JPS6216638B2 - - Google Patents
Info
- Publication number
- JPS6216638B2 JPS6216638B2 JP56189856A JP18985681A JPS6216638B2 JP S6216638 B2 JPS6216638 B2 JP S6216638B2 JP 56189856 A JP56189856 A JP 56189856A JP 18985681 A JP18985681 A JP 18985681A JP S6216638 B2 JPS6216638 B2 JP S6216638B2
- Authority
- JP
- Japan
- Prior art keywords
- culture
- aiu
- inhibitor
- inhibitors
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 102000005744 Glycoside Hydrolases Human genes 0.000 claims description 17
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims description 17
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- 238000012258 culturing Methods 0.000 claims description 8
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- 238000004519 manufacturing process Methods 0.000 claims description 5
- 241001134635 Micromonosporaceae Species 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 2
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 27
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- 235000010216 calcium carbonate Nutrition 0.000 description 6
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- 239000012138 yeast extract Substances 0.000 description 6
- 241000209140 Triticum Species 0.000 description 5
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 5
- 235000011130 ammonium sulphate Nutrition 0.000 description 5
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- 239000004471 Glycine Substances 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
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- WDMUXYQIMRDWRC-UHFFFAOYSA-N 2-hydroxy-3,4-dinitrobenzoic acid Chemical compound OC(=O)C1=CC=C([N+]([O-])=O)C([N+]([O-])=O)=C1O WDMUXYQIMRDWRC-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/896—Streptomyces fradiae
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/907—Streptosporangium
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2064092A DE2064092C2 (de) | 1970-12-28 | 1970-12-28 | Inhibitoren für Glykosidhydrolasen aus Actinomyceten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS57150395A JPS57150395A (en) | 1982-09-17 |
| JPS6216638B2 true JPS6216638B2 (nl) | 1987-04-14 |
Family
ID=5792372
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10558571A Pending JPS5734996B1 (nl) | 1970-12-28 | 1971-12-27 | |
| JP56189857A Granted JPS57150396A (en) | 1970-12-28 | 1981-11-26 | Production of inhibitor for glycoside hydrolyzing enzyme |
| JP56189856A Granted JPS57150395A (en) | 1970-12-28 | 1981-11-26 | Production of inhibitor for glycoside hydrolyzing enzyme |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10558571A Pending JPS5734996B1 (nl) | 1970-12-28 | 1971-12-27 | |
| JP56189857A Granted JPS57150396A (en) | 1970-12-28 | 1981-11-26 | Production of inhibitor for glycoside hydrolyzing enzyme |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US3876766A (nl) |
| JP (3) | JPS5734996B1 (nl) |
| KR (1) | KR780000248B1 (nl) |
| AR (1) | AR193370A1 (nl) |
| AT (1) | AT330122B (nl) |
| AU (1) | AU461521B2 (nl) |
| BE (1) | BE777387A (nl) |
| BG (3) | BG25654A3 (nl) |
| CA (1) | CA979833A (nl) |
| CH (1) | CH594051A5 (nl) |
| CS (1) | CS167961B2 (nl) |
| DD (1) | DD99395A5 (nl) |
| DE (1) | DE2064092C2 (nl) |
| DK (1) | DK139533C (nl) |
| ES (1) | ES398358A1 (nl) |
| FI (1) | FI49774C (nl) |
| FR (1) | FR2120073B1 (nl) |
| GB (1) | GB1374751A (nl) |
| IE (1) | IE35920B1 (nl) |
| IL (1) | IL38441A (nl) |
| LU (1) | LU64319A1 (nl) |
| NL (1) | NL175199C (nl) |
| NO (1) | NO135873C (nl) |
| PL (1) | PL82900B1 (nl) |
| RO (3) | RO63064A (nl) |
| SE (1) | SE398357B (nl) |
| SU (1) | SU454750A3 (nl) |
| ZA (1) | ZA718677B (nl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2209833C3 (de) * | 1972-03-01 | 1978-06-01 | Bayer Ag, 5090 Leverkusen | Herstellung eines Amylaseinhibitors |
| DE2209834C3 (de) * | 1972-03-01 | 1978-04-20 | Bayer Ag, 5090 Leverkusen | Herstellung von Saccharase-Inhibitoren |
| DE2209832C3 (de) * | 1972-03-01 | 1979-03-29 | Bayer Ag, 5090 Leverkusen | Herstellung von Saccharaseinhibitoren |
| US4062950A (en) * | 1973-09-22 | 1977-12-13 | Bayer Aktiengesellschaft | Amino sugar derivatives |
| US4010258A (en) * | 1974-03-15 | 1977-03-01 | Ajinomoto Co., Inc. | Microbial amylase inhibitor and preparation thereof with the use of streptomyces diasticus var. amylostaticus |
| US4065557A (en) * | 1974-03-21 | 1977-12-27 | Bayer Aktiengesellschaft | Amino sugars and their use in improving the meat:fat ratio in animals |
| US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| FR2338707A1 (fr) * | 1976-01-22 | 1977-08-19 | Rhone Poulenc Ind | Nouvel inhibiteur de glyco-hydrolases et sa preparation par culture d'un streptomyces |
| DE2658563A1 (de) * | 1976-12-23 | 1978-06-29 | Bayer Ag | Inhibitoren fuer glykosid-hydrolasen aus bacillen |
| DE2701890C2 (de) * | 1977-01-19 | 1983-08-04 | Hoechst Ag, 6230 Frankfurt | Peptielischer Glycosidhydrolase-Inhibitor aus einem Streptomyceten und seine Verwendung |
| DE2719912C3 (de) * | 1977-05-04 | 1979-12-06 | Bayer Ag, 5090 Leverkusen | Verfahren zur Isolierung von 0- |4,6-Dideoxy-4- [JJl S-O,4,6/5)-4,5,6-trihydroxy-3-hydroxymethyl-2cyclohexen-1-yl] -amino] - a -D-glucopyranosyl} -(I Pfeil nach rechts 4)-0- a D-glucopyranosyl-(l Pfeil nach rechts 4)-D-glucopyranose aus Kulturbrühen |
| GB2016497A (en) * | 1978-02-10 | 1979-09-26 | Taisho Pharmaceutical Co Ltd | Microbiological production of amylase inhibitor |
| CA1121290A (en) * | 1978-02-14 | 1982-04-06 | Yasuji Suhara | Amino sugar derivatives |
| JPS62160696A (ja) * | 1986-01-07 | 1987-07-16 | シャープ株式会社 | 電子式自動点滅器 |
| EP0257418B1 (de) * | 1986-08-13 | 1993-05-19 | Hoechst Aktiengesellschaft | Oxiran-Pseudooligosaccharide, Verfahren zu deren Herstellung, deren Verwendung und pharmazeutische Präparate |
| US5464828A (en) * | 1988-03-02 | 1995-11-07 | Chugai Pharmaceutical Co., Ltd. | Aqueous suspension of sucralfate |
| DE19507214A1 (de) * | 1995-03-02 | 1996-10-31 | Bayer Ag | Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung |
| EP0796915A3 (de) * | 1996-03-22 | 1999-04-14 | Bayer Ag | Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen |
| DE19637591A1 (de) * | 1996-09-13 | 1998-03-19 | Bayer Ag | Osmokontrolliertes Fermentationsverfahren zur Herstellung von Acarbose |
| AU7457300A (en) | 1999-10-28 | 2001-05-08 | Chong Kun Dang Pharmaceutical Corp. | A process for preparing acarbose with high purity |
| HRP20010792A2 (en) | 2001-10-26 | 2003-04-30 | Pliva D D | Acarbose purification process |
| EP2788373B1 (en) | 2011-12-08 | 2019-01-23 | Bayer Intellectual Property GmbH | New actinomycete integrative and conjugative element from actinoplanes sp. se50/110 as plasmid for genetic transformation of related actinobacteria |
| US9345727B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
| US9345741B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
| US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
| US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
| US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
| US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
| EP4045520A1 (en) | 2019-10-16 | 2022-08-24 | Bayer Aktiengesellschaft | Methods for the improved formation of acarbose |
| MX2022011717A (es) | 2020-03-23 | 2022-12-07 | Bay State Milling Company | Prueba rapida de pureza de semilla de trigo con alta amilosa. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3127315A (en) * | 1964-03-31 | Hypocholesterolemic agent m- |
-
1970
- 1970-12-28 DE DE2064092A patent/DE2064092C2/de not_active Expired
-
1971
- 1971-11-23 LU LU64319D patent/LU64319A1/xx unknown
- 1971-12-22 AU AU37214/71A patent/AU461521B2/en not_active Expired
- 1971-12-23 CS CS8961A patent/CS167961B2/cs unknown
- 1971-12-23 GB GB5993971A patent/GB1374751A/en not_active Expired
- 1971-12-23 CA CA130,969A patent/CA979833A/en not_active Expired
- 1971-12-23 SU SU1728264A patent/SU454750A3/ru active
- 1971-12-23 IE IE1639/71A patent/IE35920B1/xx unknown
- 1971-12-24 RO RO7100081898A patent/RO63064A/ro unknown
- 1971-12-24 RO RO9182*[A patent/RO61400A/ro unknown
- 1971-12-24 BG BG7100019320A patent/BG25654A3/xx unknown
- 1971-12-24 RO RO7181890A patent/RO63065A/ro unknown
- 1971-12-24 IL IL7138441A patent/IL38441A/xx unknown
- 1971-12-24 AT AT1111571A patent/AT330122B/de not_active IP Right Cessation
- 1971-12-27 FI FI713687A patent/FI49774C/fi active
- 1971-12-27 SE SE7116662A patent/SE398357B/xx unknown
- 1971-12-27 ES ES398358A patent/ES398358A1/es not_active Expired
- 1971-12-27 JP JP10558571A patent/JPS5734996B1/ja active Pending
- 1971-12-27 NO NO4841/71A patent/NO135873C/no unknown
- 1971-12-27 NL NLAANVRAGE7117893,A patent/NL175199C/nl not_active IP Right Cessation
- 1971-12-27 DK DK635371A patent/DK139533C/da not_active IP Right Cessation
- 1971-12-27 CH CH1899471A patent/CH594051A5/xx not_active IP Right Cessation
- 1971-12-27 PL PL1971152512A patent/PL82900B1/pl unknown
- 1971-12-27 KR KR7101871A patent/KR780000248B1/ko active
- 1971-12-27 DD DD159932A patent/DD99395A5/xx unknown
- 1971-12-28 BE BE777387A patent/BE777387A/xx not_active IP Right Cessation
- 1971-12-28 ZA ZA718677A patent/ZA718677B/xx unknown
- 1971-12-28 US US213066A patent/US3876766A/en not_active Expired - Lifetime
- 1971-12-28 AR AR239846A patent/AR193370A1/es active
- 1971-12-28 FR FR7147019A patent/FR2120073B1/fr not_active Expired
-
1973
- 1973-11-26 BG BG7325075A patent/BG26003A4/xx unknown
- 1973-11-26 BG BG7325074A patent/BG26002A4/xx unknown
-
1981
- 1981-11-26 JP JP56189857A patent/JPS57150396A/ja active Granted
- 1981-11-26 JP JP56189856A patent/JPS57150395A/ja active Granted
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