GB1374751A - Enzyme inhibitors of microbial origin - Google Patents

Enzyme inhibitors of microbial origin

Info

Publication number
GB1374751A
GB1374751A GB5993971A GB5993971A GB1374751A GB 1374751 A GB1374751 A GB 1374751A GB 5993971 A GB5993971 A GB 5993971A GB 5993971 A GB5993971 A GB 5993971A GB 1374751 A GB1374751 A GB 1374751A
Authority
GB
United Kingdom
Prior art keywords
incubated
dec
reaction mixture
enzyme inhibitors
microbial origin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5993971A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB1374751A publication Critical patent/GB1374751A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/896—Streptomyces fradiae
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/907—Streptosporangium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

1374751 Testing enzymes BAYER AG 23 Dec 1971 [28 Dec 1970 24 Sept 1971] 59939/71 Heading G1B [ Also in Divisions A5 and C3] The following methods of testing enzyme potency are disclosed. Amylase and saccharase are incubated in starch and sucrose solutions, respectively, and the reaction mixture is treated with dinitrosalicylic acid and the colour produced evaluated. Maltase is incubated with p-nitrophenyl -α-D-glucopyranoside in solution and the amount of p-nitrophenolute in the reaction mixture is determined photometrically. The tests are used to ascertain the inhibiting effect of the micro-biologically produced, glycosidehydrolase inhibitors described and claimed.
GB5993971A 1970-12-28 1971-12-23 Enzyme inhibitors of microbial origin Expired GB1374751A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2064092A DE2064092C2 (en) 1970-12-28 1970-12-28 Actinomycete glycoside hydrolase inhibitors

Publications (1)

Publication Number Publication Date
GB1374751A true GB1374751A (en) 1974-11-20

Family

ID=5792372

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5993971A Expired GB1374751A (en) 1970-12-28 1971-12-23 Enzyme inhibitors of microbial origin

Country Status (28)

Country Link
US (1) US3876766A (en)
JP (3) JPS5734996B1 (en)
KR (1) KR780000248B1 (en)
AR (1) AR193370A1 (en)
AT (1) AT330122B (en)
AU (1) AU461521B2 (en)
BE (1) BE777387A (en)
BG (3) BG25654A3 (en)
CA (1) CA979833A (en)
CH (1) CH594051A5 (en)
CS (1) CS167961B2 (en)
DD (1) DD99395A5 (en)
DE (1) DE2064092C2 (en)
DK (1) DK139533C (en)
ES (1) ES398358A1 (en)
FI (1) FI49774C (en)
FR (1) FR2120073B1 (en)
GB (1) GB1374751A (en)
IE (1) IE35920B1 (en)
IL (1) IL38441A (en)
LU (1) LU64319A1 (en)
NL (1) NL175199C (en)
NO (1) NO135873C (en)
PL (1) PL82900B1 (en)
RO (3) RO61400A (en)
SE (1) SE398357B (en)
SU (1) SU454750A3 (en)
ZA (1) ZA718677B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2209832C3 (en) * 1972-03-01 1979-03-29 Bayer Ag, 5090 Leverkusen Manufacture of saccharase inhibitors
DE2209834C3 (en) * 1972-03-01 1978-04-20 Bayer Ag, 5090 Leverkusen Manufacture of saccharase inhibitors
DE2209833C3 (en) * 1972-03-01 1978-06-01 Bayer Ag, 5090 Leverkusen Manufacture of an amylase inhibitor
US4062950A (en) * 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
US4010258A (en) * 1974-03-15 1977-03-01 Ajinomoto Co., Inc. Microbial amylase inhibitor and preparation thereof with the use of streptomyces diasticus var. amylostaticus
US4065557A (en) * 1974-03-21 1977-12-27 Bayer Aktiengesellschaft Amino sugars and their use in improving the meat:fat ratio in animals
US4065562A (en) * 1975-12-29 1977-12-27 Nippon Shinyaku Co., Ltd. Method and composition for reducing blood glucose levels
FR2338707A1 (en) * 1976-01-22 1977-08-19 Rhone Poulenc Ind NEW GLYCO-HYDROLASE INHIBITOR AND ITS PREPARATION BY CULTURE OF A STREPTOMYCES
DE2658563A1 (en) * 1976-12-23 1978-06-29 Bayer Ag Glucoside hydrolase inhibitors prodn. from bacteria - esp. Bacillus species useful, e.g., for increasing meat yields and feed efficiency
DE2701890C2 (en) * 1977-01-19 1983-08-04 Hoechst Ag, 6230 Frankfurt Streptomycete peptic glycoside hydrolase inhibitor and its use
DE2719912C3 (en) * 1977-05-04 1979-12-06 Bayer Ag, 5090 Leverkusen Process for the isolation of 0- | 4,6-dideoxy-4- [JJl SO, 4,6 / 5) -4,5,6-trihydroxy-3-hydroxymethyl-2cyclohexen-1-yl] -amino] - a - D-glucopyranosyl} - (I right arrow 4) -0- a D-glucopyranosyl- (l right arrow 4) -D-glucopyranose from culture broths
GB2016497A (en) * 1978-02-10 1979-09-26 Taisho Pharmaceutical Co Ltd Microbiological production of amylase inhibitor
CA1121290A (en) * 1978-02-14 1982-04-06 Yasuji Suhara Amino sugar derivatives
JPS62160696A (en) * 1986-01-07 1987-07-16 シャープ株式会社 Electronic automatic flicker
EP0257418B1 (en) * 1986-08-13 1993-05-19 Hoechst Aktiengesellschaft Oxirane-pseudo-oligosaccharides, process for their synthesis, their use and pharmaceutical preparations
US5464828A (en) * 1988-03-02 1995-11-07 Chugai Pharmaceutical Co., Ltd. Aqueous suspension of sucralfate
DE19507214A1 (en) * 1995-03-02 1996-10-31 Bayer Ag Acarbose biosynthesis genes from Actinoplanes sp., Process for their isolation and their use
EP0796915A3 (en) * 1996-03-22 1999-04-14 Bayer Ag Process for the preparation and use of acarviosyl-transferase in the conversion of ascarbose-homologous in acarbose and in the preparation of acarbose-homologous
DE19637591A1 (en) * 1996-09-13 1998-03-19 Bayer Ag Osmocontrolled fermentation process for the production of acarbose
JP3992497B2 (en) 1999-10-28 2007-10-17 チョン・クン・ダン・ファーマシューティカル・コーポレーション High purity acarbose manufacturing method
HRP20010792A2 (en) 2001-10-26 2003-04-30 Pliva D D Acarbose purification process
KR20140109922A (en) 2011-12-08 2014-09-16 바이엘 인텔렉쳐 프로퍼티 게엠베하 New actinomycete integrative and conjugative element from actinoplanes sp. se50/110 as plasmid for genetic transformation of related actinobacteria
US9345741B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
US9345727B2 (en) 2013-03-15 2016-05-24 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component and uses thereof
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
KR20220081991A (en) 2019-10-16 2022-06-16 바이엘 악티엔게젤샤프트 Method for improved formation of acarbose
CA3172525A1 (en) 2020-03-23 2021-09-30 Tanya Jeradechachai Rapid high amylose wheat seed purity test

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3127315A (en) * 1964-03-31 Hypocholesterolemic agent m-

Also Published As

Publication number Publication date
FI49774B (en) 1975-06-30
JPS57150395A (en) 1982-09-17
LU64319A1 (en) 1972-06-13
ATA1111571A (en) 1975-09-15
SE398357B (en) 1977-12-19
FI49774C (en) 1975-10-10
RO63065A (en) 1979-02-15
AR193370A1 (en) 1973-04-23
ZA718677B (en) 1972-09-27
CS167961B2 (en) 1976-05-28
US3876766A (en) 1975-04-08
ES398358A1 (en) 1974-09-01
NL7117893A (en) 1972-06-30
JPS6216638B2 (en) 1987-04-14
DE2064092A1 (en) 1972-07-20
AU3721471A (en) 1973-09-27
CH594051A5 (en) 1977-12-30
BG26003A4 (en) 1979-01-12
IL38441A (en) 1974-10-22
KR780000248B1 (en) 1978-07-06
DK139533C (en) 1979-08-20
FR2120073B1 (en) 1975-12-26
BG26002A4 (en) 1979-01-12
NO135873B (en) 1977-03-07
FR2120073A1 (en) 1972-08-11
NL175199B (en) 1984-05-01
JPS5734996B1 (en) 1982-07-26
RO63064A (en) 1978-06-15
DK139533B (en) 1979-03-05
RO61400A (en) 1977-01-15
BE777387A (en) 1972-06-28
DD99395A5 (en) 1973-08-05
IE35920B1 (en) 1976-06-23
IE35920L (en) 1972-06-28
SU454750A3 (en) 1974-12-25
DE2064092C2 (en) 1983-06-01
AU461521B2 (en) 1975-05-29
NL175199C (en) 1984-10-01
JPS57150396A (en) 1982-09-17
CA979833A (en) 1975-12-16
BG25654A3 (en) 1978-11-10
JPS6234396B2 (en) 1987-07-27
AT330122B (en) 1976-06-10
IL38441A0 (en) 1972-02-29
NO135873C (en) 1977-06-15
PL82900B1 (en) 1975-10-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee