JPS6188883A - 発現系におけるタンパク質輸送のための合成シグナル配列 - Google Patents

発現系におけるタンパク質輸送のための合成シグナル配列

Info

Publication number
JPS6188883A
JPS6188883A JP60221120A JP22112085A JPS6188883A JP S6188883 A JPS6188883 A JP S6188883A JP 60221120 A JP60221120 A JP 60221120A JP 22112085 A JP22112085 A JP 22112085A JP S6188883 A JPS6188883 A JP S6188883A
Authority
JP
Japan
Prior art keywords
signal sequence
dna
sequence
natural
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP60221120A
Other languages
English (en)
Japanese (ja)
Inventor
ヨアヒム、エンゲルス
ミヒヤエル、ライネベーバー
オイゲン、ウールマン
バルデマール、ベテカム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPS6188883A publication Critical patent/JPS6188883A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP60221120A 1984-10-06 1985-10-03 発現系におけるタンパク質輸送のための合成シグナル配列 Pending JPS6188883A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3436818.3 1984-10-06
DE19843436818 DE3436818A1 (de) 1984-10-06 1984-10-06 Synthetische signalsequenz zum transport von proteinen in expressionssystemen

Publications (1)

Publication Number Publication Date
JPS6188883A true JPS6188883A (ja) 1986-05-07

Family

ID=6247347

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60221120A Pending JPS6188883A (ja) 1984-10-06 1985-10-03 発現系におけるタンパク質輸送のための合成シグナル配列

Country Status (15)

Country Link
EP (1) EP0177827B1 (enExample)
JP (1) JPS6188883A (enExample)
AT (1) ATE97445T1 (enExample)
AU (1) AU595486B2 (enExample)
CA (1) CA1340280C (enExample)
DE (2) DE3436818A1 (enExample)
DK (1) DK175511B1 (enExample)
ES (1) ES8605579A1 (enExample)
GR (1) GR852405B (enExample)
HU (1) HU197355B (enExample)
IE (1) IE63262B1 (enExample)
IL (1) IL76573A (enExample)
NZ (1) NZ213717A (enExample)
PH (1) PH30819A (enExample)
PT (1) PT81253B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0196864A3 (en) * 1985-03-25 1988-03-23 Cetus Corporation Alkaline phosphatase-mediated processing and secretion of recombinant proteins, dna sequences for use therein and cells transformed using such sequences
IT1196484B (it) * 1986-07-11 1988-11-16 Sclavo Spa Vettore ad espressione e secrezione in lieviti,utile per la preparazione di proteine eterologhe
US5426036A (en) * 1987-05-05 1995-06-20 Hoechst Aktiengesellschaft Processes for the preparation of foreign proteins in streptomycetes
DE68917759T2 (de) * 1988-03-18 1995-04-27 Wang Laboratories Verteilte Referenz- und Änderungstabelle für ein virtuelles Speichersystem.
US20070020630A1 (en) 2003-03-27 2007-01-25 Trotta Christopher R Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
WO2004087070A2 (en) 2003-03-27 2004-10-14 Ptc Therapeutics, Inc. METHODS OF IDENTIFYING COMPOUNDS THAT TARGET tRNA SPLICING ENDONUCLEASE AND USES OF SAID COMPOUNDS AS ANTI-FUNGAL AGENTS
JP4990621B2 (ja) 2003-07-02 2012-08-01 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａプロセシングタンパク質複合体及びその使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5939899A (ja) * 1982-08-27 1984-03-05 Gakuzo Tamura 新規ベクタ−
US4711844A (en) * 1983-03-09 1987-12-08 Cetus Corporation Modified signal peptides
NZ207925A (en) * 1983-04-25 1988-05-30 Genentech Inc Yeast expression vehicle consisting of a yeast promoter and signal peptide encoding region linked to a heterologus peptide coding region; expression and culture
US4663280A (en) * 1983-05-19 1987-05-05 Public Health Research Institute Of The City Of New York Expression and secretion vectors and method of constructing vectors
AU3011684A (en) * 1983-05-19 1984-12-04 Public Health Research Institute Of The City Of New York, Inc., The Expression and secretion vectors & method of constructing vectors
JPS6030687A (ja) * 1983-08-01 1985-02-16 Wakunaga Seiyaku Kk Ｄνａ遺伝子，その製造法およびそれを含むプラスミド
DE3587205T2 (de) * 1984-07-30 1993-08-26 Wakunaga Seiyaku Kk Verfahren zur herstellung eines proteins und dafuer zu verwendender vektor, rekombinante dns und transformierte zelle.

Also Published As

Publication number Publication date
DE3587660D1 (de) 1993-12-23
IE852440L (en) 1986-04-06
EP0177827B1 (de) 1993-11-18
AU4833385A (en) 1986-04-10
DE3436818A1 (de) 1986-04-10
DK453285A (da) 1986-04-07
ATE97445T1 (de) 1993-12-15
EP0177827A2 (de) 1986-04-16
CA1340280C (en) 1998-12-22
ES547600A0 (es) 1986-03-16
IL76573A (en) 1992-06-21
HU197355B (en) 1989-03-28
HUT40164A (en) 1986-11-28
EP0177827A3 (en) 1987-12-02
DK453285D0 (da) 1985-10-04
NZ213717A (en) 1989-01-06
AU595486B2 (en) 1990-04-05
IE63262B1 (en) 1995-04-05
PH30819A (en) 1997-10-17
DK175511B1 (da) 2004-11-15
GR852405B (enExample) 1986-02-04
ES8605579A1 (es) 1986-03-16
PT81253B (pt) 1987-11-30
PT81253A (de) 1985-11-01
IL76573A0 (en) 1986-02-28

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