B1/en
Publication of FR2323383A1 publication Critical patent/FR2323383A1/en
Application granted granted Critical
Publication of FR2323383B1 publication Critical patent/FR2323383B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

5-Thiazolemethylamines of formula (I) and their acid-addn. salts: (where R1 is 1-6C alkyl; R2 and R3 are H, NR2R3 is a satd. heterocycle opt. contg. another N atom and opt. contg. another N atom and opt. substd. by 1-4C alkyl). Also new are inters of formula (IIa) and their acid-addn. salts: (where R1' is 2-6C alkyl and X is Cl, or R1' is 1-6C alkyl and X is Br). A typical cpd. (I) is 2-methyl-5-thiazolemethylamine. In an example, this is prepd. in hemisuccinate form by reacting 2-methyl-5-chloromethyl-thiazole with hexamethylene tetramine, treating the prod. with HCl in EtOH, and then treating with succinic acid.
FR7528095A 1975-09-12 1975-09-12 (2)-Alkyl (5)-thiazole-methyl-amines - with antilipolytic and hypoglycaemic activity Granted FR2323383A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR7528095A FR2323383A1 (en) 1975-09-12 1975-09-12 (2)-Alkyl (5)-thiazole-methyl-amines - with antilipolytic and hypoglycaemic activity
SE7609666A SE7609666L (en) 1975-09-12 1976-09-01 WAY TO PRODUCE NEW 5-AMINOMETHYLTIAZOLE DERIVATIVES
ZA765294A ZA765294B (en) 1975-09-12 1976-09-03 New 5-thiazole methane amine derivatives their salts process for preparing them and pharmaceutical compositions
US05/721,370 US4108994A (en) 1975-09-12 1976-09-08 5-thiazole-methane-amines, and their use as antilipolytics
AU17630/76A AU499425B2 (en) 1975-09-12 1976-09-10 5-thiazole methane amine derivatives
DK408176A DK408176A (en) 1975-09-12 1976-09-10 PROCEDURE FOR THE PREPARATION OF 5-THIAZOLMETHANAMINE DERIVATIVES OR SALTS THEREOF
NL7610062A NL7610062A (en) 1975-09-12 1976-09-10 PROCESS FOR THE PREPARATION OF 5-THIAZOLYL METHYLAMINS AND THEIR SALTS, AND A PROCESS FOR THE PREPARATION OF THE PREPARATIONS CONTAINING THEM.
CH1157176A CH613958A5 (en) 1975-09-12 1976-09-10 Process for the preparation of new 5-thiazolemethanamine derivatives and of their salts
BE170510A BE846059A (en) 1975-09-12 1976-09-10 NEW 5-THIAZOLE METHANE AMINE DERIVATIVES, THEIR SALTS, PROCESS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS
CA261,119A CA1082716A (en) 1975-09-12 1976-09-10 Process for the preparation of novel 5-thiazole methane amine derivatives
LU75764A LU75764A1 (en) 1975-09-12 1976-09-10
JP51107981A JPS5236664A (en) 1975-09-12 1976-09-10 Production of novel 55 thiazolemethaneamine derivatives and salts and pharmaceutical composition
ES451466A ES451466A1 (en) 1975-09-12 1976-09-11 5-thiazole-methane-amines, and their use as antilipolytics
GB37770/76A GB1526038A (en) 1975-09-12 1976-09-13 5-thiazole methane amine derivatives and salts thereof processes for preparing them and pharmaceutical compositions containing them
DE19762641129 DE2641129A1 (en) 1975-09-12 1976-09-13 DERIVATIVES OF 5-AMINOMETHYLTHIAZOLE, THEIR MANUFACTURING PROCESS AND PHARMACEUTICAL COMPOSITIONS
IE2042/76A IE44294B1 (en) 1975-09-12 1976-09-13 5-thiazole methane amine derivatives and salts thereof, processes for preparing them,and pharmaceuitcal compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7528095A FR2323383A1 (en) 1975-09-12 1975-09-12 (2)-Alkyl (5)-thiazole-methyl-amines - with antilipolytic and hypoglycaemic activity

Publications (2)

Publication Number Publication Date
FR2323383A1 true FR2323383A1 (en) 1977-04-08
FR2323383B1 FR2323383B1 (en) 1978-07-28

Family

ID=9159946

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7528095A Granted FR2323383A1 (en) 1975-09-12 1975-09-12 (2)-Alkyl (5)-thiazole-methyl-amines - with antilipolytic and hypoglycaemic activity

Country Status (3)

Country Link
BE (1) BE846059A (en)
FR (1) FR2323383A1 (en)
ZA (1) ZA765294B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0034481B1 (en) * 1980-02-14 1984-05-30 Grigg, Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NEANT *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0034481B1 (en) * 1980-02-14 1984-05-30 Grigg, Ronald Ernest 2-methyl-5-thiazole-methylamine and carboxamide derivatives

Also Published As

Publication number Publication date
FR2323383B1 (en) 1978-07-28
ZA765294B (en) 1977-10-26
BE846059A (en) 1977-03-10

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Legal Events

Date Code Title Description
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