JPS6310953B2 - - Google Patents
Info
- Publication number
- JPS6310953B2 JPS6310953B2 JP55031514A JP3151480A JPS6310953B2 JP S6310953 B2 JPS6310953 B2 JP S6310953B2 JP 55031514 A JP55031514 A JP 55031514A JP 3151480 A JP3151480 A JP 3151480A JP S6310953 B2 JPS6310953 B2 JP S6310953B2
- Authority
- JP
- Japan
- Prior art keywords
- everactone
- substance
- brown
- culture
- gray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 229960001866 silicon dioxide Drugs 0.000 description 13
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- CSTBBLHIGMTEAZ-UHFFFAOYSA-N chloroform;ethyl acetate;hexane Chemical compound ClC(Cl)Cl.CCCCCC.CCOC(C)=O CSTBBLHIGMTEAZ-UHFFFAOYSA-N 0.000 description 3
- OQNGCCWBHLEQFN-UHFFFAOYSA-N chloroform;hexane Chemical compound ClC(Cl)Cl.CCCCCC OQNGCCWBHLEQFN-UHFFFAOYSA-N 0.000 description 3
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- UNBMQQNYLCPCHS-VYNDPHDASA-N ebelactone b Chemical compound CC[C@@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)\C=C(/C)C[C@H](C)[C@@H]1OC(=O)[C@H]1CC UNBMQQNYLCPCHS-VYNDPHDASA-N 0.000 description 3
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- 235000002639 sodium chloride Nutrition 0.000 description 3
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- BBBFYZOJHSYQMW-LGDQNDJISA-N (2s)-2,4-diamino-4-oxobutanoic acid;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC(=O)[C@@H](N)CC(N)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O BBBFYZOJHSYQMW-LGDQNDJISA-N 0.000 description 2
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- 238000005273 aeration Methods 0.000 description 2
- GLMQHZPGHAPYIO-UHFFFAOYSA-L azanium;2-hydroxypropane-1,2,3-tricarboxylate;iron(2+) Chemical compound [NH4+].[Fe+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O GLMQHZPGHAPYIO-UHFFFAOYSA-L 0.000 description 2
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- 230000015572 biosynthetic process Effects 0.000 description 2
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- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
- C07D305/12—Beta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Epoxy Compounds (AREA)
Description
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Claims (1)
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Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3151480A JPS56128774A (en) | 1980-03-14 | 1980-03-14 | New physiologically active substance ebelactone and its preparation |
| US06/240,457 US4358602A (en) | 1980-03-14 | 1981-03-04 | Ebelactones and production thereof |
| GB8107651A GB2071661B (en) | 1980-03-14 | 1981-03-11 | Physiologically active substance ebelactone and production thereof |
| DE3109335A DE3109335C2 (de) | 1980-03-14 | 1981-03-12 | Ebelacton A und B, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel |
| FR8105550A FR2478096A1 (fr) | 1980-03-14 | 1981-03-13 | Lactones physiologiquement actives presentant des proprietes immunopotentialisatrices et anti-inflammatoires, leur procede de production et les compositions pharmaceutiques les renfermant |
| CA000372939A CA1153966A (en) | 1980-03-14 | 1981-03-13 | Physiologically active substance, ebelactone and production thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3151480A JPS56128774A (en) | 1980-03-14 | 1980-03-14 | New physiologically active substance ebelactone and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56128774A JPS56128774A (en) | 1981-10-08 |
| JPS6310953B2 true JPS6310953B2 (ja) | 1988-03-10 |
Family
ID=12333308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3151480A Granted JPS56128774A (en) | 1980-03-14 | 1980-03-14 | New physiologically active substance ebelactone and its preparation |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4358602A (ja) |
| JP (1) | JPS56128774A (ja) |
| CA (1) | CA1153966A (ja) |
| DE (1) | DE3109335C2 (ja) |
| FR (1) | FR2478096A1 (ja) |
| GB (1) | GB2071661B (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| US4645765A (en) * | 1984-06-25 | 1987-02-24 | Fujisawa Pharmaceutical Co., Ltd. | Tetracyclo compounds and a pharmaceutical composition containing the same |
| CA1270837A (en) * | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| US4816477A (en) * | 1987-05-26 | 1989-03-28 | Merck & Co., Inc. | Antihypercholesterolemic β-lactones |
| US4806564A (en) * | 1987-05-26 | 1989-02-21 | Merck & Co., Inc. | Antihypercholesterolemic beta-lactones |
| US5780587A (en) * | 1990-08-24 | 1998-07-14 | President And Fellows Of Harvard College | Compounds and methods for inhibiting β-protein filament formation and neurotoxicity |
| US5506097A (en) * | 1990-08-24 | 1996-04-09 | President And Fellows Of Harvard College | Method for inhibiting β-protein enzymatic activity |
| US5338663A (en) * | 1990-08-24 | 1994-08-16 | President And Fellows Of Harvard College | Method of identifying inhibitors of β-protein esterase activity |
| JPH05279374A (ja) * | 1992-03-31 | 1993-10-26 | Sawao Murao | ã¹ã€ããã¬ã¹ãã³åã³ãã®è£œé æ¹æ³ |
| TW381025B (en) * | 1993-08-05 | 2000-02-01 | Hoffmann La Roche | Pharmaceutical composition containing a glucosidase inhibitor and a lipase inhibitor |
| US20050239859A2 (en) * | 2003-09-03 | 2005-10-27 | Solvay Pharmaceuticals Gmbh | Novel medical uses of 4,5-dihydro-1h-pyrazole derivatives having cb1- antagonistic activity |
| US20050124660A1 (en) * | 2003-10-27 | 2005-06-09 | Jochen Antel | Novel medical uses of compounds showing CB1-antagonistic activity and combination treatment involving said compounds |
| US20050143441A1 (en) * | 2003-10-27 | 2005-06-30 | Jochen Antel | Novel medical combination treatment of obesity involving 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity |
| US7074822B2 (en) | 2004-02-23 | 2006-07-11 | Solvay Pharmaceuticals Gmbh | Alkyl carbamate-substituted β-lactones, process for their preparation, and pharmaceutical compositions containing them |
| BRPI0517434A (pt) * | 2004-10-25 | 2008-10-07 | Solvay Pharm Gmbh | composições farmacêuticas compreendendo antagonistas do receptor canabinóide cb1 e abridores de canal de potássio para o tratamento de diabetes mellitus do tipo i, obesidade e estados relacionados |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS608117B2 (ja) * | 1977-02-08 | 1985-02-28 | 財å£æ³äººåŸ®çç©ååŠç ç©¶äŒ | æ°çç掻æ§ç©è³ªãšã¹ãã©ã¹ãã³ããã³ãã®è£œé æ³ |
| GB2023604B (en) * | 1978-05-25 | 1982-07-28 | Microbial Chem Res Found | Physiologically active derivatives of esterastin and production thereof |
-
1980
- 1980-03-14 JP JP3151480A patent/JPS56128774A/ja active Granted
-
1981
- 1981-03-04 US US06/240,457 patent/US4358602A/en not_active Expired - Lifetime
- 1981-03-11 GB GB8107651A patent/GB2071661B/en not_active Expired
- 1981-03-12 DE DE3109335A patent/DE3109335C2/de not_active Expired
- 1981-03-13 CA CA000372939A patent/CA1153966A/en not_active Expired
- 1981-03-13 FR FR8105550A patent/FR2478096A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB2071661B (en) | 1984-02-29 |
| DE3109335A1 (de) | 1982-03-18 |
| US4358602A (en) | 1982-11-09 |
| FR2478096B1 (ja) | 1984-07-20 |
| JPS56128774A (en) | 1981-10-08 |
| CA1153966A (en) | 1983-09-20 |
| FR2478096A1 (fr) | 1981-09-18 |
| DE3109335C2 (de) | 1983-12-08 |
| GB2071661A (en) | 1981-09-23 |
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